Yale Postdoctoral Positions

A position for an ambitious junior postdoctoral researcher is immediately available in the laboratory of Chris Burd of the department of cell biology at the Yale School of Medicine. We are cell biologists with interests in understanding homeostatic pathways that maintain the functions of membrane-bounded organelles, especially the Golgi apparatus, the plasma membrane and the lysosome. Currently, we focus on sphingolipids that are produced in the Golgi apparatus. Perturbations to sphingolipid synthesis, trafficking and turnover play key roles in protection from neurodegenerative disease (e.g., Alzheimer’s and Parkinson’s), metabolic disease (e.g., diabetes) and developmental disorders. Recent discoveries from our lab include a role for very long chain sphingolipids in cholesterol homeostasis, lysosome function and growth regulation. Our laboratory relies heavily on lipidomics, metabolic lipid labeling technologies, live cell imaging and biochemistry.

The successful candidate will have experience with lipid biochemistry and analysis and have a strong desire to apply their training to investigate a cholesterol-sphingolipid homeostasis axis that controls cholesterol and sphingolipid levels of organelle membranes. The candidate will benefit from an exceptionally collaborative research community with expertise in membrane biophysics, optical imaging technologies, organelle cell biology and diverse model organisms.

Please respond with a statement of interest, your CV and a short description of relevant expertise to christopher.burd@yale.edu.

Examples of our relevant research can be found in these publications:

Kim et al., 2023 doi: 10.1083/jcb.202308055
Kim and Burd, 2023 doi: 10.1101/cshperspect.a041397
Sundberg et al, 2019. doi: 10.1016/j.devcel.2019.08.014
Deng et al, 2016. doi: 10.1073/pnas.1602875113

The Laboratory of Intelligent Global Health Technologies (LiGHT, https://www.yale-light.org/) at Yale University is looking for exceptional, multi-talented AI/ML postdocs to develop implementable predictive models adapted to low-resource settings and humanitarian response.

ABOUT YALE

Biomedical Informatics and Data Science [BIDS] is a new section in the Yale School of Medicine [YSM], driving research to ensure equity in the digital transformation of healthcare.

YSM, established in 1810, is a leading institution combining education, research, and clinical practice. With a long-standing commitment to excellence, it provides a dynamic environment with work recognized globally by several Nobel prizes and practice-changing innovation. Employees at Yale have the opportunity to work alongside respected scholars and top students and participate in a diverse range of programs.

ABOUT LiGHT

LiGHT is a research lab that focuses on using data science to improve health care in resource-limited settings. We work with university hospitals and international NGOs and have a large and diverse project portfolio, which includes running clinical trials to validate our tools in the field.

YOUR PROFILE

• You are exceptional
• You have a Ph.D. in some combination of DS/ML/AI/CS and have acquired diverse skills in all.
• You are passionate about research and teaching
• You want to create impactful tools for humanitarian and low-resource settings
• You are comfortable in a multi-project lab with a dynamic young international environment

YOUR MISSION

• Development in close collaboration with research staff working on cutting-edge deep learning algorithms and software
• Support research staff to transition research prototypes to production-grade software tools
• Implement best practices for sustainable and maintainable software development
• Education and support for research staff and students in software development

THE FOCUS AREAS (no specific experience needed here, you can learn on the job, just FYI)

• We have a range of projects that focus on equitable data management in low-resource settings (equitable, fair, provably privacy-preserving, carbon-aware federated learning which is robust to data shifts of imperfect interoperability and capable of large-scale multimodality)
• We work with multimodal models (including LLMs) and are interested in creating implementable optimization techniques that reduce their computational cost for equitable access and use in low-resource settings.

SKILLS REQUIRED

• Strong practical experience (ideally Python plus other languages too), and good expertise with at least one common ML framework
• Open source and software design expertise
• Fluent English in speech and writing
• Effective team player

SKILLS PREFERRED

• Knowledge in one or more of the areas of machine learning, deep learning, distributed computing, p2p networks, decentralized systems, PyTorch, jax, TensorFlow (in particular .js), web stack, and public cloud environments.
• Bachelor’s, Master’s, or PhD degree in computer science or equivalent.

WE VALUE

• Creativity
• Passion
• Humor
• Kindness
• Organization
• Rigor
• Autonomy
• Diversity
• Openess&Transparency
• Adventure
• Generosity
• Hard work

WE OFFER

An exciting and fun environment in a very talented and motivated international team. Strong potential impact in research, applications, and the open-source community

Start date: ASAP

Term of employment: Fixed-term

Work rate: 100% (onsite/hybrid)

Duration: 1 year fixed-contract (till Dec. 2024), with possible extension

Apply: via the LiGHT lab website https://www.yale-light.org/join-us

The Braun Lab (Yale Center of Molecular and Cellular Oncology / Yale Cancer Center / Yale School of Medicine; www.thebraunlab.org) is seeking a highly motivated experimental postdoctoral fellow or associate research scientist interested in cancer immunotherapy and immunogenomics to join our translational research team.

Our laboratory aims to understand the key determinants of effective anti-tumor immunity, utilizing high-dimensional analytic tools and patient-derived models to study human tumors. We have focused our efforts on renal cell carcinoma (kidney cancer), and our work has helped to elucidate genetic and immunologic features that impact response to immune checkpoint inhibitors (Braun, Nature Medicine, 2020) and to define the immunologic changes that occur with progression to advanced disease (Braun, Cancer Cell, 2021). We now aim to understand the antigenic and immune microenvironmental features that determine why kidney cancers respond or a resistant to current immunotherapies, and to create patient-derived pre-clinical models to aid the development of novel immunotherapy approaches in this disease (Braun, Nature Reviews Clinical Oncology, 2021).

Candidates with MD, PhD, or MD/PhD degrees and strong experimental experience in immunology, cancer biology, molecular biology, and/or or genetics/genomics are encouraged to apply. Successful candidates will be expected to work collaboratively with other postdoctoral fellows, computational biologists, graduate students, and other trainees in the laboratory. High priority will be given to candidates with prior experience in immunology techniques, functional genomics, and/or mouse modeling.

Interested applicants should send a cover letter (describing prior research and future goals, AND listing contact information for 3 references) and a CV to david.braun@yale.edu .

The Braun Lab uses reverse translation to understand human tumor immunology, with the goal of improving immunotherapies for patients with cancer. We are located at Yale University, an internationally-renowned research university located in the historic city of New Haven, Connecticut. Yale has long been recognized as an outstanding environment for nurturing young scientists, with postdoctoral researchers being an integral part of the discovery process.

Join the VACS team!

The Veterans Aging Cohort Study (VACS) is a well-established, international, collaborative network of experts, with an exceptional track record of productivity and development of early career researchers, many of whom have transitioned to independent NIH and VA funding. The team are excited to offer this opportunity to develop and apply advanced epidemiologic methods on large, complex, national cohorts derived from electronic health records (EHR) at the Department of Veterans Affairs (VA). VACS has extracted and curated 20+ years of longitudinal EHR data on alcohol and health outcomes in people with and without HIV, allowing us to seek and identify novel medications for the treatment of alcohol and substance use disorders.

