Yale Postdoctoral Positions

Yale University’s Nondiscrimination/Title IX Statements

Thank you for investigating postdoctoral opportunities at Yale.  Many faculty do not advertise open positions in their research groups, and you are encouraged to contact them directly to inquire about the possibility of training with them.  Other faculty advertise open positions in scholarly journals in their fields.  Finally, some post job openings on our website, and these positions are listed below.  Please click the links below to read more about each position and to find contact information for applying for the job.

Once you find a postdoctoral position your Yale department will contact you to begin the formal hiring process and to assist you in applying for an immigration visa to enter the United States if you require one.  Information about the visa process may be found at the Yale Office of International Students and Scholars website.

Postdoctoral position in the Section of Digestive Diseases ( Ameen Lab)
Posting Date: November 24, 2020

A position is available for a Postdoctoral Associate  in the Ameen Lab, within the  Section of Digestive Diseases at Yale School of Medicine. A major goal of the laboratory is understanding the regulation of CFTR chloride channels in the native intestine and its relevance to intestinal diseases. Studies are predominantly conducted in animal models, including normal rat, transgenic mouse models of diseases where CFTR is implicated. We also conduct studies in human intestinal organoids and cultured human intestinal cells. 

Techniques used in the laboratory include: PCR, qPCR, tail clipping, animal husbandry, cell and organoid culture, Ussing Chamber electrophysiology in tissues and cells, immunofluorescence staining of cells and tissues, fluorescence and confocal microscopy imaging, immunoblot analysis of rodent tissue lysates, co-immunoprecipitation using tissue lysates, Ussing chamber electrophysiology.  

Expectations/responsibilities for the position include:

  1. Design and Conduct experimental work as it relates to papers, and grant applications in the interest of the laboratory and as outlined by the PI. 
  2. Learn new scientific techniques relevant to the lab’s projects
  3. Seek scientific collaborations within the university and outside.
  4. Meet requirements for laboratory practice, compliance for animal, molecular and cellular studies as required by Yale.
  5. Maintain lab note books and organize work computer files in accordance with NIH and PI requirements
  6. Present weekly at laboratory meetings and monthly or quarterly at Digestive Disease joint lab meetings (power point), Physiology and other lab meetings
  7. Preparation of data, figures, and manuscript drafts and grants
  8.  Work as a team to (a) build science (b) maintain the laboratory in accordance with good laboratory practice and PI standards
  9. Develop writing skills for grant applications
  10. Prepare and Present data at national meetings.
  11.  Assist in mentoring and training students in the lab.
  12. Maintain professional conduct at all times
  13.  All other duties as assigned by the PI.

Interested candidates please contact the PI: Nadia Ameen, Professor Pediatrics, Cellular and Molecular Physiology at Nadia.Ameen@yale.edu

Postdoctoral position in Cardiovascular Research (Mani Lab)
Posting Date: November 18, 2020

A postdoctoral position is immediately available in the laboratory of Dr. Arya Mani at the Cardiovascular Research Center at Yale University. The exciting project involves in vivo and in vitro molecular- and cellular-based studies to examine the role of Cela2a, a disease gene identified in the lab for atherosclerosis, diabetes and hyperlipidemia (Nature Genetics 2019) in glucose and lipid homeostasis in a mouse model of the disease. Basic knowledge of molecular biology, cloning, expression analyses in cultured mammalian cells, protein purification, analysis of protein-protein interaction, FACS analysis, small animal handling is necessary.

The applicants are closely mentored with the expectation that they work at the bench independently, interpret data, and contribute to the troubleshooting of their experiments. Excellent communication and interpersonal skills are a requirement for this position. Salary based on research experience. Please submit a single PDF file containing a brief cover letter, CV, research experience and publications and information for 3 references to arya.mani@yale.edu

Postdoctoral position in the Center of Molecular and Cellular Oncology(Müschen Laboratory)
Posting Date: November 18,2020

Center of Molecular and Cellular Oncology, Yale School of Medicine

Antibody-producing B-cells are under intense selective pressure to remove autoreactive and pre-malignant clones, yet autoimmune disorders and B-cell malignancies are very common and often incurable diseases. In the coming years, we will pursue biological questions that will create a conceptual basis for the understanding of B-cell-selection and create new opportunities for therapeutic intervention in autoimmune diseases and B-cell tumors. Our scientific discoveries are driven by the desire to create a stimulating academic environment where we focus on rigorous, collaborative and innovative science. In the laboratory, we promote a culture of inclusivity, mentoring our trainees’ scientific growth, and striving to make science accessible to everyone.

Harnessing negative selection to treat B-cell tumors. We developed the paradigm that, unlike other cancer-types, B-cell malignancies can be treated by targeted engagement of negative selection. This can be achieved by pharmacological kinase-hyperactivation to mimic excessive signaling-strength from autoreactive B-cell receptors. Targeted cancer-therapy is traditionally focused on kinase-inhibitors to suppress oncogenic signaling. Our concept of kinase-hyperactivation effectively represents the opposite (Chen Nature 2015; Shojaee Nature Med 2016).

Metabolic gatekeeper paradigm. We pursue the new concept that negative selection is predicated on a B-lymphoid transcriptional program to restrict glucose-uptake and energy-abundance, a mechanism we termed ‘metabolic gatekeeper’. Given that pathogenic B-cells have higher energy-demands than their normal counterparts, we hypothesize that mechanisms to limit energy-supply safeguard against autoimmune disease and B-cell malignancies by setting low thresholds for elimination based on energy-stress (Chan Nature 2017; Xiao Cell 2018).

Mechanisms of energy-conservation in B-cells. We previously established that B-cells develop under conditions of chronic energy-depletion. Studying how B-cells survive acute surges of energy-consumption during physiological B-cell activation, we discovered a novel dependent feedback-mechanism of energy metabolism. One of these mechanisms involves a well-known cytokine receptor-chain. Ongoing studies illuminate how this receptor has been repurposed in B-cells to function as a dynamic feedback-regulator of energy expenditure (Chan Nature 2020; Lee Nature 2020).

Why do B-cells have the smallest cytoplasm and fewest mitochondria of all cells? Our laboratory has recently developed conceptual models to identify factors that orchestrate the unique morphology of B-cells, to examine why maintenance of a small cell-size is essential for B-cell survival and whether engineered B-cells that harbor more and larger mitochondria are prone to autoimmunity and B-cell tumors (Müschen Nature Rev Cancer 2018; Müschen Nature Rev Immunol 2019).

Qualifications: Candidates must have a Ph.D. in Cell or Molecular Biology, a strong research track record, enthusiasm for science, willingness to think beyond established concepts, and to try and learn new experimental and analytical tools. Our group takes a team science approach, therefore, a friendly personality and collaborative attitude are key attributes for successful candidates.

Methods/Techniques: Ideal candidates must be technically adept and proficient in flow cytometry, mass spectrometry/quantitative phosphoprofiling, genetic biosensors of signal transduction, optogenetics, mouse genetics, bone marrow transplantation assays, retroviral gene delivery, whole exome sequencing and RNA-seq-analysis of clonal evolution of leukemia, and pre-clinical drug testing in xenotransplantation models.

Your application should include in one single PDF:

CV, brief motivation statement, coordinates of three scientific mentors (references) sent to Markus Müschen via email (markus.muschen@yale.edu).

