Yale Postdoctoral Positions

The Gupta Lab, located in the Yale Liver Center is seeking a motivated and dedicated Postdoctoral Associate to join its research program. The lab is focused upon harnessing murine genetics, using human tissue samples, and utilizing single-cell and bulk RNA sequencing technologies to understand cellular crosstalk between biliary epithelial cells and surrounding mesenchymal cells during homeostasis and disease. The major goal of the lab is to dissect how these cell types are perturbed in the disease state to gain greater understanding of human biliary disease.

Postdoctoral training in the lab includes molecular biology, flow cytometry, mouse genetics and surgery, biliary cell isolation, next generation sequencing, confocal/multiphoton imaging, and more. Additionally, candidate will be mentored in research presentation, manuscript preparation, and is further tailored depending on the candidate’s career goals.

Applicants should have an MD, PhD, or MD/PhD with a background in cell and molecular biology, genetics, genomics and/or other related biological fields.

If you are interested in this position, please send (1) your CV, (2) a cover letter with research interests and career goals, and (3) a list of three references for contact to vikas.gupta@yale.edu. Applications will be reviewed on a rolling basis until the position is filled.

The Jackson Institute for Global Affairs and the  Economic Growth Center  (EGC) at Yale are seeking applications for a Postdoctoral Associate in international development for the 2021-22 academic year.

The Postdoctoral Fellow will conduct independent research and collaborate with Jackson Institute and EGC faculty, contributing to the intellectual life within and between the centers.  In the spring semester, the Fellow will be expected to teach Approaches to International Development, a core course for undergraduate students in Yale’s Global Affairs major.  The successful candidate will also be involved in multiple EGC data-oriented initiatives. This includes advising on the development of training materials for economics graduate students on Stata and potentially other programming packages.  In addition, the fellow will have the opportunity to collaborate with a set of EGC faculty on an initiative pushing forward data access and archiving as a public good for development research.

The ideal candidate will have a demonstrated ability in conducting high quality, policy-relevant research on topics in international development and economics. This is a full-time position.  Fellows will be expected to be in full-time residence at Yale for the duration of their appointment.

Applicants should submit a cover letter, CV, one page description of research plans, a writing sample, teaching statement with evidence of teaching excellence, and three letters of recommendation. All information from the applicant should be submitted electronically through Interfolio at  http://apply.interfolio.com/86754  .

Compensation is competitive and includes health insurance and other benefits afforded to postdoctoral associates at Yale. For more information see https://your.yale.edu/enroll#pda .

Review of applications will begin immediately and will continue until the position is filled. For questions concerning this search, please Larisa Satara at larisa.satara@yale.edu.

A postdoctoral position is available in the laboratory of Dr. Nadya Dimitrova, Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. Research in the Dimitrova laboratory focuses on investigating the roles of a novel class of genes, called long noncoding RNAs (lncRNAs) in cancer biology. To date, lncRNAs have remained largely uncharacterized but emerging evidence suggests an involvement in a broad range of biological processes and in human disease, including cancer. We select candidates based on their regulation by key oncogenes and tumor suppressors or based on their involvement in cancer processes, such as the DNA damage response, oncogenic transformation, and metastasis.

Our goal is to understand how candidate lncRNAs contribute to oncogenic and tumor suppressive networks at the molecular, cellular, and organismal level and how deregulation of lncRNAs leads to cellular transformation and tumor development. At the molecular level, we aim to elucidate the diverse mechanisms by which cis- and trans-regulatory lncRNAs fine-tune oncogenic and tumor suppressive networks by modulating transcriptional and translational pathways.

At the cellular level, we aim to understand how lncRNAs participate in the decision-making processes in complex transcriptional networks and what are the consequences of lncRNA activity for cellular homeostasis and stress response. Finally, to bring insights into the vastly understudied contribution of lncRNAs to tumorigenesis in vivo, we are testing how inappropriate expression of regulatory lncRNAs influences tumor development in mouse models of lung and breast adenocarcinomas.

A successful candidate will hold a Ph.D. degree, will be highly motivated to perform cutting edge research and to interact with a dynamic, young group of investigators. Candidates from diverse scientific backgrounds are strongly encouraged to apply.

Additional information can be found at dimitrovalab.yale.edu

Candidates should send a CV, names of three references, and a cover letter with a brief statement of future research interests and career goals to: nadya.dimitrova@yale.edu

Two postdoctoral positions in computational single-cell RNA sequencing and spatial transcriptomics & proteomics are available in the laboratory of Dr. Yuval Kluger at Yale University School of Medicine. The Kluger Lab is affiliated with the Applied Mathematics program in the Department of Mathematics, Computational Biology & Bioinformatics program, as well as the Yale Center for Biomedical Data Science and the Yale Cancer Center.

