Yale Postdoctoral Positions

Center of Molecular and Cellular Oncology, Yale School of Medicine

Antibody-producing B-cells are under intense selective pressure to remove autoreactive and pre-malignant clones, yet autoimmune disorders and B-cell malignancies are very common and often incurable diseases. In the coming years, we will pursue biological questions that will create a conceptual basis for the understanding of B-cell-selection and create new opportunities for therapeutic intervention in autoimmune diseases and B-cell tumors. Our scientific discoveries are driven by the desire to create a stimulating academic environment where we focus on rigorous, collaborative and innovative science. In the laboratory, we promote a culture of inclusivity, mentoring our trainees’ scientific growth, and striving to make science accessible to everyone.

Harnessing negative selection to treat B-cell tumors. We developed the paradigm that, unlike other cancer-types, B-cell malignancies can be treated by targeted engagement of negative selection. This can be achieved by pharmacological kinase-hyperactivation to mimic excessive signaling-strength from autoreactive B-cell receptors. Targeted cancer-therapy is traditionally focused on kinase-inhibitors to suppress oncogenic signaling. Our concept of kinase-hyperactivation effectively represents the opposite (Chen Nature 2015; Shojaee Nature Med 2016).

Metabolic gatekeeper paradigm. We pursue the new concept that negative selection is predicated on a B-lymphoid transcriptional program to restrict glucose-uptake and energy-abundance, a mechanism we termed ‘metabolic gatekeeper’. Given that pathogenic B-cells have higher energy-demands than their normal counterparts, we hypothesize that mechanisms to limit energy-supply safeguard against autoimmune disease and B-cell malignancies by setting low thresholds for elimination based on energy-stress (Chan Nature 2017; Xiao Cell 2018).

Mechanisms of energy-conservation in B-cells. We previously established that B-cells develop under conditions of chronic energy-depletion. Studying how B-cells survive acute surges of energy-consumption during physiological B-cell activation, we discovered a novel dependent feedback-mechanism of energy metabolism. One of these mechanisms involves a well-known cytokine receptor-chain. Ongoing studies illuminate how this receptor has been repurposed in B-cells to function as a dynamic feedback-regulator of energy expenditure (Chan Nature 2020; Lee Nature 2020).

Why do B-cells have the smallest cytoplasm and fewest mitochondria of all cells? Our laboratory has recently developed conceptual models to identify factors that orchestrate the unique morphology of B-cells, to examine why maintenance of a small cell-size is essential for B-cell survival and whether engineered B-cells that harbor more and larger mitochondria are prone to autoimmunity and B-cell tumors (Müschen Nature Rev Cancer 2018; Müschen Nature Rev Immunol 2019).

Qualifications: Candidates must have a Ph.D. in Cell or Molecular Biology, a strong research track record, enthusiasm for science, willingness to think beyond established concepts, and to try and learn new experimental and analytical tools. Our group takes a team science approach, therefore, a friendly personality and collaborative attitude are key attributes for successful candidates.

Methods/Techniques: Ideal candidates must be technically adept and proficient in flow cytometry, mass spectrometry/quantitative phosphoprofiling, genetic biosensors of signal transduction, optogenetics, mouse genetics, bone marrow transplantation assays, retroviral gene delivery, whole exome sequencing and RNA-seq-analysis of clonal evolution of leukemia, and pre-clinical drug testing in xenotransplantation models.

Your application should include in one single PDF:

CV, brief motivation statement, coordinates of three scientific mentors (references) sent to Markus Müschen via email (markus.muschen@yale.edu).

The laboratory of Dr. Alessandro Santin at Yale School of Medicine is looking to hire a Postdoc for a long term research appointment. He or she will work under Dr. Santin direction in the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology. Dr. Santin’s research focuses on the development of PDX mouse models in which gynecological cancer can be induced and studied to evaluate drug sensitivity. Dr. Santin laboratory has generated multiple ovarian, cervical and endometrial cancer cell lines with defined genetic alterations that could be used to develop new effective targeted treatments.

Applicants must possess a Ph.D., or M.D./Ph.D. degree. Candidates are expected to have a strong background in molecular and cell biology, tissue culture, flow cytometry and have experience with small animal surgical procedures. The ideal candidate should be highly motivated and have publications in peer-reviewed journals. Salary is commensurate with experience and skill level. Applicants must provide a CV, and references.

Interested candidates can email: stefania.bellone@yale.edu

The O’Donnell Research Group at the Yale Child Study Center seeks a Postdoctoral Associate to develop Next Generation Screening Tools to identify and support pregnant people at risk for adverse mental health outcomes.  This project will implement passive data capture within an existing, longitudinal pregnancy cohort to identify digital phenotypes that predict mental health outcomes.  A second objective of this project is to integrate digital and biological data (e.g., measures of genomic risk) to build improved prediction models.

