Yale Postdoctoral Positions

Yale University’s Nondiscrimination/Title IX Statements

Thank you for investigating postdoctoral opportunities at Yale.  Many faculty do not advertise open positions in their research groups, and you are encouraged to contact them directly to inquire about the possibility of training with them.  Other faculty advertise open positions in scholarly journals in their fields.  Finally, some post job openings on our website, and these positions are listed below.  Please click the links below to read more about each position and to find contact information for applying for the job.

Once you find a postdoctoral position your Yale department will contact you to begin the formal hiring process and to assist you in applying for an immigration visa to enter the United States if you require one.  Information about the visa process may be found at the Yale Office of International Students and Scholars website.

Postdoctoral position in Infectious Diseases (Omer Lab)
Posting Date: May 4, 2021

A postdoctoral fellow is sought for a research position in an interdisciplinary vaccine research group. Fellow should have strong quantitative skills and a doctoral degree in epidemiology, global health, economics/econometrics, or another relevant quantitative discipline. PhD in lab sciences with experience in field or clinical work will be considered. Individual with the potential for leadership, a desire to cross interdisciplinary boundaries, and aptitude for developing an independent research portfolio will be strong applicants. Researcher in their first or second postgraduate research year is preferred, but third-year researcher will also be considered.

Examples of duties:

  • Coordination of research efforts between different research sites, nationally and internationally
  • Drafting grant proposals and protocols
  • Primary and/or secondary authorship of original research manuscripts
  • Mentoring of predoctoral researchers

Minimum qualifications:

  • Doctoral degree in epidemiology, global health, economics/econometrics, or another relevant quantitative discipline
  • Strong quantitative skills with data cleaning and analysis as well as manuscript drafting and publication
  • High EQ and a strong focus on team-oriented research

Omer Research Group

Omer Research Group is involved with a diverse complement of vaccine research, ranging from field and clinical trials to epidemiological studies and studies on vaccine acceptance and policy. The group also maintains collaborative research relationships with vaccine immunology groups. The group is headed by Saad B. Omer, MBBS, MPH, PhD.

Research Group Environment and Philosophy

Omer Research Group works both domestically and internationally; the postdoctoral positions will focus on a variety of interdisciplinary projects having to do with vaccine research. This group also has an orientation towards strong mentoring and focuses on developing skills as well as the ability to lead an independent research program. We invest in mentee growth and have a culture of mutual support. The group fosters a rigorous scientific research environment but is cognizant of the importance of work-life balance - and works with members to strike a healthy balance between research and personal life.

Interested applicants should send their CV to omer.admin@yale.edu

Postdoctoral position in translational research (Herzog Lab)
Posting Date: May 4, 2021

Yale School of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM), is looking to hire a highly motivated Postdoctoral Associate to drive innovative translational research forward in the Yale ILD Center of Excellence. The post-doctoral associate will work under the supervision of Dr. Erica Herzog and Dr. Danielle Antin-Ozerkis on human oriented research projects aimed at developing molecular biomarkers and treatments for patients with pulmonary fibrosis and related disorders.  The post-doctoral associate should be able to work independently as well as in a team of translational lung biologists in the lab which include pulmonologists, postdocs, clinical fellows and students. The major experimental tools that will be used include FACS, single cell RNA sequencing, ELISA, PCR on samples from patients with several forms of pulmonary fibrosis and interstitial lung disease.  

Job Qualification:

1. A recent graduate or about to graduate with an MD, or a PhD in the field of biology and immunology or similarly related fields.

2. Experience with translational work and biomarker studies is preferred but not necessary. Knowledge of major cellular and biochemical techniques such as FACS, single cell sequencing, ELISA and PCR is a plus.  

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The individual will be expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected.  It is an excellent opportunity to learn about biomarker work in the context of clinical medicine and interventional trials.

Review of applications will begin immediately and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to erica.herzog@yale.edu

Postdoctoral position in biliary cell biology (Gupta Lab)
Posting Date: May 4, 2021

The Gupta Lab, located in the Yale Liver Center is seeking a motivated and dedicated Postdoctoral Associate to join its research program. The lab is focused upon harnessing murine genetics, using human tissue samples, and utilizing single-cell and bulk RNA sequencing technologies to understand cellular crosstalk between biliary epithelial cells and surrounding mesenchymal cells during homeostasis and disease. The major goal of the lab is to dissect how these cell types are perturbed in the disease state to gain greater understanding of human biliary disease.

Postdoctoral training in the lab includes molecular biology, flow cytometry, mouse genetics and surgery, biliary cell isolation, next generation sequencing, confocal/multiphoton imaging, and more. Additionally, candidate will be mentored in research presentation, manuscript preparation, and is further tailored depending on the candidate’s career goals.

Applicants should have an MD, PhD, or MD/PhD with a background in cell and molecular biology, genetics, genomics and/or other related biological fields.

If you are interested in this position, please send (1) your CV, (2) a cover letter with research interests and career goals, and (3) a list of three references for contact to vikas.gupta@yale.edu. Applications will be reviewed on a rolling basis until the position is filled.

Postdoctoral position in tissue engineering models of kidney disease
Posting Date: April 30, 2021

Yale School of Medicine is seeking a highly motivated Postdoctoral Associate to join a collaborative effort between the laboratories of Laura Niklason MD, PhD (Adjunct Professor in the Departments of Anesthesia and Biomedical Engineering) and William Chang MD, PhD (Assistant Professor in the Department of Medicine and Section of Nephrology). The research project will focus on tissue engineering models of kidney disease. More specifically, the Associate will develop microfluidic devices to model and analyze tubular dysfunction in polycystic kidney disease. The Associate will be supervised by Drs. Niklason and Chang. We are seeking an enthusiastic and motivated scientist who will receive intensive mentorship and training in laboratory research techniques, critical thinking, and problem solving. The Associate will participate in manuscript publications, laboratory group meetings, and will gain critical experience presenting their research.  

Applicants for the position should have an MD, PhD, or equivalent with significant experience in biomaterials, biomedical engineering, or a related field. Experience in bioinformatics would be beneficial.

Application materials consisting of a cover letter and Curriculum Vitae should be submitted electronically to Dr. Chang (w.chang@yale.edu). The cover letter should include research interests, career goals, and contact information for three potential references. Review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Fellowship in International Development at Yale, 2021-22
Posting Date: April 22, 2021

The Jackson Institute for Global Affairs and the  Economic Growth Center  (EGC) at Yale are seeking applications for a Postdoctoral Associate in international development for the 2021-22 academic year.

The Postdoctoral Fellow will conduct independent research and collaborate with Jackson Institute and EGC faculty, contributing to the intellectual life within and between the centers.  In the spring semester, the Fellow will be expected to teach Approaches to International Development, a core course for undergraduate students in Yale’s Global Affairs major.  The successful candidate will also be involved in multiple EGC data-oriented initiatives. This includes advising on the development of training materials for economics graduate students on Stata and potentially other programming packages.  In addition, the fellow will have the opportunity to collaborate with a set of EGC faculty on an initiative pushing forward data access and archiving as a public good for development research.

The ideal candidate will have a demonstrated ability in conducting high quality, policy-relevant research on topics in international development and economics. This is a full-time position.  Fellows will be expected to be in full-time residence at Yale for the duration of their appointment.

Applicants should submit a cover letter, CV, one page description of research plans, a writing sample, teaching statement with evidence of teaching excellence, and three letters of recommendation. All information from the applicant should be submitted electronically through Interfolio at  http://apply.interfolio.com/86754  .

Compensation is competitive and includes health insurance and other benefits afforded to postdoctoral associates at Yale. For more information see https://your.yale.edu/enroll#pda .

Review of applications will begin immediately and will continue until the position is filled. For questions concerning this search, please Larisa Satara at larisa.satara@yale.edu.

Postdoctoral position in Human Systems Immunology (Konnikova Lab)
Posting Date: April 21, 2021

Research in the Konnikova group is directed at studying the development and maintenance of mucosal immunity at barrier sites such as the intestine and placenta. We are interested in understanding how homeostasis is established and maintained in humans and what goes awry to cause disease such as necrotizing enterocolitis and inflammatory bowel disease in relationship to intestinal health and preterm labor in case of placental biology. We are seeking a motivated and dynamic postdoctoral candidate to join our team who is interested in applying cutting edge techniques including mass cytometry and single cell RNA sequencing in combination with cell biology and organoid approaches to studying development of human mucosal immunity at barrier sites. My group has access to the CyTOF and genomics cores at Yale as well as state-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training in translational research, in vivo model systems and a range of immunological techniques.

The candidate will be expected to have an MD, PhD, or MD/PhD with experience in immunology. Preference to candidates with involvement in human immunology will be given, but it is not a requirement. The successful candidate will be self-motivated and have the capacity for independent evaluation of the literature. Prior knowledge in primary cell isolation, flow cytometry, imaging techniques and single cell techniques would be an added benefit. For more information on our group, please visit our website – www.konnikovalab.com.

Interested applicants should send a brief statement of interest and curriculum vitae with contact information for three references to the Principal Investigator, Dr. Liza Konnikova – liza.konnikova@yale.edu.

Postdoctoral position in Regulatory RNAs in Cancer (Dimitrova Lab)
Posting Date: April 20, 2021

A postdoctoral position is available in the laboratory of Dr. Nadya Dimitrova, Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. Research in the Dimitrova laboratory focuses on investigating the roles of a novel class of genes, called long noncoding RNAs (lncRNAs) in cancer biology. To date, lncRNAs have remained largely uncharacterized but emerging evidence suggests an involvement in a broad range of biological processes and in human disease, including cancer. We select candidates based on their regulation by key oncogenes and tumor suppressors or based on their involvement in cancer processes, such as the DNA damage response, oncogenic transformation, and metastasis.

Our goal is to understand how candidate lncRNAs contribute to oncogenic and tumor suppressive networks at the molecular, cellular, and organismal level and how deregulation of lncRNAs leads to cellular transformation and tumor development. At the molecular level, we aim to elucidate the diverse mechanisms by which cis- and trans-regulatory lncRNAs fine-tune oncogenic and tumor suppressive networks by modulating transcriptional and translational pathways.

At the cellular level, we aim to understand how lncRNAs participate in the decision-making processes in complex transcriptional networks and what are the consequences of lncRNA activity for cellular homeostasis and stress response. Finally, to bring insights into the vastly understudied contribution of lncRNAs to tumorigenesis in vivo, we are testing how inappropriate expression of regulatory lncRNAs influences tumor development in mouse models of lung and breast adenocarcinomas.

A successful candidate will hold a Ph.D. degree, will be highly motivated to perform cutting edge research and to interact with a dynamic, young group of investigators. Candidates from diverse scientific backgrounds are strongly encouraged to apply.

Additional information can be found at dimitrovalab.yale.edu

Candidates should send a CV, names of three references, and a cover letter with a brief statement of future research interests and career goals to: nadya.dimitrova@yale.edu

Postdoctoral position at the Zigler Center in Child Development & Social Policy
Posting Date: April 15, 2021
The Zigler Center in Child Development & Social Policy under the Yale Child Study Center brings together a diverse group of researchers and practitioners in an effort to improve the well-being of children and families by bringing objective child development research into the policy and public arenas.
 
We seek a postdoctoral associate (postdoc) who will be responsible for analyzing data across Zigler Center projects that include (1) a national survey of child care workers around COVID-related issues (one of the largest occupational epidemiology studies ever conducted), and (2) a statewide evaluation of early childhood mental health consultation. The postdoc will also lead and/or assist in data management and data collection of an RCT of early childhood mental health consultation implementing the Infant-Toddler CHILD. The postdoc will also support other tasks related to the team’s research, such as manuscript preparation, grant writing, and the design of future studies.
 