The group is focused on methodological development of novel computational methods including deep learning, graph theory, and spectral approaches to analyze high-throughput and high-dimensional biomedical data. Most of our current applications concentrate on analysis of data generated in single cell RNA sequencing and spatial transcriptomics/proteomics studies which provide unprecedented opportunities to conduct detailed analyses of cell subpopulations. Fulfilling the promise of these studies and biomarker discovery requires robust computational approaches to support detection of rare phenotypes and unanticipated cellular responses. Current approaches for denoising, calibration, clustering and visualizing of such data types suffer from challenges such as erroneous imputation of non-expressed genes, removal of multivariate batch effects, detection of local differences between cell distributions, and inefficiencies of clustering and dimensional reduction methods of very large datasets. We have developed novel and efficient spectral and neural network prototypes suitable for addressing these issues in high throughput data contexts and further develop and adapt these methods to data generated by our collaborators.

The group is actively engaged in multi-disciplinary national collaborations with large project teams including the SCORCH consortium and the HuBMAP, as well as multiple groups from the Departments of Pathology, Immunobiology, Neurology, Genetics, Internal Medicine and the Cancer Center. The successful candidate will utilize single cell transcriptomics, spatial transcriptomics as well as other genomic, epigenomic and proteomic data from our experimental collaborators and from the public domain and develop novel techniques to characterize a variety of biological systems. The focus will be on immunology, melanoma, and lung cancers studies and single cell characterization of several brain regions relevant to persistent HIV infection and opioid use disorder. The scope of the work could extend to other systems. The successful candidates must be able to work well with groups from different disciplines and to present scientific results in a clear and effective manner.

Research projects may involve, but not limited to:

• Analysis of high throughput transcriptomics, proteomics, genomics data, such as single cell RNA sequencing data, spatial transcriptomics data in a collaborative setting.
• Data management and pipeline development for consortiums.
• Develop and implement new bioinformatics and computational biology algorithms

Qualifications:

• Ph.D. in Computational Biology, Bioinformatics, Genetics, Computer Science, Applied Mathematics, Statistics, Physics, Engineering or other related fields.
• Proficiency with the analysis of next generation sequencing data.
• Ability to develop, implement and benchmark computational methods.
• Solid programming skills.
• Experience with Python and R programming languages is preferred.
• Interest in collaborating with biologists and physician scientists.
• Familiarity with UNIX and cluster computing is preferred.

Apply:

Qualified candidates who are interested in applying should e-mail an application package, including: statement of interest, CV, and contact information for references. Please send your application package to Dr. Yuval Kluger (yuval.kluger@yale.edu). In the subject line, write “your full name, postdoc application”.

This is a Postdoctoral Research Position opening in the Dept of Cardiovascular Medicine at Yale University School of Medicine. All job duties will be performed in 10 Amistad St, New Haven, CT in a basic research laboratory which focuses on studying the role of complement using humanized disease models. The successful application will work closely with the principal investigator and with another research technician to develop projects which will form the basis for extramural funding applications.

Principal Responsibilities:
1) Perform cell culture using aseptic technique
2) Perform molecular cloning studies
3) Carry out mouse breeding and handling.
4) Communicate results and work-related issues to colleagues and supervisors

Required Education and Experience:
This position requires a PhD degree or equivalent. Prior research experience in cellular immunology and/or molecular cloning are preferred.

Candidates should email a cover letter, CV, and contact information for three references to dan.jane-wit@yale.edu. 

A postdoctoral position is available in the laboratory of Jean-Ju Chung in Department of Cellular & Molecular Physiology at Yale School of Medicine in New Haven, Connecticut. The Chung lab studies cellular signaling in sperm capacitation and fertilization under normal and pathophysiological conditions using insights from human genetics and mouse models (www.jeanjuchunglab.org). One of current focus is membrane signaling via ion channels and membrane receptors in gametes and gamete interaction. Highly motivated and independent candidate with an inquisitive nature and a quantitative mind are encouraged to apply.

Candidates must have

• A recent PhD or MD/PhD degree (or candidate) in Biochemistry, Molecular, Cell and Developmental Biology or Reproductive Biology
• Strong publication record (first author papers in peer-reviewed journals).
• Strong background in protein biochemistry, advanced imaging techniques and/or experience with mice gametes and embryos.

The ideal applicant will be pursuing an independent scientist and have excellent organization skills, written and verbal communication skills, and willingness to write grant proposals and manuscripts.

To apply, please send a single PDF file to Jean-Ju Chung at jean-ju.chung@yale.edu including

(1) a cover letter with a statement of research interests and career goals, (2) curriculum vitae, and (3) a list of three references with contact details.