Postdoctoral position in Epilepsy Research in Department of Neurosurgery (de Lanerolle Lab)
Posting Date: November 16,2020

The Epilepsy Research laboratory is looking to hire a Postdoctoral Associate to participate in research on the molecular neuropathology of animal and human temporal lobe seizure foci. This position is in the laboratory of Dr. Nihal de Lanerolle. This is a full-time paid position initially for one year and is currently open.

The laboratory seeks a motivated and creative candidate to participate in investigations of the molecular and cellular mechanisms underlying epileptogenesis in animal models of febrile seizures. Parallel studies are carried out on human seizure foci removed during epilepsy surgery for medically intractable temporal lobe epilepsy. These studies will involve induction of febrile seizures in rodents, animal surgery for implantation of electrodes for the detecting neural activity and video-EEG recording and analysis for studies of seizure development in the model and molecular techniques for gene and protein expression during epileptogenesis and spontaneous seizure development.

Candidates should have a PhD or M.D/PhD degree with a background in neuroscience and strong expertise on biochemistry and molecular biological techniques. In addition, a background in immunology is preferred but not required. The ideal candidate should be motivated to learn new things including methods in neuroanatomy as required for this research.

Review of applications will begin immediately and will continue until the position is filled.  To respond, please respond by email including a cover letter with a short description of expertise, a CV, and names of two referees as attachments to nihal.delanerolle@yale.edu.

Postdoctoral position in the Division of Gynecologic Oncology
Posting Date: November 12, 2020

The laboratory of Dr. Alessandro Santin at Yale School of Medicine is looking to hire a Postdoc for a long term research appointment. He or she will work under Dr. Santin direction in the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology. Dr. Santin’s research focuses on the development of PDX mouse models in which gynecological cancer can be induced and studied to evaluate drug sensitivity. Dr. Santin laboratory has generated multiple ovarian, cervical and endometrial cancer cell lines with defined genetic alterations that could be used to develop new effective targeted treatments.

Applicants must possess a Ph.D., or M.D./Ph.D. degree. Candidates are expected to have a strong background in molecular and cell biology, tissue culture, flow cytometry and have experience with small animal surgical procedures. The ideal candidate should be highly motivated and have publications in peer-reviewed journals. Salary is commensurate with experience and skill level. Applicants must provide a CV, and references.

Interested candidates can email: stefania.bellone@yale.edu

Postdoctoral position in Anesthesiology Research
Posting Date: November 12, 2020

A postdoc associate is sought for a position in the Benveniste lab in the Department of Anesthesiology at Yale University. The lab focuses on translational research of neurodegenerative disorders such as cerebral small vessel disease and Alzheimer’s disease Specifically we study the roles of cerebrospinal fluid flow dynamics and glymphatic-lymphatic coupling and explore novel disease modifying therapies. The lab uses a combination of magnetic resonance imaging, physiological interventions in transgenic and surgical rodent models together with molecular/histological tools. In this position, the successful candidate will be focusing on characterizing the neurodegenerative state (e.g. amyloid beta deposition, aquaporin-4 water channel expression, inflammation) and status of the meningeal lymphatic vessels and lymph nodes using multiplex immunohistochemical staining and other molecular tools.  This work involves the use of rodent models, MRI in particular multiplex immunohistochemical staining of brain and lymph node tissue to support our various projects. The candidate must be proficient in immunohistochemistry/ immunofluorescence staining, perform statistical calculations and data analysis. 

The candidate must hold a PhD, MD or MD, PhD. in biology, chemistry, psychology, or neuroscience. Experience in multiplex immunohistochemistry/ immunofluorescence staining of rodent brain and lymph node tissue and research experience in pre-clinical research with a track record of publications is preferred.

Interested candidates should email their CV including two references to Dr. Helene Benveniste, MD, PhD, Professor of Anesthesiology at helene.benveniste@yale.edu.

Postdoctoral position in Digital Phenotyping of Maternal Mental Health
Posting Date: November 4, 2020

The O’Donnell Research Group at the Yale Child Study Center seeks a Postdoctoral Associate to develop Next Generation Screening Tools to identify and support pregnant people at risk for adverse mental health outcomes.  This project will implement passive data capture within an existing, longitudinal pregnancy cohort to identify digital phenotypes that predict mental health outcomes.  A second objective of this project is to integrate digital and biological data (e.g., measures of genomic risk) to build improved prediction models.

The Postdoctoral Associate will be responsible for optimizing passive data capture protocols in addition to data analysis and manuscript preparation.  The successful candidate will join a collaborative, international research team who will support participant recruitment and mental health phenotyping.  The Associate will be mentored by Dr. Kieran O’Donnell (Principal Investigator) with an emphasis on professional development and fostering independence.

Key Responsibilities

  • Evaluate different passive data capture Apps & develop data analysis pipelines
  • Collaborate with research assistants to ensure timely participant recruitment/data collection
  • Prepare research papers for publication

Skills & Qualifications

  • Qualified candidates will have recently completed a PhD in Computer Science, Data Science, Quantitative Psychology, Biostatistics or a related field
  • Exceptional project management and organizational skills are required
  • Competence in quantitative methods, including high dimensional data analysis, is essential
  • Excellent programming skills are required (in R, Matlab or Python)
  • Familiarity with database management systems e.g., MySQL
  • Experience with App development is preferred but not essential
  • A demonstrated interest in Perinatal Mental Health is preferable

The position will start remotely in accordance with Yale University guidance around COVID-19.

To Apply

Please send your CV and a one-page letter of motivation to Dr. Kieran O’Donnell at Kieran.ODonnell@yale.edu. Review of applications will begin immediately and continue until the position is filled.  Qualified applicants may be contacted to schedule an interview and asked to submit two letters of recommendation

Postdoctoral Position in Biochemistry/Biophysics (Anderson lab)
Posting Date: October 29, 2020

The Anderson Group in the Yale School of Medicine’s Department of Pharmacology in interested in structure-function studies and structure-based drug design on a number of clinically relevant targets including HIV reverse transcriptase and SARS-Co-V2 main protease.

We are seek applications from individuals with a Ph.D. in Biochemistry/Biophysics with experience in Structural Biology. We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development. We will provide opportunities for training in complementary techniques as well as improving your communication and writing skills. You will also have the opportunity to enhance your own mentoring and teaching skills by interacting with PhD students and by supervising undergraduate students.

Interested candidates should have recently finished or will soon complete their PhD degree and have a strong research track record. Prior experience in biochemistry, including recombinant protein expression and purification in E. coli and insect cells is advantageous. Successful applicants will also possess a collaborative team spirit and demonstrate an interest in applying new technologies.

 

Please email karen.anderson@yale.edu.

 

Postdoctoral position in Membrane Signaling Regulating Mammalian Fertilization
Posting Date: October 19, 2020
A postdoctoral position is available in the laboratory of Jean-Ju Chung in Department of Cellular & Molecular
Physiology at Yale School of Medicine in New Haven, Connecticut. The Chung lab studies cellular signaling in
sperm capacitation and fertilization under normal and pathophysiological conditions using insights from
human genetics and mouse models (www.jeanjuchunglab.org). One focus is membrane signaling via ion
channels and membrane receptors in gametes and gamete interaction. Highly motivated and independent
candidate with an inquisitive nature and a quantitative mind are encouraged to apply.
Candidates must have
• PhD or MD/PhD degree (or candidate) in Biochemistry, Cell and Developmental Biology or
Reproductive Biology
• Strong publication record (first author papers in peer-reviewed journals).
• Strong background in protein biochemistry, advanced imaging techniques and/or experience with mice
gametes and embryos.
The ideal applicant will be pursuing an independent scientist and have excellent organization skills, written and
verbal communication skills, and willingness to write grant proposals and manuscripts.
To apply, please send a single PDF file to Jean-Ju Chung at jean-ju.chung@yale.edu including
(1) a cover letter with a statement of research interests and career goals, (2) curriculum vitae, and (3) a list of
three references with contact details.
Postdoctoral position in spatial genomics and spatial transcriptomics.
Posting Date: October 19, 2020

We are currently seeking postdoctoral research fellows interested in the rapidly expanding field of spatial genomics and spatial transcriptomics.