Skills and Qualifications
The successful candidate will have: (1) completed a doctoral degree in psychology, child development, psychometrics, data science, or a related field (ABD acceptable); (2) strong methodological, analytic, and writing skills; (3) specialization or demonstrated interest in the areas of preschool expulsion, equity, social justice, and anti-racism at interpersonal and systemic levels, early childhood mental health consultation, social and emotional learning; (4) the ability to balance attention to detail with a big-picture understanding of research endeavors; (5) an aptitude for and interest in data management and measurement; (6) strong interest in programs and policies aimed at improving the well-being of children and families; and (7) the ability to work both independently and collaboratively. Preference will be given to candidates with expertise in large-scale data management and complex statistical analyses, and mixed methods design. Experience/expertise in legislative and regulatory policy analyses is a plus! Bilingual applicants are highly encouraged to apply.
The postdoctoral position is a one-year appointment with renewal contingent upon satisfactory performance and availability of funding.
The anticipated start date is July 2021. The position may start remotely in accordance with Yale University guidance around COVID-19.
 
 
To Apply
Interested applicants should submit via e-mail a cover letter and CV, a first-authored writing sample, and a minimum of three (3) letters of reference (may be submitted separately, or combined with application package) to: itchild@yale.edu. Incomplete applications will not be reviewed. Please make “Zigler Center Postdoc Position” the subject line of your e-mail. Review of applications will begin immediately and continue until position is filled.
Postdoctoral position in the Department of Pathology (Kluger Lab)
Posting Date: April 13, 2021

Two postdoctoral positions in computational single-cell RNA sequencing and spatial transcriptomics & proteomics are available in the laboratory of Dr. Yuval Kluger at Yale University School of Medicine. The Kluger Lab is affiliated with the Applied Mathematics program in the Department of Mathematics, Computational Biology & Bioinformatics program, as well as the Yale Center for Biomedical Data Science and the Yale Cancer Center.

The group is focused on methodological development of novel computational methods including deep learning, graph theory, and spectral approaches to analyze high-throughput and high-dimensional biomedical data. Most of our current applications concentrate on analysis of data generated in single cell RNA sequencing and spatial transcriptomics/proteomics studies which provide unprecedented opportunities to conduct detailed analyses of cell subpopulations. Fulfilling the promise of these studies and biomarker discovery requires robust computational approaches to support detection of rare phenotypes and unanticipated cellular responses. Current approaches for denoising, calibration, clustering and visualizing of such data types suffer from challenges such as erroneous imputation of non-expressed genes, removal of multivariate batch effects, detection of local differences between cell distributions, and inefficiencies of clustering and dimensional reduction methods of very large datasets. We have developed novel and efficient spectral and neural network prototypes suitable for addressing these issues in high throughput data contexts and further develop and adapt these methods to data generated by our collaborators.

The group is actively engaged in multi-disciplinary national collaborations with large project teams including the SCORCH consortium and the HuBMAP, as well as multiple groups from the Departments of Pathology, Immunobiology, Neurology, Genetics, Internal Medicine and the Cancer Center. The successful candidate will utilize single cell transcriptomics, spatial transcriptomics as well as other genomic, epigenomic and proteomic data from our experimental collaborators and from the public domain and develop novel techniques to characterize a variety of biological systems. The focus will be on immunology, melanoma, and lung cancers studies and single cell characterization of several brain regions relevant to persistent HIV infection and opioid use disorder. The scope of the work could extend to other systems. The successful candidates must be able to work well with groups from different disciplines and to present scientific results in a clear and effective manner.

Research projects may involve, but not limited to:

  • Analysis of high throughput transcriptomics, proteomics, genomics data, such as single cell RNA sequencing data, spatial transcriptomics data in a collaborative setting.
  • Data management and pipeline development for consortiums.
  • Develop and implement new bioinformatics and computational biology algorithms

Qualifications:

  • Ph.D. in Computational Biology, Bioinformatics, Genetics, Computer Science, Applied Mathematics, Statistics, Physics, Engineering or other related fields.
  • Proficiency with the analysis of next generation sequencing data.
  • Ability to develop, implement and benchmark computational methods.
  • Solid programming skills.
  • Experience with Python and R programming languages is preferred.
  • Interest in collaborating with biologists and physician scientists.
  • Familiarity with UNIX and cluster computing is preferred.

Apply:

Qualified candidates who are interested in applying should e-mail an application package, including: statement of interest, CV, and contact information for references. Please send your application package to Dr. Yuval Kluger (yuval.kluger@yale.edu). In the subject line, write “your full name, postdoc application”.

Postdoctoral position in the Department of Therapeutic Radiology (Hayman Lab)
Posting Date: April 12, 2021

The Hayman Lab, led by Thomas Hayman, MD, PhD, in the Department of Therapeutic Radiology at Yale University is recruiting a highly motivated and creative postdoctoral fellow.  We are a cancer biology lab that is focused on utilizing genetic approaches to understand and exploit resistance mechanisms to DNA damage. 

Our research program has a particular interest in studying the interplay between the cell intrinsic immune machinery and DNA repair processes using in vitro cell models, genetic screens (such as CRISPR and RNA interference), and animal models.  We have a strong translational focus that is founded in a preclinical mechanistic understanding of basic biological processes with the ultimate goal of shaping these discoveries into therapeutic strategies for cancer patients.

We are seeking a candidate who will contribute to the discovery and translation of biological processes that modulate tumor responses to DNA damaging therapies (e.g. radiation) and immunotherapy.  Interested applicants should hold a PhD. or M.D. with considerable laboratory experience and a strong background in cancer biology, molecular biology, genetics, radiation biology or other related fields.  Prior experience with in vivo animal tumor models, CRISPR/Cas9, IF/IHC and DNA damage assays is highly desired, but not a requirement.  The candidate should be self-motivated and have a proven track record of productivity.  Excellent written and oral communication skills are expected. 

How to Apply:

Candidates should send a Curriculum Vitae, a cover letter detailing research interests and career goals, and contact information for three references to Dr. Thomas Hayman (thomas.hayman@yale.edu).

Postdoctoral position in the Dept of Cardiovascular Medicine
Posting Date: April 9, 2021

This is a Postdoctoral Research Position opening in the Dept of Cardiovascular Medicine at Yale University School of Medicine. All job duties will be performed in 10 Amistad St, New Haven, CT in a basic research laboratory which focuses on studying the role of complement using humanized disease models. The successful application will work closely with the principal investigator and with another research technician to develop projects which will form the basis for extramural funding applications.

Principal Responsibilities:
1) Perform cell culture using aseptic technique
2) Perform molecular cloning studies
3) Carry out mouse breeding and handling.
4) Communicate results and work-related issues to colleagues and supervisors

Required Education and Experience:
This position requires a PhD degree or equivalent. Prior research experience in cellular immunology and/or molecular cloning are preferred.

Candidates should email a cover letter, CV, and contact information for three references to dan.jane-wit@yale.edu

Postdoctoral position with the Adolescent Initiatives Team at the Yale Center for Emotional Intelligence
Posting Date: April 9, 2021

The Yale Center for Emotional Intelligence, part of the Child Study Center at the Yale University School of Medicine, conducts research and teaches people of all ages how to develop their emotional intelligence. Our work focuses on (1) the development and impact of social and emotional skills among diverse populations, including education settings and organizations, and (2) the mechanisms by which social and emotional skills and training impact significant life outcomes.

We are looking for a Postdoctoral Associate to join the Adolescent Initiatives Team (PIs: Drs. Jessica Hoffmann and Rachel Baumsteiger). This team works on a range of projects, including (1) the development of a web-based app designed to measure students’ perceptions of school climate; (2) the development of a tool designed to assess students’ momentary emotions and emotion regulation at school; and, (3) the development and testing of the RULER and inspirED: two complementary social emotional learning initiatives for middle and high schools.

The postdoctoral associate’s primary responsibility will be to analyze data across projects. They will also be expected to support in other tasks related to the team’s research, such as the preparation of research articles, grant writing, and the design of future studies. Jessica Hoffmann and Rachel Baumsteiger will oversee day-to-day work assignments and be the primary supervisors. The Director of Research, Dr. Christina Cipriano, will provide additional supervision and professional support.

Skills and Qualifications

• Qualified candidates will have recently completed a PhD in psychology, education, or a related field

• Specialization or demonstrated interest in the study of adolescent development, emotions, and psychological assessment

• Excellent statistics skills, including experience conducting multi-level modeling

• Ability to communicate effectively (e.g., writing research papers, giving presentations)

• Strong project management skills

• Ability to work both independently and collaboratively; an interest in mentorship is preferred

The anticipated start date is July 2021. The position may start remotely in accordance with Yale University guidance around COVID-19.

To Apply

Please send a cover letter and CV to jessica.hoffmann@yale.edu and rachel.baumsteiger@yale.edu. Within your cover letter, please describe your level of familiarity with multi-level modeling.

Reviews of applications will begin immediately and continue until position is filled. Please have three letters of reference available upon request.

ABOUT THE YALE CENTER FOR EMOTIONAL INTELLIGENCE

Emotions drive learning, decision making, creativity, relationships, and health. The Yale Center for Emotional Intelligence uses the power of emotions to create a more effective and compassionate society. Helping children and adults develop emotional intelligence is central to the mission of the Center. To date, schools have been at the center of these efforts. RULER, the Center’s signature program, draws on leading pedagogical practices as well as advances in psychology and neuroscience, and it has been honed through years of classroom observation, interviews, and the most demanding evaluations. Creating awareness—both of self and others—about emotions and developing the skills of emotional intelligence can improve children’s prospects in life and contribute, in turn, to healthier, more compassionate families, workplaces, and communities. RULER does this by teaching adults and children the skills of emotional intelligence. Since 2005, more than 600 schools have implemented RULER, affecting the lives of over 500,000 students. Accordingly, we integrate emotional intelligence skill building, the basis of RULER, into their everyday practices and into classroom curricula across grade levels

Postdoctoral position in Membrane Signaling in Mammalian Fertilization (Chung Lab)
Posting Date: April 7, 2021

A postdoctoral position is available in the laboratory of Jean-Ju Chung in Department of Cellular & Molecular Physiology at Yale School of Medicine in New Haven, Connecticut. The Chung lab studies cellular signaling in sperm capacitation and fertilization under normal and pathophysiological conditions using insights from human genetics and mouse models (www.jeanjuchunglab.org). One of current focus is membrane signaling via ion channels and membrane receptors in gametes and gamete interaction. Highly motivated and independent candidate with an inquisitive nature and a quantitative mind are encouraged to apply.

Candidates must have

  • A recent PhD or MD/PhD degree (or candidate) in Biochemistry, Molecular, Cell and Developmental Biology or Reproductive Biology
  • Strong publication record (first author papers in peer-reviewed journals).
  • Strong background in protein biochemistry, advanced imaging techniques and/or experience with mice gametes and embryos.

The ideal applicant will be pursuing an independent scientist and have excellent organization skills, written and verbal communication skills, and willingness to write grant proposals and manuscripts.

To apply, please send a single PDF file to Jean-Ju Chung at jean-ju.chung@yale.edu including

(1) a cover letter with a statement of research interests and career goals, (2) curriculum vitae, and (3) a list of three references with contact details.

Postdoctoral position in Regenerative/Cancer biology ( Dean Yimlamai Lab)
Posting Date: April 5, 2021

Research in the Yimlamai Lab is directed at understanding the drivers of human liver disease, particularly in Pediatric diseases such as biliary atresia and non-alcoholic steatohepatitis. Our focus is in the cell biology of epithelial cells with their microenvironment and we are seeking a motivated, dynamic postdoctoral candidate who is interested in applying cell biology, organoid and animal model approaches to understanding fundamental mechanisms in liver biology. As a member of the Yale Liver center, lab members have access to the Morphology cores with State-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training on in vivo models as well as a range of cell and molecular biology techniques.

The candidate will be expected to have an MD, PhD, or MD/PhD with experience in cellular and molecular biology. Preference to candidates with involvement in liver pathophysiology will be given, but it is not a requirement. The successful candidate will have the capacity for independent evaluation of the literature. Prior knowledge in cell culture techniques, primary cell isolation/culture, flow cytometry and imaging techniques would be an added benefit. For more information on our group, please see our website – www.liverstemcells.org.

Interested applicants should send a brief statement of interest and curriculum vitae with contact information for three references to the Principal Investigator, Dr. Dean Yimlamai - dean.yimlamai@yale.edu.