The VACS team is seeking a Postdoctoral Associate in Pharmacoepidemiology who will be responsible for conducting NIH-funded mentored research, focusing primarily, but not exclusively, on deriving real-world evidence on the potential safety and effectiveness of repurposed medications to treat alcohol and substance use disorders in people with and without HIV. 

The Postdoctoral Associate will join a multi-site, multidisciplinary research team, and be mentored primarily by Dr Christopher Rentsch, PhD (Yale/LSHTM) and Dr Lorenzo Leggio, MD, PhD (NIDA/NIAAA), with the opportunity to collaborate with the wider VACS team through its infrastructure of Cores and Workgroups to acquire experience and knowledge outside of their primarily responsibilities.

The Postdoctoral Associate will be encouraged to articulate research questions of clinical, population health, and mechanistic importance, design research projects, develop detailed analytic plans, perform analyses, interpret results, effectively communicate results orally and in writing, lead and submit results for peer-reviewed publication, and disseminate findings at national and international conferences. 

The ideal candidate will be self-motivated and collaborative, have strong epidemiological skills with some experience using electronic health record data and a passion for deriving high-quality real-world evidence on medication safety/effectiveness, ideally in the field of addiction.

Responsibilities

• Lead and assist in designing, conducting, and interpreting pharmacoepidemiological research; includes extracting and cleaning very large sources of electronic health records and other routinely-collected data
• Lead and assist with the preparation of abstracts and presentations at national and international scientific meetings and manuscripts for publication, including as lead author 
• Manage elements of larger grants, ensuring compliance with good practice in relation to the conduct of research, and institutional ethics policies
• Undertake high quality research and scholarship, including contributing to drafting major grant proposals and/or leading on drafting smaller grant proposals
• Other duties and responsibilities as assigned or directed by the supervisors, including, but not limited to, travel and attendance of and participation in training and data access activities required for this role.

Required Knowledge, Skills and Abilities

• Experience of conducting epidemiological analysis on large-scale health datasets, including those derived from electronic health records or other routinely-collected data
• Previous contributions to written output, preferably peer-reviewed
• Proven ability to work independently, as well as collaboratively as part of a research team, and proven ability to meet research deadlines
• Evidence of excellent interpersonal skills, including the ability to communicate effectively both orally and in writing
• Evidence of good organizational skills, including effective time management
• Proficiency in SAS, SQL, or other programming languages

Preferred Knowledge, Skills, and Abilities

• 1-2 years prior post-doctoral experience are preferred but not required
• Some experience of contributing to research grant applications
• Some experience using propensity score approaches, including propensity score matching and/or inverse probability of treatment weighting
• Some knowledge of addiction treatment
• A strong interest and willingness to learn these preferred skills will be reviewed favorably 

This position is NIH funded and available for a part-time (50% FTE) one-year appointment with the possibility of extension upon mutual agreement and availability of funds. Candidates interested in this opportunity are invited to email Dr Christopher Rentsch (christopher.rentsch@yale.edu ) with questions, or to apply, with a single PDF including:

1. Cover letter of up to 2 pages detailing previous research experience, interests, and career goals
2. Names and contact information of 2-3 academic references
3. CV

Please note: Due to the part-time (50% FTE) nature of this role, appointees who are not U.S. citizens or permanent residents should ensure such an appointment is consistent with visa requirements.

Yale University is an affirmative Acton/Equal Opportunity Employer and welcomes applications from women, persons with disabilities, protected Veterans and member of minority groups. Applications will be accepted until the position is filled.

Postdoctoral Position in RNA-splicing and Systems Biology

RNA-Splicing and Systems Biology

The Robinson lab (Yale Cancer Center Department of Therapeutic Radiology) is seeking a computationally focused postdoctoral candidate with expertise in bioinformatic analysis including analysis and visualization of RNA-seq and related whole genome assays (long read RNA-seq, single cell RNA-seq, DNA mutation analysis, proteomics etc.) to join our translational research team. Individuals who have bench experience are also welcome, but the focus of the position will be to lead bioinformatic analyses conducted in the lab.

Dr. Robinson is a physician scientist radiation oncologist with a research interest in mechanisms of resistance to radiation and T-cell therapies in relapsed and refractory large B-cell lymphomas. Work conducted in the lab has led to the identification of potential splicing-mediated mechanisms of resistance to CAR T-cell and potentially radiation therapy in diffuse large B-cell lymphoma. Applicants with an interest in pursuing an intellectually challenging field and who would like to make a difference in cancer care are encouraged to apply.

Education, Qualifications and Skills:

Required:

• MD, PhD, or MD/PhD degrees
• Expertise/experience in bioinformatics, computational biology, computer science, mathematics, physics, or statistics
• Ability to work collaboratively with experimental postdoctoral fellows and scientists, computational biologists, graduate students, and other trainees in the laboratory.
• Prior experience in bulk genomic/transcriptomic analysis
• Expertise in basic data visualization
• Basic computational biology expertise
• Basic systems biology expertise

Highly desired:

• Expertise in RNA-splicing
• Advanced computational biology skills including motif searching, machine learning, and high-dimensional data visualization skills
• Single-cell transcriptomic analysis
• Whole exome sequencing analysis
• Basic background in cancer biology
• Manuscript writing

Interested candidates should email Timothy Robinson (timothy.j.robinson@yale.edu – note the “j”) and Amy Likens (amy.likens@yale.edu) with a CV, statement of interest and contact information for 2-3 references.

Yale University is an affirmative action/equal opportunity employer. Yale values diversity in its faculty, students, and staff and especially welcomes applications from women and underrepresented minorities.

Description:

Applicants are invited to apply for a postdoctoral research position in the Department of Astronomy at Yale University in the new research group of Assistant Professor Earl Bellinger. The position is initially for one year, with the possibility of annual renewals for up to two additional years, contingent on performance. The research direction will be flexible and according to mutual interests, aligning broadly with the themes of stellar astrophysics, machine learning, and the analysis of large observational and theoretical data sets.

Conveniently located between New York City and Boston, Yale offers a lively intellectual environment and access to world-class astronomical facilities, including the Keck, Palomar and SMARTS telescopes. Yale is an institutional member of the SDSS-IV and SDSS-V collaborations, and the postdoc may develop projects with these data. The postdoc will have access to High-Performance Computing facilities at Yale. The position will involve travel to collaboration meetings and other related workshops and conferences.

Qualifications:

The successful candidate must have a Ph.D., or equivalent degree by the start date.

Application Instructions:

Applications should upload a cover letter, curriculum vitae, publication list, and a brief (2-3 page) description of research interests to the following URL: 

http://apply.interfolio.com/134999 

Applicants should also arrange for three letters of recommendation to be submitted to the above URL. The anticipated start date is September 1, 2024, although other start dates are possible. If you have questions, please email earl.bellinger@yale.edu prior to the deadline. Applicants who apply to the Yale Center for Astronomy & Astrophysics (YCAA) Fellowship will also be considered for this position. 

