Yale Postdoctoral Positions

Postdoctoral positions are available in the Laboratory of Dr. Raul J Guzman, Chief, Division of Vascular and Endovascular Surgery at Yale University School of Medicine.

The research program focuses on investigating the mechanisms that control arterial disorders including calcification and restenosis. The laboratory uses multiple approaches including gene knockdown, overexpression, and deficiency in cell culture, ex vivo organ culture, small animal models, and transgenic mice. Its goal is to identify novel mechanisms that control pathologic arterial responses and to develop therapeutic agents to prevent them.

Qualified applicants are those who have earned a Ph.D. or equivalent degree with a strong background in vascular biology or related fields. The candidates should have prior experience with cell and molecular biology and small animal techniques. Ideal candidates will have the ability to independently design, execute and troubleshoot experiments. They will have the ability to collect, analyze and interpret data in preparation for manuscript publication. They will also possess the ability to communicate in English both verbally and in writing to present experimental findings at internal meetings and scientific conferences.

To apply for this position please submit your CV, a cover letter, and contact details of three references to yujun.cai@yale.edu

The Department of Psychiatry at Yale School of Medicine invites applications for two postdoctoral associate positions focused on research in the areas of tobacco use prevention, cessation, and regulation. We have three available positions with start dates ranging from now until the positions are filled.

The postdoctoral associates could participate in projects focused on the 1) development and evaluation of e-cigarette cessation interventions in adolescent populations in collaboration with the Tobacco Research in Youth (TRY) Group, and 2) the conduct of tobacco regulatory research in adolescent and adult populations within the Yale Tobacco Center of Regulatory Science (TCORS). Within the TCORS, postdoctoral associates will have access to training on tobacco regulatory science and the opportunity to participate in a programmatic line of research aimed at investigating how flavors, sweeteners, and other constituents, as well as social media content, impact use behaviors and the appeal and addictive potential, of e-cigarettes and other tobacco products.

Competitive candidates should have: 1) a PhD in clinical, developmental, counseling, or health psychology, or a doctoral degree in public health, family studies, social work, or social welfare; 2) a strong research background; 3) interest in pursuing an academic career; 4) interest and/or background in tobacco regulatory science or tobacco prevention and cessation among youth and young adults. Strong data analytical skills would be appreciated but not required.

All postdoctoral associates will participate in core seminars on research and data analytic methods, grant development, and professional development as well as in seminars and colloquia that cover related topics, such as the ethical conduct of research and current topics in substance abuse prevention and tobacco regulatory science. Post-doctoral associates will have an opportunity to conduct independent research under the mentorship of Drs. Suchitra Krishnan-Sarin and Grace Kong.

To apply: Applicants should email a CV, a statement of interests that outlines their qualifications, research interests, and future goals, and three letters of recommendation to Dr. Grace Kong: Grace.Kong@yale.edu.

The Pitt laboratory is looking for a motivated junior postdoctoral fellow with background in cell biology to join our team. We conduct translational research in multiple sclerosis (MS) with the goal of understanding the mechanisms that underlie MS progression and neurodegeneration.

Our laboratory in the Department of Neurology, Yale School of Medicine, is embedded in a highly collaborative, translational neuroimmunology program that includes T cell biology, genetics and computational biology. 

The candidate will drive the development of astrocyte-derived exosomes as biomarkers for MS progression and other neurodegenerative conditions. Our laboratory uses cutting-edge technologies such as generation of human iPSC-derived astrocytes and microglia, highly multiplexed histological imaging (staining of individual section with 40+ antibodies), advanced computational tools for spatial analysis, as well as purification of astrocyte and oligodendrocyte nuclei from MS, Alzheimer and Parkinson’s tissue for transcriptomic and genomic profiling with sNuc-Seq and ATAC-Seq.

The candidate should have a broad neurobiology background and experience with cell-based assays in primary cultures. Please respond with CV, a short description of relevant expertise, representative publications and the names of three references by email to david.pitt@yale.edu. The successful candidate will join the Department of Neurology for a minimum of 2 years.

The Neuroimaging and Informatics Lab in the Department of Radiology and Biomedical Imaging at Yale University is seeking highly motivated postdoctoral fellows to join our team. The research focus is on application of deep-learning for automated assessment of brain CT and MRI scans in patients with stroke and brain injury. Our goal is to devise novel tools for diagnosis, outcome prediction, and risk-stratification of patients with cerebrovascular diseases, based on wealth of information extracted from medical images and clinical records.

Successful applicants will have the opportunity to work in close collaboration with Department of Bioengineering, and Department of Neurology at Yale. We are working on a large cohort of multi-institutional multi-national datasets to address some of the most pressing needs in patients who are susceptible to brain injury. Postdocs are expected to develop and deploy deep neural networks for medical image analysis, utilizing the available datasets. The postdocs will also oversee and lead graduate students and RAs working in the lab.