The Postdoctoral Associate will be responsible for optimizing passive data capture protocols in addition to data analysis and manuscript preparation.  The successful candidate will join a collaborative, international research team who will support participant recruitment and mental health phenotyping.  The Associate will be mentored by Dr. Kieran O’Donnell (Principal Investigator) with an emphasis on professional development and fostering independence.

Key Responsibilities

• Evaluate different passive data capture Apps & develop data analysis pipelines
• Collaborate with research assistants to ensure timely participant recruitment/data collection
• Prepare research papers for publication

Skills & Qualifications

• Qualified candidates will have recently completed a PhD in Computer Science, Data Science, Quantitative Psychology, Biostatistics or a related field
• Exceptional project management and organizational skills are required
• Competence in quantitative methods, including high dimensional data analysis, is essential
• Excellent programming skills are required (in R, Matlab or Python)
• Familiarity with database management systems e.g., MySQL
• Experience with App development is preferred but not essential
• A demonstrated interest in Perinatal Mental Health is preferable

The position will start remotely in accordance with Yale University guidance around COVID-19.

To Apply

Please send your CV and a one-page letter of motivation to Dr. Kieran O’Donnell at Kieran.ODonnell@yale.edu. Review of applications will begin immediately and continue until the position is filled.  Qualified applicants may be contacted to schedule an interview and asked to submit two letters of recommendation

Our Human Nature Lab has a postdoctoral position opening for a candidate with a background in chromatography and mass spectrometry (especially GCMS) to join research efforts of a multidisciplinary team. The primary responsibilities will be characterization of human biomarkers using GC-MS/MS to understand the biology of social behavior.

The Human Nature Lab (https://humannaturelab.net) is investigating the biological basis of human social interactions by bringing together approaches such as field and laboratory behavioral experiments, genomic sequencing and mass spectrometry, and computational models of networks. This position offers an opportunity to work with human samples to identify volatile organic compounds (VOCs) and metabolites that may characterize social behavior in lab experiments, may relate to the microbiome in field specimens, and may help explain the structure of social networks in real-life settings (such as our large-scale public health intervention to reduce infant and maternal mortality in Honduras). The candidate will work with scientists across a wide range of disciplines, ranging from network science to artificial intelligence to microbial metagenomics.

Responsibilities:

The successful candidate will:

• Perform GCMS characterization of human VOCs, steroid hormones, microbiome metabolites, and other biological markers, including extraction and purification.
• Follow established protocols for human biomarker GCMS profiling in a variety of sample matrices, as well as develop and validate new protocols and procedures.
• Conduct both untargeted and targeted GCMS studies, applying both qualitative and quantitative analysis, for the purposes of fingerprinting the human volatolome and identifying specific chemical messengers associated with cooperative behavior and interpersonal connection. This is part of an unprecedented project to discover and characterize human social chemosignalling as it relates to human social networks.
• Use GCMS to profile the human gut microbiome metabolome, contributing to a study of social networks and the human microbiome. This is a first-of-its-kind, large-scale study that includes to-date the largest map of face-to-face social networks and the largest metagenomic microbiome study in a single population, followed longitudinally with rich phenotyping.
• Apply appropriate statistical analysis methods for GCMS data, summarize and present results, lead publication of manuscripts.
• Collaborate with other members of the Human Nature Lab and the Yale Institute for Network Science, as well as our lab’s collaborators at other universities, to advance the existing projects and expand the research agenda in new directions.
• Actively participate in mentoring PhD candidates in the lab, and supervise research assistants.
• Work effectively with the project management team, data scientists, and developers.
• Follow established laboratory safety procedures, adhere to the lab’s data security protocols, and help enforce ethical responsibilities regarding privacy and wellbeing of human subjects.

Job Requirements:

• PhD in biochemistry, chemistry, engineering, biomedical sciences, or related or appropriate fields.
• Demonstrated expertise in GCMS techniques.
• Experience in GCMS data analysis/interpretation.
• Ability to lead independent research, as well as to collaborate in small and large team settings.
• Willingness to learn about new topics and new methods from a variety of intersecting disciplines.
• Positive attitude and ability to contribute to our open and happy lab culture.

Ideal candidates will have demonstrated a passion for science, some record of productivity/publication, and strong motivation for problem-solving and innovation.  We like candidates with risky and quirky ideas.

The lab PI and the Co-Director of the Yale Institute for Network Science (where the lab is located) is Nicholas A. Christakis, the Sterling Professor of Social and Natural Science at Yale, and Professor in the departments of Sociology, Medicine, Ecology and Evolutionary Biology, Biomedical Engineering, and Statistics and Data Science. The postdoc position will benefit from, and allow for active engagement in, activities in these various departments, as well as in the multidisciplinary Yale Institute for Network Science within the School of Engineering and Applied Science. The postdoc will also benefit from working in a lab whose work is funded by grants from the NIH, DARPA, the Bill and Melinda Gates Foundation, the NOMIS Foundation, the Templeton Foundation, the RWJ Foundation, the Tata-Yale Alliance, and others.