Postdoctoral and Research Scientists Positions

Inorganic Carbon and Water Modeling

Available at Yale University

We intend to hire seven professionals (postdoctoral associates and/or research scientists) to participate in the Global Ocean and Land Alkalinization (GOAL-A) Project.  This study, which is funded by the Department of Energy (DOE) Earth Shot Program, is a collaboration among scientists at Yale, Georgia Tech, Princeton, and Texas A&M universities that aims to create a soils-to-oceans modeling framework to evaluate the efficacy, co-benefits, and risks of enhanced mineral weathering (EMW) and ocean alkalinity enhancement (OAE).  To support this interdisciplinary initiative, we are seeking applicants with proficiency in modeling that is relevant to simulating physical and chemical processes that govern the flows of water, energy, and chemicals within and between watersheds, river networks, the atmosphere, and the ocean. We are especially interested in candidates with expertise in earth-system and climate modeling, ocean circulation/biogeochemical modeling, river-network modeling, watershed modeling, and reactive transport modeling. 

At Yale, we are searching for post-doctoral and/or research scientists to focus on:

• Large Scale modeling of water and inorganic carbon including water transport between the ocean and watersheds, the production and transport of alkalinity in soils, riverine transport of inorganic carbon and CO2 gas exchange, and coastal ocean alkalinity cycling.
• Leading and developing innovative systems modeling frameworks to understand geospatial and temporal implications of agricultural liming on CO2 sequestration and river chemistry in the Mississippi River basin
• Facilitating collaborations with researchers in different disciplines and domains
• Mentoring graduate and undergraduate students and advising student course projects.

Required education and experiences of:

1. Ph.D. in engineering, oceanography, ecology, hydrology, climate science, chemistry, or systems analysis.
2. Experience in the modeling of carbon or water.
3. A strong publication record

Successful applicants will be eligible to take part in the Yale Environmental Leadership and Mentoring certificate as well as pursue other career development opportunities available at the Yale POORVU center.

Interested candidates should email a cover letter and their CV, along with a list of at least three references to peter.raymond@yale.edu

Postdoctoral Associate Positions in Biostatistics

We seek one or two highly motivated Postdoctoral Associates to advance the frontiers of neuroscience simulation. 

Related lab projects include: combining machine learning and mechanistic modeling, multisimulation (interoperation with other tools), high-resolution simulations of subcellular chemical dynamics, and algorithm development (GPUs, initialization, performance enhancements). 

The Postdoctoral Associate will lead one or more of these projects and will present this work at conferences, in publications, and in the form of open source software. Mentorship and career development opportunities will be tailored to the Postdoctoral Associate’s interests.

Applicants should hold or be about to complete a PhD in a quantitative field (e.g., mathematics, computer science), neuroscience, or a related field. Strong programming skills in Python and C++ are essential, as is scientific excellence as demonstrated through publication history. Experience with the NEURON simulator, in machine learning, numerical methods, and/or GPU computing is desirable, but not required.

The successful candidate will join the McDougal lab (Biostatistics/Health Informatics, Computational Biology and Bioinformatics, Wu Tsai Institute, Biomedical Informatics and Data Science). We are major contributors to the development of the NEURON simulator and run the ModelDB model discovery platform. We additionally have a wide-range of collaborations at Yale and beyond, applying informatics methods to solve biomedical challenges.

Please apply online:  http://apply.interfolio.com/135170.

Interested individuals should submit a CV, cover letter, and contact information for three professional references. 

Review of applications will begin immediately and will continue until the position is filled. Initial appointment is for one year with the possibility of renewal.  Questions regarding this position should be directed to Dr. Robert McDougal at: robert.mcdougal@yale.edu

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Description:

The Yale Department of Astronomy invites applications for a postdoctoral position to work in the group of Professor Malena Rice. This is a one-year position that will be renewed annually for up to three years, contingent upon performance. The applicant will conduct research in the areas of exoplanet and/or solar system science. Particular topics of interest include exoplanet dynamics, stellar spectroscopy, and outer solar system detection.

Yale offers a lively academic community and access to world-class astronomical facilities, including the Keck and Palomar telescopes. Because Yale is an institutional member of the SDSS-IV and SDSS-V collaborations, the successful applicant can automatically join both. Postdocs in the Yale Department of Astronomy also have access to High-Performance Computing facilities at Yale. The successful applicant will have the opportunity to collaborate with others across the Yale Department of Astronomy, Department of Physics, Department of Earth and Planetary Sciences, and Department of Statistics and Data Science, among others.

The starting date of this position is flexible, with a nominal start date of August 1, 2024.

Qualifications:

Applicants must have a Ph.D., or equivalent degree in physics, astrophysics, or a closely related field by the start of the position. A background in exoplanet or solar system science, especially related to population studies and/or dynamics, is desirable.

Application Instructions:

Applications must be submitted electronically at http://apply.interfolio.com/134876 and should include a curriculum vitae (CV), bibliography, and a research statement (maximum 3 pages) providing a summary of past/current research work and an overview of future plans. Candidates should also arrange for 3 letters of recommendation to be submitted to the above URL by the application deadline of December 15, 2023. 

Applications received by December 15, 2023 will receive full consideration. If you have questions, please contact Assistant Professor, Malena Rice, malena.rice@yale.edu.

Postdoctoral Position in Applied AI, NLP, and Large Language Models in Health Care

Background:

We are thrilled to present an exciting opportunity within the Data and Decision Science Lab in Health Care (DECILE), located within the Section of Biomedical Informatics and Data Science at Yale School of Medicine. The successful candidate will dive into the intricate world of Natural Language Processing (NLP), Large Language Models, and Applied AI, exploring diverse disease states through the application of these technologies and data science methodologies. DECILE is generously funded by various agencies including AHRQ, NIH, and industry collaborations.

Mentoring:

We invite a postdoctoral associate to join our interdisciplinary team of informaticians, physicians, and computational scientists. The associate will report directly to Dr. Andrew Taylor (richard.taylor@yale.edu) and will also collaborate broadly with various researchers and professionals, both internal and external to Yale University, creating a rich, interactive, and supportive research environment.

Training:

The postdoctoral associate will undertake responsibilities related to collating, analyzing, interpreting, and presenting study findings. Training will encompass the practical application of advanced computational frameworks, including Spark and various machine learning libraries, with a pronounced focus on NLP and graph databases. The integration of common data models, such as OMOP, and the use of Electronic Health Record (EHR). Further, the role will delve deeply into Machine Learning, AI, and statistical concepts, applying these skills to investigate clinical conditions and outcomes, and to develop impactful, innovative projects within the lab.

Education, Qualifications, and Skills:

• PhD, or MD/PhD, with research experience in a relevant quantitative discipline such as epidemiology, bioinformatics, biostatistics, computer science, or a related field.

• Substantial expertise and interest in NLP, large language models, and applied AI, particularly within healthcare contexts.

• Experience or familiarity with healthcare and medical terminology.

• Adeptness in utilizing mathematical and/or statistical models.

• Profound interest in computational healthcare, clinical informatics, and data engineering.

• Capacity to analyze data, interpret findings, and present results using various research techniques.

• Proficiency in Python, R, version control, and distributed computing systems.

• Exceptional verbal and written communication skills, with experience in conveying research findings to varied audiences.

• Ability to work independently and collaboratively within an interdisciplinary research team.

This position is available for a one-year appointment, with the possibility of extension upon mutual agreement. Candidates interested in this vibrant opportunity are invited to email Dr. Andrew Taylor (richard.taylor@yale.edu ) with a CV, statement of interest, and contact information for 2-3 references.

