Yale Postdoctoral Positions

Yale University’s Nondiscrimination/Title IX Statements

Thank you for investigating postdoctoral opportunities at Yale.  Many faculty do not advertise open positions in their research groups, and you are encouraged to contact them directly to inquire about the possibility of training with them.  Other faculty advertise open positions in scholarly journals in their fields.  Finally, some post job openings on the Provost’s Office Academic Job listings and our website, listed below.  Please click the links below to read more about each position and to find contact information for applying for the job.

Once you find a postdoctoral position your Yale department will contact you to begin the formal hiring process and to assist you in applying for an immigration visa to enter the United States if you require one.  Information about the visa process may be found at the Yale Office of International Students and Scholars website.

Postdoctoral Appointees Compensation and Benefits.

In accordance with university requirements for a safe return to in-person university operations, all faculty, staff, and postdoctoral and postgraduate trainees will be required to be fully vaccinated against COVID-19 before their first day. For additional information, please visit Yale University’s Office of the President . Read Here.

Postdoctoral Associate Position (Garg Lab, Department of Laboratory Medicine)
Posting Date: June 1, 2023

 A postdoctoral position is available in the laboratory of Dr. Salil Garg (https://medicine.yale.edu/profile/salil_garg/), Assistant Professor in the Yale School of Medicine.  The Garg laboratory (http://www.garglab.org) is new to Yale and actively recruiting for multiple positions.  The lab uses approaches from genomics, molecular biology, cell biology, bioinformatics, and systems biology to understand non-genetic heterogeneity in development and cancer.  We want to understand how cell systems with the same genetic material break symmetry and generate cells with markedly different behaviors from one another.  Our hypothesis is that the processes that drive this behavior in normal mammalian development operate in cancer, driving tumor heterogeneity.  The lab’s most recent publications appear in Molecular Cell and Cancer Discovery, and mentees have gone on to success in both academic and industry careers.

Qualified applicants will have a Ph.D., M.D., or equivalent credential in a relevant discipline.  The lab employs both experimental and computational approaches; applicants should have familiarity with at least one of these areas and a willingness to learn the other.  Our philosophy is that each trainee should chase scientific questions using the best methodology available.  Candidates should be curious, hard-working, strong communicators, and above all interested in answering challenging questions.  Visa sponsorship is available.

Projects are flexible and can be crafted to the interest of the applicant, and may relate to 1) identification of molecular mechanisms driving heterogeneity in developmental or cancer contexts; 2) understanding of cellular states and non-genetic memory in cell systems; 3) construction of new diagnostic tools using connections between developmental biology and cancer.

Application process:  Interested applicants should contact Dr. Salil Garg (salil.garg@yale.edu) using subject line “Postdoctoral position in the Garg lab” and include: a cover letter addressing their research background, interests, and goals; a copy of their curriculum vitae; and names of 3 references including research supervisors.  Yale University is an equal opportunity employer and values diversity in its faculty, students, and staff.

Postdoctoral Position, Yale School of Public Health, Modeling Antimicrobial-Resistant Gonorrhea
Posting Date: June 1, 2023

Applications are welcomed for a NIH-funded postdoctoral position, available immediately. The successful candidate will have the opportunity to lead projects broadly related to optimizing efforts to control antimicrobial-resistant (AMR) gonorrhea. This includes, but is not limited to, modeling the transmission dynamics of AMR gonorrhea within and between different population groups, optimizing the surveillance of AMR gonorrhea through adaptive sampling, and evaluating the cost-effectiveness of public health strategies to control AMR gonorrhea. The successful applicant will also have the opportunity to engage in other public health related problems including adaptive response to novel viral pathogen outbreaks and mitigating drug-resistant tuberculosis epidemics in high-burden settings.

The successful applicant will be expected to participate as lead author in publications arising from this work and to communicate findings in oral presentations at national and international conferences. Strong emphasis will be placed on career development, communication skills, grantsmanship, and interdisciplinary research.

This project is an integral element of a joint research program of investigators at Yale School of Public Health, Harvard T.H. Chan School of Public Health, and the Stanford Center for Health Policy. Our team of investigators includes decision scientists, infectious disease epidemiologists, health economists, and operations researchers.

We are seeking candidates who are willing to commit to 2 years of work on this project.

Qualifications and Skills

  • Doctoral degree in Infectious Disease Modeling, Epidemiology, Operations Research, Applied Mathematics, Computational Biology, Ecology, Evolutionary Biology, Statistics, Biostatistics, Computer Science, or related quantitative disciplines.
  • While not essential, previous experience with transmission dynamic models of infectious diseases of humans or animals and agent-based modeling is ideal.
  • Strong background in mathematical/simulation models, statistics, probability, and numerical analysis.
  • Strong programming skills.

Benefit and Compensation Information

We offer a competitive salary. Compensation will be commensurate with experience.

To apply

Please submit a cover letter along with an updated resume or CV with contact information for 3 professional references and apply online at http://apply.interfolio.com/126050. 

For any additional information, please contact Associate Professor Reza Yaesoubi, Department of Health Policy and Management, Yale School of Public Health (reza.yaesoubi@yale.edu).

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Postdoctoral Associate - School of Medicine Nephrology, Chang lab
Posting Date: May 30, 2023

Yale University

School of Medicine

Department of Internal Medicine

SECTION OF NEPHROLOGY

POSTDOCTORAL RESEARCH ASSOCIATE Position

Yale School of Medicine is seeking a highly motivated Postdoctoral Research Associate interested in tissue engineering to join the laboratory of William G. Chang MD, PhD. The lab has ongoing research projects focusing on kidney tissue engineering. Candidates with experience in tissue engineering, cell/molecular biology, kidney research, or small animal surgical models are encouraged to apply.  Applicants for the position should have obtained a PhD, MD, DVM in a life science, biomedical engineering, medical, surgical, or veterinary field prior to starting. The postdoctoral training will involve tissue engineering, imaging, animal model systems, and statistical analyses.

Application materials (brief statement of scientific goals and CV/resume) should be submitted electronically to Dr. Chang (w.chang@yale.edu). Review of applications will begin immediately and will continue until the position is filled.

Yale University is an affirmative action/equal opportunity employer and welcomes applications from women, persons with disabilities, protected veterans, and members of minority groups.

Postdoctoral Appointment - Comparative Virology, Depart of Comparative Medicine, School of Medicine
Posting Date: May 30, 2023

Job Overview

Postdoctoral Fellowship in Comparative Virology in the Department of Comparative Medicine.   

The candidate will conduct comparative and evolutionary virology studies in support of development of a coronaviral surveillance system in the Northeastern USA. This work will comprise a multidisciplinary effort involving surveillance across multiple wild and domestic mammalian species, cross-species transmission experiments in a Biosafety Level 3 setting and development of predictive SEIR (Susceptible - Exposed - Infectious - Recovered) models to assess risk of animal to human SARS-CoV-2 spillback risk.

Qualifications and Responsibilities

  1. Hands-on experience with molecular biology and virology techniques is required: recombinant DNA techniques, RNA isolation, RT-PCR, sequence analysis etc.
  2. Familiarity with diverse software packages for cloning, primer design, as well as sequence alignment of novel and known coronaviruses obtained from a variety of mammalian species. 
  3. Proficient in mammalian cell culture techniques such as microscopy, transfection, virus propagation and amplification.
  4. Operate standard laboratory and experimental equipment.  
  5. Assume an increasing trajectory of project responsibility in preparation for an   independent research career. Components include routinely tracking and documenting results in laboratory notebooks and databases, analysis, summarization and presentation of experimental results to other team members, active participation in manuscript preparation and publication.
  6. Biosafety Level 3 experience or interest is desirable.
  7. Experience or interest in viral evolution in mammalian hosts is desirable.

EDUCATION REQUIREMENT:

Ph.D. in virology, microbiology or related discipline

TO APPLY: Please send a short description of interest and relevant qualifications, and a curriculum vitae to Caroline Zeiss (caroline.zeiss@yale.edu)

Yale University is committed to employment of individuals based upon their qualifications and abilities and affirmatively seeks to attract to its faculty, staff, and student body qualified persons of diverse backgrounds. The University policy is committed to affirmative action under law in employment of women, minority group members, individuals with disabilities, special disabled veterans, veterans of the Vietnam era, and other covered veterans.

Postdoctoral Fellowship in the Yale Civic Thought Initiative
Posting Date: May 25, 2023

The Civic Thought Initiative at Yale University has one opening for a a postdoctoral fellow during the 2023-2024 academic year. The Fellow would be expected to teach three undergraduate seminar courses in the history of political thought and to help organize discussions and events for undergraduates and faculty. The Fellow would also be encouraged to join the Political Theory Workshop and become an integral member of the political theory community.

Applicants must have a PhD in political theory or a closely related field and evidence of strong teaching abilities.

Review of applications will begin immediately and occur on a rolling basis until the position is filled. Applicants are encouraged to send (1) a cover letter with a brief description of their interests in the position, (2) a resume/CV, (3) one representative manuscript/publication, and (4) contacts for two professional references by email to bryan.garsten@yale.edu.

Postdoctoral Associate, Molecular Virology with Daniel DiMaio
Posting Date: May 23, 2023

The laboratory of Daniel DiMaio, M.D., Ph.D., in the Department of Genetics is seeking a postdoctoral researcher in molecular virology. We study tumor viruses to determine the mechanistic basis of fundamental biological processes and to develop new strategies to inhibit tumor virus infection and the cancers they cause.Because viruses are dependent on cellular machinery for all phases of their life cycle, they historically have been valuable tools to study many aspects of biology. Our lab focuses on human papillomaviruses (HPV), which cause approximately 5% of all human cancer. Our prior studies revealed a novel mechanism of growth factor receptor activation by a viral oncoprotein, provided the first example of oncogene addiction, designed artificial proteins with unprecedented chemical simplicity, described the first clear biological role of cell-penetrating peptides, and discovered that some proteins can act in a manner independent of their amino acid sequence. Our main current focus is the complex process by which HPV enters cells, which we study to discover new principles of cell biology and biochemistry. These studies many also lead to new approaches to inhibit virus infection and cancer formation. Our laboratory seeks to hire a highly motivated postdoctoral associate with expertise in virology, molecular and cellular biology, and/or biochemistry. Potential projects include structure-function analysis of HPV proteins involved in virus entry, development of a novel system to propagate infectious HPV pseudoviruses, and mechanistic studies of cellular proteins that are required for virus entry. Major experimental approaches include cell culture, virus propagation and infection, mutant construction and analysis, protein expression and purification, and imaging techniques in cultured cells.

Representative publications:

Heim, E., Marston, J., Federman, R., Edwards, A. B., E., Karabadzhak, A., Petti, L.M., Engelman, D.M., and DiMaio, D.  (2015) Biologically active LIL proteins built with minimal chemical diversity. Proc. Natl Acad. Sci. USA, doi:10.1073/pnas.1514230112.

Zhang, P., Monteiro da Silva, G., Deatherage, C., Burd, C., and DiMaio, D. (2018) Cell-penetrating peptide mediates intracellular membrane passage of human papillomavirus L2 protein to trigger retrograde trafficking. Cell, 174: 1465-1476. doi10.1016/j.cell.2018.07.031.

Xie, J., Zhang, P., Crite, M., and DiMaio, D. (2021) Retromer stabilizes membrane insertion of the L2 capsid protein during retrograde HPV entry. Science Advances, doi: 10.1126/sciadv.abh4276. PMID: 34193420

Oh, C., Buckley, P., Choi, J., Herrero, A., and DiMaio, D. (2023) Sequence independent activity of a long disordered segment of the human papillomavirus L2 capsid protein during virus entry. bioRxiv 2023.03.21.533711.

The successful candidate will have a doctoral degree and publication record in biochemistry, cell or molecular biology, virology, or a related field and will receive further training on how to conceptualize, design, conduct, and interpret hypothesis-driven experiments to address important issues in biology. The candidate should be self-motivated and eager to learn new techniques and should display a high level of independence and good problem solving and interpersonal skills. Interested candidates should send an email to daniel.dimaio@yale.edu including a CV, a cover letter with a brief description of research interests and how they align with the lab, and email addresses of two or three referees.

Postdoctoral Position, Microbial Pathogenesis, Yale University School of Medicine, The Vinetz Laboratory
Posting Date: May 22, 2023

The Vinetz Laboratory in the Section of Infectious Diseases is seeking postdoctoral candidates interested in 1) biotechnology of vaccines; and 2) studying mechanisms of leptospirosis pathogenesis in animal models. Our lab provides exceptional basic science and translational research environment, with direct connections to tropical disease endemic field sites.

Candidates with experience in molecular biology, recombinant protein expression (bacterial, insect, algae, mammalian cells), protein purification using various chromatographic methods, flow cytometry, confocal microscopy, immunology and small animal models of infectious disease pathogenesis are encouraged to apply. Ideal candidates should have a combination of skills in biotechnology, protein engineering/purification/characterization, immunology, molecular biology and genomic analysis. Excellent communication and writing skills are essential for this position.

Salary is based on research experience and on published university norms:

https://postdocs.yale.edu

https://postdocs.yale.edu/policies/postdoc-compensation.

Interested applicants should send a CV, cover letter describing research interest, your reasons to apply to my lab including long-term career goals, and names/contact information for 3 references to joseph.vinetz@yale.edu. Very important is a demonstrated, published track record of success in a combination of the above skills.