Postdoc position in Biochemistry and Structural Biology (Bleichert lab)
Posting Date: March 30, 2021

The Bleichert lab in the Department of Molecular Biophysics and Biochemistry at Yale University is looking for a highly motivated, goal-driven, and team-oriented postdoctoral associate to join our young and collaborative team. Research in the lab is focused on understanding fundamental mechanisms of chromosome replication and genome stability using interdisciplinary approaches ranging from reconstitution biochemistry, biophysics, structural biology (both cryo-EM and X-ray crystallography), to proteomics. Yale provides an excellent infrastructure for high-resolution cryo-EM with access to a Titan Krios (with K3 detector) and several Glacios TEMs (with K2 detector).  

We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development. We will provide numerous opportunities for training you in complementary techniques, and you will also have the opportunity to enhance your own mentoring and teaching skills by interacting with PhD students and by supervising undergraduate students. Our goal is to provide you with the mentoring and resources to launch your own independent career.

Interested candidates should have recently finished or will soon complete their PhD degree and have a strong research track record. Scientific curiosity and excitement to ask challenging questions is a must. While prior experience in biochemistry, biophysics, structural biology, or proteomics are advantageous, we welcome researchers from all backgrounds.

Qualified candidates should send their CV, a cover letter describing past and future research interests, and the contact information for two to three references to franziska.bleichert@yale.edu.

Postdoctoral position in the Curatorial Division at the Yale Center for British Art
Posting Date: March 29, 2021

The Yale Center for British Art (YCBA) is offering a Postdoctoral Associate position of up to three-years duration in the Curatorial Division. The position is for recent recipients of the PhD (degree granted within the last three years) in the field of British art. The PhD must be completed by the time the position begins and it is expected that the research associate will pursue long-term professional employment during the period of hire.

The Postdoctoral Research Associate will report to the Deputy Director and Chief Curator and contribute to the activities of the Curatorial Division. Specific projects will include the development of an exhibition on the artist Hew Locke alongside a complimentary collections display selected in collaboration with the artist. The Postdoctoral Research Associate will help to curate a display of works by Marc Quinn, undertake research on works in the collection, and collaborate with the Deputy Director and Chief Curator on the reinstallation of the Center’s permanent collection. Additional duties will include writing labels and developing scholarly programs and teaching materials in support of major projects. The postholder will occasionally mentor student interns and participate in programs organized by the Curatorial Division. One day per week will be allotted to pursue personal research in the postholder’s own area of specialization. Limited funds will be available to enable the Postdoctoral Research Associate to present annually at a professional conference.

The closing date for applications is June 7, 2021. Interviews are expected to take place in July.

Application materials should be sent by email and need to include: cover letter, CV, recent writing sample. Two letters of reference should be emailed directly from the referees. Please send all application materials to ycba.paintings@yale.edu, with the subject line Postdoctoral Research Associate Application. For enquiries about the position, please contact martina.droth@yale.edu .

Postdoctoral position at the Liver Center in the Section of Digestive Diseases (Vilarinho Lab)
Posting Date: March 29, 2021

The Vilarinho lab is seeking highly motivated and dedicated individuals who are passionate about advancing the cellular and molecular understanding of liver function in health and disease. The Liver Center provides a stimulating training environment, as well as many collaborative opportunities. Our laboratory is interested in using human genetics and genomics paired with highly informative cohorts of patients to discover new liver disease genes. Using cell based and mouse models as well as biochemistry tools we study how a mutant gene causes the liver phenotype. Thus, by uncovering new liver disease genes, we provide a diagnosis leading to new therapeutic options, and we gain new insight into liver biology.

The postdoctoral training may involve biochemistry, molecular biology, flow cytometry and cell culture methodology, primary cell isolation from mouse models, regular presentation at weekly lab meetings, and figure and manuscript preparation. It may also include mentoring and supervision of undergraduate and postgraduate students.

Successful candidates should have backgrounds in cell and molecular biology, biochemistry, genetics and genomics or other related fields. Individuals with a track record of publications, training in liver biology, iPSC biology and/or bioinformatics and recent PhD graduates are strongly encouraged to apply

If you are interested in this position, please send your CV and a statement of why you are interested in the lab to silvia.vilarinho@yale.edu.

Postdoctoral position in the Department of Anesthesiology (Benveniste lab)
Posting Date: March 29, 2021

We have an opening for a talented and highlight motivated Postdoc for a 1-year (with potential extension for 2-years) position. The Benveniste lab in the Department of Anesthesiology at Yale University focuses on translational research of neurodegenerative disorders such as cerebral small vessel disease and Alzheimer’s disease Specifically we study the roles of cerebrospinal fluid flow dynamics and glymphatic-lymphatic coupling and explore novel disease modifying therapies. The lab uses a combination of magnetic resonance imaging (MRI), physiological interventions in transgenic and surgical rodent models together with molecular/histological tools.

The successful candidate will have hands-on experience in a variety of in vivo and histological processing techniques in particular multiplex immunohistochemical staining of brain and lymph node tissue to support our various projects. The candidate must be proficient in immunohistochemistry/ immunofluorescence staining, perform statistical calculations and data analysis. As a member of the research staff, you will assist Dr. Koundal. Dr. Benveniste and research staff in the lab with the following:

Principal Responsibilities:

  • Assist lab staff with research experiments including non-survival and survival surgery (e.g., lymph vessel ligations, CSF catheter implantation, arterial cannulations), brain dissection and slice preparation
  • Using and understanding a wide variety of histological technique
  • Working with and handling research animals
  • Perform multiplex immunohistochemical staining of rodent brain and lymph node tissue in support of various research projects. Also, must have prior experience in fluorescence microscopy
  • Participate in laboratory meetings and read literature applicable to the research area
  • Help with lab organization and other support duties relating to lab operations, as required
  • Other duties as assigned.

Preferred Qualifications:

  • Bachelor’s degree in Biology or a related field
  • Prior experience working in a research laboratory
  • Excellent analytical, communication, problem solving, and organizational skills

Ability to work both independently and as a team memberAble to learn and perform new techniquesExperience in multiplex immunohistochemistry/ immunofluorescence staining of rodent brain and lymph node tissue.

To Apply:

Please submit a CV and cover letter stating your interest in the position to sunil.koundal@yale.edu or helene.benveniste@yale.edu 

Postdoctoral position in Head and Neck Cancer Research
Posting Date: March 24, 2021

A Postdoctoral Associate position is available in the laboratory of Dr. Barbara Burtness at the Yale Cancer Center, Medical Oncology, Yale University School of Medicine, New Haven, USA. Dr. Burtness’ laboratory focuses on translational cancer research to identify novel therapeutic strategies for the treatment of head and neck cancer, across an extensive research program on targeting cell cycle-related kinases, drug resistance mechanisms and immuno-oncology. This postdoctoral associate will mainly work in wet-bench-based cancer cell biology, molecular biology and in vivo study of tumor models, to understand mechanisms of drug resistance and develop of new therapeutics to treat drug-resistant head and neck cancer, funded by NIH/NCI and NIDCR, DOD, and foundations. Our lab provides a collaborative environment within the university and with external partners. This position will provide multi-disciplinary training for scientific and career development, including opportunities for national/international conference presentations and publication of first-authored original articles.

The postdoctoral training may involve (a) the development and application of genetic screening tools, such as CRISPR/Cas9 libraries, (b) bioinformatic analysis of in house/publicly available genomic datasets, (c) a translational approach using human tissue samples and animal models, (d) wet-bench methods in biochemistry, molecular cell biology and immunology, (e) collaboration with other researchers both inside and outside of Yale, (f) presentation in international conferences, and (g) manuscript preparation and grant applications.

The postdoctoral associate will be mentored directly by Dr. Burtness, with possible co-mentorship from qualified Yale Cancer Center faculty members, or others in the Fox Chase Cancer Center. Applications will be accepted until the position is filled.

Candidates are expected to have (a) a recent PhD degree (<4 years or current PhD students graduating by May 2021) in cell biology, cancer biology, molecular biology, immunology, or a related discipline, (b) hand-on research expertise with animal handling skills (cell culture, transfection/transduction, qRT-PCR, cloning and western blotting, immuno-staining, confocal microscopy, flow cytometry, murine tumor modeling, injections and breeding), (c) first-authored original publication(s) in peer-reviewed journals, (c) independence to lead a project as well as willingness to work as a team player, and (d) good scientific oral presentation and writing skills. Previous experience in organoid culture or tumor immunology is preferred but not required. Previous experience or strong interest in programming languages such as R or Python is highly preferred.  

Please send a CV, statement of interest and 2 potential references to barbara.burtness@yale.edu

Postdoctoral position in Reproductive Immunology (Laboratory of Dr. Vikki Abrahams) in the Department of Obstetrics, Gynecology & Reproductive Sciences
Posting Date: March 23, 2021

The laboratory of  Dr. Vikki Abrahams, PhD in the Department Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine is looking to recruit a motivated Postdoctoral scientist.

The Abrahams Lab focuses on understanding the role of innate immune Toll-like receptor, Nod-like receptor and inflammasome family members in placental, fetal membrane, and maternal-fetal immune responses to infectious and non-infectious stimuli, and their role in regulating pregnancy outcome, including those complicated by infections and by autoimmune diseases. The lab uses basic and translational approaches; primarily in human models systems and samples, but also using animal models. The current position will involve studying the mechanisms by which antiphospholipid autoantibodies trigger placental trophoblast inflammation and communication with the maternal vasculature. The position is for 2 years initially and is anticipated to start summer-fall 2021. 

Applicants should have a PhD in a relevant field such as Immunology; Reproductive Sciences; or Cellular and/or Molecular Biology. Prior Reproductive Immunology and/or Reproductive Biology experience is preferred but not essential. Applicants should have skills that include, but are not limited to cell culture, Western blot analysis, ELISA, and qRT-PCR.

Candidates should be enthusiastic, highly organized, self-motivated, hard-working and reliable, with excellent interpersonal and written and oral communication skills. Applicants must have good attention to detail and problem-solving skills, be able to multi-task, and be able to perform both independently as well as in a team environment. Successful applicants will have a strong track record of research productivity, presentations, and publications.

Applicants should email: 1) a Curriculum Vitae; 2) contact information for three references; and 3) a description of their research background and interests and career goals to Dr. Vikki Abrahams (vikki.abrahams@yale.edu)

Postdoctoral position analyzing immune responses in autoimmunity in the Department of Immunobiology
Posting Date: March 17, 2021

The laboratory of Dr. Kevan Herold in the Immunobiology Dept at Yale University is looking to recruit a motivated Postdoctoral scientist to join our team.  

The Herold lab advances immunology through its focus on understanding the mechanisms of autoimmune disease, primarily Type 1 diabetes. Our studies are translational but involve both the use of human samples and animal models, including humanized mice, where needed to address mechanistic questions. The position is focused on understanding the changes in autoreactive T cells following immune therapies, specifically to identify changes in their numbers, phenotypes and activation, and the pathways that are modulated by the therapy. The samples are acquired from patients receiving anti-T and B cell therapies. The qualified candidate will receive the following while in this position:

Training – The individual will receive training in methods used to analyze research samples by flow cytometry, molecular studies, and with cell culture techniques. If the postdoc has not previously had training in bioinformatics, he/she will be encouraged to learn these methods through course work or other educational opportunities at the University.

Mentoring – The PI (Dr. Herold) will mentor the trainee. In addition, there are members of the laboratory who will provide training in methods.

Education - A PhD in relevant fields such as Immunobiology is required and skills that include, but are not limited to cell culture, flow cytometry, and basic molecular methods. Experience with more advanced molecular methods such as RNA-seq and single cell RNA-seq are preferred.

Interested candidates should email their CV and cover letter, with the words “Postdoc Opportunity in the Herold Lab” in the subject line, to dana.kalina@yale.edu to be considered. 