Research in our lab focuses on the development and application of state-of-the-art imaging-based omics approaches to understand the spatial organization of mammalian genome and transcriptome, and how they impact cellular states. Recent advances include the development of the first highly multiplexed and automated imaging method to trace the spatial folding of genome, and to profile the abundance and single-molecule localizations of hundreds-to-thousands of different RNA species in individual cells (Science 2016, Science 2015, Molecular Cell, 2020, Nature Communications 2020). As one of the leading labs in this field, we are well funded with $9M through four NIH mechanisms received in 2019-2020. We have established a very productive lab culture, and have 6 papers published or under review this year, despite the current small size of the lab (5 lab members till summer 2020) and the Covid-19 lockdown.

The postdoctoral fellow will actively engage in further development of this set of advanced techniques and/or the application of these techniques to different biomedical investigations. Individuals with expertise in any one of the following areas are strongly encouraged to apply: 1) sequencing-based omics technology development; 2) light microscopy and optical instrumentation; 3) molecular and cellular biology with mammalian/clinical cell culture AND tissue.

We expect successful candidates to have strong academic background and publication record, at the level of being able to compete in postdoctoral fellowship competitions in the US, although successful fellowship competition is not required for the renewal of the appointment.

The position is renewable annually, with immediate start availability.

To apply, please send your CV and cover letter with a description of previous research, and have 3 letters of recommendation sent to siyuan.wang@yale.edu

Postdoctoral position in Human Nature Lab (Yale Institute for Network Science)
Posting Date: October 15, 2020

Our Human Nature Lab has a postdoctoral position opening for a candidate with a background in chromatography and mass spectrometry (especially GCMS) to join research efforts of a multidisciplinary team. The primary responsibilities will be characterization of human biomarkers using GC-MS/MS to understand the biology of social behavior.

The Human Nature Lab (https://humannaturelab.net) is investigating the biological basis of human social interactions by bringing together approaches such as field and laboratory behavioral experiments, genomic sequencing and mass spectrometry, and computational models of networks. This position offers an opportunity to work with human samples to identify volatile organic compounds (VOCs) and metabolites that may characterize social behavior in lab experiments, may relate to the microbiome in field specimens, and may help explain the structure of social networks in real-life settings (such as our large-scale public health intervention to reduce infant and maternal mortality in Honduras). The candidate will work with scientists across a wide range of disciplines, ranging from network science to artificial intelligence to microbial metagenomics.

Responsibilities:

The successful candidate will:

  • Perform GCMS characterization of human VOCs, steroid hormones, microbiome metabolites, and other biological markers, including extraction and purification.
  • Follow established protocols for human biomarker GCMS profiling in a variety of sample matrices, as well as develop and validate new protocols and procedures.
  • Conduct both untargeted and targeted GCMS studies, applying both qualitative and quantitative analysis, for the purposes of fingerprinting the human volatolome and identifying specific chemical messengers associated with cooperative behavior and interpersonal connection. This is part of an unprecedented project to discover and characterize human social chemosignalling as it relates to human social networks.
  • Use GCMS to profile the human gut microbiome metabolome, contributing to a study of social networks and the human microbiome. This is a first-of-its-kind, large-scale study that includes to-date the largest map of face-to-face social networks and the largest metagenomic microbiome study in a single population, followed longitudinally with rich phenotyping.
  • Apply appropriate statistical analysis methods for GCMS data, summarize and present results, lead publication of manuscripts.
  • Collaborate with other members of the Human Nature Lab and the Yale Institute for Network Science, as well as our lab’s collaborators at other universities, to advance the existing projects and expand the research agenda in new directions.
  • Actively participate in mentoring PhD candidates in the lab, and supervise research assistants.
  • Work effectively with the project management team, data scientists, and developers.
  • Follow established laboratory safety procedures, adhere to the lab’s data security protocols, and help enforce ethical responsibilities regarding privacy and wellbeing of human subjects.

Job Requirements:

  • PhD in biochemistry, chemistry, engineering, biomedical sciences, or related or appropriate fields.
  • Demonstrated expertise in GCMS techniques.
  • Experience in GCMS data analysis/interpretation.
  • Ability to lead independent research, as well as to collaborate in small and large team settings.
  • Willingness to learn about new topics and new methods from a variety of intersecting disciplines.
  • Positive attitude and ability to contribute to our open and happy lab culture.

Ideal candidates will have demonstrated a passion for science, some record of productivity/publication, and strong motivation for problem-solving and innovation.  We like candidates with risky and quirky ideas.

The lab PI and the Co-Director of the Yale Institute for Network Science (where the lab is located) is Nicholas A. Christakis, the Sterling Professor of Social and Natural Science at Yale, and Professor in the departments of Sociology, Medicine, Ecology and Evolutionary Biology, Biomedical Engineering, and Statistics and Data Science. The postdoc position will benefit from, and allow for active engagement in, activities in these various departments, as well as in the multidisciplinary Yale Institute for Network Science within the School of Engineering and Applied Science. The postdoc will also benefit from working in a lab whose work is funded by grants from the NIH, DARPA, the Bill and Melinda Gates Foundation, the NOMIS Foundation, the Templeton Foundation, the RWJ Foundation, the Tata-Yale Alliance, and others.

Required application materials:

Send your cover letter with an attached CV to thomas.keegan@yale.edu.

Postdoctoral position in Human Translational Immunology
Posting Date: October 13, 2020

Research in the Konnikova group is directed at studying the development and maintenance of mucosal immunity at barrier sites such as the intestine and placenta. We are interested in understanding how homeostasis is established and maintained in humans and what goes awry to cause disease such as necrotizing enterocolitis and inflammatory bowel disease in relationship to intestinal health and preterm labor in case of placental biology. We are seeking a motivated and dynamic postdoctoral candidate to join our team who is interested in applying cutting edge techniques including mass cytometry and single cell RNA sequencing in combination with cell biology and organoid approaches to studying human mucosal immunology. My group has access to the CyTOF and genomics cores at Yale as well as state-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training in translational research, in vivo model systems and a range of immunological techniques.

The candidate will be expected to have an MD, PhD, or MD/PhD with experience in immunology. Preference to candidates with involvement in human immunology will be given, but it is not a requirement. The successful candidate will be self-motivated and have the capacity for independent evaluation of the literature. Prior knowledge in primary cell isolation, flow cytometry, imaging techniques and single cell techniques would be an added benefit. For more information on our group, please visit our website – www.konnikovalab.com.

Interested applicants should send a brief statement of interest and curriculum vitae with contact information for three references to the Principal Investigator, Dr. Liza Konnikova – liza.konnikova@yale.edu.