Yale University is an affirmative action/equal opportunity employer. Yale values diversity among its faculty, students, and staff and strongly encourages applications from women and underrepresented minorities.

The Yale School of Medicine, Department of Psychiatry, is recruiting one highly motivated bioinformatics postdoctoral associate (2-year appointment) to begin immediately, who aspires to become an independent academic researcher in the areas of addiction genetics and epigenetics and computational psychiatry.  

The postdoctoral associate will work primarily with Dr. Ke Xu, Associate Professor of Psychiatry, on NIH-funded studies identifying epigenetic (e.g., DNA methylation) alterations associated with substance misuses in humans. The role will involve analyzing high throughput genomic data, including DNA methylation sequencing, RNAseq, and single cell RNAseq; performing integrative analyses; and delivering analytical results. The applicant will be expected to have the capacity to work independently as well as collaboratively with other members of the lab, experience in developing workflows for sequencing data, and the ability to multitask.

Other research duties will include authoring and co-authoring several manuscripts per year, assisting with grant writing, collaborating with other investigators, and attending professional conferences. 

Qualifications include a doctoral degree in genetics/epigenetics, statistical genetics, mental health, bioinformatics, or other relevant areas at the time the position begins and excellent project management and writing skills. Excellent programming skills (R or Python, Linux shell scripting) and experience with high performance computing in Linux environment is required. Experience with psychiatric disorder research and 1-2 years prior post-doctoral experience are preferred but not required. Yale University is an Equal Opportunity/Affirmative Action Employer and actively solicits applications from women and minority candidates.

Applicant Instructions: 

To apply, please send a single PDF documenting the following to ke.xu@yale.edu:

1. Cover letter detailing previous research experience, interests, and career goals 
2. CV
3. Names and contact information of three academic references

1. characterizing the emergence of a transient progenitor population derived from alveolar stem cells following injury using precision cut lung slice culture and live timelapse imaging of intact lung tissue.
2. combined scRNA-seq and scATAC-seq to define the cell trajectories and gene regulatory networks that drive stem cell transitions in the in vivomouse lung following injury.
3. multiphoton live imaging via a permanent lung window in the mouse to uncover dynamic behavior of individual alveolar stem cells over 2 – 4 weeks following injury.
4.  in vivo single cell ablation to uncover fundamental principles of alveolar stem cell-niche interactions and how different cells in the niche are important for homeostasis and repair.
5. a microfluidics-based approach to uncover key signaling pathways and other mechanisms that modulate alveolar stem cell migration

• Mentorship and career development are a priority in the lab.
• Trainees will have regular meetings with the PI (Mau Chioccioli) to discuss the project, the relevant scientific background and career goals.
• The postdoctoral scientist will develop laboratory technical skills as well as data presentation, visualization, and scientific writing and presentation, with the expectation that the candidate will gain independence and autonomy.
• The postdoctoral scientist will have the opportunity to conduct cuttingresearch under the PI supervision.
• The postdoctoral scientist will be able to attend the Genetics and CMED seminars, retreats, gatherings and be part of a vibrant research community.
• Mentoring will be tailored to individual needs based on the successful applicant’s long-term career goals.

Education & qualifications

Applicants should have, or be close to obtaining, a PhD in a relevant field such as genetics, cell biology, molecular biology, developmental biology, or related areas.

Key Experience and Competencies

• Hands-on experience with mouse genetic models.
• Interest in the lung epithelial stem cell field.
• Essential mammalian cellular/molecular biology techniques.
• Proficient in the application of both 2P and confocal is considered a plus.
• Quantitative image processing and analysis, combining tools such as ImageJ, IMARIS
• Skilled in the use of programming languages including R and Matlab.
• Publish research findings in high-impact scientific journals and present at international conferences.
• The candidate should display a high level of personal initiative and be able to organize their time effectively to tackle both short- and long-term goals
• The candidate should be able to work responsibly with others and have excellent listening skills and strong verbal and written communication skills, with the ability to keep accurate and informative lab notebooks and create and deliver in-person presentations.

Yale’s Institute for Foundations of Data Science (FDS) is seeking applications for postdoctoral positions. These will be generously supported postdoctoral positions, expected to last 2-3 years, for independent scholars working on the foundations of data science. FDS postdocs can select multiple mentors from among the members of the institute, and can change their mentors during their fellowship. This is an opportunity to work with leading theorists as well as domain scientists who are eager to collaborate. A list of the members may be found on our web page, fds.yale.edu.

Yale’s Data Science Initiative has supported the rapid growth of the departments of Statistics & Data Science and Computer Science, as well as many interdisciplinary activities in which the postdocs could participate, including a Data Intensive Social Science Center, a center for Biomedical Data Science, and the Schmidt Program on Artificial Intelligence, Emerging Technologies, and National Power.

FDS launched in October of 2022 and moved into a newly renovated Kline Tower in the summer of 2023 along with the departments of Statistics & Data Science, Mathematics, and Astronomy. The institute was created to advance research in the mathematical, algorithmic, and statistical foundations of data science and their application to other disciplines. In addition to providing support to core foundational research, the institute hosts activities to help scholars across the university apply new methods of data science to their research. In turn, those scholars help us discover their unmet needs and thereby inspire the development of new methods and theories.

Applying

Follow this link to apply: https://academicjobsonline.org/ajo/jobs/25695
Timeline: Postdoctoral appointments typically begin in July to September, but other arrangements are possible. We will begin reviewing applications on November 1st, 2023. Applications received by then will receive full consideration.

Please submit your application materials via this portal only. Questions may be sent to FDS Managing Director Tom Keegan at thomas.keegan@yale.edu

AWE Postdoctoral Position in Urban Ecology

A postdoctoral position is available with the Applied Wildlife Ecology (AWE) Lab at the Yale School of the Environment under the supervision of Prof. Nyeema C. Harris, Knobloch Family Associate Professor of Wildlife and Land Conservation. The AWE Lab investigates antagonistic interactions in mammal systems including parasitism, competition, and predation namely in terrestrial carnivores. Our work has direct implications to species management through understanding ecological and environmental interactions.

We seek a committed, self-motivated, problem solving individual to investigate urban ecology through lens of social science, public health, and global change. The individual will be conscious of the myriad social and ecological interactions that cities create, which can lead to vulnerable populations within a landscape of fear for urban carnivores. We are interested in identifying areas of vulnerability for human-wildlife conflict in cities across North America. We are also interested in launching new wildlife surveys for comparative studies in cities around the world, particularly in the Global South. This includes investigating movement patterns of carnivores across gradients of air-quality, noise and environmental pollution. Additionally, the individual will help to plan and implement natural experiments testing how carnivores respond to stress and pressure from living in close proximity to humans.

Qualifications for the position include a Ph.D. in ecology, wildlife biology, geography, or a related field. Experience and familiarity with experience in chemical immobilization, carnivore collaring, trail cameras, and environmental sampling and data are preferred for this position. Demonstrated analytical experience includes hotspot analysis both from occupancy modelling, as well as movement data from GPS collars. This individual will have a growing publication record, and exceptional research and communication skills needed for leading teams in urban fieldwork settings. The ideal candidate should have demonstrated competency or emergent interests in urban fieldwork, as well as Arc GIS, RGoogle Earth Engine. Interest or familiarity with climatic data, iNaturalist or other crowd sourced data, participatory mapping, maximum entropy modelling, machine learning are also a bonus.