Yale University is an Affirmative Action/Equal Opportunity Employer and welcomes applications from women, members of minority groups, persons with disabilities and protected veterans

Postdoctoral Associate, Extrachromosomal DNA in Cancer (Verhaak lab)
Posting Date: May 22, 2023

The Verhaak lab is looking to recruit a postdoctoral associate who will help us understand how oncogenic extrachromosomal DNA elements contribute to tumor evolution. The ideal candidate has experience with functional interrogation of cell line models via genetic engineering approaches and cancer biology. Previous work with high-throughput approaches is desirable. First author peer-reviewed papers are required.

The Verhaak lab is a hybrid dry and wet lab allowing us to generate and analyze complex data from emerging technologies including high-throughput 3D content screens, live cell tracking of extrachromosomal DNA, and single cell genomics/proteomics to better answer our biologically-driven questions. Candidates will be able to pursue studies on the behavior of extrachromosomal DNA in cancer, and to participate in the activities of Cancer Grand Challenge eDynamic Consortium.

We offer a supportive environment that is highly conducive to effectively working towards a great future. If you are a PhD-level or MD-level scientist with first author publications and an interest in cancer genomics, we strongly encourage you to apply. Gender parity and diversity in thought, beliefs, and backgrounds in the lab lead to better, more thoughtful science. We welcome applicants from all backgrounds. We place greater emphasis on your ambition and curiosity to confront some of formidable questions in cancer evolution than your current skillset.  The goal of your postdoc is to help you achieve your career goal(s), including the ability to develop computational skills, and as evidenced by the many alumni who successfully started their own laboratories. Please take look at our lab website: www.verhaaklab.com to learn more about our recent news and get to know our team members.

Qualifications

  1. MD or PhD in genetics, molecular/cell biology, cancer biology.
  2. Track record of productivity supported by first-author publication(s) in peer-reviewed journals.
  3. Outstanding writing and communication skills, with an ability to work both independently and within collaborative teams productively.

Click here to apply for this position, or email Roel with questions.

For questions regarding available training opportunities, please contact Roel.

Postdoctoral Position Agent-Based Model Development for Environmental and Archaeological Applications
Posting Date: 5/18/23

Postdoctoral Position Agent-Based Model Development for Environmental and Archaeological Applications

The Yale Paleoarchaeology Laboratory seeks to fill a one-year postdoctoral position for a project entitled “Modelling the Evolution and Future of the Zambezian Biome”. The aim of the project is to develop and deploy agent-based (or generative) models to understand human-environment interactions in the Zambezian Biome of southern-central Africa over the last ~30,000 years. The position is funded through a Yale Bioscience Postdoctoral Fellowship, and will begin on 1 September 2023.

The time period under study spans the global climatic transition from the Last Glacial Maximum into the Holocene ca. 11,500 years ago, as well as the regional economic transition of humans from hunter-gatherers to food producers ca. 2,000-3,000 years ago. The goal is to understand the changing resource landscape for ancient humans across those transitions, as well as potentially the iterative environmental impacts of those same humans on available resources. Ultimately, these models will provide testable hypotheses for interpreting the archaeological and paleoenvironmental records relevant to reconstructing ancient human social organization. They will also inform development of strategies for mitigating paired human-climate impacts on environments in the region, by identifying where and under what conditions ecosystem tipping points may be anticipated.

One year of this two-year project has already been completed. Therefore, the incoming candidate will build on existing data and code structure, but the position will not be renewable for a second year. The successful candidate will publish results from this project collaboratively with the PI (Dr. Jessica Thompson), the initial model developer Dr. Benjamin Davies (Tufts University), and other contributors. They are also encouraged to use this opportunity to advance their own independent scholarly profile and will receive mentorship on research, job searches, and other related academic professional development.

The appointment will be as a Postdoctoral Associate. Compensation and benefits are outlined at the Office for Postdoctoral Affairs. The candidate must be physically present in New Haven and will receive office space in the Department of Anthropology. In addition to resources through the Yale library system, the candidate will have access to any necessary resources for the project through the Yale Center for Research Computing: https://docs.ycrc.yale.edu/.

Required Qualifications

  • PhD within the last 4 years in Anthropology, Environmental Science, Ecology, Archaeology, or a related field
  • Demonstrated experience with code development and application in agent-based models
  • Expertise in human behavioral ecology, optimal foraging theory, and/or paleoecology

Preferred Qualifications

  • Familiarity with Paleolithic archaeology
  • Expertise on the ecological context of ancient Africa

Qualified candidates should email a cover letter of no more than two pages, a CV, and a list of contact details for three references to Dr. Jessica Thompson at jessica.thompson@yale.edu. Review of applications will begin on 1 June 2023 and continue until the position is filled.

Postdoctoral Researcher in Immunology
Posting Date: May 16, 2023

Overview

The laboratory of Dr. Wei Hu at Yale University School of Medicine seeks two postdoctoral researchers.

The Hu Lab, located at the Yale University West Campus (West Haven, Connecticut), is jointly affiliated with the Department of Immunobiology and the Institute of Biomolecular Design and Discovery (IBDD), with an interdisciplinary focus on immunology and chemical biology. The lab will develop and utilize novel genetic, biochemical, and chemical biological tools to probe the biology of regulatory T cells in various physiological and pathological settings, such as infection, autoimmunity, cancer, and transplantation. We aim to dissect how Treg cells exert context-specific function at a cellular and molecular level and develop strategies to manipulate Treg cells for disease intervention. For more information, please visit the lab website: www.weihulab.org.

We are excited to invite scientists from diverse backgrounds to join our growing team. The lab’s dual affiliation enables your interaction with two highly dynamic groups of scientists at Yale, a rare opportunity to broaden the scope of your scientific knowledge and vision. As one of the founding members, you will benefit from frequent interaction with and prompt feedback from the principal investigator. You will also have more freedom to explore different directions based on your expertise and scientific interests or develop new directions that you are passionate about. We value the professional growth of our team members, and you will be encouraged to apply for fellowships and awards, attend courses and conferences, and engage in other networking and career development activities.

Responsibilities

Working in collaboration with the principal investigator and under the overarching theme of the lab, the postdoctoral researcher will:

  1. Conduct specific research as assigned, and develop new projects based on their own interest. This includes conceiving the project, designing the research strategy, conducting the experiments, analyzing and interpreting the data, presenting the progress in lab meetings and departmental seminars, and preparing manuscripts for publication.
  2. Assist and advise other lab members with his/her technical and scientific expertise.
  3. Assist the PI in laboratory management and developing proposals for funding.

Requirements

  1. Ph.D. in Biomedical Sciences, Chemistry, or related field at the time of hiring. A strong background in immunology, functional genomics, chemical biology, or mouse genetics is highly desirable.
  2. Passionate about scientific discovery; capable of working independently and willing to collaborate with team members.‍

Salary and Benefits:

The salary follows the compensation guidelines for postdoctoral researchers at Yale University. The University also provides health plans, paid leave, parenting leave, and other benefits. For more information, please see below.

Compensation: ‍https://postdocs.yale.edu/policies/compensation

Benefits: https://postdocs.yale.edu/applicants/yale-benefit-summary

How to apply

Please submit a cover letter, curriculum vitae, and the contact information of 2-3 references. The application may also send the application materials to wei.hu.wh477@yale.edu. The review of applications will begin immediately, and interviews will be scheduled for highly rated candidates. The hiring will continue until the positions are filled.

Postdoctoral Associate - Aging and Computational Biology (Higgins-Chen Lab)
Posting Date: May 16, 2023

The Higgins-Chen Lab at Yale University invites applications for up to 2 postdoctoral associate positions in the biology of aging, supported by multiple NIH grants. The lab is focused on using machine learning approaches to identify omics-based biomarkers to estimate the biological age of individuals, then adapt the biomarkers for use in clinical trials of geroscience-based interventions to prevent or treat age-related diseases. The lab also studies the interaction between aging and mental health. Lab members primarily perform computational analysis, collaborating with clinicians, experimental biologists, epidemiologists, social scientists, and industry to train and validate biomarkers.

Postdoctoral associates may work on one or more projects and are encouraged to incorporate their other research interests into the work. They may work collaboratively with one or more current lab members for these projects. Projects we are currently hiring for include:

  1. Molecular signatures of Alzheimer’s resilience: Work with a unique multi-omics multi-region brain dataset for Alzheimer’s disease, highly enriched in individuals with ApoE E4 alleles yet are resilient to cognitive decline. All somatic mutation, DNA methylation, and proteomics data from 3 brain regions are already collected, along with detailed phenotypic data. A postdoctoral associate would work to identify molecular signatures of resilience using individual data types and perform multi-omic integration.
  2. Epigenetic clocks to link aging hallmarks, interventions, and outcomes: Epigenetic clocks based on DNA methylation are commonly used aging biomarkers in epidemiological studies. However, there is little mechanistic understanding of how they relate to molecular hallmarks of aging, risk for age-related disease, and response to aging interventions, limiting their potential use in clinical trials. With collaborators, we are collecting data from humans, human cell culture, and mouse models concerning DNA methylation relationships with aging hallmarks, interventions, and outcomes. A postdoctoral associate would work to integrate this data and test new computational approaches to develop mechanistically informed epigenetic aging clocks.
  3. Computational solutions for adapting aging biomarkers to longitudinal studies and clinical trials: Aging biomarkers are needed to longitudinally monitor an individual’s aging process and their response to interventions. However, current aging biomarkers are mostly trained and validated using cross-sectional measurements, and they also can be affected by a variety of confounders that make it unclear whether changes in biomarkers can be truly attributed to a modification of aging. A postdoctoral associate would work with longitudinal biomarker data from large aging cohorts and other datasets to develop computational methods for utilizing longitudinal data in training and validation of aging biomarkers, and methods for detecting and correcting for confounders.

Another major focus of the lab is investigating how mental health influences the aging process and identifying ways to improve the long-term health of individuals with psychiatric disorders. Postdoctoral associates are welcome to contribute to these projects.

Qualifications:

  1. Excellent collaboration skills and ability to contribute to a positive, supportive, and collegial lab environment
  2. A PhD, MD, or MD/PhD and experience in geroscience, cellular and molecular biology, computational biology, bioinformatics, or a related field.
  3. Strong computational skills, including experience with programming languages such as R or Python, and supervised and unsupervised machine learning methods
  4. Motivated and self-directed to complete research projects and learn new skills needed for that research

Preferred Qualifications:

  1. Experience and domain knowledge relevant to one or more projects listed above (Alzheimer’s Disease, mouse or cell culture aging studies, epidemiology of aging, etc)
  2. Expertise in computational methods relevant to one or more projects listed above (proteomics analysis, multi-omics data integration, advanced longitudinal modeling, etc.)

Application Process:

Appointments are initially for 1-2 years, are renewable, and have flexible start dates. The positions are available immediately and will be reviewed on a rolling basis. Qualified applicants may be contacted to schedule an interview.
Interested candidates should submit the following application materials:

  1. A 1-page cover letter describing your research interests, career goals, and how your expertise may contribute to one of the above projects (please focus your letter on one project – we may discuss other projects during the interview).
  2. A detailed CV or Biosketch
  3. Contact information for three professional references who can provide letters of recommendation or discussions by phone upon request.

Send materials as a single PDF file to:

Albert Higgins-Chen, MD, PhD

a.higginschen@yale.edu

Department of Psychiatry, Department of Pathology

Yale University

Postdoctoral Fellow, Pitt Laboratory, Yale School of Medicine
Posting Date: May 9, 2023

The Pitt laboratory is seeking a motivated postdoctoral fellow to join our team (https://medicine.yale.edu/lab/pitt/). We conduct translational research focused on understanding the mechanisms that underlie progression/neurodegeneration in multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). We are using cutting-edge technologies such as multiomic single nucleus profiling (DOGMA-Seq), highly multiplexed histological imaging of brain tissue sections, and advanced computational tools for spatial analysis. The PI is a co-director of the National MS Brain Bank, and the laboratory is embedded in a highly collaborative, translational neuroimmunology program that includes genetics and computational biology.

The candidate will participate in our larger effort to produce and integrate spatial proteomic and single cell multiomic datasets of MS lesion and ALS tissue in order to determine cellular states and subpopulations in these diseases, and to define their spatial and functional interactions.

Applicants should have deep expertise with CNS histology and a broad neurobiology background. Experience with computational analysis tools such as Squidpy and HistoCat is a plus. The successful candidate will join the Department of Neurology for a minimum of 2 years. To apply, please send your CV, a short description of the relevant expertise, representative publications, and the names of three references via email to david.pitt@yale.edu.

The Yale School of Medicine is a world-renowned institution that provides employees with unparalleled access to state-of-the-art facilities, cutting-edge research, and the opportunity to work alongside some of the most prominent figures in the medical field. In addition, Yale provides its employees with competitive salaries, comprehensive benefits packages, and ample opportunities for professional growth and development.

Yale University is an Affirmative Action/Equal Opportunity Employer and welcomes applications from women, persons with disabilities, protected veterans, and members of minority groups.

Postdoctoral Position, School of Public Health, Department of Policy and Management
Posting Date: May 9, 2023

Postdoctoral position in discrete-choice analysis of non-pharmaceutical interventions during pandemics

Job Description

Applications are welcomed for a NIH-funded postdoctoral position under the direction of Dr. Reza Yaesoubi (Yale School of Public Health, Department of Health Policy and Management) and Dr. Janel Hanmer (University of Pittsburgh Medical Center, Center for Research on Health Care). The successful candidate will have the opportunity to lead projects related to the discrete-choice analysis of non-pharmaceutical intervention to control pandemics and the development of decision models to inform the optimal use of these interventions during pandemics.