Postdoctoral position in Pediatric Psychology (Yale Child Study Center)
Posting Date: March 17, 2021
The Yale Child Study Center, in collaboration with Yale New Haven Children’s Hospital, is offering a full-time Pediatric Psychology Postdoctoral Fellowship position for the 2021-2022 training year. Clinical training activities will take place within the pediatric floors, our inpatient psychiatric unit, the pediatric emergency room, several ambulatory specialty clinics, and the Child Study Center’s outpatient clinical services.
The mission of the Yale Child Study Center is to improve the mental health of children and families, advance the understanding of their psychological and developmental needs, and treat and prevent childhood mental illness through the integration of research, clinical practice, and professional training.
The Yale Child Study Center Psychology Training Program takes a scientist practitioner approach to clinical training and seeks to prepare professionals to successfully address the complexities associated with children and families who are psychologically vulnerable. Those trained at the Center work within traditional and nontraditional settings and are trained to embrace diverse roles and responsibilities. An over-riding goal is to demonstrate to fellows, through a combination of applied and didactic experiences, that provision of mental health services to children requires intervention at multiple and interacting levels of influence. Our aim is to prepare future leaders in the areas of clinical service, research, training, policy development and prevention services.
 
Fellowship Rotations:
-Inpatient Pediatric Consultation-Liaison Service: The postdoctoral fellow will work for one full year with the Yale Child Study Center’s multidisciplinary Pediatric CL Service. The C/L Service provides a range of behavioral health services to medically ill children and adolescents for all pediatric inpatient services at Yale New Haven Children’s Hospital.
-Specialty Clinics: The postdoctoral pediatric fellow will provide neuropsychological evaluations as part of the Child Study Center Pediatric Neuropsychology program for 12 months. Additionally, the fellow will provide a range of psychological services in several outpatient pediatric specialty clinics for two-days per week for 6-month rotations (e.g. neurology clinic, gender clinic). There will also be opportunities to co-lead the Comfort Ability Program (https://www.thecomfortability.com/) for pain management.
-Pediatric Emergency Department: The Child Study Center provides crisis evaluation and consultation to the Pediatric Emergency Department at Yale-New Haven Hospital. The postdoctoral fellow will work 1 day/month within the pediatric emergency department conducting these assessments, which are completed in collaboration with hospital social work staff and pediatricians within the ED.
-Children’s Psychiatric Inpatient Service: The postdoctoral fellow will have a 6-month rotation on the Children’s Psychiatric Inpatient unit in which they will serve as a primary clinician. As primary clinicians, fellows develop skills in evidence based individual psychotherapy, as well as behavior consultation for the unit staff in designing therapeutic interventions. The fellow will be a member of the multidisciplinary team comprised of child psychology, child psychiatry, social work, pediatric nurses, special education teachers, and recreation therapists.
 
Curriculum: The training curriculum consists of both generalist and specialized training in assessment, treatment, consultation, knowledge of childhood disorders, and professional development.
Fellows Seminar: Fellows meet weekly with the training director and other faculty to discuss a broad range of clinical and professional issues relevant to the practice of psychology, such as: advances in assessment and treatment, diversity and anti-racism, models of consultation, theories of supervision, and program evaluation, career planning, job preparation, and EPPP study approaches.
Clinical Supervision: In keeping with the multidisciplinary orientation of training at the Child Study Center, fellows may receive supervision from professionals from varied disciplines. Currently, each fellow receives approximately 3 hours of individual supervision each week. An individual supervisor is provided for each pediatric/hospital area of practice.
Pediatric Consultation Liaison Seminar: The fellow participates in a multidisciplinary seminar which covers a range of topics related to assessment approaches and evidence-based practices in pediatric settings.
Departmental Conference: Theoretical, research and clinical work by faculty, trainees, and outside speakers are presented in a Grand Rounds format. All Child Study Center faculty and trainees attend this weekly conference.
 
Eligibility:
 Successful completion of the doctoral requirements and internship requirements of APA approved doctoral programs and internships is strongly preferred. Completion of the dissertation defense before beginning fellowship is required. Preference is given to individuals that have previous clinical experience in pediatric psychology, especially in a hospital setting.
 
Postdoctoral Fellows are paid $50,629 for a full year. Postdoctoral fellows pay a fee of $50 per month for individual health coverage through Yale Health. Four weeks of vacation/personal time, all Yale holidays, and a holiday recess between Christmas and New Year’s Day are granted to all trainees. Finally, all psychology trainees are appointed Fellows of the Yale University School of Medicine. With this appointment, they receive all the privileges and rights of membership in the Yale University community including access to libraries and other facilities.
 
Salary and Benefits:
Postdoctoral Fellows are paid $50,629 for a full year. Postdoctoral fellows pay a fee of $50 per month for individual health coverage through Yale Health. Four weeks of vacation/personal time, all Yale holidays, and a holiday recess between Christmas and New Year’s Day are granted to all trainees. Finally, all psychology trainees are appointed Fellows of the Yale University School of Medicine. With this appointment, they receive all the privileges and rights of membership in the Yale University community including access to libraries and other facilities.
 
Application Procedures:
1. Submit a letter of interest describing previous clinical training, highlighting experience providing therapy and psychological assessment with children, including experience in pediatric settings, and outlining specific training goals. Include a description of eligibility for post-doctoral fellowship (i.e. internship completion date, dissertation status).
2. Curriculum Vitae
3. Three letters of reference
4. Written Work Sample: Comprehensive Psychological Assessment Report
 
Review of applications will begin immediately and continue until the position is filled.
The preferred start date is July 1, 2021, with flexibility to start in August.
 
Submit your application materials to our administrative assistant: Tasha.Brooks@yale.edu
Postdoctoral position in Breast Cancer Research in the Yale Cancer Center
Posting Date: March 15, 2021

Postdoctoral position is available for recent PhD or MD graduates in the laboratory of Dr. Lajos Pusztai, Section of Medical Oncology, Department of Medicine, Yale University School of Medicine.

The successful applicant will work together with bioinformaticians and clinicians on translational research projects in breast cancer. Independence, creative thinking, and motivation are required. Our lab works on identifying novel therapeutic targets for breast cancer through the analysis of the cancer genome and performs functional studies in in vitro an in vivo models.

Desired skills include experience in applying a wide range of molecular and cell biology tools and ability to adopt and learn new methods. Experience in analysis of metabolic pathways and high dimensional gene expression and DNA sequence data is desirable.

Please send CV and list of references to: Lajos Pusztai, MD, DPhil, email: lajos.pusztai@yale.edu

Postdoctoral position to Study the Dynamics of Immunity to SARS-CoV-2
Posting Date: March 15, 2021

A postdoctoral associate position in mathematical/statistical modeling of SARS-CoV-2 immune responses and correlates of protection is available within the Department of Epidemiology of Microbial Diseases at the Yale School of Public Health in collaboration with the Department of Biology and the Emerging Pathogens Institute and at the University of Florida.

Environment

The Department of Epidemiology of Microbial Diseases at the Yale School of Public Health has a tradition of applying advanced laboratory and analytical approaches to integrated community and patient-based investigations for the purpose of delineating the transmission dynamics and evaluating interventions to emerging and neglected infectious diseases, such as Zika, dengue and leptospirosis. It has played a leading role in the public health and research response to the COVID-19 pandemic in the US and internationally.

Job description
We are seeking a postdoctoral associate to analyze longitudinal data from a cohort of individuals infected by SARS-CoV-2. The Yale Schools of Public Health and Medicine and the University of Florida are collaborating to study the dynamics of immune responses to SARS-CoV-2 infection and vaccination. The postdoctoral associate will be based at the Yale School of Public Health and work under the supervision of both Dr. Albert Ko, Department Chair of Epidemiology of Microbial Disease at the Yale University School of Public Health, and Dr. Derek Cummings, Professor in the Department of Biology and the Emerging Pathogens Institute at the University of Florida. There will also be opportunities to work with other members of the project team, including Dr. Wade Schulz, Assistant Professor and Director of Informatics and the Center for Computational Health at Yale. The overall goal of the research is to describe the long-term trajectory of the SARS-CoV-2 pandemic and the effect of vaccines and to refine understanding of the contribution of immune status and function to the risk of multiple outcomes upon SARS-CoV-2 infection. The main research objectives for the postdoctoral position are to develop mathematical and statistical models to analyze longitudinal measurements of immune responses to SARS-CoV-2, measure vaccine effectiveness, identify correlates of protection from infection and disease and understand the contribution of other individual level factors associated with immune responses and risk of COVID-19.

Required skills and qualifications:

  • PhD in one of the following areas: epidemiology, mathematics, statistics, immunology, physics, computer science, population biology or a similarly quantitative discipline.
  • Research experience with mathematical and/or statistical models.
  • Excellent verbal and written communication skills.
  • Strong interest in infectious disease epidemiology.
  • Ability to collate and analyze data, interpret and present results to a high standard using a range of specialized research techniques.
  • Good knowledge of R.
  • Experience in communicating research findings to a non-specialist audience.
  • Ability to work independently but also as part of a larger interdisciplinary research team.

This will be a one-year appointment with the possibility to extend, should both parties agree.

To apply, please submit a CV, statement of interest, and contact information for 3 references.  Please apply online: http://apply.interfolio.com/85223

For questions, please email Ryan Borg (ryan.borg@yale.edu).

Postdoctoral position in the Department of Immunobiology (Herold Lab)
Posting Date: March 10, 2021

We have an opening for a post-doc position in the Herold Laboratory at Yale University in the Department of Immunobiology. The laboratory is focused on understanding the mechanisms of autoimmune disease, primarily Type 1 diabetes. Our studies are translational but involve both the use of human samples and animal models, including humanized mice, where needed to address mechanistic questions.

Position Description

The position is focused on understanding the changes in autoreactive T cells following immune therapies, specifically to identify changes in their numbers, phenotypes and activation, and the pathways that are modulated by the therapy. The samples are acquired from patients receiving anti-T and B cell therapies.

Education

A PhD in relevant fields such as Immunobiology is required and skills that include, but are not limited to cell culture, flow cytometry, and basic molecular methods. Experience with more advanced molecular methods such as RNA-seq and single cell RNA-seq are preferred.

To Apply

If interested, please send CV and contact information to:

Kevan Herold, MD

Professor of Immunology and Internal Medicine

Yale University

300 George St, #353E

New Haven, CT 06853

Postdoctoral position in Pediatric Depression and Suicidality Clinical Trials
Posting Date: March 8, 2021

The Developmental Affective Neuropharmacology (DAN) Lab and Pediatric Treatment Resistant Depression Program at the Yale Child Study Center seek a highly qualified post-doctoral associate to participate in cutting-edge clinical research on adolescent depression and suicidality. This NIMH-funded work assesses novel interventions for treatment-resistant affective disorders in adolescents and incorporates assessment of neuroimaging biomarkers into clinical trial designs.

The DAN Lab at Yale is hiring a post-doctoral associate for training in the context of a clinical trial that tests ketamine as an anti-suicidal agent in teenagers with treatment resistant depression and suicidal thinking, incorporating fMRI imaging to identify biomarkers predictive of treatment response. Responsibilities will include conducting diagnostic and clinical assessments of teenagers with depression and suicidality, providing oral and written clinical feedback to families, and conducting longitudinal assessments of mood and cognition, as well as other research activities within the Yale Pediatric Treatment Resistant Depression Program. Applicants should have experience in the clinical and diagnostic assessment of adolescents with affective disorders; clinical trial experience in adult or pediatric depression is appreciated, but not required.

As part of the broader study, the post-doctoral associate will be part of an interdisciplinary research team conducting a wide range of longitudinal assessments, including diagnostic, observational, and fMRI measures. As part of the appointment, there will be opportunities for supervising post-graduate associates with clinical training, as well as potential for participation in research dissemination through publication or conference presentations. There may also be opportunities to accrue clinical hours for those who are pursing licensure. We are seeking a two-year commitment (all initial appointments are one year, with the potential for renewal).

Eligibility Requirements
(1) Excellent interpersonal and clinical skills; (2) Doctoral degree in clinical, developmental, or school psychology, with emphasis on pediatric mood disorders; (3) Clinical assessment experience with adolescents with psychiatric illness; (4) Preferable research reliability in clinical depression scales such as the Montgomery Asberg Depression Scale (MADRS) and the Children’s Depression Rating Scale-Revised (CDRS-R)
 
Application Information
A complete application includes the following items (please include your full name on every page of your application):
1. Letter of interest
2. Resume or CV
3. Names and contact information for two references
4. Written work sample (de-identified) of a mood disorder assessment
 
Due to the COVID-19 pandemic, please submit applications via email to jennifer.dwyer@yale.eduReview of applications will begin immediately and continue until the position is filled.
 