Postdoctoral position in the Section of Pulmonary, Critical Care and Sleep Medicine
Posting Date: October 7, 2020

Yale School of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM), is looking to hire a highly motivated Postdoctoral Fellow to drive innovative research projects forward in the laboratory of Dr. Shervin Takyar, MD, PhD. The post-doctoral fellow will work on understanding the role of non-coding RNAs in tumor endothelial cells and in inflammatory lung disorders including ARDS and severe asthma. The post-doctoral fellow should be able to work independently as well as in a team of other researchers in the lab which include other postdocs, clinical fellows and students. The major experimental platforms that will be used include animal models, RNA sequencing, qRT-PCR, signaling studies, immunohistochemistry, multicolor flow cytometry, knockdown and overexpression studies and imaging techniques, cell culture, Western blotting and ELISA.

Job Qualification:

1. A recent graduate or about to graduate from PhD in the field of biology, immunology, bacteriology, virology or similarly related fields.

2. Experience with animal handling is preferred but not necessary. Knowledge about the major cellular and biochemical techniques will be plus.

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The Postdoctoral Fellow is expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected.

Review of applications will begin immediately, and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to carol.barfield@yale.edu

Postdoctoral position in Pediatric diseases ( Dean Yimlamai Lab)
Posting Date: October 7, 2020

Research in the Yimlamai Lab is directed at understanding the drivers of human liver disease, particularly in Pediatric diseases such as biliary atresia and non-alcoholic steatohepatitis. Our focus is in the cell biology of epithelial cells with their microenvironment and we are seeking a motivated, dynamic postdoctoral candidate who is interested in applying cell biology, organoid and animal model approaches to understanding fundamental mechanisms in liver biology. As a member of the Yale Liver center, lab members have access to the Morphology cores with State-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training on in vivo models as well as a range of cell and molecular biology techniques.

The candidate will be expected to have an MD, PhD, or MD/PhD with experience in cellular and molecular biology. Preference to candidates with involvement in liver pathophysiology will be given, but it is not a requirement. The successful candidate will have the capacity for independent evaluation of the literature. Prior knowledge in cell culture techniques, primary cell isolation/culture, flow cytometry and imaging techniques would be an added benefit. For more information on our group, please see our website – www.liverstemcells.org.

Interested applicants should send a brief statement of interest and curriculum vitae with contact information for three references to the Principal Investigator, Dr. Dean Yimlamai - dean.yimlamai@yale.edu.

Postdoctoral position in the department of Molecular Biophysics and Biochemistry (Bleichert lab)
Posting Date: October 7, 2020

The Bleichert lab in the department of Molecular Biophysics and Biochemistry (MB&B) at Yale University is looking for enthusiastic, dynamic,  goal-driven, and team-oriented postdoctoral associates with a strong background in biochemistry, biophysics, structural biology, or proteomics. Research in the lab is focused on understanding the mechanisms that control the initiation of DNA and chromatin replication. To address fundamental questions in this research area, the Bleichert lab uses a broad range of biochemical, biophysical, structural (both cryo-EM and X-ray crystallography), and cellular approaches. Yale provides an excellent infrastructure for high-resolution cryo-EM with access to a Titan Krios (with K3 detector) and several Glacios TEMs (with K2 detector).  

We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development. We will provide numerous opportunities for training you in complementary techniques, and we will mentor you to improve your communication and writing skills. You will also have the opportunity to enhance your own mentoring and teaching skills by interacting with PhD students and by supervising undergraduate students.

Interested candidates should have recently finished or will soon complete their PhD degree and have a strong research track record. Prior experience in biochemistry, including recombinant protein expression and purification in E. coli and insect cells is advantageous. Successful applicants will also possess a collaborative team spirit and demonstrate an interest in applying new technologies.

Qualified candidates should send their CV, a cover letter describing past and future research interests, and the contact information for two to three references to Dr. Franziska Bleichert (franziska.bleichert@yale.edu). To ensure full consideration, please submit your application by November 15, 2020.

Postdoctoral position with the Yale Center for Emotional Intelligence ( How We Feel research team)
Posting Date: October 7, 2020

The Yale Center for Emotional Intelligence seeks a full-time postdoctoral research associate to join the How We Feel research team (PIs: Dr. Zorana Ivcevic Pringle & Dr. Marc Brackett). The primary objectives of this project include understanding the emotional responses to the COVID-19 pandemic and examining questions about predictors of social and emotional well-being. Data used in this project will come from the How We Feel app that was originally designed to study the course of the COVID-19 pandemic and is developing into a general well-being app and tool (including emotional and social well-being, as well as physical health and self-care behavior). The postdoctoral associate will be responsible for data analysis of the existing large scale longitudinal data, as well as for formulating new research questions for future data collections and writing research articles. The Project Director, Dr. Zorana Ivcevic Pringle, will oversee day-to-day work assignments and be the primary supervisor. The Director of Research, Dr. Christina Cipriano, will provide additional supervision and professional support.

Key Responsibilities

• Data analysis of large scale longitudinal data

• Co-design longitudinal studies addressing questions of emotional and social well-being

• Work with the research team to prepare conference presentations of research results

• Supervise research assistants and research aides

• Prepare research papers for publication in peer-reviewed journals in psychology

Skills & Qualifications

• Qualified candidates will have recently completed a PhD in psychology, education, or a related field

• Specialization or demonstrated interest in the study of emotions

• Ability to communicate (e.g., through writing, presentations) with different audiences (research community, general public)

• Excellent writing skills demonstrated in research publications

• Exceptional project management skills

• Competence in quantitative methods, including longitudinal data analysis

• Excellent statistics skills, proficiency with SPSS and R required, experience with large data sets a plus

The position would start remotely in accordance with Yale University guidance around COVID-19.

To Apply : Applications will be reviewed on a rolling basis through October 30, 2020. Please write a one-page proposal detailing a research study you are designing to contribute to understanding emotional well-being. Imagine you have data from an emotion tracking app, along with questions of self-care, physical health, and social relationships. Note that you can only ask few questions and cannot administer full multiitem scales. What would you want to study and how? 

Please send this proposal along with your CV, and a one-page cover letter to Dr. Zorana Ivcevic Pringle at zorana.ivcevic@yale.edu.

Be sure to include where you learned about the position in your cover letter.

Qualified applicants may be contacted to schedule an interview and asked to submit two letters of recommendation. PO Box 208376 New Haven CT 06520-8376 ei.yale.edu office 350 George Street New Haven CT 06511

ABOUT THE YALE CENTER FOR EMOTIONAL INTELLIGENCE Emotions drive learning, decision making, creativity, relationships, and health. The Yale Center for Emotional Intelligence uses the power of emotions to create a more effective and compassionate society. Helping children and adults develop emotional intelligence is central to the mission of the Center. To date, schools have been at the center of these efforts. RULER, the Center’s signature program, draws on leading pedagogical practices as well as advances in psychology and neuroscience, and it has been honed through years of classroom observation, interviews, and the most demanding evaluations. Creating awareness—both of self and others—about emotions and developing the skills of emotional intelligence can improve children’s prospects in life and contribute, in turn, to healthier, more compassionate families, workplaces, and communities. RULER does this by teaching adults and children the skills of emotional intelligence. Since 2005, more than 600 schools have implemented RULER, affecting the lives of over 500,000 students. Accordingly, we integrate emotional intelligence skill building, the basis of RULER, into their everyday practices and into classroom curricula across grade levels

Postdoctoral position in the Section of Digestive Diseases, in the Laboratory of Dr. Wajahat Mehal
Posting Date: October 6, 2020

This is a postdoctoral position in liver biology focusing on liver inflammation and fibrosis. As a part of the Yale Liver center core, the lab members have access to the Morphology cores with State-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training on in vivo models as well as a range of cell and molecular biology techniques.