The successful applicant will be expected to participate as lead author in publications arising from this work and to communicate findings in oral presentations at national and international conferences. Strong emphasis will be placed on career development, communication skills, grantsmanship, and interdisciplinary research.

Qualifications and Skills

  • Doctoral degree in decision sciences, economics, health economics, public policy, or other relevant fields.
  • Previous experience in discrete-choice/conjoint analysis.
  • Strong background in statistics.
  • While not essential, working knowledge of decision modeling and cost-effectiveness analysis, is ideal.

Benefit and Compensation Information

We offer a competitive salary. Compensation will be commensurate with experience.

To apply:

Please apply online: http://apply.interfolio.com/124814

Candidates should submit a cover letter along with an updated resume or CV and contact information for 3 professional references. 

For any additional information, please contact Associate Professor Reza Yaesoubi, Department of Health Policy and Management, Yale School of Public Health (reza.yaesoubi@yale.edu).

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Postdoctoral Position - The Martinez Lab
Posting Date: May 9, 2023

If you are you fascinated by emerging and re-emerging viruses that are a threat to global health, and you also interested in better understanding the mechanisms of viral pathobiology and the host defense against these viruses, we are looking for highly enthusiastic and motivated individuals to join our team! The Martinez lab is seeking a postdoctoral candidate interested in joining us at Yale Immunobiology to investigate mechanisms of viral pathogenesis and humoral mechanisms of protective immunity against emerging viruses.

The Laboratory of Viral Pathobiology and Immunity (Martinez lab) in the department of Immunobiology at the Yale School of Medicine studies fundamental mechanisms viral pathobiology and host immunity to alphaviruses (Chikungunya virus), coronaviruses (SARS-CoV-2, bat zoonotic SARS-related viruses, and MERS-CoV), and flaviviruses (Dengue virus, West Nile virus, and Zika virus). The Martinez lab is focused on characterizing fundamental mechanisms of protective immunity both on the host side, using human and mouse models, and on the pathogen side, utilizing viral reverse genetics and tissue culture models. Candidates will be expected to work in a biosafety level 2 (BSL2), enhanced animal biosafety level 2 (ABSL2+), and depending on their project also biosafety level 3 (BSL3) and ABSL3 laboratory.

Qualifications and requirements

  • Recent PhD, or MD
  • Experience with mouse handling
  • Previous experience in immunology, microbiology, and virology are preferred though not required
  • Ability to communicate clearly and efficiently
  • Ability to effectively work as a part of team
  • Experience in molecular biology and cell and tissue culture

Successful candidates should be excellent communicators and will be encouraged to achieve independence. Successful candidates will be encouraged to pursue independent ideas that overall fit the Martinez lab vision on viral pathogenesis and host immunity.

Successful candidates will become part of the Immunobiology department, which is a dynamic, vibrant, and energetic community. The department of immunobiology at Yale School of Medicine is considered as one of the best immunology departments in the world. Successful candidates will primarily work in 300 George and will work closely with Martinez laboratory members.

Qualified candidates should email their cover letter and CV to Dr. David Martinez at david.martinez@yale.edu

Postdoctoral Associate - Yale Child Study Center
Posting Date: May 8, 2023

The Education Collaboratory at Yale, part of the Child Study Center at the Yale University School of Medicine, conducts research to advance the science and practice of social and emotional learning (SEL). Through intentional collaboration with students, educators, leaders, and organizations, we investigate, inspire, and address open questions in the Who, What, and How of inclusive and equitable SEL.

We are seeking a Postdoctoral Associate to join our Collaboratory. The primary project the PDA would support is the development and validation of the Social and Emotional Learning Observation Checklist (SELOC) for elementary school. This project is funded by the Institute of Education Science (R305A210262). Under the direction and supervision of Principal Investigator, Dr. Christina Cipriano, and in partnership with 50 school leaders and 300 elementary school classroom teachers, the SELOC-E is being co-developed and implemented to improve the quality of SEL teaching practices in classrooms across the nation.  

The postdoctoral associate’s primary responsibility will be to support all data collection efforts during the 2023-24 school year including the ongoing management and maintenance of student and educator data, data coding and analysis, liaising and troubleshooting with participants across the project, and readying the data sets for analyses. The PDA will be welcomed to contribute to the team’s rich research tasks, including the preparation of collaborative research articles, school facing resources, academic and public presentations, grant writing, and the design of future studies. Due to the nature of our collaborative research agenda at the lab, the PDA will have opportunities to support across additional project streams during their training. Professor Cipriano will oversee day-to-day work assignments and be the primary supervisor alongside providing additional professional development support.  

Skills and Qualifications

  • Doctorate (PhD or EdD) in psychology, education, or a related field
  • Experience as a classroom educator, educational practitioner, or related school-based professional
  • Specialization or demonstrated interest in the study of social emotional learning and equity and/or related fields of inquiry in education
  • Excellent statistics skills, including experience with multi-level modeling and experience with mixed methods and community-based research designs.
  • Demonstrated ability to or interest in learning with school communities (educators, students, families)
  • Excellent communication skills (e.g., writing research papers, giving presentations)
  • Ability to work both independently and collaboratively

The Postdoctoral Associate position is a one-year appointment with an opportunity to renew to a maximum of four years contingent upon satisfactory performance and availability of funding. Compensation is determined by experience. This is not a remote opportunity. This position is located at the Child Study Center on the campus of Yale University in New Haven, CT.

The anticipated start date is July 1, 2023.

Please note that the university has a COVID vaccination and booster requirement for all students, staff & faculty which is described in the COVID-19 Vaccine Program. You are required to comply with the Vaccine Program prior to the first day of your Yale appointment. Should you not be eligible for the Booster at this time, you will be required to receive your booster within seven (7) days of your eligibility. Please see the Yale COVID-19 Vaccine Program for information on how to schedule a vaccination and/or how to Submit or Confirm your vaccination documentation. For up-to-date university information on COVID-19, please visit: https://covid19.yale.edu/.

To Apply

Please send a cover letter and CV to linda.torv@yale.edu with the email subject “Postdoc Applicant: Education Collaboratory”. Review of applications will begin immediately and continue until the position is filled. Please have contact information available for three references upon request.

ABOUT THE EDUCATION COLLABORATORY AT YALE

At The Education Collaboratory at Yale, our approach emphasizes community partnerships and collaborative engagements with schools and communities, designed to balance rigor, relevance, and reality in SEL design, implementation, and evaluations to support all students, schools, and communities, to benefit. Under the direction of Dr. Christina Cipriano, the Education Collaboratory at Yale is leading the national discourse to evolve the definition of SEL alongside the burgeoning field; identifying promising practices for inclusive and equitable implementation and evaluation of SEL in school settings, undertaking critical evidence synthesis, and supporting the next generation of data practices through novel SEL assessments and community-based approaches to intervention science. Learn more at www.educationcollaboratory.org.  

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

POSTDOCTORAL ASSOCIATE - XR IN PEDIATRICS AT YALE (XRPEDS)
Posting Date: May 3, 2023

The XR in Pediatrics (XRPeds) Lab in the Department of Pediatrics at Yale University focuses on the use of extended reality technologies (virtual, augmented, and mixed reality) in research, clinical practice, and health education with the goal of improving lives and reducing health disparities among youth, young adults, and their families. We are seeking a Postdoctoral Associate with an interest in technology-based interventions (including augmented and virtual reality-based interventions (AR/VR)), serious games, health behavior or public health, clinical research, and appropriate experience to join our multidisciplinary team of researchers, pediatricians, and educators.

The Postdoctoral Associate will work with Drs. Hieftje and Marks XRPeds’ to support researchers, clinicians, and educators in the early stages of exploring and developing projects that utilize XR technology. The Postdoctoral Associate will therefore collaborate on multiple ongoing and upcoming research projects in areas as diverse as social VR-based support groups for oncology patients, substance use prevention interventions for adolescents, infection prevention training and simulation for family members of hospitalized patients, and the development and exploration of novel multisensory interfaces for XR experiences.

The Postdoctoral Associate will gain skills in intervention development; recruitment of study participants; focus group/playtesting facilitation; pilot program evaluation; data collection, management, and analysis; developing a manuscript; and presenting findings to both community and academic audiences.

Furthermore, the Postdoctoral Associate will be expected to further XRPeds’ mission to provide outreach and programming to underserved youth within the community and will be involved in overseeing community-building events such as workshops and internships.

Skills and Qualifications

  1. PhD in Public Health, Education, Social Behavioral Sciences, Psychology or related field
  2. Excellent methodological and statistical skills, including working with qualitative and quantitative data
  3. Demonstrated ability (or potential to learn) to forge connections with community members
  4. Independence to lead a project as well as willingness to work in a team and learn new methods from collaborators
  5. Excellent scientific presentation and writing skills

This position is a one-year, full-time appointment with renewal contingent upon satisfactory performance and availability of funding and is eligible to start immediately.

Position begins July 1, 2023, materials should be submitted no later than June 1, 2023.

To Apply:

Interested applicants should submit the following materials via e-mail to: Dr. Kimberly Hieftje (kimberly.hieftje@yale.edu) and Dr. Asher Marks (//asher.marks@yale.edu/">asher.marks@yale.edu)

  • A short letter of interest outlining your suitability for the position
  • Curriculum Vitae or Resume
  • A first-authored writing sample, if available
  • 3 names of references

Reviews of applications will begin immediately.

Postdoctoral Associate Position – Department of Therapeutic Radiology (Gueble Lab)
Posting Date: May 2, 2023

The Gueble laboratory in the Department of Therapeutic Radiology at Yale School of Medicine is looking for a highly motivated postdoctoral researcher in translational cancer biology.

Our laboratory seeks to understand and exploit DNA repair abnormalities in cancer with the goal of developing novel anti-cancer strategies.  We are applying a variety of research techniques to study the mechanisms and therapeutic potential of novel DNA modifying agents which take advantage of tumor specific DNA repair defects.  We are also interested in the effect of DNA modifying agents in the context of the tumor microenvironment and in understanding the development of resistance to these agents.  We aim to translate these findings into clinical studies through collaborations within the Yale School of Medicine community.

The postdoctoral associate will develop a research project investigating the mechanisms and therapeutic potential of DNA modifying agents under the mentorship of Dr. Gueble.  Research techniques may include standard molecular biology research assays, tissue culture, mouse xenograft models, genetic manipulation, DNA repair assays, next-generation sequencing, and high-throughput screening assays.  In addition to bench research and data analysis, the postdoctoral associate will participate in manuscript preparation, conference presentations, and development of collaborations with other scientists.

Qualified candidates will have graduated from an PhD or MD/PhD program in a relevant field, such as cellular or molecular biology, cancer biology, genetics, or a similar program.  The candidate must be proficient in cellular and molecular biology research techniques, have a strong interest in translational cancer biology, and be a collaborative and self-motivated scientist.  Prior experience with mouse xenograft models is highly preferred.

To apply, please send a cover letter, curriculum vitae, 1-page research summary, and contact information for three references to:

Susan Gueble, MD, PhD

susan.gueble@yale.edu

Department of Therapeutic Radiology

Yale School of Medicine

Postdoctoral Association Position in the Yale Collaboration for Research Integrity and Transparency (CRIT): Division of General Internal Medicine, Yale School of Medicine
Posting Date: May 1, 2023

Postdoctoral Association Position in the Yale Collaboration for Research Integrity and Transparency (CRIT): Division of General Internal Medicine, Yale School of Medicine

Location: New Haven, CT

Description: A full-time Postdoctoral Association position is available as part of the Yale Collaboration for Research Integrity and Transparency (CRIT) within the Department of Internal Medicine, Section of General Internal Medicine at Yale School of Medicine. The candidate will be mentored by Drs. Joseph S. Ross and Reshma Ramachandran.

Position Details: Successful candidates will have the opportunity to gain experience from Drs. Ross and Ramachandran who direct Yale CRIT as well as collaborators across campus at the Yale School of Medicine, School of Public Health, and School of Law as well as academics at other institutions on projects at the intersection of regulatory science, epidemiology, health economics, and health policy. The position will focus on the evaluation of FDA regulation of health technologies on patient outcomes and payer decisions as well as spending.

As part of Yale CRIT, candidates will also have an opportunity to receive training in the translation and dissemination of research findings into actionable policy recommendations to various audiences including policymakers, collaborating organizations, and the public. Successful candidates will also be expected to lead 1-2 research projects that will be published in high-impact medical journals. For examples of prior CRIT projects, please see: https://law.yale.edu/centers-workshops/collaboration-research-integrity-and-transparency-crit/our-work

Qualifications

Minimum qualifications:

1.           PhD/ScD/MD or equivalent degree and years of experience in epidemiology, econometrics (particularly around cost-effectiveness analyses), and pharmaceutical or medical device policy

2.           Strong background in epidemiological/statistical methods, including coursework and research experience in causal inference and evidence synthesis.

3.           Programming experience using large datasets (e.g., R, SAS, STATA).

4.           Strong written and oral communication skills.

5.           Experience in translation and dissemination of research findings to broader audiences is preferred, but not required.

Salary will be based on the NIH postdoctoral research salary scale. The position is for one year, with possible renewal at the second year depending on funding and performance.

Application Instructions

To apply, please submit a CV, cover letter of up to two pages, and contact information for three references (name with position title, phone, and email address). In your cover letter, please summarize your relevant research experience.

Applications and questions regarding the position should be directed to Dr. Reshma Ramachandran [reshma.ramachandran@yale.edu]. Applications will be accepted until the position is filled.