Preferred qualifications include:

• PhD in computer science, electrical engineering, or biomedical engineering
• Experience with application of CNN for image classification and segmentation – preferably medical images
• Advanced programming experience and analytical skills
• A record of publication and/or conference presentations

Qualified candidates should submit a cover letter describing previous programming experience, CV, and three references to the PI: sam.payabvash@yale.edu

Yale School of Medicine is seeking a several motivated Postdoctoral Associates to join research programs in the laboratory of Stefan Somlo focused on the study of human genetics, cilia biology and signaling as it pertains to human genetic kidney, liver and intracranial aneurysm diseases—all part of the spectrum of human polycystic kidney disease. The research opportunities run the spectrum from human disease modifier gene discovery to utilization of novel mouse and fish disease models for in vivo pathway discovery and validation. The approaches are founded on interpretation of large data sets from human genome level sequence data and mouse cell type specific transcriptome sequence data coupled with model organism genetics and basic cellular and molecular biology. The goals of the program are to discovery new biology and define targets for human disease treatment.

Applicants should have a Ph.D. and/or M.D., with interest in genetics, model organisms, molecular biology, cell biology, or related fields. Interest in combining these with basic bioinformatics analyses is desirable but not necessary.

All applications materials should be submitted electronically to: Carol Brown, HR Administrator at carol.brown@yale.edu. Review of applications will begin immediately and will continue until the position is filled.

The Powers Laboratory at Yale is recruiting two full-time post-doctoral fellows to work on two new NIMH-funded studies in psychosis. 

The first is a multi-site study involving Yale, Northwestern University, UMBC, and UGA, evaluating the efficacy of a battery of behavioral tests for tracking symptom severity and risk of conversion among patients at Clinical High Risk for Psychosis (CHR-P).  In addition to collaborating across sites, candidates will also work with Drs. Phil Corlett, Scott Woods, and Barbara Walsh at Yale. 

The second project uses performance on a simple perceptual task and computational modeling to predict behavioral and neural responses to cholinergic manipulation.  Our goal is to use the knowledge generated to take the first steps toward a computationally-informed, personalized treatment approach to hallucinations.

Activities for both positions will include data collection, analysis of behavioral and functional imaging data using cutting-edge computational modeling, and reporting in the form of journal articles and presentations at national and international meetings.  Ideal candidates will have experience with behavioral data collection and analysis, basic working knowledge of MATLAB or other technical computing languages, expertise in sensory neuroscience, and a background in working with individuals with psychosis-spectrum illness. Duration and start date are negotiable but a minimum of a two-year commitment is required.  Timing of hire will also depend on resolution of hiring restrictions currently in place due to the COVID-19 crisis.

Salary and benefits package are highly competitive. Interested candidates should send a letter of interest, CV, and the names of three references to Al Powers, M.D., Ph.D. by email: albert.powers@yale.edu . 

Yale School of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM), is looking to hire a highly motivated Postdoctoral Fellow to drive innovative research projects forward in the laboratory of Dr. Charles Dela Cruz, MD, PhD. The post-doctoral fellow will work on understanding the host-pathogen interactions at cellular and molecular levels during bacterial and viral infections in disease models of pneumonia, COPD and fibrosis. The post-doctoral fellow should be able to work independently as well as in a team of other researchers in the lab which include other postdocs, clinical fellows and students. The major experimental tools that will be used include animal models, multicolor flow cytometry, knockdown and overexpression studies and imaging techniques using bacterial and viral infection along with techniques of viral and or bacterial culture, western blotting and ELISA.

Job Qualification:

1. A recent graduate or about to graduate from PhD in the field of biology, immunology, bacteriology, virology or similarly related fields.

2. Experience with animal handling is preferred but not necessary. Knowledge about the major cellular and biochemical techniques will be plus.

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The Postdoctoral Fellow is expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected.

Review of applications will begin immediately, and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to charles.delacruz@yale.edu

The Wilson laboratory in the Section of Medical Oncology and the Yale Cancer Center is seeking candidates for a postdoctoral position.  Interests in the laboratory focus on identifying and characterizing genetic vulnerabilities in cancer and molecular mechanisms of drug resistance with an emphasis on lung cancer therapeutics (https://medicine.yale.edu/bbs/people/frederick_wilson-1.profile). The lab leverages genome-scale functional genomic screening approaches (such as CRISPR and RNA interference) to identify cancer vulnerabilities and dissect resistance mechanisms in relevant cancer cell models.  The lab also applies sequencing-based approaches to identify candidate driver gene alterations from patient tumor specimens for mechanistic studies in cell model systems.  A major priority is to translate laboratory findings into therapeutic strategies for patients with lung and other cancers.
 
Applicants must have a recent PhD degree in a relevant field and at least one first author publication in a peer-reviewed journal. Applicants should have experience in molecular biology, genetics / genomics, tumor cell biology, or other related fields.  Excellent written and oral communication skills are expected.
 
Candidates should send a Curriculum Vitae, a statement of research interests and career goals and the names / contact information for three references to: frederick.wilson@yale.edu.
 

The Escobar-Hoyos lab in the Department of Therapeutic Radiology and Yale Cancer Center at Yale University is seeking a highly motivated and creative post-doctoral researcher with a background in cancer biology and/or RNA biology, or related fields to join our team.