The Bleichert lab in the Department of Molecular Biophysics and Biochemistry at Yale University is looking for a highly motivated, goal-driven, and team-oriented postdoctoral associate to join our young and collaborative team. Research in the lab is focused on understanding fundamental mechanisms of chromosome replication and genome stability using interdisciplinary approaches ranging from reconstitution biochemistry, biophysics, structural biology (both cryo-EM and X-ray crystallography), to proteomics. Yale provides an excellent infrastructure for high-resolution cryo-EM with access to a Titan Krios (with K3 detector) and several Glacios TEMs (with K2 detector).  

We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development. We will provide numerous opportunities for training you in complementary techniques, and you will also have the opportunity to enhance your own mentoring and teaching skills by interacting with PhD students and by supervising undergraduate students. Our goal is to provide you with the mentoring and resources to launch your own independent career.

Interested candidates should have recently finished or will soon complete their PhD degree and have a strong research track record. Scientific curiosity and excitement to ask challenging questions is a must. While prior experience in biochemistry, biophysics, structural biology, or proteomics are advantageous, we welcome researchers from all backgrounds.

Qualified candidates should send their CV, a cover letter describing past and future research interests, and the contact information for two to three references to franziska.bleichert@yale.edu.

The Vilarinho lab is seeking highly motivated and dedicated individuals who are passionate about advancing the cellular and molecular understanding of liver function in health and disease. The Liver Center provides a stimulating training environment, as well as many collaborative opportunities. Our laboratory is interested in using human genetics and genomics paired with highly informative cohorts of patients to discover new liver disease genes. Using cell based and mouse models as well as biochemistry tools we study how a mutant gene causes the liver phenotype. Thus, by uncovering new liver disease genes, we provide a diagnosis leading to new therapeutic options, and we gain new insight into liver biology.

The postdoctoral training may involve biochemistry, molecular biology, flow cytometry and cell culture methodology, primary cell isolation from mouse models, regular presentation at weekly lab meetings, and figure and manuscript preparation. It may also include mentoring and supervision of undergraduate and postgraduate students.

Successful candidates should have backgrounds in cell and molecular biology, biochemistry, genetics and genomics or other related fields. Individuals with a track record of publications, training in liver biology, iPSC biology and/or bioinformatics and recent PhD graduates are strongly encouraged to apply

If you are interested in this position, please send your CV and a statement of why you are interested in the lab to silvia.vilarinho@yale.edu.

A Postdoctoral Associate position is available in the laboratory of Dr. Barbara Burtness at the Yale Cancer Center, Medical Oncology, Yale University School of Medicine, New Haven, USA. Dr. Burtness’ laboratory focuses on translational cancer research to identify novel therapeutic strategies for the treatment of head and neck cancer, across an extensive research program on targeting cell cycle-related kinases, drug resistance mechanisms and immuno-oncology. This postdoctoral associate will mainly work in wet-bench-based cancer cell biology, molecular biology and in vivo study of tumor models, to understand mechanisms of drug resistance and develop of new therapeutics to treat drug-resistant head and neck cancer, funded by NIH/NCI and NIDCR, DOD, and foundations. Our lab provides a collaborative environment within the university and with external partners. This position will provide multi-disciplinary training for scientific and career development, including opportunities for national/international conference presentations and publication of first-authored original articles.

The postdoctoral training may involve (a) the development and application of genetic screening tools, such as CRISPR/Cas9 libraries, (b) bioinformatic analysis of in house/publicly available genomic datasets, (c) a translational approach using human tissue samples and animal models, (d) wet-bench methods in biochemistry, molecular cell biology and immunology, (e) collaboration with other researchers both inside and outside of Yale, (f) presentation in international conferences, and (g) manuscript preparation and grant applications.

The postdoctoral associate will be mentored directly by Dr. Burtness, with possible co-mentorship from qualified Yale Cancer Center faculty members, or others in the Fox Chase Cancer Center. Applications will be accepted until the position is filled.

Candidates are expected to have (a) a recent PhD degree (<4 years or current PhD students graduating by May 2021) in cell biology, cancer biology, molecular biology, immunology, or a related discipline, (b) hand-on research expertise with animal handling skills (cell culture, transfection/transduction, qRT-PCR, cloning and western blotting, immuno-staining, confocal microscopy, flow cytometry, murine tumor modeling, injections and breeding), (c) first-authored original publication(s) in peer-reviewed journals, (c) independence to lead a project as well as willingness to work as a team player, and (d) good scientific oral presentation and writing skills. Previous experience in organoid culture or tumor immunology is preferred but not required. Previous experience or strong interest in programming languages such as R or Python is highly preferred.  

Please send a CV, statement of interest and 2 potential references to barbara.burtness@yale.edu

The laboratory of Dr. Kevan Herold in the Immunobiology Dept at Yale University is looking to recruit a motivated Postdoctoral scientist to join our team.  