Postdoctoral Associate Research Position in Sickle Cell Disease
Posting Date: April 28, 2023

The Yale Department of Pediatrics is seeking a post-doctoral associate to pursue clinical research in sickle cell disease (SCD) and pain under the mentorship of Dr. Nitya Bakshi, incoming Associate Professor of Pediatrics and Director of the Pediatric SCD Program at Yale University. The research laboratory is focused on the study of chronic pain in SCD and is funded by federal (NIH) and foundation awards. Work from the lab includes studying chronic pain phenotypes and their outcomes in SCD using survey instruments, EMA methods, as well as quantitative sensory testing approaches. The lab is also studying pain in the context of curative hematopoietic cell transplant, and treatment interventions for chronic SCD pain. The lab also has significant expertise in qualitative methods, and their application to study pain and therapeutic decision making in SCD. The candidate will be under the mentorship and supervision of Dr. Bakshi and will have the opportunity to collaborate with several national leaders in the field, including some in the Division of Pediatric Hematology-Oncology at Yale University. 

The post-doctoral associate’s responsibilities will include management of lab research projects, fulfilling regulatory requirements, data management, analyses, and interpretation of data, and supervision of students. It is anticipated that the candidate will also recruit people with SCD for clinical studies and clinical trials in SCD. The candidate will have an opportunity for authorship and co-authorship of manuscripts and assist with grant writing. This position will enhance the candidate’s skillset in SCD observational and clinical trials design and data analyses, EMA methodology, and qualitative research methods in SCD. The candidate will be expected to develop and individual career development plan, and there will be some flexibility to tailor the position to the candidate’s specific interests. The candidate’s career development will also be supported to attend national conferences.

The position will start on October 1, 2023, but the start date may be negotiable. The duration of the position will be for 2-3 years and may be extended if desired and contingent on the availability of funding. A 1-year term may be considered on a case-by-case basis.

Candidates must have a doctoral degree, i.e., PhD, MD, or MBBS (or equivalent).  If interested, please email a cover letter detailing their interest in the position, CV, a writing sample (prior publication, thesis, or similar), and names of 3 references to:  nityabakshi@gmail.com

Postdoctoral Position in Yale Comprehensive Epilepsy Center at Yale School of Medicine
Posting Date: April 25, 2023

Postdoctoral Position in Yale Comprehensive Epilepsy Center at Yale School of Medicine 

The Yale Comprehensive Epilepsy Center in the Department of Neurology at the Yale School of Medicine has an opening for a Postdoctoral Associate interested in gaining clinical research experience in epilepsy and status epilepticus clinical trials.

IDEAL CANDIDATE:

  • Recent MD, Ph.D., or equivalent.
  • Background in research experience is strongly preferred but not required. Mentoring and courses are provided as needed for principles of experimental design, problem-solving, writing, and data analysis.
  • Prior experience in a medical setting is preferred.
  • Excellent writing skills and verbal communication skills are mandatory.
  • Experience with database software is preferred, especially REDCap.
  • Prior experience in a clinical setting is preferred. Ability to multitask clinical trial coordination (setup to fulfillment), liaising between academic entities and pharmaceutical companies, medical writing, governmental and regulatory affairs, event organization, project management, coordination of intricate international teams, multicultural integration, and project execution.

The selected candidate will be the primary study coordinator for the NORSE study (New Onset Refractory Status Epilepticus), The NORSE/ FIRES Biorepository, and participate in other projects. There are ample opportunities for attending daily educational conferences in the Department of Neurology and the epilepsy center and for shadowing attending physicians in the clinic and on hospital rounds.

The position is initially for a period of 1 year, with a scope for multi-year renewal subject to satisfactory progress. Candidates will be reviewed on a rolling basis until the position is filled.

Yale provides an outstanding environment for conducting successful and rigorous postdoctoral training toward obtaining an independent research position. Yale Comprehensive Epilepsy Center in the Department of Neurology at the Yale School of Medicine is highly active and involves interdisciplinary collaborations across multiple academic units, including the Departments of Neuroscience, Psychology, Psychiatry, Computer Science, Statistics & Data Science, Molecular, Cellular & Developmental Biology and more. The Wu Tsai Institute, Kavli Institute for Neuroscience, and the Swartz Center for Theoretical Neurobiology provide excellent opportunities for training and cross-disciplinary dialog.

Yale and our labs are highly committed to promoting diversity among its students, faculty, and staff. Women, persons with disabilities, protected veterans, and individuals from underrepresented minority groups are strongly encouraged to apply.

Interested candidates should e-mail their applications to lawrence.hirsch@yale.edu, or Margaret.gopaul@yale.edu.The application should include: (1) CV; (2) a one-page description of research interests; (3) contact information for 3 referees.

Postdoctoral Fellow position - Department of Dermatology (Vesely Lab)
Posting Date: April 20, 2023

Postdoctoral Fellow position - Department of Dermatology (Vesely Lab)

Matthew Vesely, MD, PhD, is seeking a Postdoctoral Fellow for a position in his laboratory in the Department of Dermatology at the Yale School of Medicine.

Education - The ideal candidate has a PhD in relevant fields such as immunobiology, cellular biology, or molecular biology.

Training - As a Postdoctoral Fellow, the candidate will perform basic science and/or translational research related to two ongoing projects: 1) characterizing immune cells from skin in human autoimmune diseases such as lupus, lichen planus, and psoriasis as well as in mouse models and 2) developing and testing pathogenesis-targeted therapies for these skin diseases. The projects employ a broad range of techniques in the lab including disease modeling, molecular and cellular biology, single-cell RNA sequencing, spatial proteomics (multiplex ion beam imaging) and spatial transcriptomics (digital spatial profiling).

Mentoring - The candidate will have opportunities to present his/her data at intramural and/or national/international conferences, should this be of interest. The overall goal is to gain experience in designing and performing both basic and translational scientific work that can be used as a foundation for a future career in science and/or medicine. In addition, the candidate will be given career development opportunities (e.g. scientific writing and public speaking skills) that are individually tailored to her/his long-term career goals. The ultimate goal is to create an experience that is rewarding and engaging for the successful applicant and to foster scientific, professional, and/or educational advancement.

The candidate will be expected to perform some or all the following duties:

  1. Assist with mouse colony management, husbandry and genotyping
  2. Immunohistochemical stains of tissue followed by visualization using various microscopy techniques including confocal microscopy and basic immunofluorescence/brightfield microscopy
  3. Basic molecular biology techniques such as quantitative PCR and Western blots
  4. Preparation of mouse and human tissues for bulk and single-cell RNA sequencing as well as for fluorescence-activated cell sorting (FACS) and analysis
  5. Basic tissue culture techniques
  6. Use basic software/statistical tools such as Adobe Photoshop, Illustrator, Fiji, etc. Opportunity to develop advanced programming/data analysis skills if desired.
  7. Assist with data analysis, interpretation, and generation of figure quality data for publication and/or presentations
  8. Attend conferences where he/she can network and/or present research data
  9. Attend weekly dermatology and/or pathology research in progress conferences if of interest as well as weekly lab meetings
  10. Assist with shipment of samples
  11. Assist with writing scientific papers and reviews

Interested candidates should email a cover letter that briefly describes their personal and career goals as well as their research/scientific background, their CV, and at least 3 letters of reference to matthew.vesely@yale.edu.

Postdoctoral Scholar - Energy, Climate and Well-being Lab (ECWL) at Yale School of the Environment
Posting Date: April 20, 2023

Postdoctoral Scholar - Energy, Climate and Well-being Lab (ECWL) at Yale School of the Environment

Position Summary

The Energy, Climate and Well-being Lab (ECWL) at the Yale School of the Environment is looking to hire a postdoctoral scholar to work on household energy modeling in the context of energy transitions in the US. The candidate will work primarily as part of a project team developing fresh approaches to modeling household energy choices in low-carbon pathways that reflect enabling and constraining factors related to well-being, health, social relations, and the built environment. The candidate will have the opportunity to conduct empirical research, lead model development and work with team members with engineering and social science backgrounds on cutting edge interdisciplinary research.

The successful candidate will have a quantitative background in energy systems or modeling, a PhD in engineering, economics, energy systems, operations research, or related field, programming experience and an interest in interdisciplinary research.

The candidate will work under the supervision of Prof. Narasimha Rao, Associate Professor of Energy Systems, and collaborate with other postdocs, students and faculty collaborators at other universities. Prof Rao’s ECWL lab conducts mixed methods research on the distributional and multidimensional well-being impacts of energy system transformation and climate policy in the US and around the world. Topics include energy insecurity, food-energy systems, heat stress and cooling, mobility and poverty, and environmental justice. 

This is a one-year appointment with the option to continue for a total of three years based on performance and funding. 
 

Minimum Requirements

  • PhD in engineering, economics, operations research, or a related field using systems analysis
  • Proficiency in a programming language (R or Python)
  • Experience with energy modeling
  • Interest in interdisciplinary research
  • Excellent oral and written communication skills
     

Preferred qualifications

  • Record of prior publications in energy studies
  • Experience with data analytic/machine learning tools
  • Familiarity with Agent-based Models
Post-Doctoral Fellowship in the Epidemiology of Aging and Disability (Gill Lab)
Posting Date: April 14, 2023

The Center on Disability and Disabling Disorders (https://medicine.yale.edu/intmed/geriatrics/research/disability/?tab=Ong…) at Yale University o4ers a 2-year postdoctoral fellowship in the Epidemiology of Aging and Disability. This experience provides fellows with the opportunity to address fundamental issues related to the epidemiology and prevention of disability among older persons; train with mentors who are experts in the epidemiology of disability; and produce high impact research papers that will help them establish a successful research career.

The Center, under the leadership of Dr. Thomas Gill (http://medicine.yale.edu/intmed/geriatrics/people/thomas_gill.profile) , conducts longitudinal studies and clinical trials to enhance the scientific knowledge base of the disablement process in older persons and to rigorously evaluate promising intervention strategies. The Center works closely with the superb Resource Cores of the Yale Program on Aging (Biostatistics and Operations) and has access to data from several large NIH-sponsored studies, including (among others) the Precipitating Events Project (PEP Study) (https://pubmed.ncbi.nlm.nih.gov/32242212/) and National

Health and Aging Trends Study (NHATS) (https://pubmed.ncbi.nlm.nih.gov/31237935/) . Current NIH- funded research is focusing intently on distressing symptoms, functional outcomes, serious health events such as major surgery, end of life, disadvantaged older populations, and health disparities.

Ample training opportunities are available through the Yale Program on Aging/Pepper Center (https://medicine.yale.edu/intmed/geriatrics/peppercenter/) , Investigative Medicine Program (https://medicine.yale.edu/investigativemedicine/courses/course-descriptions/) , and School of Public Health (http://catalog.yale.edu/ysph/course-descriptions/) . Suitable candidates should have a PhD or an MD, prior training in epidemiology, demography, biostatistics, or a related field, and strong communication skills. Expertise in statistical programming, including SAS, is highly desirable.

Stipends are commensurate with experience. Although not required, US citizenship or permanent residence is preferred for training grant eligible positions. Candidates from diverse backgrounds are encouraged to apply.

Interested candidates should send a letter of interest and CV to: Ms. Robbin Bonanno at robbin.bonanno@yale.edu. Yale University is an Affirmative Action/Equal Opportunity Employer.

Postdoc Associate - Functional analysis of neurodevelopmental disorder genes in zebrafish (Hoffman Lab)
Posting Date: April 14, 2023

POST-DOCTORAL  ASSOCIATE

Functional analysis of neurodevelopmental disorder genes in zebrafish

The Hoffman Laboratory at Yale University is recruiting for a post-doctoral position, available immediately.

The main goal of the Hoffman Laboratory is to gain new insights into the roles of genes associated with neurodevelopmental disorders at the cellular, molecular, and behavioral levels and to develop improved pharmacological treatments. To accomplish this, we use zebrafish CRISPR-generated mutants to perform high-throughput functional screens.

We are seeking post-doctoral researchers interested in the following projects:

  • High-throughput functional screens of risk genes at the cellular, molecular, and behavioral levels in zebrafish
  • In vivo imaging of neural circuit deficits in zebrafish mutants
  • Pharmaco-behavioral profiling to identify pharmacological candidates

Candidates should have a Ph.D. in neuroscience, genetics, or a related field. Preference will be given to those with prior experience with zebrafish neurobiology or animal models of neurodevelopmental disorders. Candidates should be highly motivated, enthusiastic, and collaborative.

To apply:

Please send an email with your CV, contact information for 3 references, and a brief statement describing your research interests as a single PDF to

Dr. Ellen Hoffman (ellen.hoffman@yale.edu) using the subject line:

Postdoctoral applicant: Your name.

More information about the lab can be found at www.hoffmanlab.net.

Postdoctoral Associate positions in the Digital Ethics Center (DEC), Yale University
Posting Date: April 8, 2023

Postdoctoral Associate positions in the Digital Ethics Center (DEC), Yale University

The Center for Digital Ethics (DEC) at Yale University, directed by Prof. Luciano Floridi, seeks to appoint full-time, Postdoctoral Associates, to join this multidisciplinary center newly established at Yale. We are eager to recruit and welcome candidates who add to the diversity of the Center.

Postdoctoral Associate positions are intended for individuals who are interested and experienced in (a) addressing the human, societal, and environmental issues brought about by the development of digital technology (from the Web and social media to AI and robotics), (b) informing and steering policy and legal debates nationally and internationally on these issues, and (c) deepening their expertise to transition to their independent research careers.