Submit your application with the subject line: LAST NAME_Position Title (e.g., SMITH_Clinical Post-Doc). For additional questions, interested applicants should contact jennifer.dwyer@yale.edu or call (203) 433-2788.
Direct applications to:
Jennifer Dwyer, M.D., Ph.D.
Assistant Professor of Child Psychiatry and Radiology and Biomedical Imaging
Co-Director, Yale Pediatric Treatment-Resistant Depression Program
Principal Investigator, Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
Postdoctoral position in Computational Healthcare Research: Clinical AI and Data Engineering
Posting Date: March 5, 2021

The successful candidate will be working in a team-oriented environment within the Yale School of Medicine Department of Laboratory Medicine studying a wide array of disease states using the innovative applications of data science tools. Clinical areas of interest range from COVID-19 (immune response factors, protection afforded by both natural infection and vaccine derived immunity, and reinfection risk factors) to oncology with the application of high-throughput data analysis pipelines, clinical predictive models, and data visualization techniques.

Mentoring:

We are seeking a postdoctoral associate to work within our team of informaticians, physicians, and computational scientists. The postdoctoral associate will be based in the Department of Laboratory Medicine and will report directly to Dr. Wade Schulz, Assistant Professor; Director of Informatics, Laboratory Medicine; Director, CORE Center for Computational Health, Center for Outcomes Research & Evaluation (CORE). The associate will also be interacting with other collaborators both within and outside of Yale University, including Dr. Albert Ko, Department Chair of Epidemiology of Microbial Disease at the Yale University School of Public Health, and Dr. Harlan Krumholz, Director, Center for Outcomes Research and Evaluation (CORE).

Training:

The postdoctoral associate will be responsible for collating, analyzing, interpreting and presenting results of various studies being conducted. Training will focus on the translation of real world data to evidence to elucidate clinical disease states, facilitate patient care and improve outcomes. The use of advanced computational frameworks will be a focus of the training, including Spark and various machine learning libraries. The use of common data models, such as OMOP, and the integration of electronic health record (EHR) and laboratory information systems (LIS) data into these models, will be key aspects of the training. Machine Learning, AI, and statistical concepts and skills will be developed and used to evaluate the clinical conditions and outcomes being investigated by the study by the team.

Education, Qualifications and Skills:

  • MD, PhD, or MD/PhD with research experience in one of the following areas: epidemiology, bioinformatics, biostatistics, immunology, microbiology, public health, computer science, cancer biology or a similarly quantitative discipline.
  • Health care exposure and experience with medical terminology
  • Research experience with mathematical and/or statistical models.
  • Strong interest in computational healthcare, clinical informatics, and data engineering
  • Ability to collate and analyze data, interpret and present results to a high standard using a range of specialized research techniques.
  • Good knowledge of Python, R, version control, and distributed computing systems.
  • Excellent verbal and written communication skills.
  • Experience in communicating research findings to a non-specialist audience.
  • Ability to work independently but also as part of a larger interdisciplinary research team.

This will be a one-year appointment with the possibility to extend, should both parties agree. Interested candidates should email Wade Schulz (wade.schulz@yale.edu) and David Ferguson (david.ferguson@yale.edu) with a CV, statement of interest and contact information for 2-3 references.

Postdoctoral position in the Department of Pathology ( Liu Lab)
Posting Date: March 2, 2021

The Liu Research Lab in the Department of Pathology at Yale University has an opening for a postdoctoral position.  The lab is focused on understanding the pathogenesis and immunobiology of human solid tumors using quantitative pathology, genetic/epigenetic analysis, in vitro/in vivo cell models, and molecular biology to interrogate relevant immunomodulatory pathways and identify determinants of sensitivity and resistance to treatments, as well as to develop novel therapeutic approaches for cancer. Our lab has access to cutting-edge technology and has unique opportunities to develop translational research projects in human liver and other GI cancers.  More information can be found at https://medicine.yale.edu/lab/chen_liu/research/

We are looking for a highly motivated individual interested in studying cancer immunology and/or cancer epigenetics. Interested applicants should hold a Ph.D. or MD/Ph.D. degree and a strong background in the field of immunology and/or translational oncology. The candidate should be self-motivated with a proven track record of productivity.  In addition to individual projects, the lab encourages a collaborative and positive working environment with other lab members and throughout the University and Cancer Center.

The competitive candidate should have knowledge and expertise in the following areas:

  1. Immune-oncology and immunomodulatory therapies
  2. Solid tumor oncology, cancer epigenetics, and translational pathology
  3. Advanced cancer diagnostics and immune-based anti-cancer therapeutics
  4. Computational analysis of images and large datasets (optional, but preferred)

Candidates with the following qualifications will be given preference:

  1. Interest and expertise in the field of immune-oncology/cancer epigenetics
  2. Productivity, quality of previous projects and independence
  3. Ability and interest to work in translational research within a multidisciplinary team

Qualified candidates who are interested in applying should e-mail an application package, including; statement of interest, CV, and contact information for three references. Please send your application package to Drs. Chen Liu (chen.liu@yale.edu) or Kien Pham (kien.pham@yale.edu) and in the subject line include your last name and reference to the job posting.

Postdoc position in Cancer Immunology (Lu Lab)
Posting Date: February 25, 2021

A postdoc position is available in Dr. Jun Lu’s laboratory at Yale University School of Medicine. The position is to conduct studies in the exciting field of cancer immunology. Studies will be carried out under existing NIH grants in the laboratory, with the goals of systematically studying epigenetic and signaling regulation in anti-tumor immunity.

The studies will leverage the strengths of the Lu laboratory in cancer, stem cell biology and immunology. Located in the state-of-the-art Yale Stem Cell Center, the Lu laboratory studies non-coding and epigenetic mechanisms in hematopoietic and immune cells. We utilize multidisciplinary tools including mouse models, functional genomics, biochemistry, single-cell genomics, and cell biology approaches such as live-cell and super-resolution imaging.

Postdocs will receive training on research, research management, mentoring, grant writing and career development. Candidates with strong backgrounds in cancer biology, immunology, hematology, epigenetics or RNA biology are particularly encouraged to apply.

Applicants with a Ph.D., M.D. or expecting such a degree in the next year should submit curriculum vitae and names of three references to Dr. Jun Lu (jun.lu@yale.edu).

Postdoctoral position in Behavioral Neuroscience
Posting Date: February 23, 2021
 
The Kim Laboratory at Yale School of Medicine is inviting applications for a postdoctoral position. The main research objective for this position is to define retinal circuits that regulate defensive behavioral responses to threatening stimuli. To identify such circuits, we will utilize mouse genetics, AAV-based neurocircuitry analysis, confocal microscopy and behavioral tests.
 
The ultimate goal is to understand structural and functional properties of the fear-related visual circuits and elucidate the mechanisms that might be responsible for disruption of such circuitry in fear- and anxiety-related disorders.
 
The ideal candidate for this position would have a strong background in behavioral neuroscience or related field. Familiarity with mouse models, in vivo surgery, and/or computer programming would be a plus.
 
Interested candidates should e-mail their application to in-jung.kim@yale.edu. The application should include: (1) CV with a full publication list, (2) a brief description of research interests, (3) contact information for 2-3 references.
Postdoctoral positions in Mucosal Immunity and Intestinal Inflammation (Dr. Clara Abraham)
Posting Date: February 12, 2021

Investigator: Clara Abraham, MD

Mucosal Immunity and Intestinal Inflammation

Yale University, New Haven, CT

Postdoctoral positions are available for research on mucosal immunity, intestinal immune homeostasis/intestinal inflammation, and innate immunity. 

The laboratory focuses on understanding mechanisms regulating innate immune responses, host pathogen interactions, and immunological pathways regulating mucosal immunity and inflammatory bowel disease. The current position will involve examination of molecular and biochemical mechanisms regulating innate cells and pattern recognition pathways, and in vivo intestinal and intestinal-pertinent immune responses, along with potential cross-talk of intestinal immunity with additional immunological sites. Studies incorporate approaches in both primary human immune cells and mouse model systems. 

Education and experience:  Candidates must have a PhD or equivalent degree with a strong background in cellular and molecular immunology, biochemistry, molecular biology, and mouse models of inflammation.  Experience in examination of intestinal tissues, multiparameter flow cytometry, and genetic modification of model organisms is desired. 

To Apply: Please send curriculum vitae, three names of reference and a one page summary of research background and interests to Clara Abraham, M.D. (Clara.Abraham@yale.edu)

Postdoctoral position in RNA biology and Immunology in the Grace Chen Lab
Posting Date: February 2, 2021

We are seeking postdoctoral fellows to join the laboratory of Dr. Grace Chen in the Department of Immunobiology. The Chen lab investigates the mechanisms and regulation of circular RNAs (circRNAs), a newly identified class of ubiquitous RNAs in essentially all eukaryotes and some viruses. Thus far, circRNAs have been found to function as miRNA sponges, regulate transcription, and act as templates for translation. However, there are still many unanswered questions: What other functions do circRNAs possess? How are circRNAs degraded? What are their interacting proteins? Specifically, we aim to understand how different layers of regulation including RNA modifications and cellular localization affect RNA function to enable new insights into both normal function and how dysregulation leads to disease.

The Chen Laboratory applies molecular, cellular, and chemical biology techniques coupled with next-generation sequencing to address these questions. We aim to generate novel therapies based on our new insight about circRNA function and regulation. For more information, visit gracechenlab.org.

Applicants should have recently completed a Ph.D. degree in molecular biology, chemical biology, immunology or genomics. High priority will be given to those candidates with strong backgrounds in RNA or chemical biology.

Interested applicants please send a brief statement of interest and curriculum vitae with contact information for three references to the PI Dr. Grace Chen at ye.grace.chen@yale.edu.

Postdoctoral position in Computational Immunology (Kleinstein Lab)
Posting Date: February 2, 2021

The Kleinstein Lab (Yale School of Medicine, Department of Pathology) is seeking a highly motivated postdoctoral associate in computational immunology. The successful candidates will work in a highly collaborative environment on systems-level human immune profiling studies, with a specific focus on high-throughput B cell receptor (BCR) and T cell receptor (TCR) repertoire analysis (including bulk and single cell RNA-seq + BCR). For interested candidates, there are opportunities for computational methods development.

The Kleinstein lab (https://medicine.yale.edu/lab/kleinstein) pairs big data analyses with immunological expertise to better understand how the dynamic processes of the immune system affect the course of infection, vaccination and autoimmunity. The lab has developed many widely used analysis methods for high-throughput immune profiling data, particularly transcriptomic and B cell receptor repertoire sequencing data (https://medicine.yale.edu/lab/kleinstein/software). We currently make available the Immcantation tool suite (http://immcantation.org), a start-to-finish analytical ecosystem for high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) datasets.

The biological applications for this position will be related to ongoing NIH-funded collaborations with several experimental/clinical labs, including:

The Shelli Farhadian Lab: The scientific focus of the Farhadian laboratory is to study the neurological effects of systemic infections. The research group focuses on immune and gene expression correlates and biomarkers of neurological dysfunction during and following acute infection. Studies are primarily translational, involving research participants recruited locally. The postdoc will collaborate on studies generating transcriptomic, including AIRR-seq, datasets to characterize patient cohort biospecimens, including from those with acute and post-acute COVID-19, HIV and other infections, with a goal of understanding central nervous system viral immunity through detailed analysis of cerebrospinal fluid immune cells.

The Kevin O’Connor Lab: The scientific focus of the O’Connor lab is to define the mechanisms by which B cells, and the antibodies they produce, affect tissue damage in autoimmunity. A major goal is to define the mechanisms of autoantibody production in human neurologic autoimmune diseases with the aim of improving therapeutic approaches. Examples of specific projects include characterizing the B cell repertoire (using bulk and single cell RNA-seq + BCR) to understand (i) B cell trafficking between disease specific tissues and blood, (ii) B cell clonal persistence through disease course and treatment, (iii) identify correlates of clinical status, and (iv) defining candidate biomarkers correlating with treatment response.

Other biological areas of focus may include Influenza vaccination, Lyme disease and West Nile Virus infection as part of the NIH HIPC (https://immuneprofiling.org).