We are seeking a dynamic individual who will be responsible, as a member of a team, for designing and executing studies focused on understanding and targeting altered RNA processing mechanisms in pancreatic cancer.

As the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) has emerged as the 3rd leading cause of cancer death in the United States, in part because this malignancy is highly resistant to chemotherapeutic  intervention.

Recently, it’s been shown that PDAC is composed of distinct molecular subtypes, based on RNA expression and patient outcome, underscoring that much remains to be understood about RNA expression, processing and regulation in this disease. Our research is focused on 1) characterizing the molecular pathways and functions controlled by aberrant RNA splicing and 2) designing RNA- targeted therapies to uncover novel therapeutic vulnerabilities in this disease.

Our group is heavily involved with RNA Sequencing of human and mouse pancreatic cancers. The candidate is expected to perform experiments exploring alterations in RNA splicing and additional steps in RNA processing, using a variety of preclinical model systems that include cell lines, xenografts, genetically engineered mouse models, and patient-derived models. A desire to develop and implement new methodologies is highly advantageous. There will be numerous opportunities for training to complement current skills, collaborate with other outstanding scientists, and to enhance grant writing skills.

The candidate will work within an integrated, multidisciplinary team composed of basic scientists, computational biologists, pathologists, medical oncologists, and radiologists, with significant resources for bioinformatics support, access to clinical specimens, and studies in human and animal tissues.

Applicants should have completed a PhD in cell biology or a related field and have a strong publication record, excellent verbal and written communication skills and strong research experience in signal transduction, transcriptional control, RNA splicing, genomics and bioinformatics, or related fields. Recent PhD graduates or current PhD candidates completing their studies are encouraged to apply.

Experience with several of the following activities are desirable: characterization of genetically engineered mouse models, work with patient-derived xenografts or organoids, and culture of primary cells. Initial salary is commensurate with experience. Applying for independent funding is not required but is strongly encouraged for the career development of the candidate.

Qualified candidates should send a curriculum vitae, a cover letter detailing research interests and career goals, and contact information for three references to Dr. Luisa Escobar-Hoyos (luisa.escobar-hoyos@yale.edu).

Peggy Myung, MD, PhD, is seeking a highly motivated Postdoctoral Associate (Ph.D., M.D., or M.D./Ph.D.) in her laboratory in the Department of Dermatology, Yale School of Medicine. In the Myung lab, we study how programs of hair follicle development work at the interface of regeneration and skin tumorigenesis (Developmental Cell, 2019; Cell, 2016). In particular, our lab aims to dissect the molecular and cellular mechanisms that govern embryonic hair follicle development to gain insight into how these same mechanisms are reutilized during adult hair follicle regeneration and or dysregulated in basal cell carcinoma, the most common human skin cancer. As a post-doctoral fellow in our lab, you will have the opportunity to work within a team to perform basic science research that explores the cellular and molecular dynamics that controls these processes, using novel in vivo and genomic approaches. The projects employ a broad range of cutting-edge techniques, including mouse genetics, multi-photon live imaging, quantitative RNA fluorescent in situ hybridization, and single-cell RNA/ATAC sequencing.  Prior research experience using these techniques is a plus but not required. The candidate will also have opportunities to present his/her data at weekly lab meetings and at intramural and national/international conferences. The overall goal is to construct and perform scientific experiments that can be shared with the scientific community at large through peer-reviewed publications and speaking opportunities. In addition, the candidate will be given career development opportunities (e.g. grant-writing and public speaking skills) that are individually tailored to his/her long-term career goals. The ultimate goal is to create an experience that is rewarding and engaging for everyone in the lab and that fosters scientific and professional growth!

The Postdoctoral Associate candidate will be expected to perform the following:

1. Assist with mouse colony management, husbandry and genotyping
2. RNA in situ hybridization and immunohistochemical stains of mouse or human tissue followed by visualization using various microscopy techniques including multiphoton microscopy, confocal microscopy, and basic immunofluorescence/brightfield microscopy
3. Basic molecular biology techniques such as quantitative PCR, subcloning, and preparation of RNA for bulk and single-cell RNA sequencing
4. Preparation of single-cell suspensions from mouse skin for flow cytometry and FACS sorting
5. Basic tissue culture techniques using primary skin cells and cell lines
6. Embryonic and adult skin dissections
7. Intraperitoneal and gavage administration of soluble compounds (e.g. tamoxifen) to mice
8. Use basic software/statistical tools to analyze genomic data, including R packages for single-cell RNA sequence analysis
9. Assist with data analysis, interpretation, and generation of figure quality data for publication and/or presentations
10. Attend intra-mural and extra-mural conferences where he/she can present research data and build professional relationships
11. Review and present relevant literature at journal clubs or lab meetings
12. Attend weekly dermatology and/or pathology research in progress conferences as well as weekly lab meetings
13. Attend one-on-one meetings with the PI to review scientific data/progress and goals and to provide reciprocal constructive feedback
14. Prepare manuscripts of his/her primary research for publication
15. Assist with lab organization

Interested candidates should email a cover letter that briefly describes their personal and career goals as well as their research/scientific background, their CV, and at least 3 letters of reference to peggy.myung@yale.edu.