The Herold lab advances immunology through its focus on understanding the mechanisms of autoimmune disease, primarily Type 1 diabetes. Our studies are translational but involve both the use of human samples and animal models, including humanized mice, where needed to address mechanistic questions. The position is focused on understanding the changes in autoreactive T cells following immune therapies, specifically to identify changes in their numbers, phenotypes and activation, and the pathways that are modulated by the therapy. The samples are acquired from patients receiving anti-T and B cell therapies. The qualified candidate will receive the following while in this position:

Training – The individual will receive training in methods used to analyze research samples by flow cytometry, molecular studies, and with cell culture techniques. If the postdoc has not previously had training in bioinformatics, he/she will be encouraged to learn these methods through course work or other educational opportunities at the University.

Mentoring – The PI (Dr. Herold) will mentor the trainee. In addition, there are members of the laboratory who will provide training in methods.

Education - A PhD in relevant fields such as Immunobiology is required and skills that include, but are not limited to cell culture, flow cytometry, and basic molecular methods. Experience with more advanced molecular methods such as RNA-seq and single cell RNA-seq are preferred.

Interested candidates should email their CV and cover letter, with the words “Postdoc Opportunity in the Herold Lab” in the subject line, to dana.kalina@yale.edu to be considered. 

Postdoctoral position is available for recent PhD or MD graduates in the laboratory of Dr. Lajos Pusztai, Section of Medical Oncology, Department of Medicine, Yale University School of Medicine.

The successful applicant will work together with bioinformaticians and clinicians on translational research projects in breast cancer. Independence, creative thinking, and motivation are required. Our lab works on identifying novel therapeutic targets for breast cancer through the analysis of the cancer genome and performs functional studies in in vitro an in vivo models.

Desired skills include experience in applying a wide range of molecular and cell biology tools and ability to adopt and learn new methods. Experience in analysis of metabolic pathways and high dimensional gene expression and DNA sequence data is desirable.

Please send CV and list of references to: Lajos Pusztai, MD, DPhil, email: lajos.pusztai@yale.edu. 

We have an opening for a post-doc position in the Herold Laboratory at Yale University in the Department of Immunobiology. The laboratory is focused on understanding the mechanisms of autoimmune disease, primarily Type 1 diabetes. Our studies are translational but involve both the use of human samples and animal models, including humanized mice, where needed to address mechanistic questions.

Position Description

The position is focused on understanding the changes in autoreactive T cells following immune therapies, specifically to identify changes in their numbers, phenotypes and activation, and the pathways that are modulated by the therapy. The samples are acquired from patients receiving anti-T and B cell therapies.

Education

A PhD in relevant fields such as Immunobiology is required and skills that include, but are not limited to cell culture, flow cytometry, and basic molecular methods. Experience with more advanced molecular methods such as RNA-seq and single cell RNA-seq are preferred.

To Apply

If interested, please send CV and contact information to:

Kevan Herold, MD

Professor of Immunology and Internal Medicine

Yale University

300 George St, #353E

New Haven, CT 06853

The successful candidate will be working in a team-oriented environment within the Yale School of Medicine Department of Laboratory Medicine studying a wide array of disease states using the innovative applications of data science tools. Clinical areas of interest range from COVID-19 (immune response factors, protection afforded by both natural infection and vaccine derived immunity, and reinfection risk factors) to oncology with the application of high-throughput data analysis pipelines, clinical predictive models, and data visualization techniques.

Mentoring:

We are seeking a postdoctoral associate to work within our team of informaticians, physicians, and computational scientists. The postdoctoral associate will be based in the Department of Laboratory Medicine and will report directly to Dr. Wade Schulz, Assistant Professor; Director of Informatics, Laboratory Medicine; Director, CORE Center for Computational Health, Center for Outcomes Research & Evaluation (CORE). The associate will also be interacting with other collaborators both within and outside of Yale University, including Dr. Albert Ko, Department Chair of Epidemiology of Microbial Disease at the Yale University School of Public Health, and Dr. Harlan Krumholz, Director, Center for Outcomes Research and Evaluation (CORE).

Training:

The postdoctoral associate will be responsible for collating, analyzing, interpreting and presenting results of various studies being conducted. Training will focus on the translation of real world data to evidence to elucidate clinical disease states, facilitate patient care and improve outcomes. The use of advanced computational frameworks will be a focus of the training, including Spark and various machine learning libraries. The use of common data models, such as OMOP, and the integration of electronic health record (EHR) and laboratory information systems (LIS) data into these models, will be key aspects of the training. Machine Learning, AI, and statistical concepts and skills will be developed and used to evaluate the clinical conditions and outcomes being investigated by the study by the team.