The candidate will be expected to have a PhD., with experience in cellular and molecular biology preferably but not related to liver pathophysiology, and have the capacity for independent evaluation of the literature. Prior knowledge in cell culture techniques, primary cell isolation/culture, flow cytometry and imaging techniques would be an added advantage.

Please send CV’s to: wajahat.mehal@yale.edu

Postdoctoral positions in the Department of Genetics ( Hall Lab)
Posting Date: October 1, 2020

The Hall laboratory at Yale University School of Medicine is searching for two postdoctoral associates to work on multiple projects in the areas of human genetics, genomics, bioinformatics and data science. Join a vibrant and inclusive community in the Genetics Department and newly-formed Yale Center for Genomic Health.

We have projects open in two general areas: (1) developing new methods for the analysis of genome variation in DNA sequencing-based human genetics studies, with a focus on structural variation and other difficult-to-detect forms; and (2) integrative analysis of genome sequencing datasets towards the discovery of new variants and genes that confer risk to human disease. These projects involve large-scale data resources and collaborative NIH-funded consortia including the NHGRI Centers for Common Disease Genomics, the Human Pangenome Reference Consortium, and AnVIL, as well as local initiatives such as the Yale Generations Project. There is ample project flexibility depending on applicant interests.

The candidate should have a background in genomics or bioinformatics and relevant experience with software development, genomic data analysis, and/or statistical genetics. Please respond with CV, a short description of relevant expertise, representative publications and the names of three references by email to ira.hall@yale.edu<mailto:ira.hall@yale.edu>.

Postdoctoral position in Therapeutic Radiology (Escobar-Hoyos Lab)
Posting Date: September 25, 2020

The Escobar-Hoyos lab in the Department of Therapeutic Radiology and Yale Cancer Center at Yale University is seeking a highly motivated and creative post-doctoral researcher with REQUIRED mechanistic-based cancer biology and/or RNA biology research experience. Applicants should have completed (soon to complete) a PhD with a strong publication record, excellent verbal and written communication skills and strong research experience in signal transduction, transcriptional control, RNA splicing, or related fields.

We are seeking a dynamic individual who will be responsible, as a member of a team, for designing and executing studies focused on understanding and targeting altered RNA processing mechanisms in pancreatic cancer.

As the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) has emerged as the 3rd leading cause of cancer death in the United States, in part because this malignancy is highly resistant to chemotherapeutic intervention.

Recently, it’s been shown that PDAC is composed of distinct molecular subtypes, based on RNA expression and patient outcome, underscoring that much remains to be understood about RNA expression, processing and regulation in this disease. Our research is focused on 1) characterizing the molecular pathways and functions controlled by aberrant RNA splicing and 2) designing RNA- targeted therapies to uncover novel therapeutic vulnerabilities in this disease.

Our group is heavily involved with RNA Sequencing of human and mouse pancreatic cancers. The candidate is expected to perform experiments exploring alterations in RNA splicing and additional steps in RNA processing, using a variety of preclinical model systems that include cell lines, xenografts, genetically engineered mouse models, and patient-derived models. A desire to develop and implement new methodologies is highly advantageous. There will be numerous opportunities for training to complement current skills, collaborate with other outstanding scientists, and to enhance grant writing skills.

The candidate will work within an integrated, multidisciplinary team composed of basic scientists, computational biologists, pathologists, medical oncologists, and radiologists, with significant resources for bioinformatics support, access to clinical specimens, and studies in human and animal tissues.

Experience with several of the following activities are desirable: characterization of genetically engineered mouse models, work with patient-derived xenografts or organoids, and culture of primary cells. Initial salary is commensurate with experience. Applying for independent funding is not required but is strongly encouraged for the career development of the candidate.

Qualified candidates should send a curriculum vitae, a cover letter detailing research interests and career goals, and contact information for three references to Dr. Luisa Escobar-Hoyos (Luisa.escobar-hoyos@yale.edu ).

Contact Information:

Dr. Luisa Escobar-Hoyos

Postdoctoral position in the Yale Cancer Center
Posting Date: September 25, 2020

Yale Cancer Center has an opening for a Postdoctoral trainee to conduct bench research geared towards improving therapies for cancer patients. The laboratory conducts translational studies geared to elucidate specific mechanisms involved in melanoma brain metastasis and identify novel molecules that could be harnessed for drug discovery. Additionally, we focus on the development of biomarkers predictive of response to novel therapies using metastatic melanoma human tissues.

The outcome of these studies would be groundbreaking and likely lead to the identification of novel therapeutic targets and the possible development of new drugs for melanoma treatment. This work will require the use of a wide variety of approaches ranging from Molecular/Cellular Biology, and Biochemistry based techniques to study patient derived cell lines and unique mouse model systems of disease. Innovative analytical technologies for in situ biomarker assessment of patient samples will also be employed.

This is an excellent opportunity for individuals interested in a career in Cancer Biology and Cancer Immunology. The trainee will have exposure to outstanding training venues and lectures and Yale Cancer Center.

Requirements:

Candidates must have a doctoral degree in biological sciences. Candidates with experience in handling mouse models of disease are encouraged to apply. A good publication record, excellent communication skills and ability to work in a team are important.

Interested applicants should submit a CV as well as the contact information (email address and phone number) for three references, and a brief statement of research skills and interest to Tarissa.Klarman@yale.edu

Postdoctoral position in the Department of Pathology (Braddock Lab)
Posting Date: September 24, 2020

A Postdoctoral Research Associate is sought in the Braddock laboratory to assist with our development efforts on investigating the pathogenesis and treatment of Rare Diseases. The Braddock lab demonstrable success designing and validating biologic therapeutics for human disease, and the position will span biochemistry, cell biology, protein design, and murine models of human disease. A major focus of the position will be in vitro and in vivo experiments to define the mechanism of a newly described form of osteoporosis described by our laboratory (J Bone Miner Res. 2020 Mar;35(3):528-539). The candidate may also participate in a newly developing project on autoimmune disease and tumor metastasis, and be involved in characterizing an newly developed animal model of metabolic disease associated with polymorphisms in ENPP1.

As discussed above, the candidate must be comfortable performing animal studies. Candidates with experience in primary eukaryotic cell culture, lentiviral transfection assays, murine models of tumor metastasis, and experience with RNAseq and bioinformatics are especially encouraged to apply, but all recent graduates from strong PhD programs in the biological sciences interested in translational research are also encouraged.

Applicants are requested to submit an application packet consisting of a cover letter, updated CV, the names of 3 references, and a copy of their academic transcripts.

Demetrios Braddock M.D. Ph.D.

Associate Professor of Pathology

Yale University School of Medicine

310 Cedar Street

New Haven CT 06510

Demetrios.braddock@yale.edu

Postdoctoral position in the Strazzabosco Lab, Department of Internal Medicine, Section of Digestive Diseases and Yale Liver Center
Posting Date: September 21, 2020

A post-doctoral position is available in Dr. Strazzabosco Lab, Department of Internal Medicine, Section of Digestive Diseases and Yale Liver Center at the Yale University School of Medicine. The primary aim of the project is to study the determinants of peribiliary fibrosis in fibropolycystic liver diseases. The applicant will work with a genetic mouse model harboring a deleting mutation in Pkhd1 and different cell systems including generation and culture of liver organoids and performing studies of scRNAseq.