The position responsibilities include tasks related to research topics above, co-authoring papers, and mentoring students and technicians. AWE Lab members are expected to participate in lab meetings, retreats, field work and training activities as well as public engagement initiatives throughout the year. Public engagement and public science are fundamental to the AWE Lab, which seeks to inspire new generations of scientists and create opportunities for non-scientists to contribute in combatting the ecological and environmental challenges facing our planet. Diversity, equity, justice and inclusion are also core values in the AWE Lab and we are committed to ensuring the lab reflects those values and integrates them into our work. As such, we strongly encourage applications from researchers identifying as members of marginalized or underrepresented groups.

Yale University provides a stimulating academic community, situated among the Peabody Museum and Institute of Biospheric Studies(YIBS). The University offers its postdocs and staff a generous benefits package and is located in New Haven (75 miles north of New York City). This is a one-year position supported directed by Dr. Harris and YIBS, beginning asap with reappointment for an addition year based on outstanding performance and availability of funds. In addition to a competitive salary and full research support, the successful candidate will receive an annual professional development budget for additional trainings and conference participation.

To apply, please send a cover letter, CV (hyperlink publications), contact info for three referees, and “Urban Ecology Postdoc” in the subject line to: joseph.poggi@yale.edu. Joe serves as the Lab Manager for the AWE Lab and will support the hiring process. Ideally, the anticipated start date for this position is on or before October 31^st.

• PhD in a relevant field (biology, immunology, cancer biology or similar)
• Demonstrated scientific contributions to the field
• Proven ability to solve challenging technical problems
• Clarity of thought in communications (written and oral)

Vascular Biology Postdoctoral Research Position

Vascular Biology and Therapeutics Program

Department of Pediatrics, Section of Critical Care Medicine

A postdoc position is available in the laboratory of Dr. Ric Pierce. Research in the Pierce group focuses on blood vessel dysfunction in the setting of acute critical illness. Our group exists to understand how to identify and treat blood vessel dysfunction, with the ultimate goal to reduce death and disability in patients. Our work is highly translational, with research questions arising directly from critically ill children. We are highly collaborative, working with many medical and scientific subspecialties to solve critical clinical problems that will ultimately improve the health of children. Check us out at: https://medicine.yale.edu/lab/pierce/ and on Twitter @Pierce_Vasc_Lab

We are seeking highly self-motivated applicants with competence in standard cellular and molecular biology techniques. Experience with culturing primary human endothelial cells, such as HUVEC, is required. Additional training for more specific assays and techniques utilized by our lab will be provided as needed. As a core member of the Pierce lab, you will be expected to work at the bench, interpret data, and troubleshoot experiments independently. Personal drive for independent investigation, creativity, and excellent communication skills are expected, and we will help develop these skills during training. Information about salary, benefits, and career development opportunities can be found at https://postdocs.yale.edu/postdocs.

Yale‘s Department of Pediatrics (https://medicine.yale.edu/pediatrics/research/),Vascular Biology and Therapeutics (https://medicine.yale.edu/vbt/) and Human and Translational Immunology (https://medicine.yale.edu/immuno/programs/hti/) Programs are unique, highly supportive and collaborative environments which combine the investigative strengths of outstanding laboratory-based faculty with strong interdisciplinary clinical teams. We will help you achieve your goals by continuous professional development and regular career progression sessions along with participation in seminars, annual retreats, and programs within Pediatrics, VBT, HTI and Yale School of Medicine. This is an excellent and supportive environment for a highly motivated candidate. Grant and manuscript writing classes, mentorship seminars, near-peer workgroups and other opportunities are available to assist with professional development and are expected aspects of training.

Interested applicants should send a curriculum vitae and contact information for three references to the following address: lisa.palmieri@yale.edu or Lisa Palmieri, Department of Pediatrics, 333 Cedar Street, PO Box 208064, New Haven, CT 06520-8064.

Yale University is an Affirmative Action/Equal Opportunity Employer and strongly encourages applications from women, persons who identify with groups traditionally underrepresented in science and medicine, persons with disabilities, and protected veterans.

Yale University School of Medicine

The Vinetz Laboratory in the Section of Infectious Diseases is seeking postdoctoral candidates interested in 1) biotechnology of vaccines; and 2) immunology of vaccine-mediated protection against bacterial infectious diseases. 

Our lab provides exceptional basic science and translational research environment, with direct connections to tropical disease-endemic field sites.

Candidates with experience in molecular biology, recombinant protein expression (bacterial, insect, algae, mammalian cells), protein purification using various chromatographic methods, flow cytometry, confocal microscopy, immunology and small animal models of infectious disease pathogenesis are encouraged to apply.  Ideal candidates should have a combination of skills in biotechnology, protein engineering/purification/characterization, immunology, molecular biology and genomic analysis.  Excellent communication and writing skills are essential for this position. Salary is based on research experience and on published university norms:

https://postdocs.yale.edu

https://postdocs.yale.edu/policies/postdoc-compensation

Interested applicants should send a CV, cover letter describing research interest, your reasons to apply to my lab including long-term career goals, and names/contact information for 3 references to joseph.vinetz@yale.edu. Very important is a demonstrated, published track record of success in a combination of the above skills.

Yale University is an Affirmative Action/Equal Opportunity Employer and welcomes applications from women, members of minority groups, persons with disabilities and protected veterans.

Yale School of Medicine, Nephrology (CTRA)

Full-time paid postdoctoral associate training position beginning Summer 2023 in the Department of Internal Medicine within the Clinical and Translational Research Accelerator. The position is available for 1 or more years (renewal is contingent on ongoing funding and satisfactory performance).

Mentorship

The lab has several ongoing clinical research studies focusing on developing novel technologies and biomarkers related to various kidney diseases.  Past graduates have pursued residency in Internal Medicine/Pediatrics after completion. The Clinical and Translational Research Accelerator is composed of a collaborative group of physician-scientists, research fellows, post-docs, post-grads, biostatisticians, nurses, and study coordinators. Our group prides itself in providing strong mentorship for trainees, promoting academic excellence, and achieving work-life balance.

Education

Requirements for the position include MD (or foreign equivalent) or PhD with expected graduation June 2023 or earlier. Prior experience in a research laboratory or hospital is preferred. Statistical skills and interpersonal skills are highly valued.  

Training

The position provides hands-on training in patient-oriented biomedical research with the opportunity to interact with both patients and healthcare professionals in hospital, clinic, and laboratory settings. Responsibilities may include but are not limited to: assistance in clinical data and quality management, consenting/interacting with patients, developing presentations, biospecimen processing, reporting at team meetings, and data management/analysis.  There will be opportunities to participate in abstract and manuscript publication and to lead studies. 