Education, Qualifications and Skills:

• MD, PhD, or MD/PhD with research experience in one of the following areas: epidemiology, bioinformatics, biostatistics, immunology, microbiology, public health, computer science, cancer biology or a similarly quantitative discipline.
• Health care exposure and experience with medical terminology
• Research experience with mathematical and/or statistical models.
• Strong interest in computational healthcare, clinical informatics, and data engineering
• Ability to collate and analyze data, interpret and present results to a high standard using a range of specialized research techniques.
• Good knowledge of Python, R, version control, and distributed computing systems.
• Excellent verbal and written communication skills.
• Experience in communicating research findings to a non-specialist audience.
• Ability to work independently but also as part of a larger interdisciplinary research team.

This will be a one-year appointment with the possibility to extend, should both parties agree. Interested candidates should email Wade Schulz (wade.schulz@yale.edu) and David Ferguson (david.ferguson@yale.edu) with a CV, statement of interest and contact information for 2-3 references.

A postdoc position is available in Dr. Jun Lu’s laboratory at Yale University School of Medicine. The position is to conduct studies in the exciting field of cancer immunology. Studies will be carried out under existing NIH grants in the laboratory, with the goals of systematically studying epigenetic and signaling regulation in anti-tumor immunity.

The studies will leverage the strengths of the Lu laboratory in cancer, stem cell biology and immunology. Located in the state-of-the-art Yale Stem Cell Center, the Lu laboratory studies non-coding and epigenetic mechanisms in hematopoietic and immune cells. We utilize multidisciplinary tools including mouse models, functional genomics, biochemistry, single-cell genomics, and cell biology approaches such as live-cell and super-resolution imaging.

Postdocs will receive training on research, research management, mentoring, grant writing and career development. Candidates with strong backgrounds in cancer biology, immunology, hematology, epigenetics or RNA biology are particularly encouraged to apply.

Applicants with a Ph.D., M.D. or expecting such a degree in the next year should submit curriculum vitae and names of three references to Dr. Jun Lu (jun.lu@yale.edu).

Investigator: Clara Abraham, MD

Mucosal Immunity and Intestinal Inflammation

Yale University, New Haven, CT

Postdoctoral positions are available for research on mucosal immunity, intestinal immune homeostasis/intestinal inflammation, and innate immunity. 

The laboratory focuses on understanding mechanisms regulating innate immune responses, host pathogen interactions, and immunological pathways regulating mucosal immunity and inflammatory bowel disease. The current position will involve examination of molecular and biochemical mechanisms regulating innate cells and pattern recognition pathways, and in vivo intestinal and intestinal-pertinent immune responses, along with potential cross-talk of intestinal immunity with additional immunological sites. Studies incorporate approaches in both primary human immune cells and mouse model systems. 

Education and experience:  Candidates must have a PhD or equivalent degree with a strong background in cellular and molecular immunology, biochemistry, molecular biology, and mouse models of inflammation.  Experience in examination of intestinal tissues, multiparameter flow cytometry, and genetic modification of model organisms is desired. 

To Apply: Please send curriculum vitae, three names of reference and a one page summary of research background and interests to Clara Abraham, M.D. (Clara.Abraham@yale.edu)

The Kleinstein Lab (Yale School of Medicine, Department of Pathology) is seeking a highly motivated postdoctoral associate in computational immunology. The successful candidates will work in a highly collaborative environment on systems-level human immune profiling studies, with a specific focus on high-throughput B cell receptor (BCR) and T cell receptor (TCR) repertoire analysis (including bulk and single cell RNA-seq + BCR). For interested candidates, there are opportunities for computational methods development.

The Kleinstein lab (https://medicine.yale.edu/lab/kleinstein) pairs big data analyses with immunological expertise to better understand how the dynamic processes of the immune system affect the course of infection, vaccination and autoimmunity. The lab has developed many widely used analysis methods for high-throughput immune profiling data, particularly transcriptomic and B cell receptor repertoire sequencing data (https://medicine.yale.edu/lab/kleinstein/software). We currently make available the Immcantation tool suite (http://immcantation.org), a start-to-finish analytical ecosystem for high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) datasets.

The biological applications for this position will be related to ongoing NIH-funded collaborations with several experimental/clinical labs, including:

The Shelli Farhadian Lab: The scientific focus of the Farhadian laboratory is to study the neurological effects of systemic infections. The research group focuses on immune and gene expression correlates and biomarkers of neurological dysfunction during and following acute infection. Studies are primarily translational, involving research participants recruited locally. The postdoc will collaborate on studies generating transcriptomic, including AIRR-seq, datasets to characterize patient cohort biospecimens, including from those with acute and post-acute COVID-19, HIV and other infections, with a goal of understanding central nervous system viral immunity through detailed analysis of cerebrospinal fluid immune cells.