The successful candidate can expect significant intellectual autonomy coupled with supportive mentorship to develop and deliver novel and meaningful research in the Governance, Ethical, Legal, and Social Implications (GELSI) of digital technologies in the following areas (in alphabetical order):

·       computer science and its GELSI;

·       computer games and their GELSI

·       cyberwar, cyberconflicts, and their GELSI;

·       data science and its GELSI;

·       digital economy, especially the GELSI of blockchain, cryptocurrencies, Insurtech, DEFI, game theory and online behavior (e.g., digital advertisement, recommender systems), changing nature of work, gig economy, app economy, network effect;

·       digital ethics, including computer ethics, cyber ethics, ethics of AI, information ethics, machine ethics; roboethics;

·       e-art, digital art, new aesthetics, NFT, and their GELSI

·       e-health, digital welfare, well-being, and their GELSI;

·       HCI and its GELSI;

·       human rights, human dignity, digital divide, UN SDG;

·       information, disinformation, misinformation, deepfakes, fake news, censorship, propaganda, the future of journalism and media, and their GELSI

·       law and regulations concerning digital technologies, especially AI and copyright, patent, IP, antitrust, AI auditing, AI legislation;

·       network theory and its GELSI

·       political science, especially digital democracy (e-democracy, democracy in digital society), agile governance, platform governance, digital geopolitics, digital sovereignty;

·       smart cities, twin cities, digital urbanization, and their GELSI

·       social data science, especially FAccT*ML issues;

·       security (including dark web, ransomware, surveillance) and its GELSI;

·       virtual reality, augmented reality, immersive reality, metaverse, XR, and their GELSI.

The postdoctoral researchers will be responsible for developing research projects and studies, writing peer-reviewed articles, and formulating new research questions for future analysis. The DEC Director, Prof. Luciano Floridi, will oversee day-to-day collaborations and be the primary supervisor.

Key Responsibilities

·       Analyse significant GELSI of digital technologies

·       Design of qualitative or quantitative studies addressing significant GELSI of digital technologies

·       Publish research papers in international peer-reviewed journals or conferences in areas relevant to the study of the GELSI of digital technologies, possibly in collaboration with other DEC members

·       Collaborate with other DEC members to prepare and deliver conference presentations of research results

·       Work on dissemination and outreach

·       Edit research outputs (e.g., edited volumes or conference proceedings)

Skills & Qualifications

·       Qualified candidates will have recently completed a PhD in relevant fields, including, for example (the list is not exhaustive): anthropology, computer science, data science, economics, ethics, jurisprudence, mass media, philosophy, political science, psychology, and sociology.

·       Proven record of publications and research outputs commensurate with career stage

·       Knowledge or experience of normative analysis

·       Specialization or demonstrated interest in the study of GELSI of digital technologies

·       Excellent writing skills demonstrated in research publications

·       Exceptional project management skills

·       Competence in quantitative or quantitative methods

·       Ability to communicate effectively (e.g., through writing, presentations) with different audiences (research community, general public, policymakers)

The Position

The Postdoctoral Associate position is envisaged to last up to four years, with an initial appointment of one year renewable upon satisfactory progress. Compensation is determined by experience. Yale’s minimum postdoctoral compensation scale starts at $56,448 (for more information see here). The position give access to a personal, yearly research budget. This is not a remote opportunity. The position is located at the Center for Digital Ethics, on the campus of Yale University in New Haven, CT.

To Apply

A relevant doctoral degree and research experience with a strong publication record are required.

Applications will be reviewed on a rolling basis through 1 June 2023.

The anticipated start date is 1 September 2023, but later starts are possible.

Please send application documents to Krystal Whittaker, PA to Prof. Luciano Floridi, at lucianofloridi.pa@gmail.com, using the subject line: “Postdoc Applicant”, and including the following documents:

1)     cover letter, explaining your background and motivation for the position (2 pages maximum), including contact information for 3 referees;

2)     CV (maximum 3 pages); and

3)     short (ca. 2,000 words long) proposal about a GELSI research project you would like to develop at the DEC, indicating the problem to be addressed, the working hypothesis about the solution, and the methodology that may be used.

Please submit your materials as PDF files and name them LastName-FirstName.coverletter.pdf, LastName-FirstName.CV.pdf, and LastName-FirstName.proposal.pdf

Qualified applicants may be contacted to schedule an online interview and asked to submit the letters of recommendation.

ABOUT THE YALE CENTER FOR DIGITAL ETHICS

The Center for Digital Ethics (DEC) builds on Yale’s unique depth, breadth, and reach of scholarship in the humanities and social sciences to provide an internationally recognized hub for the study of the governance, ethical, legal, and social implications (GELSI) of digital technologies and their human, societal, and environmental impact. Strengths in other areas of the university—from the natural sciences, computer science, data science, and engineering to Yale’s unique array of professional schools—provide an essential and valuable complement. The DEC expands multidisciplinary opportunities at Yale and facilitates connections to other academic institutions, businesses, and government agencies. By bringing together a diverse community of stakeholders, the DEC implements three essential requirements for understanding the human, social, and environmental implications of digital technologies and for equitably and sustainably developing them: a firm footing in GELSI analysis and scholarship; the rigorous and scientific treatment of vital facets of digital technologies (from computer and data science to law and social sciences); and the ability to learn from, and influence, important societal endeavors outside academia (from policy- and law-making to business strategies). Digital technologies in general, and AI in particular, build on computer science, data science, and statistics, rely on human psychology and sociology, draw on insights from linguistics, literature, and philosophy, and call for new frameworks for governance, law, and business. Attention to social implications and questions of value throughout this process is essential. Thus, the DEC enables and supports scholars from a wide range of disciplines and beyond to meet, exchange ideas, and collaborate. The DEC is deeply engaged with informing and steering emerging policy initiatives on the socio-ethical value and implications of AI, digital technologies, and their applications. It sponsors public discussions that build an understanding of the socio-ethical and socio-legal aspects of digital technologies. Visitors and speakers include academics and researchers as well as civil servants, members of the technology industry, policymakers and lawmakers, and experts in culture and mass media. The DEC brings together leadership with the vision and ability to think innovatively and boldly and to move those ideas forward. It ensures diversity in its membership, promotes the inclusion of views, and arrives at consensus through open and constructive exchanges of ideas and balanced debate.

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented m

A Postdoctoral Position in Computational Healthcare Research: Clinical AI and Data Engineering
Posting Date: April 3, 2023

A Postdoctoral Position in Computational Healthcare Research: Clinical AI and Data Engineering

Background:

The successful candidate will be working in a team-oriented environment within the Yale School of Medicine Department of Laboratory Medicine studying a wide array of disease states using the innovative applications of data science tools. The position will be centered on the NIH’s Bridge2AI program for the Cell Maps for Artificial Intelligence (CM4AI) Data Generation Project, within the Skills and Workforce Development module, which is working to develop training and workforce development tools for visible machine learning using cell maps.

Mentoring:

We are seeking a postdoctoral associate to work within our team of informaticians, physicians, and computational scientists. The postdoctoral associate will be based in the Department of Laboratory Medicine and will report directly to Dr. Wade Schulz, Assistant Professor; Director of Informatics, Laboratory Medicine; Director, Center for Computational Health. The associate will also be interacting with other collaborators both within and outside of Yale University, including those from other Bridge2AI Data Generation Project modules.

Training:

The postdoctoral associate will be responsible for collating, analyzing, interpreting and presenting results of various studies being conducted. Training will focus on the translation of real world data to evidence to elucidate clinical disease states, facilitate patient care and improve outcomes. The use of advanced computational frameworks will be a focus of the training, including Spark and various machine learning libraries, with an emphasis on the use of graph databases. The use of common data models, such as OMOP, and the integration of electronic health record (EHR) and laboratory information systems (LIS) data into these models, will be key aspects of the training. Machine Learning, AI, and statistical concepts and skills will be developed and used to evaluate the clinical conditions and otucomes being investigated by the study by the team, and used to develop training and workforce development materials for the Bridge2AI program.

Education, Qualifications and Skills:

  • MD, PhD, or MD/PhD with research experience in one of the following areas: epidemiology, bioinformatics, biostatistics, immunology, microbiology, public health, computer science, cancer biology or a similarly quantitative discipline.
  • Health care exposure and experience with medical terminology
  • Research experience with mathematical and/or statistical models.
  • Strong interest in computational healthcare, clinical informatics, and data engineering
  • Ability to collate and analyze data, interpret and present results to a high standard using a range of specialized research techniques.
  • Good knowledge of Python, R, version control, and distributed computing systems.
  • Excellent verbal and written communication skills.
  • Experience in communicating research findings to a non-specialist audience.
  • Ability to work independently but also as part of a larger interdisciplinary research team.

This will be a one-year appointment with the possibility to extend, should both parties agree. Interested candidates should email Wade Schulz (wade.schulz@yale.edu) and David Ferguson (david.ferguson@yale.edu) with a CV, statement of interest and contact information for 2-3 references.

Yale University is an affirmative action/equal opportunity employer. Yale values diversity in its faculty, students, and staff and especially welcomes applications from women and underrepresented minorities.

Postdoctoral Position - Digestive Diseases, Liver Biology (Liu Lab)
Posting Date: April 3, 2023

Postdoctoral Position - Digestive Diseases, Liver Biology (Liu Lab)

We are a liver biology lab focused on basic and translational studies of alcohol-associated liver disease. We are located in the TAC building and participate in the Yale Liver Center. We study the regulatory mechanisms of liver inflammation in the setting of alcohol-associated liver disease, with particular interest in the role of liver endothelial cells in regulating liver inflammation. Our current project studies liver IL17 signaling, epigenetics, and chromatin-structure regulation of gene expression. Our lab utilizes primary human and mouse cells, next generation sequencing, chromatin interaction assays, microscopy, and other molecular biology techniques. As a part of the Yale Liver Center, lab members have access to the core resources and state-of-art facilities.

We are seeking motivated candidates with MD or PhD degrees or equivalent. The candidate should have prior experience in cellular and molecular biology. Preferably experience with liver biology but this is not required. Prior knowledge in cell culture techniques, primary cell isolation/culture techniques, flow cytometry and imaging skills would also be beneficial.

If you are interested in this position, please send (1) your CV, (2) a brief description of any previous research experience to mengfei.liu@yale.edu.

LGBTQ Mental Health Postdoctoral Clinical Research Associate in NYC
Posting Date: March 30, 2023

LGBTQ Mental Health Postdoctoral Clinical Research Associate in NYC

The Yale LGBTQ Mental Health Initiative, part of the Yale School of Public Health, is seeking a postdoctoral associate to 1) deliver and supervise the delivery of LGBTQ-affirmative cognitive behavioral therapy (CBT) from our community-based clinical research lab in NYC and (2) become involved in LGBTQ mental health research, including supporting clinical trials operations, analyzing data, and supporting and leading empirical manuscripts regarding LGBTQ mental health, as interests and background permit. The primary responsibilities for this position are clinical in the context of research.

The Yale LGBTQ Mental Health Initiative is currently conducting several NIH-funded studies of LGBTQ-affirmative treatments and mechanisms, as well as community implementation research.  The postdoctoral associate would join a dynamic team of faculty, research scientists, and students committed to advancing LGBTQ mental health through research (https://medicine.yale.edu/lgbtqmentalhealth/).

The primary duties for this position involve: (a) delivering short-term LGBTQ-affirmative CBT to LGBTQ individuals living in New York State, remotely from our research offices in Midtown Manhattan, upon receiving training in this therapy from our team, (b) providing supervision to externs and student therapists who are delivering LGBTQ-affirmative CBT, (c) conduct trainings in LGBTQ-affirmative CBT with staff and community partners, (d) overseeing the fidelity of LGBTQ-affirmative CBT delivered in the context of clinical trials, (e) implementing clinical and research protocols, and (f) participating in the research process, including research coordination, data analysis and manuscript preparation.

The position will provide postdoctoral clinical hours and supervision necessary for licensure in New York and other states.

Our office is located in Midtown Manhattan, easily accessible by public transportation.  

Successful candidates will possess a doctoral degree in clinical or counseling psychology or related fields. Ideal candidates will possess theoretical and practical knowledge of CBT, have experience working with the LGBTQ community, and have experience treating diverse mental health and substance use problems.

Please apply online: http://apply.interfolio.com/123212

Interested applicants should submit a copy of their CV; a cover letter detailing research interests, relevant experience, and professional goals; and the contact information of three professional references. 

For additional information, please contact Dr. Dani Chiaramonte (danielle.chiaramonte@yale.edu). Anticipated start is July 1, 2023, but flexible for outstanding candidates.

Competitive salary and fringe benefits.

Yale University is an Affirmative Action/Equal Opportunity Employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Postdoctoral Associate (Vallabhajosyula lab)
Posting Date: March 24, 2023

Postdoctoral Associate (Vallabhajosyula lab)

The Vallabhajosyula lab is enthusiastically looking for a Postdoctoral Associate to pursue a project studying cell specific extracellular microvesicles (EVs), including exosomes, as novel biomarkers of immune rejection in solid organ transplantation. Research in the laboratory is focused on understanding the functional roles and diagnostic implications of cell/ tissue specific EVs in cardiovascular diseases, including heart and lung transplantation, aneurysm biology, and diabetes. Work in our laboratory demonstrated that transplant tissue specific EVs and immune cell EVs in peripheral circulation have potential to serve as novel biomarkers of transplant organ rejection. This project will specifically focus on studying circulating EVs in clinical models of heart transplantation and kidney transplantation.