Further details about the Clinical and Translational Research Accelerator is available at https://medicine.yale.edu/intmed/ctra/profile/dennis-moledina/

Interested applicants should send their resume with cover letter todennis.moledina@yale.edu"> dennis.moledina@yale.edu

A postdoctoral associate position is available in the Miller-Jensen laboratory in the Department of Biomedical Engineering at Yale University. We are seeking a highly motivated individual to join our interdisciplinary team using systems biology approaches to study the regulatory networks of innate immune cells in health and disease. We are particularly interested in studying macrophage and myeloid cell functional plasticity and defining the signaling and transcriptional regulatory networks that control macrophage heterogeneity.

The postdoctoral candidate will the develop genome engineering strategies to tune cell-to-cell heterogeneity in primary murine macrophages and explore the biological functionality of these engineered cells in vitro and in vivo. The postdoctoral candidate will work closely with collaborators to develop mathematical models of the emergent population-level behaviors. This position is supported through NSF- and NIH-funded grants. Our lab is a member of the new Center for Systems and Engineering Immunity (CSEI) where the postdoctoral candidate will join a vibrant and growing community of systems immunologists at Yale.

Applicants should hold, or be about to complete, a PhD or MD/PhD in immunology or biomedical engineering, or related fields. Individuals with experience in innate immunity, genome engineering, cell signaling biology, or any relevant experimental experience and a strong interest in immunology are encouraged to apply. Strong oral and written communication skills, along with a record of research productivity, are essential.

The position is available immediately but will be held for an ideal candidate. Applicants should include a summary of research interests and goals, CV, and names and contact information of three references. Please send materials as a PDF to:

Kathryn Miller-Jensen, PhD

kathryn.miller-jensen@yale.edu

Department of Biomedical Engineering

Yale University

An exciting Postdoctoral Fellowship opportunity is currently available in the laboratory of Arya Mani, M.D. at the Yale University Cardiovascular Research Center. We are seeking a highly motivated individual to join our team of researchers and contribute to a study focused on investigating the role of exocrine pancreas and macrophages in the development of type 2 diabetes. This research project involves an animal model of a human disease gene discovered by our lab (Esteghamat & Mani, Nat. Genet 2019).
To be considered for this position, candidates should meet the following education, experience, and skill requirements:

• PhD in the field of biological sciences.
• Proficiency in animal breeding and handling, along with a strong foundation in basic techniques of molecular biology and metabolism.
• Prior experience working with pancreas, as well as possessing critical thinking, communication, teamwork, organizational skills, and scientific writing abilities.

Our laboratory is highly productive, and our team members consistently publish their work in high-impact journals. This opportunity provides an excellent environment for professional growth and collaboration.

Interested candidates are encouraged to contact Dr. Arya Mani directly via email at arya.mani@yale.edu<mailto:arya.mani@yale.edu>.

A postdoctoral associate position is available in the laboratory of Dr. Mark Lee (https://medicine.yale.edu/profile/mark_n_lee/?tab=research) at the Yale School of Medicine in New Haven, Connecticut. This position is partially funded through the Rudolph J. Anderson Endowed Postdoctoral Fellowship program.

The Lee laboratory is a human immunology/immunogenetics research group that builds and applies new functional genomic techniques to profile the human immune system using patient samples. The lab seeks to uncover therapeutic targets in immune-related diseases by bridging next-generation/single-cell sequencing with high-throughput co-culture screens. Currently, a major focus of the lab is to identify disease-relevant T cell receptors in tissue/blood samples from patients with lung cancer and with a variety of autoimmune diseases. The lab aims to solve central problems in the field such as: how to identify new shared epitopes for cancer immunotherapy; how to solve long-standing mechanisms that underlie HLA associations with autoimmune/alloimmune diseases; and how to enable precise control of adaptive immune responses through engineered cellular and recombinant therapies. Available projects relate to these efforts, although postdoctoral associates are encouraged to push beyond current efforts in the laboratory.

Qualified applicants will have a Ph.D. or M.D./Ph.D. in immunology, genetics, genomics, molecular biology, cellular biology, or a related discipline. We are particularly interested in candidates with research experience in cellular immunology, human immunology, high-throughput functional genomics, and/or computational biology. Candidates should be highly collegial, hard-working, reliable, and curious, with a strong professional track record and excellent written and oral communication skills.

Application Process:

Interested applicants should contact Dr. Mark Lee, MD, PhD (mark.n.lee@yale.edu) with the Subject line: “Postdoctoral associate position in the Lee lab”; include a copy of their CV; include a Cover Letter addressing their research background, interest in the position, and goals; and include the names of 3 references. Yale University is an equal opportunity employer and values diversity in its faculty, students, and staff.

Yale School of Medicine is seeking a motivated Postdoctoral Associate to join research programs in the laboratory of Madhav C Menon focused on the study of renal tubular and podocyte cell biology with specific reference to mechanisms of renal fibrosis and proteinuria, respectively. The goals of the lab are to understand fundamental biological mechanisms, develop biomarkers and novel therapeutic strategies to mitigate progressive kidney failure in native and allograft kidneys. 

Our well-funded research opportunities follow a bedside-to-bench template starting from gene variants already identified in human native and allograft kidney disease, to elucidating mechanisms via invitro tools to the development and/or application of unique mouse models for in vivo pathway discovery and validation. Experience in immunological techniques, and interest in allograft rejection/failure are highly desirable. The approaches are founded on interpretation of large data sets from human genome level sequence data and/or mouse cell type specific transcriptome sequence data coupled with model organism pathophysiology and basic cellular biology.

Applicants should have a Ph.D. and/or M.D., with interest in model organisms, molecular biology, cell biology, immunology, or related fields.

All applications materials should be submitted electronically to: Brian Kelly, Staff and Academic Affairs Coordinator at brian.kelly@yale.edu. Review of applications will begin immediately and will continue until the position is filled.

Yale University is an affirmative action/equal opportunity employer and welcomes applications from women, persons with disabilities, protected veterans and members of minority groups.

 A postdoctoral position is available in the laboratory of Dr. Salil Garg (https://medicine.yale.edu/profile/salil_garg/), Assistant Professor in the Yale School of Medicine.  The Garg laboratory (http://www.garglab.org) is new to Yale and actively recruiting for multiple positions.  The lab uses approaches from genomics, molecular biology, cell biology, bioinformatics, and systems biology to understand non-genetic heterogeneity in development and cancer.  We want to understand how cell systems with the same genetic material break symmetry and generate cells with markedly different behaviors from one another.  Our hypothesis is that the processes that drive this behavior in normal mammalian development operate in cancer, driving tumor heterogeneity.  The lab’s most recent publications appear in Molecular Cell and Cancer Discovery, and mentees have gone on to success in both academic and industry careers.

Qualified applicants will have a Ph.D., M.D., or equivalent credential in a relevant discipline.  The lab employs both experimental and computational approaches; applicants should have familiarity with at least one of these areas and a willingness to learn the other.  Our philosophy is that each trainee should chase scientific questions using the best methodology available.  Candidates should be curious, hard-working, strong communicators, and above all interested in answering challenging questions.  Visa sponsorship is available.

Projects are flexible and can be crafted to the interest of the applicant, and may relate to 1) identification of molecular mechanisms driving heterogeneity in developmental or cancer contexts; 2) understanding of cellular states and non-genetic memory in cell systems; 3) construction of new diagnostic tools using connections between developmental biology and cancer.