The Kevin O’Connor Lab: The scientific focus of the O’Connor lab is to define the mechanisms by which B cells, and the antibodies they produce, affect tissue damage in autoimmunity. A major goal is to define the mechanisms of autoantibody production in human neurologic autoimmune diseases with the aim of improving therapeutic approaches. Examples of specific projects include characterizing the B cell repertoire (using bulk and single cell RNA-seq + BCR) to understand (i) B cell trafficking between disease specific tissues and blood, (ii) B cell clonal persistence through disease course and treatment, (iii) identify correlates of clinical status, and (iv) defining candidate biomarkers correlating with treatment response.

Other biological areas of focus may include Influenza vaccination, Lyme disease and West Nile Virus infection as part of the NIH HIPC (https://immuneprofiling.org).

The ideal candidate will have strong quantitative and programming abilities (ideally R and Python), along with an interest in applying these skills to problems in immunology. A Ph.D. in a quantitative discipline is desired (Bioinformatics, Computer Science, Statistics, Physics, Applied Mathematics, etc.).

Interested candidates should forward a CV and short description of research interests together with the names and addresses of three references to: steven.kleinstein@yale.edu

Review of applications will begin immediately and will continue until the position is filled.

The Ho Lab at Yale University School of Medicine (https://medicine.yale.edu/lab/yachiho/) is recruiting motivated, productive, independent, and collegial postdoctoral research associates interested in innovative single-cell genomics on HIV-induced immune dysfunction and HIV persistence. This postdoctoral researcher will combine wet-bench molecular biology methods, dry-lab bioinformatic analysis, and a translational approach using clinical samples from people with HIV. The overall goal is to understand mechanism of HIV persistence and guide the development of HIV cure strategies.

Funded by several NIH grants (R01, R61, and UM1), our lab provides a collaborative environment and multi-disciplinary training for scientific and career development. Our lab has a track record of training postdoctoral researchers: our postdocs have international conference presentations and first-authored original articles (Science Translational Medicine and JCI) within three years after they joined the lab. Our lab members have received New Investigator Award, pilot award, and travel grant in the past three years. Our lab is dedicated to recruiting researchers from a diverse background.

The postdoctoral training will involve (a) the development and application of innovative single-cell RNAseq methods (Science Translational Medicine), (b) bioinformatic analysis of single-cell genomics datasets (see bioRxiv below), (c) a translational approach using blood or tissue samples from humans, (d) wet-bench methods in virology (such as sterile cell culture in an enhanced biosafety level 2 (BSL2+) lab), immunology  (such as flow cytometry), and molecular biology (such as CRISPR, real-time PCR, and western blot)(see Journal of Clinical Investigation), (e) collaboration with other researchers both inside and outside of Yale, including virologists, immunologists, bioinformaticians, computer scientists, and clinicians, (f) presentation in international conferences, and (g) manuscript preparation and grant applications.

A successful candidate will likely have (a) a recent (<4 years) PhD degree in genetics, microbiology, molecular biology, immunology, or a related discipline; (b) a track record of research productivity, as evidenced by first-authored original publication(s) in high-quality peer-reviewed journals; (c) experience in programming languages such as R or python; (d) willingness to work with HIV+ samples following BSL2+ procedures; (e) independence to lead a project as well as willingness to work in a team; (f) an open mind to learn new methods from junior researchers and collaborators; (f) good scientific presentation and writing skills. Previous experience and publications in bioinformatics, immunology, or virology is preferred but not required. A successful candidate should expect the initial scope of work to be similar to our recent work posted at bioRxiv. People who have no interest in bioinformatic analysis should not apply. Salary will commensurate with experience and qualifications.

Interested candidates may send a CV, personal statement, and contact information for three referees to ya-chi.ho@yale.edu. Applications will be reviewed on a rolling basis until the position is filled.

References:

Collora et al., bioRxiv 2021, https://www.biorxiv.org/content/10.1101/2021.01.27.428491v1

Liu et al., Science Translational Medicine 2020, PMID 32404504

Yeh et al., Journal of Clinical Investigation 2020, PMID 32573496

Pollack et al., Cell Host Microbe 2017, PMID 28407485

Ho et al., Cell 2013, PMID 24243014

Three postdoctoral positions in the fields of microbial pathogenesis and translational medicine are available immediately in the Mamoun Lab.

Candidates with Ph.D. or M.D./Ph.D. degrees with prior experience in the fields of cellular, molecular biology, genetics and biochemistry are encouraged to apply. Yale University offers a competitive postdoctoral salary, a comprehensive benefits package, and an excellent work environment.

To apply

Please send a curriculum vitae, description of research experience,

and three references to:

Dr. Choukri Ben Mamoun, Professor of Medicine and

Microbial Pathogenesis, Department of Internal Medicine, Section of Infectious

Disease, Yale School of Medicine.