Responsibilities will include contribution to research design and concept development, conducting EV experiments, data analysis, IRB protocol development, and writing scientific manuscripts. Although experience with EV biology is desired, it is not a requirement. It is important that the postdoctoral candidate is comfortable in molecular biology techniques, including PCR, qPCR, FACS, cell culture, Western blot, ELISA, and RNA sequencing.

Duration: 1 year renewable annually up to 4 years

Please contact Dr. Prashanth Vallabhajosyula at prashanth.vallabhajosyula@yale.edu

Postdoctoral Position - Department of Pathology, Yale School of Medicine (Katz Lab)
Posting Date: March 24, 2023

Postdoctoral Position - Department of Pathology, Yale School of Medicine (Katz Lab)

The Katz Laboratory in the Department of Pathology at Yale School of Medicine seeks applicants for an open Postdoctoral position. Accomplished PhD graduates seeking postdoctoral fellowship training in translational immunotherapy are invited to apply to the laboratory of Samuel Katz, MD, PhD, Associate Professor of Pathology.

Adoptive cell therapy with tumor infiltrating lymphocytes (TILs) is a highly promising form of immunotherapy. TILs are isolated from a tumor, amplified ex vivo to attain a pure and highly active T cell population and infused back into patients to achieve objective response rates of up to 55% in melanoma. Recent work has focused on single cell analysis of the ex vivo expanded TIL to identify targetable pathways through cellular reprogramming that may enhance TIL function. The Katz Laboratory employs a multidisciplinary approach including human T cell reprogramming, mouse modeling, and spatial transcriptomics. Our effort is highly cooperative through close collaborations with Drs. Marcus Bosenberg, a leader in melanoma biology and the Director of the Yale Center for Immuno-Oncology; Diane Krause, the director of the advanced cell therapy lab at Yale; Mike Hurwitz, an oncologist in clinical cell therapy, and Yang Liu, a developer of novel spatial transcriptomic technologies.

Big picture questions of interest include:

  • How to enhance TIL survival and cytotoxicity?
  • How to shift TIL products to more stem/central memory phenotypes?
  • How to enrich for tumor-antigen specific TIL?

The Postdoctoral Fellow will be trained to develop an independent research career under the mentorship of Drs. Katz and Bosenberg. Motivated self-starters with exceptional writing and presentation skills and expertise in culturing primary human T cells, flow cytometry, mRNA production and electroporation, and patient derived xenografts are preferred. Interested candidates should forward a cover letter highlighting relevant qualifications (i.e., laboratory skills, publication record) and research interests, curriculum vitae, one sample publication, and the names and addresses of three references via e-mail to Dr. Katz.

Yale is an affirmative action/equal opportunity employer. Yale values diversity among its students, faculty and staff and welcomes applications from women, members of minority groups, persons with disabilities, and protected veterans.

Postdoctoral Position in Human-carnivore conflict and coexistence
Posting Date: March 20 , 2023

Postdoctoral Position in Human-carnivore conflict and coexistence

A postdoctoral position is available with the Applied Wildlife Ecology (AWE) Lab at the Yale School of the Environment under the supervision of Prof. Nyeema C. Harris, Knobloch Family Associate Professor of Wildlife and Land Conservation. The AWE Lab investigates antagonistic interactions in mammal systems including parasitism, competition, and predation namely in terrestrial carnivores. Our work has direct implications to protected area effectiveness and species conservation.

We seek a committed, self-motivated, and creative individual to explore effects of conservation efforts, climate and land use change, social tolerance, and cultural diversity on human-carnivore conflict. We are particularly interested in the spatial distribution of livestock depredation at a global scale as well as anticipating conflicts across carnivore ranges. Additionally, the candidate will support and use newly acquired movement data from carnivores to investigate socio-ecological dynamics in urban environments. Qualifications for the position include a Ph.D. in ecology, wildlife biology, geography, or a related field, experience in collecting and analyzing movement data from GPS collars, strong publication record, and exceptional research and communication skills. The ideal candidate should have demonstrated competency using GIS, python, R, Google Earth Engine, remote sensing and image processing, LIDAR as well as occupancy modeling, step selection, agent-based modeling, circuit theory and habitat selection. Interest or familiarity with environmental data (e.g. air quality), participatory mapping, machine learning and crowd-sourcing ecological data are also a bonus.

The position responsibilities include tasks related to research topics above, co-authoring papers, and mentoring students. AWE Lab members are expected to participate in lab meetings, retreats, field work and training activities as well as public engagement initiatives throughout the year. Public engagement and public science are fundamental to the AWE Lab, which seeks to inspire new generations of scientists and create opportunities for non-scientists to contribute in combatting the ecological and environmental challenges facing our planet. Diversity, equity, justice and inclusion are also core values in the AWE Lab and we are committed to ensuring the lab reflects those values and integrates them into our work. As such, we strongly encourage applications from researchers identifying as members of marginalized or underrepresented groups.

The position is based at Yale University, situated among the Peabody Museum, Institute of Biospheric Studies, and Max Planck-Yale Center for Biodiversity Movement and Global Change, all providing a stimulating academic community. The University offers its postdocs and staff a generous benefits package and is located in New Haven (75 miles north of New York City). This is a one-year position supported by an Endowed Postdoc Fellowship through Provost Office, beginning summer 2023 with reappointment for an addition year based on outstanding performance and availability of funds. In addition to a competitive salary and full research support, the successful candidate will receive an annual professional development budget for additional trainings and conference participation.

To apply, please send a cover letter, CV (hyperlink publications), contact info for three referees, and “Coexistence Carnivore Postdoc” in the subject line to: joseph.poggi@yale.edu. Joseph serves as the Lab Manager for the AWE Lab and will support the hiring process. The anticipated start date for this position is on or before August 1st.

Postdoctoral Positions in Biochemistry, Biophysics, and Structural Biology (Bleichert lab)
Posting Date: March 20, 2023

Postdoctoral Positions in Biochemistry, Biophysics, and Structural Biology (Bleichert lab)

The Bleichert lab (www.bleichertlab.org) in the Department of Molecular Biophysics and Biochemistry (MB&B) at Yale University is looking for postdoctoral associates. Our research seeks to understand fundamental mechanisms of DNA replication and chromatin biology and how they cooperate to maintain genome stability. We use a wide range of approaches, including biochemistry, biophysics, and structural biology.

We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development. Candidates will be mentored to advance their scientific research, science communication, grantsmanship, and management skills. Postdocs will have the opportunity to broaden their expertise in cryo-EM and single-molecule biophysics and will be embedded in a strong and vibrant structural biology and biophysics community in MB&B and at Yale. Yale MB&B provides an excellent infrastructure for high-resolution cryo-EM and biophysics, with access to several high-end cryo-electron microscopes and a recently acquired Lumicks C-trap single-molecule setup.

Successful candidates will have recently finished or will soon complete their PhD degree and possess scientific curiosity, a collaborative team spirit, and have a strong background in biochemistry, structural biology, or biophysics.

Postdoc compensation and benefits will be according to Yale policies. More information about salaries and other resources can be found at https://postdocs.yale.edu/postdocs.

Qualified candidates should send their CV, a cover letter describing past and future research interests, and the contact information for two to three references to franziska.bleichert@yale.edu.  

For recent publications, please see

https://www.nature.com/articles/s41467-022-28695-w

https://www.nature.com/articles/s41467-020-18067-7

Postdoctoral Positions Now Available for 2023 - Yale School of Medicine Department of Psychiatry
Posting Date: March 15, 2023

Postdoctoral Positions Now Available for 2023 - Yale School of Medicine Department of Psychiatry

The Yale University School of Medicine Department of Psychiatry invites applications for highly qualified candidates (within 5 years of the award of their PhD) for a new postdoctoral associate position (2-3 year appointment) in digital health and data science. Appointments will begin Spring 2023.

This is a multi-year position to become an independent scientist working in:

  1. Problems in machine learning and advanced statistical modeling and their applications to digital phenotyping in substance use
  2. Problems of substance use and other lifestyle risk factors (e.g., inadequate sleep, physical activity) and their co-occurring relationships
  3. The development of personalized healthcare models and precision diagnostics via technological platforms. 

The fellow will work primarily with Drs. Lisa Fucito and Kelly DeMartini on multiple completed and ongoing young adult studies that utilize smartphones and/or biosensors (e.g., alcohol biosensors, sleep actiwatches, PPG sensors) to monitor lifestyle risk factors, identify risk profiles, deliver personalized health feedback to motivate behavior change, and intervene to improve health and well-being. The fellow will also have the opportunity to work on completed and ongoing studies of smoking/vaping cessation and tobacco regulatory science. The fellow will also have the opportunity to collaborate on the development of algorithms for large-scale datasets of biosensor data.

The fellow will be primarily involved in authoring and co-authoring several manuscripts per year, assisting with grant writing, and leading and collaborating on multiple projects. The position may also include supervision of other students/junior staff members. The position will also assist the fellow to develop a career as an independent scientist. The associate will create an individual development plan with their mentors and complete training in areas including but not limited to: clinical trials design, implementation science frameworks, EMA methodology, qualitative research methods, biosensor technology, advanced quantitative and statistical methods. 

Applications are now being accepted for 1 position, with a start date beginning immediately. Reviews of applications will begin immediately and continue until the position is filled.

Competitive candidates should have: 1) a Ph.D. in behavioral sciences, public health, data science or related fields; 2) excellent writing skills; 3) strong research background; 3) excellent data and statistical skills; and 4) experience with technology for recruiting, assessing, and/or treating individuals preferred.  Knowledge of machine learning and artificial intelligence, as well as advanced statistical modeling strongly preferred.

Submission requirements: CV, representative reprints, research statement of interests and future goals, and three letters of recommendation. Email these materials to Lisa Fucito, PhD and Kelly DeMartini, PhD at:  lisa.fucito@yale.edu and kelly.demartini@yale.edu. Yale University is an Affirmative Action/Equal Opportunity Employer. Women and minority group members are encouraged to apply.

Postdoctoral Associate - Yale School of Medicine (Gruber Lab)
Posting Date: March 9, 2023

Postdoctoral Associate - Yale School of Medicine (Gruber Lab)

Dr. Peter Gruber´s Laboratory in the Yale University School of Medicine is seeking an enthusiastic Postdoctoral Associate, position immediately available to develop interdisciplinary research projects focused on cardiac development and contribute to increase the knowledge of innovative therapies to improve cardiac function.
The Gruber Lab (NIH funded through U01) utilizes a multi-disciplinary approach to investigate the molecular and genetic basis of human congenital heart disease. Through deep sequencing (WES and WGS) of both large cohorts and informative families, we have identified several novel genetic associations that require mechanistic investigation. Recent works (Dev Cell, Stem Cells) have uncovered a series of progenitor cell populations whole single cell transcriptional signal is enriched with damaging mutations identified in human cohorts.

Our lab employs mouse modeling, tissue culture, human ES and IPSC targeting, biochemical assays, and a variety of informatic approaches to understand the mechanisms that guide tissue movements in the developing heart.

Minimum Qualifications
The ideal candidate should be a highly motivated applicant with an MD, PhD, or MD/PhD in Basic Science, Health Science, or a related field, and be prepared to perform self-directed research in a close-knit laboratory environment at Yale University.

Preferred Qualifications
Knowledge of common molecular biological techniques, mouse modeling, and R are preferred.

Contact Information:
Eva Luna, MD
eva.lunarivera@yale.edu

Postdoctoral Position in Immunoengineering (Miller-Jensen)
Posting Date: March 8, 2023

Postdoctoral Position in Immunoengineering (Miller-Jensen)

A postdoctoral associate position is available in the Miller-Jensen laboratory in the Department of Biomedical Engineering at Yale University. We are seeking a highly motivated individual to join our interdisciplinary team using systems biology approaches to study the regulatory networks of innate immune cells in health and disease. We are particularly interested in studying macrophage and myeloid cell functional plasticity and defining the signaling and transcriptional regulatory networks that control macrophage heterogeneity.

The postdoctoral candidate will the develop genome engineering strategies to tune cell-to-cell heterogeneity in primary murine macrophages and explore the biological functionality of these engineered cells in vitro and in vivo. The postdoctoral candidate will work closely with collaborators to develop mathematical models of the emergent population-level behaviors. This position is supported through NSF- and NIH-funded grants. Our lab is a member of the new Center for Systems and Engineering Immunity (CSEI) where the postdoctoral candidate will join a vibrant and growing community of systems immunologists at Yale.

Applicants should hold, or be about to complete, a PhD or MD/PhD in immunology or biomedical engineering, or related fields. Individuals with experience in innate immunity, genome engineering, cell signaling biology, or any relevant experimental experience and a strong interest in immunology are encouraged to apply. Strong oral and written communication skills, along with a record of research productivity, are essential.

The position is available immediately but will be held for an ideal candidate. Applicants should include a summary of research interests and goals, CV, and names and contact information of three references. Please send materials as a PDF to:

Kathryn Miller-Jensen, PhD

kathryn.miller-jensen@yale.edu

Department of Biomedical Engineering

Yale University

Postdoctoral Position in Computational Systems Immunology (Miller-Jensen Lab)
Posting Date: March 8, 2023

Postdoctoral Position in Computational Systems Immunology (Miller-Jensen Lab)

A postdoctoral associate position is available in the Miller-Jensen laboratory in the Department of Biomedical Engineering at Yale University. We are seeking a highly motivated individual to join our interdisciplinary team using systems biology approaches to study the regulatory networks of innate immune cells in health and disease. We are particularly interested in studying macrophage and myeloid cell functional plasticity, and how these heterogeneous cells coordinate biological processes. We have active collaborative projects in skin wound healing (with Dr. Valerie Horsley at Yale) and in cancer immunotherapy in melanoma (with Dr. Marcus Bosenberg at Yale).