Application process:  Interested applicants should contact Dr. Salil Garg (salil.garg@yale.edu) using subject line “Postdoctoral position in the Garg lab” and include: a cover letter addressing their research background, interests, and goals; a copy of their curriculum vitae; and names of 3 references including research supervisors.  Yale University is an equal opportunity employer and values diversity in its faculty, students, and staff.

Yale University

School of Medicine

Department of Internal Medicine

SECTION OF NEPHROLOGY

POSTDOCTORAL RESEARCH ASSOCIATE Position

Yale School of Medicine is seeking a highly motivated Postdoctoral Research Associate interested in tissue engineering to join the laboratory of William G. Chang MD, PhD. The lab has ongoing research projects focusing on kidney tissue engineering. Candidates with experience in tissue engineering, cell/molecular biology, kidney research, or small animal surgical models are encouraged to apply.  Applicants for the position should have obtained a PhD, MD, DVM in a life science, biomedical engineering, medical, surgical, or veterinary field prior to starting. The postdoctoral training will involve tissue engineering, imaging, animal model systems, and statistical analyses.

Application materials (brief statement of scientific goals and CV/resume) should be submitted electronically to Dr. Chang (w.chang@yale.edu). Review of applications will begin immediately and will continue until the position is filled.

Yale University is an affirmative action/equal opportunity employer and welcomes applications from women, persons with disabilities, protected veterans, and members of minority groups.

The laboratory of Daniel DiMaio, M.D., Ph.D., in the Department of Genetics is seeking a postdoctoral researcher in molecular virology. We study tumor viruses to determine the mechanistic basis of fundamental biological processes and to develop new strategies to inhibit tumor virus infection and the cancers they cause.Because viruses are dependent on cellular machinery for all phases of their life cycle, they historically have been valuable tools to study many aspects of biology. Our lab focuses on human papillomaviruses (HPV), which cause approximately 5% of all human cancer. Our prior studies revealed a novel mechanism of growth factor receptor activation by a viral oncoprotein, provided the first example of oncogene addiction, designed artificial proteins with unprecedented chemical simplicity, described the first clear biological role of cell-penetrating peptides, and discovered that some proteins can act in a manner independent of their amino acid sequence. Our main current focus is the complex process by which HPV enters cells, which we study to discover new principles of cell biology and biochemistry. These studies many also lead to new approaches to inhibit virus infection and cancer formation. Our laboratory seeks to hire a highly motivated postdoctoral associate with expertise in virology, molecular and cellular biology, and/or biochemistry. Potential projects include structure-function analysis of HPV proteins involved in virus entry, development of a novel system to propagate infectious HPV pseudoviruses, and mechanistic studies of cellular proteins that are required for virus entry. Major experimental approaches include cell culture, virus propagation and infection, mutant construction and analysis, protein expression and purification, and imaging techniques in cultured cells.

Representative publications:

Heim, E., Marston, J., Federman, R., Edwards, A. B., E., Karabadzhak, A., Petti, L.M., Engelman, D.M., and DiMaio, D.  (2015) Biologically active LIL proteins built with minimal chemical diversity. Proc. Natl Acad. Sci. USA, doi:10.1073/pnas.1514230112.

Zhang, P., Monteiro da Silva, G., Deatherage, C., Burd, C., and DiMaio, D. (2018) Cell-penetrating peptide mediates intracellular membrane passage of human papillomavirus L2 protein to trigger retrograde trafficking. Cell, 174: 1465-1476. doi10.1016/j.cell.2018.07.031.

Xie, J., Zhang, P., Crite, M., and DiMaio, D. (2021) Retromer stabilizes membrane insertion of the L2 capsid protein during retrograde HPV entry. Science Advances, doi: 10.1126/sciadv.abh4276. PMID: 34193420

Oh, C., Buckley, P., Choi, J., Herrero, A., and DiMaio, D. (2023) Sequence independent activity of a long disordered segment of the human papillomavirus L2 capsid protein during virus entry. bioRxiv 2023.03.21.533711.

The successful candidate will have a doctoral degree and publication record in biochemistry, cell or molecular biology, virology, or a related field and will receive further training on how to conceptualize, design, conduct, and interpret hypothesis-driven experiments to address important issues in biology. The candidate should be self-motivated and eager to learn new techniques and should display a high level of independence and good problem solving and interpersonal skills. Interested candidates should send an email to daniel.dimaio@yale.edu including a CV, a cover letter with a brief description of research interests and how they align with the lab, and email addresses of two or three referees.

Postdoctoral Position Agent-Based Model Development for Environmental and Archaeological Applications

The Yale Paleoarchaeology Laboratory seeks to fill a one-year postdoctoral position for a project entitled “Modelling the Evolution and Future of the Zambezian Biome”. The aim of the project is to develop and deploy agent-based (or generative) models to understand human-environment interactions in the Zambezian Biome of southern-central Africa over the last ~30,000 years. The position is funded through a Yale Bioscience Postdoctoral Fellowship, and will begin on 1 September 2023.

The time period under study spans the global climatic transition from the Last Glacial Maximum into the Holocene ca. 11,500 years ago, as well as the regional economic transition of humans from hunter-gatherers to food producers ca. 2,000-3,000 years ago. The goal is to understand the changing resource landscape for ancient humans across those transitions, as well as potentially the iterative environmental impacts of those same humans on available resources. Ultimately, these models will provide testable hypotheses for interpreting the archaeological and paleoenvironmental records relevant to reconstructing ancient human social organization. They will also inform development of strategies for mitigating paired human-climate impacts on environments in the region, by identifying where and under what conditions ecosystem tipping points may be anticipated.

One year of this two-year project has already been completed. Therefore, the incoming candidate will build on existing data and code structure, but the position will not be renewable for a second year. The successful candidate will publish results from this project collaboratively with the PI (Dr. Jessica Thompson), the initial model developer Dr. Benjamin Davies (Tufts University), and other contributors. They are also encouraged to use this opportunity to advance their own independent scholarly profile and will receive mentorship on research, job searches, and other related academic professional development.

The appointment will be as a Postdoctoral Associate. Compensation and benefits are outlined at the Office for Postdoctoral Affairs. The candidate must be physically present in New Haven and will receive office space in the Department of Anthropology. In addition to resources through the Yale library system, the candidate will have access to any necessary resources for the project through the Yale Center for Research Computing: https://docs.ycrc.yale.edu/.

Required Qualifications

• PhD within the last 4 years in Anthropology, Environmental Science, Ecology, Archaeology, or a related field
• Demonstrated experience with code development and application in agent-based models
• Expertise in human behavioral ecology, optimal foraging theory, and/or paleoecology

Preferred Qualifications

• Familiarity with Paleolithic archaeology
• Expertise on the ecological context of ancient Africa

Qualified candidates should email a cover letter of no more than two pages, a CV, and a list of contact details for three references to Dr. Jessica Thompson at jessica.thompson@yale.edu. Review of applications will begin on 1 June 2023 and continue until the position is filled.