TAC-S215, 300 Cedar Street, New Haven, CT

06520. Email: choukri.benmamoun@yale.edu

The Pediatric Research Group in Childhood Obesity & Type 2 Diabetes, within the Yale School of Medicine, has an open position as a post-doctoral fellow available from January 2021. The position is funded by an established 5 year NIH grant.  The goal of this work is to investigate the role of adipocyte biology in lean and obese adolescents.  The position is renewable annually for up to 5 years contingent upon satisfactory performance and funding.

The position involves  clinical studies  to determine dynamic lipid flux and laboratory work to assess  adipocyte proliferation by employing the novel method of deuterium incorporation into DNA and TG moieties to quantify triglyceride  synthesis, de novo lipogenesis (DNL), lipolysis and adipocyte proliferation in the abdominal and gluteal subcutaneous adipose tissue. Additional methods to be done in the lab are   measures of adipocyte size distribution, gene expression, western blotting, adipocyte cell culture and adipose tissue inflammation.

Qualifications and Requirements:
• Post-Doctoral candidates should have a PhD or MD/PhD with 2 or more years as a Post-Doctoral fellow and experience in adipose tissue biology, metabolism or obesity and diabetes.
• Experience with cell culture, measuring cell size, gene expression (rt-PCR and protein levels (e.g. western Blotting)
• Knowledge in proper experimental planning and statistical evaluation of experimental data.
• Excellent written and oral communication skills
• An enthusiastic, dedicated and collaborative attitude to research.

To apply, please email a resume and contact information for three references to Sonia Caprio, MD at 01sonia.caprio@yale.edu.

The Scharfe laboratory is searching for a postdoctoral biomedical researcher for innovative, novel molecular technology development applied to biomedical research as well as novel clinical diagnostics. The postdoctoral candidate will have the opportunity to work in developing a number of novel tools and genomic approaches for molecular screening and diagnostics and the study of disease pathogenesis. Examples of ongoing work include technology development for screenable disorders in newborns, rapid genotyping of genomic variants to improve patient care, microhaplotype sequencing for population genetics and forensics, and multiplex capture and sequencing for viral nucleic acid testing. Most of our work use next-generation sequencing, microarrays and quantitative PCR for analysis of genomes, complex genetic rearrangements, and genomic haplotypes. Our laboratory has a major interest in the analysis of challenging clinical samples such as genetic materials from dried blood spots, cell free circulating DNA and small forensic samples. Our lab is located in a highly translational setting next to the DNA Diagnostic lab and we collaborate with the Yale Center for Genome Analysis (YCGA) and with colleagues and researcher at Yale and other institutions. Please visit our lab website for more information: https://medicine.yale.edu/lab/scharfe/research/

Qualified candidates will have a PhD in molecular biology, biomedical engineering, analytical chemistry, genetics or related fields. Experience in molecular technologies (i.e., next generation sequencing, microarrays) and/or experience in bioinformatics tools for omics analysis (e.g. R and python packages, and software) is desired, but not essential. Individuals with an MD or MD/PhDs are highly encouraged to apply as well.
Please respond with a cover letter that includes a brief explanation of your research interests, a CV with publication list, and the names and contact information of two references, by email to: Curt.Scharfe@yale.edu

 The Sozen laboratory is looking for talented postdoctoral associates with a background in mammalian developmental stem cell biology to join our team. We conduct research in early mouse/human embryogenesis with the goal of understanding the mechanisms that underlie developmental programming in human health and disease.

Our laboratory in the Department of Genetics, Yale School of Medicine, is a part of a highly collaborative, translational developmental biology program that includes stem cell biology, reproductive biology, genetics and computational biology.

The candidate will lead a project to participate in our larger efforts to unravel how the developmental environment impacts on physiologic, metabolic, transcriptomic and epigenomic landscapes during embryo implantation and gastrulation, the time when the maternal-fetal interface is established. The project will integrate cutting-edge technologies such as the generation of 3D stem cell models of mammalian embryos (Harrison et al. Science 2017, Sozen et al. Nature Cell Bio. 2018, Sozen et al. Dev. Cell 2019), advanced imaging techniques and transcriptomic profiling to map developmental trajectories and cellular function during tissue patterning under environmental challenges.

The postdoctoral candidate will have the opportunity to work in collaboration with a team of world-leading researchers, clinicians, and bioinformaticians, and there will be opportunities to develop additional independent projects with clinical collaborators at Yale University. 