The postdoctoral candidate will lead the computational analysis of single-cell multi-omic data sets collected by members of our lab and our collaborators. These data are from mouse models, as well as clinical patient samples, and include scRNA-sequencing and CITE-seq, spatial transcriptomics, and single-cell secretion measurements, among others. The postdoctoral candidate will work closely with experimentalists, and will participate in experimental design, hypothesis generation, and data interpretation. Project goals include developing novel approaches for data integration, analysis of cell communication networks, and cell state evolution in tissues from the single-cell data. This work is supported by multiple NIH grants. Our lab is also a member of the new Center for Systems and Engineering Immunity (CSEI) where the postdoctoral candidate will join a vibrant and growing community of systems immunologists at Yale.

Applicants should hold, or be about to complete, a PhD in computational biology, biomedical engineering, or related fields. Individuals with experience in single-cell data analysis, modeling of signaling networks, or any relevant computational experience and a strong interest in immunology are encouraged to apply. Strong oral and written communication skills, along with a record of research productivity, are essential.

The position is available immediately but will be held for an ideal candidate. Applicants should include a summary of research interests and goals, CV, and names and contact information of three references. Please send materials as a PDF to:

Kathryn Miller-Jensen, PhD

kathryn.miller-jensen@yale.edu

Department of Biomedical Engineering

Yale University

Postdoctoral Associate (Center for Emotional Intelligence)
Posting Date: March 1, 2023

Postdoctoral Associate (Center for Emotional Intelligence)

The Yale Center for Emotional Intelligence seeks a full-time postdoctoral research associate to join the Emotion Revolution in the Workplace research team (PIs: Dr. Zorana Ivcevic Pringle & Dr. Marc Brackett). The primary objectives of this project are to develop and test a new measure of emotionally intelligent behavior in school leaders. Previous research has shown that leader emotionally intelligent behavior is related to employees’ emotional experiences at work, as well as their work behavior and achievement. In the present project, we seek to expend this research by developing a multidimensional measure and test the role of leader emotionally intelligent behavior for employee outcomes in educational settings.

The postdoctoral associate will be responsible for scale development and data analysis, as well as for formulating new research questions for future data collections and writing research articles. The Project Director, Dr. Zorana Ivcevic Pringle will oversee day-to-day work assignments and be the primary supervisor.

Key Responsibilities

  • Data analysis of large-scale nested data
  • Co-design studies addressing questions of the role of leader emotionally intelligent behavior on educator emotional and performance outcomes
  • Work with the research team to prepare conference presentations of research results
  • Collaborate with research assistants and research aides
  • Prepare research papers for publication in peer-reviewed journals in psychology, education, and related areas

Skills & Qualifications

  • Qualified candidates will have recently completed a PhD in psychology, education, or a related field
  • Knowledge or experience of scale development
  • Specialization or demonstrated interest in the study of emotions
  • Ability to communicate (e.g., through writing, presentations) with different audiences (research community, general public)
  • Excellent writing skills demonstrated in research publications
  • Exceptional project management skills
  • Competence in quantitative methods, including data analysis for nested data designs
  • Excellent statistics skills, proficiency with SPSS and R required, experience with large data sets a plus

The Postdoctoral Associate position is a one-year appointment with an opportunity to renew to a maximum of four years contingent upon satisfactory performance and availability of funding. Compensation is determined by experience. This is not a remote opportunity. This position is located at the Child Study Center on the campus of Yale University in New Haven, CT.

The anticipated start date is July 2023. Please note that the university has a COVID vaccination and booster requirement for all students, staff & faculty which is described in the COVID-19 Vaccine Program. You are required to comply with the Vaccine Program prior to the first day of your Yale appointment. Should you not be eligible for the Booster at this time, you will be required to receive your booster within seven (7) days of your eligibility. Please see the Yale COVID-19 Vaccine Program for information on how to schedule a vaccination and/or how to Submit or Confirm your vaccination documentation. For up-to-date university information on COVID-19, please visit: https://covid19.yale.edu/.

To Apply

Applications will be reviewed on a rolling basis through April 15, 2023.

Send application documents to Dr. Zorana Ivcevic Pringle at Zorana.ivcevic@yale.edu, using the subject line: “Postdoctoral Associate Applicant”. Include the following documents: (1) A one-page proposal detailing a research study you design to contribute to understanding how school leaders might influence educators. Situate your proposal in existing research, describe the model you are testing, and present how you would assess your variables of interest. (2) CV, and (3) A one-page cover letter. Be sure to include where you learned about the position in your cover letter. (Please submit your materials as PDF files and name them LastName.CV.pdf, LastName.coverletter.pdf, and LastName.proposal.pdf.)

Qualified applicants may be contacted to schedule an interview and asked to submit two letters of recommendation.

ABOUT THE YALE CENTER FOR EMOTIONAL INTELLIGENCE

Emotions drive learning, decision making, creativity, relationships, and health. The Yale Center for Emotional Intelligence uses the power of emotions to create a more effective and compassionate society. Helping children and adults develop emotional intelligence is central to the mission of the Center. To date, schools have been at the center of these efforts. RULER, the Center’s signature program, draws on leading pedagogical practices as well as advances in psychology and neuroscience, and it has been honed through years of classroom observation, interviews, and the most demanding evaluations. Creating awareness—both of self and others—about emotions and developing the skills of emotional intelligence can improve children’s prospects in life and contribute, in turn, to healthier, more compassionate families, workplaces, and communities. RULER does this by teaching adults and children the skills of emotional intelligence. Since 2005, more than 600 schools have implemented RULER, affecting the lives of over 500,000 students. Accordingly, we integrate emotional intelligence skill building, the basis of RULER, into their everyday practices and into classroom curricula across grade levels.

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Research Position in Cellular and Molecular Biology (Post-doc and ARS) Department of Pediatrics and Vascular Biology and Therapeutics Program
Posting Date: February 28, 2023

Research Position in Cellular and Molecular Biology (Post-doc and ARS)

Department of Pediatrics and Vascular Biology and Therapeutics Program

A research position (Post-doctoral or Associate Research Scientist) is immediately available in the laboratory of Dr. Richard Pierce. The Pierce Lab is a small group working on highly translational mechanisms of vascular dysfunction in the setting of acute critical illness. We utilize samples from critically ill children to identify genetic and molecular targets to investigate in cultured primary human endothelial cells and ev vivo perfused organs. Open projects involved investigating the interrogating the signaling cascades leading to endothelial permeability changes in human endothelial cell cultures.

We are seeking self-motivated applicants with competence in cellular and molecular biology techniques. Extra consideration will be given to candidates that demonstrate expertise in endothelial cell culture, manipulation of human cells with si/shRNA, immunoblotting and pull-down assays, RT-PCR/RNA-sequencing analysis and confocal and electron microscopy. It is expected that applicants can work at the bench independently, interpret data, and troubleshoot experiments. Due to the translational aspect of our research, passion, creativity and communication skills are required. Salary based on position and experience (https://postdocs.yale.edu/)

          Yale‘s Department of Pediatrics, Programs in Vascular Biology and Therapeutics and Human and Translational Immunology are unique, supportive and collaborative environments which combine the investigative strengths of outstanding laboratory-based faculty with strong interdisciplinary clinical teams. Researchers will be encouraged to participate in seminars, annual retreats and career development programs within these programs and Yale School of Medicine. This is an excellent environment for a highly motivated candidate to join a collaborative and growing laboratory.

Interested applicants should send a brief statement of research interests, curriculum vitae and contact information for three references to Richard Pierce, MD c/o Lisa Palmieri at the following address: lisa.palmieri@yale.edu or Lisa Palmieri, Department of Pediatrics, 333 Cedar Street, PO Box 208064, New Haven, CT 06520-8064.

More information at https://medicine.yale.edu/lab/pierce/ and @Pierce_Vasc_Lab

Yale University is an Affirmative Action/Equal Opportunity Employer and strongly encourages applications from women, members of groups traditionally underrepresented in science and medicine, persons with disabilities and protected veterans.

Postdoctoral Position Combining Interdisciplinary Research and Museum Program Development on Assyrian Stone Reliefs
Posting Date: February 28, 2023

Postdoctoral Position Combining Interdisciplinary Research and Museum Program Development on Assyrian Stone Reliefs

Yale Institute for the Preservation of Cultural Heritage (IPCH), Technical Studies Laboratory

The Technical Studies Laboratory of the Yale Institute for the Preservation of Cultural Heritage (IPCH) is seeking applicants for a one-year position at the postdoctoral or the postgraduate associate level, supported by a grant from the Avangrid Foundation. This description is for postdoctoral level applicants.

The postdoctoral associate will carry out a project with two overlapping objectives: research on the polychrome color schema of Assyrian stone reliefs and developing educational materials about polychromy and pigment analysis for use by the Yale Peabody Museum in gallery interpretation and programming.

The Yale Peabody Museum is currently undergoing a transformative renovation, which includes the creation of new spaces dedicated to ancient Mesopotamia. The gallery will feature two relief fragments from the palace of Ashurnasirpal II. Long deprived of their original painted surfaces, the reliefs will have that history of color restored through dynamic light projection to simulate how the reliefs would have appeared in situ. To anchor the light projection design in the materiality of the stone reliefs as much as possible, the appointee will work with IPCH scientists to locate and characterize any remaining microscopic paint residues using a combination of scientific imaging and micro-analysis techniques. They will also collaborate with colleagues at the Yale Babylonian Collection at the Yale Peabody Museum to contextualize the scientific findings with respect to similar research available in other collections and historic sources. The outcome of the project will include light projection color schema in addition to other visual and textual elements for use in gallery and digital platforms. A key aspect of the project involves working with the Peabody Museum’s EVOLUTIONS program (Evoking Learning and Understanding through Investigations of the Natural Sciences, or EVO for short), which is a free youth program for New Haven and West Haven high school students.

Position and application information:

The postdoctoral associate position is a full-time, 12-month position (renewable for a 2nd year pending funding). A starting date between May 1 and June 30, 2023 is desired. Salary will be based on Yale’s guidelines for postdoctoral positions, which establish a minimum of $56,448 for 1st year postdocs (https://postdocs.yale.edu/policies/compensation). Allowable relocation costs up to $4000 will be reimbursed. For a description of benefits, including health insurance, please visit https://postdocs.yale.edu/applicants/yale-benefit-summary. Support for travel associated with projects is provided. This position is based primarily on Yale’s West Campus on the border of West Haven and Orange CT, and requires visits to collection spaces on Central Campus in New Haven. There is a free shuttle service between Yale’s campuses, parking at West Campus is free of charge.

Application process:

  • The closing date for applications is March 24, 2023; review will begin immediately and continue until the position is filled.
  • Send an email or document describing your interest in the position, your CV, and the names of and contact information for two references to Marcie Wiggins (marcie.wiggins@yale.edu) at the Institute for the Preservation of Cultural Heritage.
  • At IPCH and the Yale Peabody Museum we are working on Diversity, Equity, Accessibility, and Inclusion institutional priorities so that we can learn to better serve our communities, amplify marginalized voices and perspectives, and create a welcoming and inclusive environment for all. The ideal candidate will be ready to share their experience with and interest in contributing to this work. Please address in your cover letter how Diversity, Equity, Accessibility, and Inclusion relate to your professional experience and goals.
  • We welcome and encourage applications from individuals of all backgrounds, especially those from traditionally underrepresented groups in the museum field.

Required qualifications:

  • Recent completion of a graduate degree at the doctoral level in fields including archaeology/anthropology, cultural heritage science (conservation science), physical sciences (chemistry, materials science and engineering), Near Eastern or Classical studies, technical art history, or related fields.

Desired Skills & Related Activities

  • Experience with imaging and instrumental analysis techniques used to identify pigments and colorants. Ability to collect and analyze data using methods including in-situ x-ray fluorescence spectroscopy and Raman spectroscopy as well as sample-based techniques (FTIR, SEM-EDS, etc.).
  • Ability to engage with scholarship on the cultural history of Assyrian art (applicants do not need to be experts in Assyrian history) and current research into ancient polychromy. Connect with curators, conservators, and scientists at other institutions to learn about and incorporate their findings into this study.
  • Ability to work collaboratively within a multidisciplinary and cross-institutional setting involving scientists, cultural historians, museum programming and outreach specialists, as well as a wide range of supporting departments.
  • Demonstrated robust verbal and written communication skills. The selected candidate will communicate scientific findings to audiences ranging from specialists to the public. Modalities may include written analytical reports; gallery content in the form of graphic representations of polychromy and written description of analysis processes for museum audiences; in-person engagement with high-school student participants in the Yale Peabody Museum’s EVO program; written and visual website and social media content.
  • Organizational skills needed for project management.

About the Institute for the Preservation of Cultural Heritage

The Institute for the Preservation of Cultural Heritage (IPCH) is the collaborative and programmatic nexus of preservation and conservation expertise across Yale’s libraries, museums, and special collections. Established in 2011, IPCH enacts its mission to advance the preservation and interpretation of the world’s cultural heritage through collaborative research, practice, training, and outreach. Located on the Yale West Campus, IPCH engages with scholars and students and with its world-class collections, including those of the Yale University Art Gallery, the Yale Peabody Museum of Natural History, the Yale Center for British Art, and the Yale University Library. The Technical Studies Lab at IPCH decodes art and artifacts, enabling scholars across disciplines to incisively interpret origins and histories. Fundamental to this work is understanding and managing change, especially deterioration and its detection, monitoring, and treatment. We also develop tools and methodologies that enable new modes of studying art and artifacts. Facilities include a variety of XRF instruments, optical microscopes, FTIR microscope, Raman microscope, SEM/EDS, GC/MS, UV/visible spectroscopy, and an array of accelerated aging and mechanical testing equipment.