Dr. Strazzabosco lab is part of the Yale Liver Center and the candidate will take advantage of the Cellular and Molecular Physiology and the Morphology Cores that includes a state-of-the-art imaging facility available for the lab members. The candidate will be supported by the laboratory’s experience in the field of liver cell biology, including handling and characterization of several transgenic mouse models of liver diseases and in vitro establishment of primary cell lines both mouse and human (iPSC) and liver organoids. The candidate will learn how to apply these methodologies to the study of genetic cholangiopathies, such as fibropolycistic liver disease. The candidate will have the opportunity to perform sophisticated molecular analysis such as scRNAseq. Finally, the candidate will participate to the seminars and meetings in the Section of Digestive Diseases, in the Liver Center and in the Department of Internal Medicine at Yale School of Medicine.

The candidate must have a Ph.D and proof of knowledge in molecular and cellular biology preferably but not limited to liver pathophisiology is required. 

Candidates should send a CV, a statement of research interests and the names of two references to: 

mario.strazzabosco@yale.edu

romina.fiorotto@yale.edu

Postdoctoral position in the Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM),
Posting Date: September 9, 2020

Yale School of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM), is looking to hire a highly motivated Postdoctoral Associate to drive innovative translational research forward in the Yale ILD Center of Excellence.

The post-doctoral associate will work under the supervision of Dr. Erica Herzog and Dr. Danielle Antin-Ozerkis on human oriented research projects aimed at developing molecular biomarkers and treatments for patients with pulmonary fibrosis and related disorders.  The post-doctoral associate should be able to work independently as well as in a team of translational lung biologists in the lab which include pulmonologists, postdocs, clinical fellows and students. The major experimental tools that will be used include FACS, single cell RNA sequencing, ELISA, PCR on samples from patients with several forms of pulmonary fibrosis and interstitial lung disease.  

Job Qualification:

1. A recent graduate or about to graduate with an MD, or a PhD in the field of biology and immunology or similarly related fields.

2. Experience with translational work and biomarker studies is preferred but not necessary. Knowledge of major cellular and biochemical techniques such as FACS, single cell sequencing, ELISA and PCR is a plus.  

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The individual will be expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected.  It is an excellent opportunity to learn about biomarker work in the context of clinical medicine and interventional trials.

Review of applications will begin immediately and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to erica.herzog@yale.edu

Postdoctoral position defining and modeling severe, pediatric immune diseases in the Department of Immunobiology
Posting Date: September 2, 2020

The laboratory of Dr. Carrie Lucas in the Immunobiology Dept at Yale University is looking to recruit a motivated postdoc scientist to join our team.   

The Lucas lab advances immunology through discovery and mechanistic investigation of severe, pediatric immunodeficiency or autoinflammatory disorders, often caused by single-gene defects. Starting with humans and extending to innovative mouse models, our work dives deeply into translationally relevant fundamental biology of T cells, B cells, and monocytes/macrophages. We use genetic, cellular, molecular, and in-vivo approaches to elucidate immune derangements and novel genes/pathways critical for healthy immune function. Current areas of emphasis include single-cell RNA sequencing and disease mechanisms in COVID-19-related ‘multisystem inflammatory syndrome in children’ (MIS-C), regulation of adaptive immunity, and inflammation at barrier tissues.  https://www.carrielucaslab.org

Interested candidates should send their CV to Dr. Lucas at Carrie.Lucas@yale.edu.  

Postdoctoral position in the Department of Pharmacology
Posting Date: November 20, 2020

The laboratory of Joseph Schlessinger in the Department of Pharmacology at the Yale School of Medicine has immediate openings for highly motivated Postdoctoral Associates to investigate mechanisms involved in cell signaling.

The Schlessinger Lab has been at the forefront of cell signaling, helping to define cell signaling by receptor tyrosine kinases (RTKs) and making many seminal discoveries within the field. The research in the Schlessinger lab is focused on structural elucidation, biophysical and biochemical analyses as well as studying the role RTKs and other signaling molecules in murine model systems of RTK signaling.

Priority will be given to applicants with a Ph.D. degree with extensive experiences in developing and analyzing the phenotypes and underlying physiological mechanism of genetically modified murine model systems, and excellent written and oral communication skills.

Positions are also available for candidates with a Ph.D. degree with experiences in recombinant protein production (E.coli and mammalian cells), mammalian cell culture and quantitative biophysical analyses including structural biology technique (X-ray crystallography or cryo-EM), and excellent written and oral communication skills.

Interested candidates should send a current CV, a statement of research interests, and the names and contact information of three references to: Joseph Schlessinger (joseph.schlessinger@yale.edu) and Nathan Kucera (nathan.kucera@yale.edu).

Postdoctoral position in Early Psychosis Research
Posting Date: August 31, 2020

The Program for Specialized Treatment Early In Psychosis (STEP, www.step.yale.edu) at Yale University School of Medicine is recruiting for an immediately available 1-2 year position.

STEP includes an early detection and intervention service integrated with several clinical and services level research projects. STEP also hosts a Learning Health System with a custom-built informatics platform to support quality improvement and practice-based research.

The PDA will:

- Lead pilot analyses for grant submissions and publications;

- Develop new clinical research projects related to the mission of the Program;

- Oversee and participate in screening, diagnostic evaluation and structured assessment of early psychosis patients and families;

- Oversee and participate in maintaining our research databases;

- Support our clinical informatics platform and support quality improvement projects;

- Assist in referrals to several collaborating laboratories

This an excellent opportunity for those interested in a clinical research career related to serious mental illness. 

A doctoral degree is required (MD or PhD); licensure is preferred but not necessary.  Ideal candidates will have a strong research interest in psychosis and a strong record of publication in the area. At least one year of clinical experience with psychotic disorders in a clinical or research setting is required. Working familiarity with a statistical package is desirable, but statistical consultation is available.

Interested candidates should submit a CV, writing sample and two letters of recommendation to: 

Vinod H. Srihari, MD (vinod.srihari@yale.edu)
Professor and Director, STEP Program

Department of Psychiatry

Yale University School of Medicine

Connecticut Mental Health Center (CMHC)
34 Park Street
New Haven, CT 06519
 

Postdoctoral position in regenerative and immunomodulating effects of stem cells (Dr. Dereck Steinbacher Lab)
Posting Date: August 27, 2020

Postdoctoral research fellowships for highly qualified applicants are now available in the lab of Dr. Derek Steinbacher at the Yale School of Medicine. The laboratory focuses on a broad range of questions relevant to our understanding of bone, chondrogenic, and adipose tissue engineering. We are seeking postdoctoral scholars interested in research on the regenerative and immunomodulating effects of stem cells derived from various tissue sources (e.g. adipose, bone, muscle).

Among the current research projects include: 1) how chondrocyte respond to crush injury when combined with adipose-derived stem cells in vitro 2) how adipose-derived stem cells modulate vascularization and bone regeneration in 3D-printed bone scaffolds; and 3) how arteriovenous microvascular flow channels can enhance bone regeneration. The postdoctoral scholar will reside in a supportive environment with experienced mentors that will provide a research experience combined with training in grant writing and other critical academic skills. Applicants with a recent Ph.D. or M.D./Ph.D., publications in major journals and a strong background in tissue engineering, stem cell biology, immunology, cell biology, animal models and/or imaging are encouraged to apply.

Interested applicants should have a recent PhD degree in Biology, Biotechnology, Bioengineering Genetics, Biochemistry or equivalent research related field in addition to a strong background in molecular biology assays. Ideally, these will include experience with mammalian cell culture techniques, PCR, qPCR, immunostaining, ELISA, Western blot and FACS analysis. Experience in stem cell or bone biology is a plus. Prospective candidates will be part of a research team and expected to be highly motivated, passionate about science and collaborative.