The Higgins-Chen Lab at Yale University invites applications for up to 2 postdoctoral associate positions in the biology of aging, supported by multiple NIH grants. The lab is focused on using machine learning approaches to identify omics-based biomarkers to estimate the biological age of individuals, then adapt the biomarkers for use in clinical trials of geroscience-based interventions to prevent or treat age-related diseases. The lab also studies the interaction between aging and mental health. Lab members primarily perform computational analysis, collaborating with clinicians, experimental biologists, epidemiologists, social scientists, and industry to train and validate biomarkers.

Postdoctoral associates may work on one or more projects and are encouraged to incorporate their other research interests into the work. They may work collaboratively with one or more current lab members for these projects. Projects we are currently hiring for include:

1. Molecular signatures of Alzheimer’s resilience: Work with a unique multi-omics multi-region brain dataset for Alzheimer’s disease, highly enriched in individuals with ApoE E4 alleles yet are resilient to cognitive decline. All somatic mutation, DNA methylation, and proteomics data from 3 brain regions are already collected, along with detailed phenotypic data. A postdoctoral associate would work to identify molecular signatures of resilience using individual data types and perform multi-omic integration.
2. Epigenetic clocks to link aging hallmarks, interventions, and outcomes: Epigenetic clocks based on DNA methylation are commonly used aging biomarkers in epidemiological studies. However, there is little mechanistic understanding of how they relate to molecular hallmarks of aging, risk for age-related disease, and response to aging interventions, limiting their potential use in clinical trials. With collaborators, we are collecting data from humans, human cell culture, and mouse models concerning DNA methylation relationships with aging hallmarks, interventions, and outcomes. A postdoctoral associate would work to integrate this data and test new computational approaches to develop mechanistically informed epigenetic aging clocks.
3. Computational solutions for adapting aging biomarkers to longitudinal studies and clinical trials: Aging biomarkers are needed to longitudinally monitor an individual’s aging process and their response to interventions. However, current aging biomarkers are mostly trained and validated using cross-sectional measurements, and they also can be affected by a variety of confounders that make it unclear whether changes in biomarkers can be truly attributed to a modification of aging. A postdoctoral associate would work with longitudinal biomarker data from large aging cohorts and other datasets to develop computational methods for utilizing longitudinal data in training and validation of aging biomarkers, and methods for detecting and correcting for confounders.

Another major focus of the lab is investigating how mental health influences the aging process and identifying ways to improve the long-term health of individuals with psychiatric disorders. Postdoctoral associates are welcome to contribute to these projects.

Qualifications:

1. Excellent collaboration skills and ability to contribute to a positive, supportive, and collegial lab environment
2. A PhD, MD, or MD/PhD and experience in geroscience, cellular and molecular biology, computational biology, bioinformatics, or a related field.
3. Strong computational skills, including experience with programming languages such as R or Python, and supervised and unsupervised machine learning methods
4. Motivated and self-directed to complete research projects and learn new skills needed for that research

Preferred Qualifications:

1. Experience and domain knowledge relevant to one or more projects listed above (Alzheimer’s Disease, mouse or cell culture aging studies, epidemiology of aging, etc)
2. Expertise in computational methods relevant to one or more projects listed above (proteomics analysis, multi-omics data integration, advanced longitudinal modeling, etc.)

Application Process:

Appointments are initially for 1-2 years, are renewable, and have flexible start dates. The positions are available immediately and will be reviewed on a rolling basis. Qualified applicants may be contacted to schedule an interview.
Interested candidates should submit the following application materials:

1. A 1-page cover letter describing your research interests, career goals, and how your expertise may contribute to one of the above projects (please focus your letter on one project – we may discuss other projects during the interview).
2. A detailed CV or Biosketch
3. Contact information for three professional references who can provide letters of recommendation or discussions by phone upon request.

Send materials as a single PDF file to:

Albert Higgins-Chen, MD, PhD

a.higginschen@yale.edu

Department of Psychiatry, Department of Pathology

Yale University

Postdoctoral position in discrete-choice analysis of non-pharmaceutical interventions during pandemics

Job Description

Applications are welcomed for a NIH-funded postdoctoral position under the direction of Dr. Reza Yaesoubi (Yale School of Public Health, Department of Health Policy and Management) and Dr. Janel Hanmer (University of Pittsburgh Medical Center, Center for Research on Health Care). The successful candidate will have the opportunity to lead projects related to the discrete-choice analysis of non-pharmaceutical intervention to control pandemics and the development of decision models to inform the optimal use of these interventions during pandemics.

The successful applicant will be expected to participate as lead author in publications arising from this work and to communicate findings in oral presentations at national and international conferences. Strong emphasis will be placed on career development, communication skills, grantsmanship, and interdisciplinary research.

Qualifications and Skills

• Doctoral degree in decision sciences, economics, health economics, public policy, or other relevant fields.
• Previous experience in discrete-choice/conjoint analysis.
• Strong background in statistics.
• While not essential, working knowledge of decision modeling and cost-effectiveness analysis, is ideal.

Benefit and Compensation Information

We offer a competitive salary. Compensation will be commensurate with experience.

To apply:

Please apply online: http://apply.interfolio.com/124814

Candidates should submit a cover letter along with an updated resume or CV and contact information for 3 professional references. 

For any additional information, please contact Associate Professor Reza Yaesoubi, Department of Health Policy and Management, Yale School of Public Health (reza.yaesoubi@yale.edu).

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

The Yale Department of Pediatrics is seeking a post-doctoral associate to pursue clinical research in sickle cell disease (SCD) and pain under the mentorship of Dr. Nitya Bakshi, incoming Associate Professor of Pediatrics and Director of the Pediatric SCD Program at Yale University. The research laboratory is focused on the study of chronic pain in SCD and is funded by federal (NIH) and foundation awards. Work from the lab includes studying chronic pain phenotypes and their outcomes in SCD using survey instruments, EMA methods, as well as quantitative sensory testing approaches. The lab is also studying pain in the context of curative hematopoietic cell transplant, and treatment interventions for chronic SCD pain. The lab also has significant expertise in qualitative methods, and their application to study pain and therapeutic decision making in SCD. The candidate will be under the mentorship and supervision of Dr. Bakshi and will have the opportunity to collaborate with several national leaders in the field, including some in the Division of Pediatric Hematology-Oncology at Yale University. 

The post-doctoral associate’s responsibilities will include management of lab research projects, fulfilling regulatory requirements, data management, analyses, and interpretation of data, and supervision of students. It is anticipated that the candidate will also recruit people with SCD for clinical studies and clinical trials in SCD. The candidate will have an opportunity for authorship and co-authorship of manuscripts and assist with grant writing. This position will enhance the candidate’s skillset in SCD observational and clinical trials design and data analyses, EMA methodology, and qualitative research methods in SCD. The candidate will be expected to develop and individual career development plan, and there will be some flexibility to tailor the position to the candidate’s specific interests. The candidate’s career development will also be supported to attend national conferences.

The position will start on October 1, 2023, but the start date may be negotiable. The duration of the position will be for 2-3 years and may be extended if desired and contingent on the availability of funding. A 1-year term may be considered on a case-by-case basis.

Candidates must have a doctoral degree, i.e., PhD, MD, or MBBS (or equivalent).  If interested, please email a cover letter detailing their interest in the position, CV, a writing sample (prior publication, thesis, or similar), and names of 3 references to:  nityabakshi@gmail.com