Yale University considers applicants for employment without regard to and does not discriminate on the basis of an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression.

Postdoctoral Associate Research Fellows (Wang Lab)
Posting Date: February 28, 2023

Postdoctoral Associate Research Fellows (Wang Lab)
 

Our lab is seeking multiple highly motivated postdoctoral research fellows interested in the rapidly expanding field of spatial genomics, spatial multi-omics, and 4D nucleome.

Research in our lab focuses on the development and application of state-of-the-art imaging-based omics approaches to understand the spatial organization of mammalian genome and transcriptome, and how they impact cellular states. Recent advances include the development of the first-in-kind image-based 3D genomics method termed chromatin tracing to trace the spatial folding of genome, co-development of MERFISH for spatial transcriptome profiling (See Nature Methods Method of the Year 2020), and the development of MINA for highly multiplexed integrative DNA-RNA-protein imaging, to measure multiscale chromatin folding, copy numbers of numerous RNA species, and associations of numerous genomic regions with nuclear landmarks in the same, single cells in mammalian tissue (Science 2016, Science 2015, Molecular Cell, 2020, Nature Communications 2020, Trends in Cell Biology 2020, Nature Protocols, 2021, Cell Discovery 2021, Genome Biology 2021). As one of the leading labs in this field, we are well funded with over $10 million through five NIH and private foundation mechanisms received in 2019-2022. Professor Wang is a highly recognized pioneer in the field and was awarded with the “2016 International Union of Pure and Applied Physics Young Scientist Prize in Biological Physics”, the “2018 MIT Technology Review 35 Innovators Under 35 of China”, the “2019 NIH Director’s New Innovator Award”, the “2022 Pershing Square Sohn Prize for Young Investigators in Cancer Research”, and the “2023 Biophysical Society Early Career Award in Physical Cell Biology.”

We have established a very dynamic and productive lab culture (lab publications). Trainees in the lab receive unique, comprehensive training in this rising field and abundant research opportunities. Devoted trainees often rapidly achieve significant track records.

The postdoctoral fellow will lead the development of the next generation of image-based spatial omics technologies and/or the application of these technologies to high-impact biomedical investigations. Individuals with expertise in any one of the following areas are strongly encouraged to apply: 1) sequencing-based omics technology development; 2) light microscopy and optical instrumentation; 3) molecular and cellular biology with mammalian/human cell culture or tissue especially in stem cell biology, cancer, aging, or immunobiology; 4) computational biology/bioinformatics.

The position is renewable annually, with immediate start availability. The position requires the candidates to have PhD degree by the time of start.
To Apply: http://apply.interfolio.com/121986
Questions may be sent to: Siyuan.wang@yale.edu

Postdoctoral Scientist in Functional Neurogenomics (Brennand Lab)
Posting Date: February 23, 2023

Postdoctoral Scientist in Functional Neurogenomics

The research group of Dr. Kristen Brennand (Departments of Psychiatry and Genetics, Yale University) is seeking multiple postdoctoral scientists.  The scope of currently funded projects is broad, and scientists from any discipline with training or interest in applying stem cell models to neurogenomics are welcome to apply.  Our mission is to unravel the mysteries of the human genome within a collaborative, inclusive, and supportive training environment.

The Brennand laboratory combines expertise in human stem cell models, genomic engineering, and neuroscience to identify the mechanisms that underlie brain development, traits, and disease. Understanding the basic biology governing the complex interplay between genetic variants and the environment will springboard the development of novel, personalized approaches to improve health and prevent disease. Our highly collaborative approach strives to uncover the convergence and synergy arising from the complex interplay of genetic and environmental risk factors associated with brain disease. Our team science approach supports each lab member in undertaking cutting-edge, rigorous, and high-quality science. The culture of our laboratory is inclusive and supportive; the goals of trainees are centered. Dr. Brennand is committed to achieving more equitable training for the next generation of rigorous scientists, compassionate physicians, and collaborative teams of cross-disciplinary researchers. We especially encourage applications from women, minorities, and individuals with a commitment to mentoring disadvantaged demographics in the sciences. All Brennand laboratory team members sign a code of conduct posted on our laboratory website.

Post-doctoral scientists will pursue biological follow-up of emerging genetic and genomic findings in brain development and disease. The successful candidate should have experience in lab-based work including induced pluripotent stem cells (human or mouse), CRISPR-engineering, genetics and genomics, MPRA, CRISPR-screens, neuronal/glial differentiation, cell/synaptic imaging, molecular cell biology, and/or proteomics. 

Responsibilities:

  • Interact with the PI to pursue biological follow-up of emerging genetic and cellular findings in brain disease.
  • Publish and present novel research findings in academic journals and conferences.
  • Actively collaborate with other members of the research team.
  • Mentor junior scientists in the laboratory.

Preferred Qualifications:

  • Candidates with a doctoral degree in human genetics, neuroscience, molecular biology, or related field with deep expertise in molecular and cellular biology techniques.
  • Stem cell culture, CRISPR, molecular biology, and/or bioinformatic skills.
  • Desire and ability to work both collaboratively and independently.
  • Motivated self-starter capable of managing multi-site collaborations.
  • Effective oral, written, and interpersonal communication skills.

Qualified applicants should send the following to Kristen Brennand at kristen.brennand@yale.edu as a single pdf: curriculum vitae, a brief statement of research interests, and contact details for three references

Yale University is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. 

Postdoc position in cancer therapeutics (Sheltzer Lab)
Posting Date: February 22, 2023

Postdoc position in cancer therapeutics (Sheltzer Lab)

The Sheltzer Lab at Yale University is seeking postdoctoral researchers for a funded project researching and developing anti-cancer therapeutic strategies.

Our laboratory is developing and applying cutting-edge genetic techniques to uncover unique cancer “dependencies” and to characterize the mechanism-of-action of different anti-cancer agents. Unexpectedly, we have found that many drugs used in human patients act via mechanisms that are independent of their reported target(s). We are applying a combination of techniques, including CRISPR screens, targeted mutagenesis, live-cell microscopy, and molecular pharmacology, to study a variety of cancer drugs and to figure out how they actually work. Through these approaches, we have found that one mis-characterized drug functions by targeting the cyclin-dependent kinase CDK11 – the first inhibitor of this kinase to be discovered. We are seeking to both learn more CDK11B’s function in cancer and to apply similar approaches to characterize other small molecule drugs. By discovering the true mechanism-of-action of mis-characterized inhibitors, we hope to identify biomarkers that can be used to accurately predict patient sensitivity and to monitor drug efficacy in vivo. More information can be found in our publications, including:

Bhattacharjee, D., Bakar, J., Sausville, E.L., Mendelson, B.E., Long, K., Smith, J.C., Sheltzer, J.M. (2022). A drug’s most potent target is not necessarily the source of its anti-cancer activity<https://www.biorxiv.org/content/10.1101/2022.10.16.512438v1.full>. bioRxiv. doi.org/10.1101/2022.10.16.512438.
Lin A., and Sheltzer J.M. (2020). Discovering and validating cancer genetic dependencies: approaches and pitfalls<https://www.nature.com/articles/s41576-020-0247-7>. Nature Reviews Genetics. doi:10.1038/s41576-020-0247-7.
Lin, A., Giuliano, C.J., Palladino, A., John, K.M., Abramowicz, C., Yuan, M.L., Sausville, E.L., Lukow, D.A., Luwei, L., Chait, A.R., Galluzzo., Z.C., Tucker, C., Sheltzer, J.M. (2019). Off-target toxicity is a common mechanism-of-action of cancer drugs undergoing clinical trials<https://www.science.org/doi/10.1126/scitranslmed.aaw8412>. Science Translational Medicine. 11, eaaw8412.

The Sheltzer Lab is a highly-collaborative environment that values rigorous experimental design and that welcomes scientists from all backgrounds. We are located at Yale University, an internationally-renowned research university located in the historic city of New Haven, Connecticut. Yale has long been recognized as an outstanding environment for nurturing young scientists, with postdoctoral researchers being an integral part of the discovery process.

Additional information on research in the Sheltzer Lab can be found on our website:www.sheltzerlab.org. Candidates who are interested in applying to this position should send a CV and cover letter to Dr. Sheltzer at Jason.Sheltzer@yale.edu.

Postdoctoral fellowship in lactation science and neonatal nutrition
Posting Date: February 15, 2023

Postdoctoral fellowship in lactation science and neonatal nutrition

Yale University invites applications for a Postdoctoral Fellow position for research in lactation science and preterm infant nutrition, growth, and development through the Neonatal NOuRISH Team lead by Dr. Sarah Taylor, Professor in the Yale College of Medicine and Yale School of Public Health.

Research in the Yale Neonatal NOuRISH (Nutrition Outcomes Research In Sustaining mother and infant Health) team focuses on patient-oriented health outcomes affected by pregnancy and lactation especially when preterm birth occurs. We are seeking a motivated and dynamic individual who has completed residency training, PhD or other terminal degree. The objective of this program is to provide research training in the clinical nutritional science to an individual who is committed to prevention of disease and health promotion through a career in human nutrition. The fellowship will include experience in clinical study coordination in both the neonatal intensive care unit and outpatient clinic setting and development of skills to elucidate the determinants of growth and neurodevelopment in preterm infants with an emphasis on exposure to human milk.

For more information on our group, please see our website—Yale Neonatal NOuRISH Team < Neonatal-Perinatal Medicine.

Interested applicants should send a brief statement of interest, your work experience and a resume with contact information for three references to the Principal Investigator, Dr. Sarah Taylor (sarah.n.taylor@yale.edu).

Postdoc Position in Biochemistry and Drug Discovery (Bleichert lab)
Posting Date: February 13, 2023

Postdoc Position in Biochemistry and Drug Discovery (Bleichert lab)

The Bleichert lab in the Department of Molecular Biophysics and Biochemistry at Yale University is looking for a highly motivated, goal-driven, and team-oriented postdoctoral associate with a strong background in biochemistry and/or drug discovery to study small-molecule inhibitors of DNA replication initiation. This position will allow the candidate to leverage our expertise in applying biochemical and structural biology approaches to understand fundamental mechanisms of chromosome replication and genome stability. We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development.

Interested candidates should have recently finished or will soon complete their PhD degree and have a strong research track record. The successful candidate will possess scientific curiosity, a collaborative team spirit, and should be skilled in recombinant protein expression and purification.  Prior expertise in drug discovery is not essential but advantageous.

Qualified candidates should send their CV, a cover letter describing past and future research interests, and the contact information for two to three references to franziska.bleichert@yale.edu.

Postdoctoral Associate in Pain & Addiction Neuropsychopharmacology (De Aquino Lab)
Posting Date: February 3, 2023

Postdoctoral Associate in Pain & Addiction Neuropsychopharmacology (De Aquino Lab)

The De Aquino Lab, located within the Division of Addictions of the Department of Psychiatry at the Yale University School of Medicine, is seeking to hire a postdoctoral associate to work on developing novel pain and addiction therapeutics, through translating advances in neuropsychopharmacological research. The ideal candidate should have recently completed a Ph.D. or M.D., with a background in psychiatry or psychology, and experience in behavioral data analysis, with proficiency in R or similar programs.

The postdoctoral associate will have the opportunity to work on Phase 1/2 human laboratory studies aiming to understand the pharmacodynamics and pharmacokinetics of substances that have both analgesic and addictive potential (e.g., phytocannabinoids, NDMA antagonists, nicotine). The postdoctoral associate will work on studies recruiting healthy persons and persons with substance use disorders. Potential experiences include contributing to ongoing data collection; working on data already collected within the lab; and applying data analysis skills to larger, nationwide datasets.

The postdoctoral associate will receive training in state-of-the-art behavioral pharmacology techniques (delivering psychoactive substances using various routes of administration and manipulating processes that are clinically relevant for pain and addiction treatment); computerized quantitative sensory testing (QST) of pain; and real-world clinical trial methods. These training opportunities are bolstered by the rich intellectual environment of the Yale Division of Addictions with adjacent PI’s Mehmet Sofuoglu (expertise in addiction psychopharmacology), Mohini Ranganathan (expertise in cannabinoid science) and R. Ross MacLean (expertise in ecological momentary assessment applied to the study of co-occurring pain and addiction).

Expectations of the postdoctoral associate include the processing and analysis of complex behavioral data, aiming towards publishing manuscripts and generating novel scientific directions. Additional opportunities include behavioral and psychophysical task design and pharmacokinetics modeling.

The ideal candidate should be self-driven, creative, ethical, and collaborative, and able to integrate feedback. Ultimately, there will be project flexibility based on the interests and motivation of the postdoctoral associate, and a lack of formal experience should not preclude the motivation to be trained. Experience in multidimensional assessment of pain, clinical neuroscience, or prior work with populations with pain and/or addiction are a plus. 

The starting date is negotiable. The duration of the position will be two years, with the opportunity to extend if agreed upon by the post-doctoral associate and the PI. 

If interested, please email a letter of interest, CV or resume, and the names of three references to: joao.deaquino@yale.edu and julia.meyerovich@yale.edu.