Qualifications Required/Academic Background
Applicants with a recent Ph.D. or M.D./Ph.D., publications in major journals and a strong background in tissue engineering, stem cell biology, immunology, cell biology, animal models and/or imaging are encouraged to apply.

Salary/Stipend
commensurate with previous accomplishments and experience.

Application Procedure
Please submit interests, Curriculum Vita and names of three references to:  Derek.Steinbacher@yale.edu

Derek Steinbacher MD DMD, Professor, Yale School of Medicine
Director, Cleft and Craniofacial Surgery

Chief, Oral and Maxillofacial Surgery
Department of Surgery

Post-doctoral fellowship position in epigenetic dysregulation mechanisms in gastrointestinal cancers
Posting Date: August 24, 2020

A Postdoctoral Fellowship position is available in the laboratory of Dr. Nita Ahuja at the Department of Surgery, Yale School of Medicine. The research in the Ahuja laboratory is focused on understanding the epigenetic dysregulation in various cancers during disease progression using patient samples, patient derived organoids, PDX mouse and various cell line models, as well as translating the findings to develop novel detection biomarkers and identify novel treatment targets.

We are looking for motivated individuals interested in studying the molecular, cellular, and epigenetic dysregulation of gastrointestinal cancers and other disorders. Applicants should have a PhD or MD/PhD in biological sciences, molecular/cell biology, genetics or related fields. The candidate should be self-motivated and have a proven track record of productivity. Experience in RNA biology, epigenetic techniques, CRISPR and other gene editing techniques, immune-priming using epigenetic drugs, and analyzing genomic data sets will be an advantage. Candidates with a PhD in epigenetics would be given preference; however, candidates with 1 to 2 years of post-doctoral experience with a strong focus in epigenetics would also be considered. Any relevant experience in chromatin modulation biology will be plus. The candidate should possess excellent written and verbal communication skills, as well as ability to work collaboratively.

We are also looking for a lab manager with masters and minimum 2-3 years of experience with basic molecular and cell biology expertise and animal experience will be a plus.

Qualified applicants should email the application package (statement of interest, CV, and contact information for three referees) as a single pdf document. To apply or any other questions regarding the position please directly contact Anup Sharma (anup.sharma@yale.edu) for consideration.

Postdoctoral position in epigenetic dysregulation mechanisms in gastrointestinal cancers
Posting Date: August 18, 2020

A Postdoctoral Fellowship position is available in the laboratory of Dr. Nita Ahuja at the Department of Surgery, Yale School of Medicine. The research in the Ahuja laboratory is focused on understanding the epigenetic dysregulation in various cancers during disease progression using patient samples, patient derived organoids, PDX mouse and various cell line models, as well as translating the findings to develop novel detection biomarkers and identify novel treatment targets.

We are looking for motivated individuals interested in studying the molecular, cellular, and epigenetic dysregulation of gastrointestinal cancers and other disorders. Applicants should have a PhD or MD/PhD in biological sciences, molecular/cell biology, genetics or related fields. The candidate should be self-motivated and have a proven track record of productivity. Experience in RNA biology, epigenetic techniques, CRISPR and other gene editing techniques, immune-priming using epigenetic drugs, and analyzing genomic data sets will be an advantage. Candidates with a PhD in epigenetics would be given preference; however, candidates with 1 to 2 years of post-doctoral experience with a strong focus in epigenetics would also be considered. Any relevant experience in chromatin modulation biology will be plus. The candidate should possess excellent written and verbal communication skills, as well as ability to work collaboratively.

Qualified applicants should email the application package (statement of interest, CV, and contact information for three referees) as a single pdf document. To apply or any other questions regarding the position please directly contact Anup Sharma (anup.sharma@yale.edu) for consideration.

Postdoctoral positions in the Yale Cancer Prevention and Control Training Program
Posting Date: August 12, 2020

The Yale School of Public Health and the Yale Comprehensive Cancer Center (YCC) have received a Cancer Prevention and Control (CPC) T32 training award from the National Institutes of Health (NIH, T32 CA250803, 08/01/2020 – 07/31/2025), under which up to three (3) postdoctoral trainees are being recruited. Below are key aspects of the training program:

  • The Yale CPC Training Program aims to train postdoctoral fellows in five thematic areas critical to CPC: cancer etiology, cancer outcomes, lifestyle behavioral interventions, implementation science and community-engaged research.
  • The program is enabled by 22 Primary Faculty and 14 Resource Faculty at the Yale School of Public Health and School of Medicine, who have an outstanding track record in CPC research and mentoring of junior investigators.
  • Fellows will also directly participate and interact with the 7 YCC Research Programs and 14 YCC Disease-Aligned Research Teams.
  • Our training program will include a comprehensive mentoring program; a structured CPC Fellows research in progress meetings; participation in CPC research assistantship; and annual ½ day workshops in our 5 thematic areas.
  • Our program will select highly qualified and diverse candidates who wish to pursue a career in CPC. It is our goal that CPC Fellows will develop the knowledge and skills necessary to function independently, and develop and carry out innovative, impactful studies filling key gaps in CPC research, potentially changing the standard of care and impacting policy.
  • Selected candidates will receive stipend support at the prescribed NIH postdoctoral level based on NIH Notice NOT-OD-  20-070, and may request training related expenses up to $11,000 each year.

Application Details:

Review of applications will commence on August 21, 2020 at 5:00 PM and will continue until positions are filled.

Earliest start date: October 1, 2020.

Applications must be submitted online: http://apply.interfolio.com/77888

Requirements:

  • Applicants should have a doctoral degree in epidemiology, biostatistics, environmental health sciences, social and behavioral sciences, health policy, medicine, or other areas in life or data sciences, as well as a strong interest in CPC. Previous research experience in CPC is desirable but not required.
  • Applicants will need to meet NIH eligibility requirements for appointment to NRSA training grants. In particular, applicants must be US citizens or permanent residents at the time of application.
  • Applicants may not have received more than two years of previous support through a NIH postdoctoral training grant. Their support by the CPC T32 training program will not exceed two years.
  • Applicants must submit
    • A curriculum vitae that includes the names and contact information of two references; and
    • A one-page statement about your aims for postdoctoral training through the Yale CPC T32 training program.

Questions:

For questions about the application process, please contact Melinda Irwin (melinda.irwin@yale.edu) or Xiaomei Ma (xiaomei.ma@yale.edu) and be sure to include “CPC T32” in the Subject line of your email. 

Postdoctoral position in the laboratory of Dr. Vincent Pieribone at the John B. Pierce Laborator
Posting Date: August 6, 2020

A full-time position is available for a Postdoctoral Research Associate in the laboratory of Dr. Vincent Pieribone at the John B. Pierce Laboratory (http://jbpierce.org/research-laboratory/cellular-neurophysiology/), a nonprofit research institute affiliated with Yale University.

The Pieribone lab is developing state-of-the-art genetically encoded fluorescent voltage indicators and bioluminescent indicators for recording neuronal activity. The projects also include the study of bioluminescence pathways in native organisms in efforts to identify and characterize novel luciferases and their substrates that can be adopted for functional imaging.

The work involves design and development of high throughput screening platforms, and further optimization of the indicators for in vitro and in vivo imaging in various model organisms using multi- and single-photon microscopy.

REQUIREMENTS:
Candidates should hold a PhD in the field of Neuroscience, Molecular Biology, or Biochemistry and have an interest in systems neuroscience and the development and application of optical methods to study neuronal activity. Techniques of interest include electrophysiology, behavior, optical imaging using 2P and 1P microscopy, molecular cloning, protein expression and purification, protein engineering, and biochemistry. Applicants are expected to be able to design and execute independent research projects.