The ideal candidate will have strong quantitative and programming abilities (ideally R and Python), along with an interest in applying these skills to problems in immunology. A Ph.D. in a quantitative discipline is desired (Bioinformatics, Computer Science, Statistics, Physics, Applied Mathematics, etc.).

Interested candidates should forward a CV and short description of research interests together with the names and addresses of three references to: steven.kleinstein@yale.edu

Review of applications will begin immediately and will continue until the position is filled.

Postdoctoral position with the Autism Biomarkers Consortium for Clinical Trials (ABC-CT)
Posting Date: February 2, 2021

The Autism Biomarkers Consortium for Clinical Trials (ABC-CT) seeks a highly qualified post-doctoral associate to participate in cutting-edge clinical research on autism spectrum disorder at the Yale Child Study Center. The ABC-CT is a network of leading scientists at five sites (Boston Children’s Hospital/Harvard University, University of Washington/Seattle Children’s Research Institute, Duke University, University of California – Los Angeles, and Yale University). The goal of this consortium is to generate a set of reliable behavioral and psychophysiological tools for use in clinical trials with children with ASD. Specifically, we will be working to integrate diagnostic, behavioral, EEG, and eye tracking methods to create biomarkers that can be used to reduce the heterogeneity of autism and indicate efficacy of treatments.

The ABC-CT at Yale is hiring a post-doctoral associate for clinical training in the context of this multi- site, longitudinal research project examining biomarkers in autism. Responsibilities will include conducting diagnostic and clinical assessments of children with ASD, providing oral and written clinical feedback to families, and providing clinical oversight for families’ participation in the ABC-CT, as well as other research studies within the Yale Autism Program. Applicants should have experience in the clinical and diagnostic assessment of children with ASD and other developmental disabilities.

As part of the broader study, the post-doctoral associate will be part of an interdisciplinary research team conducting a wide range of longitudinal assessments, including diagnostic, observational, eye- tracking, and EEG measures. As part of the appointment, there will be opportunities for supervising post-graduate associates with clinical training, as well as potential for participation in research dissemination through publication or conference presentations. The appointment will be for one year, with the potential for renewal.

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Eligibility Requirements

(1) Excellent interpersonal and clinical skills; (2) Doctoral degree in clinical, developmental, or school psychology, with emphasis in developmental disabilities; (3) Clinical assessment experience with children with autism, including cognitive and diagnostic assessment; (4) Preferable research reliability in the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview – Revised (ADI-R).

Application Information

A complete application includes the following items (please include your full name on every page of your application):

  1. Letter of interest
  2. Resume or CV
  3. Names and contact information for three references
  4. Written work sample (de-identified) of an ASD assessment

Due to the COVID-19 pandemic, please submit applications via email to   mcp.lab@yale.edu 

Submit your application with the subject line: LAST NAME_Position Title (e.g., SMITH_Clinical Post- Doc). For additional questions, interested applicants should contact mcp.lab@yale.edu or call (203) 737-4586.

Direct applications to:

James McPartland, Ph.D.

Professor of Child Psychiatry and Psychology Director, Yale Developmental Disabilities Clinic

Principal Investigator, Autism Biomarkers Consortium for Clinical Trials

http://www.asdbiomarkers.org http://www.autism.fm http://www.mcp-lab.org

Postdoctoral position in single-cell genomics of HIV-induced immune dysfunction (Ho Lab)
Posting Date: January 29, 2021

The Ho Lab at Yale University School of Medicine (https://medicine.yale.edu/lab/yachiho/) is recruiting motivated, productive, independent, and collegial postdoctoral research associates interested in innovative single-cell genomics on HIV-induced immune dysfunction and HIV persistence. This postdoctoral researcher will combine wet-bench molecular biology methods, dry-lab bioinformatic analysis, and a translational approach using clinical samples from people with HIV. The overall goal is to understand mechanism of HIV persistence and guide the development of HIV cure strategies.

Funded by several NIH grants (R01, R61, and UM1), our lab provides a collaborative environment and multi-disciplinary training for scientific and career development. Our lab has a track record of training postdoctoral researchers: our postdocs have international conference presentations and first-authored original articles (Science Translational Medicine and JCI) within three years after they joined the lab. Our lab members have received New Investigator Award, pilot award, and travel grant in the past three years. Our lab is dedicated to recruiting researchers from a diverse background.

The postdoctoral training will involve (a) the development and application of innovative single-cell RNAseq methods (Science Translational Medicine), (b) bioinformatic analysis of single-cell genomics datasets (see bioRxiv below), (c) a translational approach using blood or tissue samples from humans, (d) wet-bench methods in virology (such as sterile cell culture in an enhanced biosafety level 2 (BSL2+) lab), immunology  (such as flow cytometry), and molecular biology (such as CRISPR, real-time PCR, and western blot)(see Journal of Clinical Investigation), (e) collaboration with other researchers both inside and outside of Yale, including virologists, immunologists, bioinformaticians, computer scientists, and clinicians, (f) presentation in international conferences, and (g) manuscript preparation and grant applications.

A successful candidate will likely have (a) a recent (<4 years) PhD degree in genetics, microbiology, molecular biology, immunology, or a related discipline; (b) a track record of research productivity, as evidenced by first-authored original publication(s) in high-quality peer-reviewed journals; (c) experience in programming languages such as R or python; (d) willingness to work with HIV+ samples following BSL2+ procedures; (e) independence to lead a project as well as willingness to work in a team; (f) an open mind to learn new methods from junior researchers and collaborators; (f) good scientific presentation and writing skills. Previous experience and publications in bioinformatics, immunology, or virology is preferred but not required. A successful candidate should expect the initial scope of work to be similar to our recent work posted at bioRxiv. People who have no interest in bioinformatic analysis should not apply. Salary will commensurate with experience and qualifications.

Interested candidates may send a CV, personal statement, and contact information for three referees to ya-chi.ho@yale.edu. Applications will be reviewed on a rolling basis until the position is filled.

References:

Collora et al., bioRxiv 2021, https://www.biorxiv.org/content/10.1101/2021.01.27.428491v1

Liu et al., Science Translational Medicine 2020, PMID 32404504

Yeh et al., Journal of Clinical Investigation 2020, PMID 32573496

Pollack et al., Cell Host Microbe 2017, PMID 28407485

Ho et al., Cell 2013, PMID 24243014

Postdoctoral position in Energy Economics at The Yale School of the Environment
Posting Date: January 22, 2021

The Yale School of the Environment invites applications for a Postdoctoral Associate in Energy Economics. The successful candidate will work on both their own research in energy economics and support a major U.S. Department of Energy-funded project on the co-adoption of solar photovoltaics and related energy technologies under the supervision of Prof. Ken Gillingham.

The project brings to bear unique data, and will allow a deeper understanding of consumer behavior and the effects on the electricity grid of co-adoption. The hire will be expected to perform econometric analyses, co-author papers, and participate fully in the environmental economics community at Yale. The ideal candidate has a Ph.D. focusing on topics in empirical environmental and energy economics with exceptional research, writing, and verbal communication skills, as well as an inclusive and flexible approach to collaborating with a diverse team of individuals and organizations. This is a one-year position with an expected reappointment for a second year upon satisfactory performance.

Yale values diversity among its students, staff, and faculty and strongly encourages applications from and nominations of women, persons with disabilities, protected veterans, and underrepresented minorities. Consideration of applicants will begin immediately, but applications will be accepted until March 1st, 2021. The start date of the position is negotiable, with the default of a July 1st 2021 start date.

Interested candidates should email a cover letter and their CV, along with a list of at least three references to Kenneth Gillingham, PhD, Associate Professor of Environmental & Energy Economics at kenneth.gillingham@yale.edu.

Postdoctoral positions in microbial pathogenesis and translational medicine (Mamoun Lab)
Posting Date: January 14, 2021

Three postdoctoral positions in the fields of microbial pathogenesis and translational medicine are available immediately in the Mamoun Lab.

Candidates with Ph.D. or M.D./Ph.D. degrees with prior experience in the fields of cellular, molecular biology, genetics and biochemistry are encouraged to apply. Yale University offers a competitive postdoctoral salary, a comprehensive benefits package, and an excellent work environment.

To apply

Please send a curriculum vitae, description of research experience,

and three references to:

Dr. Choukri Ben Mamoun, Professor of Medicine and

Microbial Pathogenesis, Department of Internal Medicine, Section of Infectious

Disease, Yale School of Medicine.

TAC-S215, 300 Cedar Street, New Haven, CT

06520. Email: choukri.benmamoun@yale.edu

Postdoctoral position in renal tubular and podocyte cell biology ( Dr. Madhav Menon Lab)
Posting Date: January 14, 2021

Yale School of Medicine is seeking a motivated Postdoctoral Associate to join research programs in the laboratory of Madhav C Menon focused on the study of renal tubular and podocyte cell biology with specific reference to mechanisms of renal fibrosis and proteinuria, respectively. The goals of the lab are to develop biomarkers and novel therapeutic strategies to understand mechanisms and mitigate progressive kidney failure in native and allograft kidneys. 

The research opportunities run the spectrum from human disease modifier gene discovery to utilization of novel mouse disease models for in vivo pathway discovery and validation. Experience in immunological techniques, and interest in allograft rejection are desirable. The approaches are founded on interpretation of large data sets from human genome level sequence data and mouse cell type specific transcriptome sequence data coupled with model organism pathophysiology and basic cellular biology.

Applicants should have a Ph.D. and/or M.D., with interest in model organisms, molecular biology, cell biology, immunology or related fields.

All applications materials should be submitted electronically to: Carol Barfield, HR Administrator at carol.barfield@yale.edu. Review of applications will begin immediately and will continue until the position is filled.

Postdoctoral position in the John B. Pierce Laboratory/Yale
Posting Date: January 14, 2021
Job Code: VP013
 
A full-time position is available for a Postdoctoral Research Associate in the laboratory of Dr. Vincent Pieribone at the John B. Pierce Laboratory (http://jbpierce.org/research-laboratory/cellular-neurophysiology/), a nonprofit research institute affiliated with Yale University.
 
The Pieribone lab is developing and using state-of-the-art genetically encoded fluorescent voltage indicators for recording neuronal activity.
 
REQUIREMENTS:
Candidates should hold a PhD in the field of Neuroscience and have an interest in systems neuroscience and the application of optical methods to study neuronal activity. Techniques used include electrophysiology, behavior, optical imaging using 2P and 1P microscopy, molecular cloning, protein expression and purification, protein engineering, and biochemistry. Applicants are expected to be able to design and execute independent research projects.
A coterminous postdoctoral appointment is available in the Department of Cellular and Molecular Physiology in the Yale School of Medicine. The John B. Pierce Laboratory offers excellent benefits with employer paid health insurance and free parking.
 
TO APPLY:
Please submit a single PDF file to NeurosciPD@jbpierce.org including: 1) A cover letter with a (brief) statement of research experience and interest, 2) Curriculum Vitae, and 3) A list of three references.
 
The John B. Pierce Laboratory recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. We strive to create an inclusive community of faculty, staff, and students whose voices and contributions are valued and respected. The Pierce Laboratory seeks employees who support the research, and public service mission of the laboratory. To learn more about diversity at the John B. Pierce Laboratory: http://jbpierce.org/diversity-committee/
 
The John B. Pierce Laboratory is an Equal Employment Opportunity employer that does not unlawfully discriminate in any of its programs or activities on the basis of race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity or expression, or on any other basis prohibited by applicable law.
Postdoctoral position in Infectious Diseases (Shaw Lab)
Posting Date: January 8, 2021

Postdoctoral research positions are available to investigate mechanisms underlying aging of the immune system, with projects in human immunology including studies of innate immune pattern recognition receptor dysfunction and chronic inflammation, effects of age on the immunologic and transcriptomic response to influenza or SARS-CoV-2 vaccination, as well as studies of circadian variation in immune response and immune system aging in HIV infection. 

Education                                                                                                                                         

Ph.D. or M.D. degree with strong background in molecular biology, cell biology, or immunology required.  Available methodologies in the lab include flow cytometry and cell sorting, and 10x Genomics transcriptomic analysis; we also utilize the Yale mass cytometry (CyTOF) core.  We are seeking highly motivated individuals with a track record of productivity.  Candidates should have excellent verbal and written communication skills and particularly the ability to work collaboratively with others. 