In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided. Additional information on being a postdoc at Yale University School of Medicine can be found at https://postdocs.yale.edu/

Qualified candidates should have a PhD in Developmental Biology, Stem Cell Biology, Reproductive Biology, Bioengineering or a relevant field. The candidate must have hands-on experience with mammalian embryo culture and/or mammalian stem cell culture. Expertise in 3D cell culture techniques and gene editing methods (e.g. Crispr-Cas9, to engineer stem cell lines with multiple fluorescent reporters) are highly desirable. Experience in genomic profiling techniques (e.g. single-cell RNA-seq) and bioinformatics analyses are desirable but not essential. Please respond with a cover letter that includes a short description of relevant expertise, a CV with publication list, and the names of two references by email to: berna.sozen@yale.edu

A position is available for a Postdoctoral Associate  in the Ameen Lab, within the  Section of Digestive Diseases at Yale School of Medicine. A major goal of the laboratory is understanding the regulation of CFTR chloride channels in the native intestine and its relevance to intestinal diseases. Studies are predominantly conducted in animal models, including normal rat, transgenic mouse models of diseases where CFTR is implicated. We also conduct studies in human intestinal organoids and cultured human intestinal cells. 

Techniques used in the laboratory include: PCR, qPCR, tail clipping, animal husbandry, cell and organoid culture, Ussing Chamber electrophysiology in tissues and cells, immunofluorescence staining of cells and tissues, fluorescence and confocal microscopy imaging, immunoblot analysis of rodent tissue lysates, co-immunoprecipitation using tissue lysates, Ussing chamber electrophysiology.  

Expectations/responsibilities for the position include:

1. Design and Conduct experimental work as it relates to papers, and grant applications in the interest of the laboratory and as outlined by the PI. 
2. Learn new scientific techniques relevant to the lab’s projects
3. Seek scientific collaborations within the university and outside.
4. Meet requirements for laboratory practice, compliance for animal, molecular and cellular studies as required by Yale.
5. Maintain lab note books and organize work computer files in accordance with NIH and PI requirements
6. Present weekly at laboratory meetings and monthly or quarterly at Digestive Disease joint lab meetings (power point), Physiology and other lab meetings
7. Preparation of data, figures, and manuscript drafts and grants
8.  Work as a team to (a) build science (b) maintain the laboratory in accordance with good laboratory practice and PI standards
9. Develop writing skills for grant applications
10. Prepare and Present data at national meetings.
11.  Assist in mentoring and training students in the lab.
12. Maintain professional conduct at all times
13.  All other duties as assigned by the PI.

Interested candidates please contact the PI: Nadia Ameen, Professor Pediatrics, Cellular and Molecular Physiology at Nadia.Ameen@yale.edu

The Epilepsy Research laboratory is looking to hire a Postdoctoral Associate to participate in research on the molecular neuropathology of animal and human temporal lobe seizure foci. This position is in the laboratory of Dr. Nihal de Lanerolle. This is a full-time paid position initially for one year and is currently open.

The laboratory seeks a motivated and creative candidate to participate in investigations of the molecular and cellular mechanisms underlying epileptogenesis in animal models of febrile seizures. Parallel studies are carried out on human seizure foci removed during epilepsy surgery for medically intractable temporal lobe epilepsy. These studies will involve induction of febrile seizures in rodents, animal surgery for implantation of electrodes for the detecting neural activity and video-EEG recording and analysis for studies of seizure development in the model and molecular techniques for gene and protein expression during epileptogenesis and spontaneous seizure development.

Candidates should have a PhD or M.D/PhD degree with a background in neuroscience and strong expertise on biochemistry and molecular biological techniques. In addition, a background in immunology is preferred but not required. The ideal candidate should be motivated to learn new things including methods in neuroanatomy as required for this research.

Review of applications will begin immediately and will continue until the position is filled.  To respond, please respond by email including a cover letter with a short description of expertise, a CV, and names of two referees as attachments to nihal.delanerolle@yale.edu.

A postdoc associate is sought for a position in the Benveniste lab in the Department of Anesthesiology at Yale University. The lab focuses on translational research of neurodegenerative disorders such as cerebral small vessel disease and Alzheimer’s disease Specifically we study the roles of cerebrospinal fluid flow dynamics and glymphatic-lymphatic coupling and explore novel disease modifying therapies. The lab uses a combination of magnetic resonance imaging, physiological interventions in transgenic and surgical rodent models together with molecular/histological tools. In this position, the successful candidate will be focusing on characterizing the neurodegenerative state (e.g. amyloid beta deposition, aquaporin-4 water channel expression, inflammation) and status of the meningeal lymphatic vessels and lymph nodes using multiplex immunohistochemical staining and other molecular tools.  This work involves the use of rodent models, MRI in particular multiplex immunohistochemical staining of brain and lymph node tissue to support our various projects. The candidate must be proficient in immunohistochemistry/ immunofluorescence staining, perform statistical calculations and data analysis. 

The candidate must hold a PhD, MD or MD, PhD. in biology, chemistry, psychology, or neuroscience. Experience in multiplex immunohistochemistry/ immunofluorescence staining of rodent brain and lymph node tissue and research experience in pre-clinical research with a track record of publications is preferred.

Interested candidates should email their CV including two references to Dr. Helene Benveniste, MD, PhD, Professor of Anesthesiology at helene.benveniste@yale.edu.