The Ho Lab at Yale University School of Medicine (https://medicine.yale.edu/lab/yachiho/) is recruiting motivated, productive, independent, and collegial postdocs interested in viral infection, T cell immunology, mucosal immunology, and cancer immunology using animal models and single-cell multiomics/spatial transcriptomics approaches. This postdoctoral researcher will combine wet-lab molecular biology methods, dry-lab bioinformatic analysis, and a translational approach using clinical samples, including blood and tissue samples from people with HIV. This postdoctoral researcher may also be mechanistic interrogations using models, such as conditional knock-out or CRISPR-mediated targeted insertion. The goal is to understand T cell homeostasis in the context of viral infection, chronic infection, mucosal immunology in the gut, cancer, and autoimmune diseases.
Scope of work
The postdoctoral training may involve (a) the development and application of innovative single-cell RNAseq methods, (b) bioinformatic analysis of single-cell genomics datasets, (c) a translational approach using blood or tissue samples from humans, (d) wet-lab methods in virology (such as sterile cell culture in an enhanced biosafety level 2 (BSL2+) lab), immunology (such as flow cytometry and CAR-T engineering), molecular biology (such as CRISPR, RNA biology), or animal models, (e) collaboration with other researchers both inside and outside of Yale, including virologists, immunologists, bioinformaticians, computer scientists, and clinicians, (f) presentation in international conferences, and (g) manuscript preparation and grant applications.
Training opportunity
Funded by several NIH grants (R01, U01, and P01), our lab provides a collaborative environment and multi-disciplinary training for scientific and career development from virology, single-cell genomics, bioinformatics, immunology, to translational research. Our lab has a track record of training postdoctoral researchers: our postdocs have international conference presentations, New Investigator Awards, pilot grants, and first-authored original articles.
Qualifications
The successful applicant should be driven by scientific curiosity, be able to ask important questions, with a track record of in-depth mechanistic interrogations evidence by publications. A successful candidate will likely have
(a) a recent (<4 years) PhD degree in microbiology, immunology, genomics, genetics, molecular biology, bioinformatics, or a related discipline;
(b) a track record of research productivity, as evidenced by first-authored original publication(s) in high-quality peer-reviewed journals;
(c) experience or interests in programming languages such as R or python;
(d) willingness to work with HIV+ samples following BSL2+ procedures;
(e) willingness to work with mouse models;
(f) independence to lead a project as well as willingness to work in a team;
(g) an open mind to learn new methods from junior researchers and collaborators;
(h) good scientific presentation and writing skills. Current PhD students who will graduate by summer 2026 are encouraged to apply.
Applicants with prior experience in mammalian cell culture, mouse models, or bioinformatics are preferred. People seeking dry-lab only positions should not apply. We are not able to sponsor work visa categories at this time. Salary will be commensurate with experience and qualifications based on Yale University regulations, starting at $68,500 per year.
Applications will be reviewed on a rolling basis until the positions are filled. Interested candidates may send applications to ya-chi.ho@yale.edu with
(a) CV,
(b) personal statement, describing the scientific part of this lab that interests the applicant,
(c) contact info of 3 referees.