To Apply                                                                                                                                                                             

Interested candidates should send a cover letter, curriculum vitae, and names of three references to: albert.shaw@yale.edu.

Postdoctoral position in in Pediatric Obesity & Type 2 Diabetes ( Caprio Lab)
Posting Date: January 5, 2021

The Pediatric Research Group in Childhood Obesity & Type 2 Diabetes, within the Yale School of Medicine, has an open position as a post-doctoral fellow available from January 2021. The position is funded by an established 5 year NIH grant.  The goal of this work is to investigate the role of adipocyte biology in lean and obese adolescents.  The position is renewable annually for up to 5 years contingent upon satisfactory performance and funding.

The position involves  clinical studies  to determine dynamic lipid flux and laboratory work to assess  adipocyte proliferation by employing the novel method of deuterium incorporation into DNA and TG moieties to quantify triglyceride  synthesis, de novo lipogenesis (DNL), lipolysis and adipocyte proliferation in the abdominal and gluteal subcutaneous adipose tissue. Additional methods to be done in the lab are   measures of adipocyte size distribution, gene expression, western blotting, adipocyte cell culture and adipose tissue inflammation.

Qualifications and Requirements:
• Post-Doctoral candidates should have a PhD or MD/PhD with 2 or more years as a Post-Doctoral fellow and experience in adipose tissue biology, metabolism or obesity and diabetes.
• Experience with cell culture, measuring cell size, gene expression (rt-PCR and protein levels (e.g. western Blotting)
• Knowledge in proper experimental planning and statistical evaluation of experimental data.
• Excellent written and oral communication skills
• An enthusiastic, dedicated and collaborative attitude to research.

To apply, please email a resume and contact information for three references to Sonia Caprio, MD at 01sonia.caprio@yale.edu.

Postdoctoral position in Environmental Health Sciences
Posting Date: December 17, 2020

Dr. Vasilis Vasiliou, Chair of the Environmental Health Sciences Department at the Yale School of Public Health (New Haven, CT, USA), is seeking a bioinformatician for the role of Postdoctoral Associate.  Experience in “big data” analysis, specifically in the fields of mass spectrometry-based metabolomics, exposomics, and/or tissue imaging mass spectrometry, is preferred.

Dr. Vasiliou’s research focuses on investigating the etiologies and molecular mechanisms of environmentally-induced human disease, such as liver disease, obesity & diabetes, cancer, and neurodegenerative diseases. More specifically, research in his lab focuses on the means by which the exposome (total exposures throughout life), metabolism (specifically aldehyde dehydrogenases and cytochrome P-450s) and antioxidants (glutathione and catalase) contribute to human health and disease. Dr. Vasiliou’s laboratory utilizes state-of-the-art integrated system approaches that include metabolomics, lipidomics, redox proteomics, exposomics, tissue imaging mass spectrometry, machine-learning, as well as human cohorts and genetically-engineered mouse models in order to elucidate mechanisms, and to discover biomarkers and novel interventions for human disease. His laboratory is fully equipped with 4 state-of-the-art mass spectrometers, a UHPLC-QTOF MS (Waters), a UHPLC-QqQ MS with an ESI source (Waters), a QTOF with a MALDI and DESI source (Waters) and a GC-MS (Agilent).

The primary research field of a successful candidate includes developing “Big Data” analytics capabilities for metabolomics, exposomics and tissue imaging mass spectrometry in collaboration with Dr. Vasiliou’s group, as well as the group’s collaborator from Imperial College London.  Specifically, a successful candidate should be capable of developing computational algorithms and software tools in collaboration with the Vasiliou lab, for:

(1) Extracting compound information from raw liquid-chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) metabolomics, exposomics and tissue imaging mass spectrometry data.
(2) Annotating and identifying ions based-on existing large-scale compound and mass spectral libraries.

(3) Integrating metabolomics and exposomics data with other -omics/meta-data for biological applications.

(4) Developing algorithms and software tools for tissue imaging mass spectrometry data interrogation.

The applicant must hold a Ph.D. degree in Computer Science, Bioinformatics or Chemistry/Biological Chemistry discipline, and have experience in mass spectrometry-based metabolomics and/or analytical chemistry.

This position will be funded for two years, with the potential for extension. The candidate will be expected to apply for additional external postdoctoral funding (e.g., F32 or other foundations), publish original research and assist in writing other grant applications.

Interested applicants should submit a CV, cover letter and contact information for 3 references to http://apply.interfolio.com/82141

For questions, contact:

Vasilis Vasiliou, PhD

vasilis.vasiliou@yale.edu

Postdoctoral position for Genomic Molecular Technology Development (Scharfe Lab)
Posting Date: December 17, 2020

The Scharfe laboratory is searching for a postdoctoral biomedical researcher for innovative, novel molecular technology development applied to biomedical research as well as novel clinical diagnostics. The postdoctoral candidate will have the opportunity to work in developing a number of novel tools and genomic approaches for molecular screening and diagnostics and the study of disease pathogenesis. Examples of ongoing work include technology development for screenable disorders in newborns, rapid genotyping of genomic variants to improve patient care, microhaplotype sequencing for population genetics and forensics, and multiplex capture and sequencing for viral nucleic acid testing. Most of our work use next-generation sequencing, microarrays and quantitative PCR for analysis of genomes, complex genetic rearrangements, and genomic haplotypes. Our laboratory has a major interest in the analysis of challenging clinical samples such as genetic materials from dried blood spots, cell free circulating DNA and small forensic samples. Our lab is located in a highly translational setting next to the DNA Diagnostic lab and we collaborate with the Yale Center for Genome Analysis (YCGA) and with colleagues and researcher at Yale and other institutions. Please visit our lab website for more information: https://medicine.yale.edu/lab/scharfe/research/

Qualified candidates will have a PhD in molecular biology, biomedical engineering, analytical chemistry, genetics or related fields. Experience in molecular technologies (i.e., next generation sequencing, microarrays) and/or experience in bioinformatics tools for omics analysis (e.g. R and python packages, and software) is desired, but not essential. Individuals with an MD or MD/PhDs are highly encouraged to apply as well.
Please respond with a cover letter that includes a brief explanation of your research interests, a CV with publication list, and the names and contact information of two references, by email to: Curt.Scharfe@yale.edu

Postdoctoral position in Cancer Biology ( Wilson Lab)
Posting Date: December 14, 2020

CANCER BIOLOGY POSTDOC POSITION AT YALE

The Wilson laboratory in the Section of Medical Oncology and the Yale Cancer Center is seeking candidates for a postdoctoral position.  Interests in the laboratory focus on identifying and characterizing genetic vulnerabilities in cancer and molecular mechanisms of drug resistance with an emphasis on lung cancer therapeutics (https://medicine.yale.edu/bbs/people/frederick_wilson-1.profile). The lab leverages genome-scale functional genomic screening approaches (such as CRISPR and RNA interference) to identify cancer vulnerabilities and dissect resistance mechanisms in relevant cancer cell models.  The lab also applies sequencing-based approaches to identify candidate driver gene alterations from patient tumor specimens for mechanistic studies in cell model systems.  A major priority is to translate laboratory findings into therapeutic strategies for patients with lung and other cancers.
 
Applicants must have a recent PhD degree in a relevant field and at least one first author publication in a peer-reviewed journal. Applicants should have experience in molecular biology, genetics / genomics, tumor cell biology, or other related fields.  Excellent written and oral communication skills are expected.
 
Candidates should send a Curriculum Vitae, a statement of research interests and career goals and the names / contact information for three references to: frederick.wilson@yale.edu.
 

Postdoctoral position in Neuroscience ( Kim Lab)
Posting Date: December 14, 2020
The Kim Laboratory at Yale School of Medicine is inviting applications for a postdoctoral position to investigate mechanisms regulating subcortical circuit formation. We are focusing on the assembly of the visual circuits in the underexplored brain areas, such as between superior colliculus and thalamus. Our research methodology combines mouse genetics, AAV-mediated neurocircuit analysis, bioinformatics, confocal microscopy, and behavioral tests. The ultimate goal is to define molecular mechanisms regulating long range axon-target selection in mammalian midbrain that are involved in specific visual and emotional behavioral responses.
The ideal candidate would have a background in neuroscience, molecular genetics, cell biology, or a related field. Previous experience in molecular biology and histology is a must. Familiarity with mouse models, in vivo surgery, and behavioral testing would be a plus, but not required.
Interested candidates should e-mail their application to in-jung.kim@yale.edu. The application should include: (1) CV with a full publication list, (2) a brief description of research interests, (3) contact information for 2-3 references.
Postdoctoral position in Neuroscience
Posting Date: December 14, 2020
The laboratories of Hyojung Seo and In-Jung Kim in the Departments of Psychiatry and Ophthalmology at Yale School of Medicine are recruiting a motivated postdoctoral researcher for an interdisciplinary project that investigates the potential role of GABAergic interneurons of primate prefrontal cortex (PFC) in higher cognition as well as in psychiatric illnesses. The aims of our collaborative project are twofold. First, we will develop and validate genetic methods to restrict the expression of chemogenetic tools in the distinct subpopulations of GABAergic interneurons in multiple regions of the PFC. We will adapt approaches successfully conducted in lower vertebrates and establish their feasibility in non-human primates. Second, we will investigate the functional roles of the interneurons by selectively enhancing and/or inhibiting their activities, and by analyzing and modeling the effects of manipulations on the neurophysiology of PFC network as well as behavioral performance.
 
Successful candidate will have a Ph.D. degree with extensive training in molecular genetics or related fields and be strongly motivated to apply cutting-edge techniques to higher organisms such as non-human primates.
 
Interested candidates should e-mail their application to hyojung.seo@yale.edu or in-jung.kim@yale.edu. The application should include: (1) CV with the publication list, (2) a brief description of research interests, (3) contact information for 2-3 references.
Postdoctoral position in Genetics(Sozen Lab)
Posting Date: December 14, 2020

 The Sozen laboratory is looking for talented postdoctoral associates with a background in mammalian developmental stem cell biology to join our team. We conduct research in early mouse/human embryogenesis with the goal of understanding the mechanisms that underlie developmental programming in human health and disease.

Our laboratory in the Department of Genetics, Yale School of Medicine, is a part of a highly collaborative, translational developmental biology program that includes stem cell biology, reproductive biology, genetics and computational biology.

The candidate will lead a project to participate in our larger efforts to unravel how the developmental environment impacts on physiologic, metabolic, transcriptomic and epigenomic landscapes during embryo implantation and gastrulation, the time when the maternal-fetal interface is established. The project will integrate cutting-edge technologies such as the generation of 3D stem cell models of mammalian embryos (Harrison et al. Science 2017, Sozen et al. Nature Cell Bio. 2018, Sozen et al. Dev. Cell 2019), advanced imaging techniques and transcriptomic profiling to map developmental trajectories and cellular function during tissue patterning under environmental challenges.

The postdoctoral candidate will have the opportunity to work in collaboration with a team of world-leading researchers, clinicians, and bioinformaticians, and there will be opportunities to develop additional independent projects with clinical collaborators at Yale University. 

In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided. Additional information on being a postdoc at Yale University School of Medicine can be found at https://postdocs.yale.edu/

Qualified candidates should have a PhD in Developmental Biology, Stem Cell Biology, Reproductive Biology, Bioengineering or a relevant field. The candidate must have hands-on experience with mammalian embryo culture and/or mammalian stem cell culture. Expertise in 3D cell culture techniques and gene editing methods (e.g. Crispr-Cas9, to engineer stem cell lines with multiple fluorescent reporters) are highly desirable. Experience in genomic profiling techniques (e.g. single-cell RNA-seq) and bioinformatics analyses are desirable but not essential. Please respond with a cover letter that includes a short description of relevant expertise, a CV with publication list, and the names of two references by email to: berna.sozen@yale.edu

Postdoc position in phase separation and cancer immunology (Su Lab)
Posting Date: December 1, 2020
The Su Lab at Yale School of Medicine is recruiting 1-2 postdoctoral fellows. We study membrane remodeling and signal transduction during immune responses. Using combined approaches of biochemical reconstitution, microscopy, cell engineering, and mouse models, we aim to address fundamental questions in the interface between cell biology and immunology. Our work also involves the development of new therapeutic targets and strategies for immune diseases and cancers.
 