A coterminous postdoctoral appointment in the Department of Cellular and Molecular Physiology in the Yale School of Medicine is anticipated. The John B. Pierce Laboratory offers excellent benefits with employer paid health insurance and free parking.

TO APPLY:

Please submit a single PDF file to pdneuro@jbpierce.org including:
1) A cover letter with a (brief) statement of research experience and interest, 2) Curriculum Vitae, and 3) A list of three references.

Job Code: VP010

The John B. Pierce Laboratory is an Equal Employment Opportunity employer that does not unlawfully discriminate in any of its programs or activities on the basis of race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity or expression, or on any other basis prohibited by applicable law.

Postdoctoral postion in Optical imaging and optogenetics of the mouse olfactory bulb during virtual odor navigation
Posting Date: August 6, 2020

A postdoctoral position is available in the laboratory of Dr. Justus Verhagen at the John B. Pierce Laboratory, a nonprofit research institute affiliated with Yale University. The position is supported by a large collaborative NSF research project to elucidate the neurobiological basis odor source localization in transgenic mice. The project uses optical imaging and optogenetics of the olfactory bulb in a virtual odor navigation task to further our understanding of how animals navigate to odor sources.

REQUIREMENTS:

Candidates should be a new or recent PhD working in neuroscience or a related discipline, proficient in spoken and written English, efficient and self-motivated, and work well in a team environment. Prior experience with rodent behavior, imaging and surgery, Matlab, and the chemical senses is preferred.

A coterminous postdoctoral appointment in the Department of Neuroscience in the Yale School of Medicine is anticipated. The John B. Pierce Laboratory offers competitive salary and excellent benefits with employer paid health insurance and free parking.

TO APPLY:

Please send application with C.V., contact information for three references, and statement of interests to neuropd@jbpierce.org. Anticipated start date of October 2020. Job Code: JV003

Visit us at:  Verhagen Lab and Publications
 

The John B. Pierce Laboratory is an Equal Employment Opportunity employer that does not unlawfully discriminate in any of its programs or activities on the basis of race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity or expression, or on any other basis prohibited by applicable law.

Postdoctoral positions in microbial pathogenesis and translational medicine
Posting Date: July 17th, 2020

Two postdoctoral positions in the fields of microbial pathogenesis and translational medicine are available immediately. Ph.D. and M.D./Ph.D. degree with prior experience in the fields of cellular, molecular biology, genetics and biochemistry is required. Yale University offers a competitive postdoctoral salary, a comprehensive benefits package, and an excellent work environment.

To apply please send a curriculum vitae, description of research experience, and three references to: Dr. Choukri Ben Mamoun, Professor of Medicine and Microbial Pathogenesis, Department of Internal Medicine, Section of Infectious Disease, Yale School of Medicine. TAC-S215, 300 Cedar Street, New Haven, CT 06520. Email: choukri.benmamoun@yale.edu.

Postdoctoral position in the Grace Chen Lab in Immunobiology
Posting Date: July 9, 2020

We are seeking postdoctoral fellows to join the laboratory of Dr. Grace Chen in the Department of Immunobiology at Yale University. The Chen lab investigates the mechanisms and regulation of circular RNAs (circRNAs), a newly identified class of ubiquitous RNAs in essentially all eukaryotes and some viruses. Thus far, circRNAs have been found to function as miRNA sponges, regulate transcription, and act as templates for translation. However, there are still many unanswered questions: What other functions do circRNAs possess? How are circRNAs degraded? What are their interacting proteins? Specifically, we aim to understand how different layers of regulation including RNA modifications and cellular localization affect RNA function to enable new insights into both normal function and how dysregulation leads to disease. The Chen Laboratory applies molecular, cellular, and chemical biology techniques coupled with next-generation sequencing to address these questions. We aim to generate novel therapies based on our new insight about circRNA function and regulation. For more information, visit gracechenlab.org.

Applicants should have recently completed a Ph.D. degree in molecular biology, chemical biology, immunology or genomics. High priority will be given to those candidates with strong backgrounds in RNA or chemical biology. 

Interested applicants please send a brief statement of interest and curriculum vitae with contact information for three references to the PI Dr. Grace Chen at ye.grace.chen@yale.edu.

Postdoctoral position in Cancer Biology in the Department of Therapeutic Radiology (Hayman Lab)
Posting Date: July 8, 2020

The Hayman Lab, led by Thomas Hayman, MD, PhD, in the Department of Therapeutic Radiology at Yale University is recruiting a highly motivated and creative postdoctoral associate.  We are a cancer biology lab that is focused on utilizing genetic approaches to understand and exploit resistance mechanisms to DNA damage. 

Our research program has a particular interest in studying the interplay between the cell intrinsic immune machinery and DNA repair processes using in vitro cell models, genetic screens (such as CRISPR and RNA interference), and animal models.  We have a strong translational focus that is founded in a preclinical mechanistic understanding of basic biological processes with the ultimate goal of shaping these discoveries into therapeutic strategies for cancer patients.

We are seeking a candidate who will contribute to the discovery and translation of biological processes that modulate tumor responses to DNA damaging therapies (e.g. radiation) and immunotherapy.  Interested applicants should hold a PhD. or M.D. with considerable laboratory experience and a strong background in cancer biology, molecular biology, genetics, radiation biology or other related fields.  Prior experience with in vivo animal tumor models, CRISPR/Cas9, IF/IHC and DNA damage assays is highly desired, but not a requirement.  The candidate should be self-motivated and have a proven track record of productivity.  Excellent written and oral communication skills are expected. 

How to Apply:

Candidates should send a Curriculum Vitae, a cover letter detailing research interests and career goals, and contact information for three references to Dr. Thomas Hayman (thomas.hayman@yale.edu).

Postdoctoral position in molecular and circuit mechanisms in the Department of Genetics ( Jiang Lab)
Posting Date: July 1, 2020

The Jiang laboratory is looking for highly motivated candidates with PhD or MD/PhD degree from molecular genetics, molecular biology, and neuroscience for a Postdoctoral Associate appointment.  The successful candidate will work on NIH supported projects to study the molecular and circuit mechanisms underlying autism using mouse models including Shank3, Shank2, and Angelman, and new autism models. Experience and skills in molecular biology, optogenetics and chemo-genetics, ex and in vivo recording, mouse behaviors, and mouse models are preferred.  Anticipated start date will be after September 1, 2020.

Please respond with CV, a short description of relevant expertise, and the names of three references by email to yong-hui.jiang@yale.edu.

Postdoctoral position in molecular genetics and neuro-epigenetic mechanisms in the Department of Genetics (Jiang Lab)
Posting Date: July 1, 2020

The Jiang laboratory is looking for highly motivated candidates with PhD or MD/PhD degree from molecular genetics, molecular biology, and neuroscience for a Postdoctoral Associate appointment.  The successful candidate will work on NIH supported projects to study molecular genetics and neuro-epigenetic mechanisms and develop new treatments for Prader-Will and Angelman syndrome. Dissect the role of epigenetics in brain function and neurodevelopmental disorders.  Experience and skills in molecular genetics and epigenetics, genomics, CRISPR/Cas9, IPSC and brain organoids and mouse models are preferred.  Anticipated start date will be after September 1, 2020.

Please respond with CV, a short description of relevant expertise, and the names/emails of three references by email to yong-hui.jiang@yale.edu.