Position Description
Currently we have two research directions for incoming postdocs: 1) CAR engineering; 2) Phase separation in immune responses. For more information, please visit our website (www.sulab.net).
The Su Lab is located in the Department of Cell Biology at Yale School of Medicine. We are building up a team driven by highly motivated and dedicated young scientists. Candidates with first-author publication(s) in immunology or relevant fields are encouraged to apply. Experience in T cell biology or mouse tumor model is highly appreciated though not required. Postdocs are expected to work independently and receive mentorship from Dr. Su in both science and professional skills that lead to starting a faculty position. The enrolled postdoc will receive standard salary and benefits of Yale postdoc employees.
 
To Apply
Candidates interested in this position may contact Dr. Xiaolei Su, attaching a CV and briefly stating your research interest (xiaolei.su@yale.edu). 
 
About the PI: Xiaolei Su
Dr. Su majored in Biological Sciences in Peking University as an undergraduate. He obtained a Ph.D. degree at Harvard University in the subject of Cell and Developmental Biology. As a postdoc fellow in Ron Vale’s Lab at UCSF, Dr. Su discovered how phase separation of signaling molecules promotes T cell activation. In 2018, the Su Lab was established in the Department of Cell Biology at Yale School of Medicine. The PI is currently supported by NIH, Hood Foundation, B+ Foundation, Rally Foundation, and Gilead Science.
 
Postdoctoral position in the Section of Digestive Diseases ( Ameen Lab)
Posting Date: November 24, 2020

A position is available for a Postdoctoral Associate  in the Ameen Lab, within the  Section of Digestive Diseases at Yale School of Medicine. A major goal of the laboratory is understanding the regulation of CFTR chloride channels in the native intestine and its relevance to intestinal diseases. Studies are predominantly conducted in animal models, including normal rat, transgenic mouse models of diseases where CFTR is implicated. We also conduct studies in human intestinal organoids and cultured human intestinal cells. 

Techniques used in the laboratory include: PCR, qPCR, tail clipping, animal husbandry, cell and organoid culture, Ussing Chamber electrophysiology in tissues and cells, immunofluorescence staining of cells and tissues, fluorescence and confocal microscopy imaging, immunoblot analysis of rodent tissue lysates, co-immunoprecipitation using tissue lysates, Ussing chamber electrophysiology.  

Expectations/responsibilities for the position include:

  1. Design and Conduct experimental work as it relates to papers, and grant applications in the interest of the laboratory and as outlined by the PI. 
  2. Learn new scientific techniques relevant to the lab’s projects
  3. Seek scientific collaborations within the university and outside.
  4. Meet requirements for laboratory practice, compliance for animal, molecular and cellular studies as required by Yale.
  5. Maintain lab note books and organize work computer files in accordance with NIH and PI requirements
  6. Present weekly at laboratory meetings and monthly or quarterly at Digestive Disease joint lab meetings (power point), Physiology and other lab meetings
  7. Preparation of data, figures, and manuscript drafts and grants
  8.  Work as a team to (a) build science (b) maintain the laboratory in accordance with good laboratory practice and PI standards
  9. Develop writing skills for grant applications
  10. Prepare and Present data at national meetings.
  11.  Assist in mentoring and training students in the lab.
  12. Maintain professional conduct at all times
  13.  All other duties as assigned by the PI.

Interested candidates please contact the PI: Nadia Ameen, Professor Pediatrics, Cellular and Molecular Physiology at Nadia.Ameen@yale.edu

Postdoctoral position in the Center of Molecular and Cellular Oncology(Müschen Laboratory)
Posting Date: November 18,2020

Center of Molecular and Cellular Oncology, Yale School of Medicine

Antibody-producing B-cells are under intense selective pressure to remove autoreactive and pre-malignant clones, yet autoimmune disorders and B-cell malignancies are very common and often incurable diseases. In the coming years, we will pursue biological questions that will create a conceptual basis for the understanding of B-cell-selection and create new opportunities for therapeutic intervention in autoimmune diseases and B-cell tumors. Our scientific discoveries are driven by the desire to create a stimulating academic environment where we focus on rigorous, collaborative and innovative science. In the laboratory, we promote a culture of inclusivity, mentoring our trainees’ scientific growth, and striving to make science accessible to everyone.

Harnessing negative selection to treat B-cell tumors. We developed the paradigm that, unlike other cancer-types, B-cell malignancies can be treated by targeted engagement of negative selection. This can be achieved by pharmacological kinase-hyperactivation to mimic excessive signaling-strength from autoreactive B-cell receptors. Targeted cancer-therapy is traditionally focused on kinase-inhibitors to suppress oncogenic signaling. Our concept of kinase-hyperactivation effectively represents the opposite (Chen Nature 2015; Shojaee Nature Med 2016).

Metabolic gatekeeper paradigm. We pursue the new concept that negative selection is predicated on a B-lymphoid transcriptional program to restrict glucose-uptake and energy-abundance, a mechanism we termed ‘metabolic gatekeeper’. Given that pathogenic B-cells have higher energy-demands than their normal counterparts, we hypothesize that mechanisms to limit energy-supply safeguard against autoimmune disease and B-cell malignancies by setting low thresholds for elimination based on energy-stress (Chan Nature 2017; Xiao Cell 2018).

Mechanisms of energy-conservation in B-cells. We previously established that B-cells develop under conditions of chronic energy-depletion. Studying how B-cells survive acute surges of energy-consumption during physiological B-cell activation, we discovered a novel dependent feedback-mechanism of energy metabolism. One of these mechanisms involves a well-known cytokine receptor-chain. Ongoing studies illuminate how this receptor has been repurposed in B-cells to function as a dynamic feedback-regulator of energy expenditure (Chan Nature 2020; Lee Nature 2020).

Why do B-cells have the smallest cytoplasm and fewest mitochondria of all cells? Our laboratory has recently developed conceptual models to identify factors that orchestrate the unique morphology of B-cells, to examine why maintenance of a small cell-size is essential for B-cell survival and whether engineered B-cells that harbor more and larger mitochondria are prone to autoimmunity and B-cell tumors (Müschen Nature Rev Cancer 2018; Müschen Nature Rev Immunol 2019).

Qualifications: Candidates must have a Ph.D. in Cell or Molecular Biology, a strong research track record, enthusiasm for science, willingness to think beyond established concepts, and to try and learn new experimental and analytical tools. Our group takes a team science approach, therefore, a friendly personality and collaborative attitude are key attributes for successful candidates.

Methods/Techniques: Ideal candidates must be technically adept and proficient in flow cytometry, mass spectrometry/quantitative phosphoprofiling, genetic biosensors of signal transduction, optogenetics, mouse genetics, bone marrow transplantation assays, retroviral gene delivery, whole exome sequencing and RNA-seq-analysis of clonal evolution of leukemia, and pre-clinical drug testing in xenotransplantation models.

Your application should include in one single PDF:

CV, brief motivation statement, coordinates of three scientific mentors (references) sent to Markus Müschen via email (markus.muschen@yale.edu).

Postdoctoral position in Epilepsy Research in Department of Neurosurgery (de Lanerolle Lab)
Posting Date: November 16,2020

The Epilepsy Research laboratory is looking to hire a Postdoctoral Associate to participate in research on the molecular neuropathology of animal and human temporal lobe seizure foci. This position is in the laboratory of Dr. Nihal de Lanerolle. This is a full-time paid position initially for one year and is currently open.

The laboratory seeks a motivated and creative candidate to participate in investigations of the molecular and cellular mechanisms underlying epileptogenesis in animal models of febrile seizures. Parallel studies are carried out on human seizure foci removed during epilepsy surgery for medically intractable temporal lobe epilepsy. These studies will involve induction of febrile seizures in rodents, animal surgery for implantation of electrodes for the detecting neural activity and video-EEG recording and analysis for studies of seizure development in the model and molecular techniques for gene and protein expression during epileptogenesis and spontaneous seizure development.

Candidates should have a PhD or M.D/PhD degree with a background in neuroscience and strong expertise on biochemistry and molecular biological techniques. In addition, a background in immunology is preferred but not required. The ideal candidate should be motivated to learn new things including methods in neuroanatomy as required for this research.

Review of applications will begin immediately and will continue until the position is filled.  To respond, please respond by email including a cover letter with a short description of expertise, a CV, and names of two referees as attachments to nihal.delanerolle@yale.edu.

Postdoctoral position in the Division of Gynecologic Oncology
Posting Date: November 12, 2020

The laboratory of Dr. Alessandro Santin at Yale School of Medicine is looking to hire a Postdoc for a long term research appointment. He or she will work under Dr. Santin direction in the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology. Dr. Santin’s research focuses on the development of PDX mouse models in which gynecological cancer can be induced and studied to evaluate drug sensitivity. Dr. Santin laboratory has generated multiple ovarian, cervical and endometrial cancer cell lines with defined genetic alterations that could be used to develop new effective targeted treatments.

Applicants must possess a Ph.D., or M.D./Ph.D. degree. Candidates are expected to have a strong background in molecular and cell biology, tissue culture, flow cytometry and have experience with small animal surgical procedures. The ideal candidate should be highly motivated and have publications in peer-reviewed journals. Salary is commensurate with experience and skill level. Applicants must provide a CV, and references.

Interested candidates can email: stefania.bellone@yale.edu

Postdoctoral position in Anesthesiology Research
Posting Date: November 12, 2020

A postdoc associate is sought for a position in the Benveniste lab in the Department of Anesthesiology at Yale University. The lab focuses on translational research of neurodegenerative disorders such as cerebral small vessel disease and Alzheimer’s disease Specifically we study the roles of cerebrospinal fluid flow dynamics and glymphatic-lymphatic coupling and explore novel disease modifying therapies. The lab uses a combination of magnetic resonance imaging, physiological interventions in transgenic and surgical rodent models together with molecular/histological tools. In this position, the successful candidate will be focusing on characterizing the neurodegenerative state (e.g. amyloid beta deposition, aquaporin-4 water channel expression, inflammation) and status of the meningeal lymphatic vessels and lymph nodes using multiplex immunohistochemical staining and other molecular tools.  This work involves the use of rodent models, MRI in particular multiplex immunohistochemical staining of brain and lymph node tissue to support our various projects. The candidate must be proficient in immunohistochemistry/ immunofluorescence staining, perform statistical calculations and data analysis. 

The candidate must hold a PhD, MD or MD, PhD. in biology, chemistry, psychology, or neuroscience. Experience in multiplex immunohistochemistry/ immunofluorescence staining of rodent brain and lymph node tissue and research experience in pre-clinical research with a track record of publications is preferred.

Interested candidates should email their CV including two references to Dr. Helene Benveniste, MD, PhD, Professor of Anesthesiology at helene.benveniste@yale.edu.

Postdoctoral position in the Department of Pharmacology
Posting Date: November 20, 2020

The laboratory of Joseph Schlessinger in the Department of Pharmacology at the Yale School of Medicine has immediate openings for highly motivated Postdoctoral Associates to investigate mechanisms involved in cell signaling.

The Schlessinger Lab has been at the forefront of cell signaling, helping to define cell signaling by receptor tyrosine kinases (RTKs) and making many seminal discoveries within the field. The research in the Schlessinger lab is focused on structural elucidation, biophysical and biochemical analyses as well as studying the role RTKs and other signaling molecules in murine model systems of RTK signaling.

Priority will be given to applicants with a Ph.D. degree with extensive experiences in developing and analyzing the phenotypes and underlying physiological mechanism of genetically modified murine model systems, and excellent written and oral communication skills.

Positions are also available for candidates with a Ph.D. degree with experiences in recombinant protein production (E.coli and mammalian cells), mammalian cell culture and quantitative biophysical analyses including structural biology technique (X-ray crystallography or cryo-EM), and excellent written and oral communication skills.

Interested candidates should send a current CV, a statement of research interests, and the names and contact information of three references to: Joseph Schlessinger (joseph.schlessinger@yale.edu) and Nathan Kucera (nathan.kucera@yale.edu).