Required application materials:

Send your cover letter with an attached CV to thomas.keegan@yale.edu.

Yale School of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM), is looking to hire a highly motivated Postdoctoral Fellow to drive innovative research projects forward in the laboratory of Dr. Shervin Takyar, MD, PhD. The post-doctoral fellow will work on understanding the role of non-coding RNAs in tumor endothelial cells and in inflammatory lung disorders including ARDS and severe asthma. The post-doctoral fellow should be able to work independently as well as in a team of other researchers in the lab which include other postdocs, clinical fellows and students. The major experimental platforms that will be used include animal models, RNA sequencing, qRT-PCR, signaling studies, immunohistochemistry, multicolor flow cytometry, knockdown and overexpression studies and imaging techniques, cell culture, Western blotting and ELISA.

Job Qualification:

1. A recent graduate or about to graduate from PhD in the field of biology, immunology, bacteriology, virology or similarly related fields.

2. Experience with animal handling is preferred but not necessary. Knowledge about the major cellular and biochemical techniques will be plus.

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The Postdoctoral Fellow is expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected.

Review of applications will begin immediately, and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to carol.barfield@yale.edu

The Bleichert lab in the department of Molecular Biophysics and Biochemistry (MB&B) at Yale University is looking for enthusiastic, dynamic,  goal-driven, and team-oriented postdoctoral associates with a strong background in biochemistry, biophysics, structural biology, or proteomics. Research in the lab is focused on understanding the mechanisms that control the initiation of DNA and chromatin replication. To address fundamental questions in this research area, the Bleichert lab uses a broad range of biochemical, biophysical, structural (both cryo-EM and X-ray crystallography), and cellular approaches. Yale provides an excellent infrastructure for high-resolution cryo-EM with access to a Titan Krios (with K3 detector) and several Glacios TEMs (with K2 detector).  

We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating your career development. We will provide numerous opportunities for training you in complementary techniques, and we will mentor you to improve your communication and writing skills. You will also have the opportunity to enhance your own mentoring and teaching skills by interacting with PhD students and by supervising undergraduate students.

Interested candidates should have recently finished or will soon complete their PhD degree and have a strong research track record. Prior experience in biochemistry, including recombinant protein expression and purification in E. coli and insect cells is advantageous. Successful applicants will also possess a collaborative team spirit and demonstrate an interest in applying new technologies.

Qualified candidates should send their CV, a cover letter describing past and future research interests, and the contact information for two to three references to Dr. Franziska Bleichert (franziska.bleichert@yale.edu). To ensure full consideration, please submit your application by November 15, 2020.

This is a postdoctoral position in liver biology focusing on liver inflammation and fibrosis. As a part of the Yale Liver center core, the lab members have access to the Morphology cores with State-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training on in vivo models as well as a range of cell and molecular biology techniques.

The candidate will be expected to have a PhD., with experience in cellular and molecular biology preferably but not related to liver pathophysiology, and have the capacity for independent evaluation of the literature. Prior knowledge in cell culture techniques, primary cell isolation/culture, flow cytometry and imaging techniques would be an added advantage.

Please send CV’s to: wajahat.mehal@yale.edu

The Escobar-Hoyos lab in the Department of Therapeutic Radiology and Yale Cancer Center at Yale University is seeking a highly motivated and creative post-doctoral researcher with REQUIRED mechanistic-based cancer biology and/or RNA biology research experience. Applicants should have completed (soon to complete) a PhD with a strong publication record, excellent verbal and written communication skills and strong research experience in signal transduction, transcriptional control, RNA splicing, or related fields.

We are seeking a dynamic individual who will be responsible, as a member of a team, for designing and executing studies focused on understanding and targeting altered RNA processing mechanisms in pancreatic cancer.

As the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) has emerged as the 3rd leading cause of cancer death in the United States, in part because this malignancy is highly resistant to chemotherapeutic intervention.

Recently, it’s been shown that PDAC is composed of distinct molecular subtypes, based on RNA expression and patient outcome, underscoring that much remains to be understood about RNA expression, processing and regulation in this disease. Our research is focused on 1) characterizing the molecular pathways and functions controlled by aberrant RNA splicing and 2) designing RNA- targeted therapies to uncover novel therapeutic vulnerabilities in this disease.

Our group is heavily involved with RNA Sequencing of human and mouse pancreatic cancers. The candidate is expected to perform experiments exploring alterations in RNA splicing and additional steps in RNA processing, using a variety of preclinical model systems that include cell lines, xenografts, genetically engineered mouse models, and patient-derived models. A desire to develop and implement new methodologies is highly advantageous. There will be numerous opportunities for training to complement current skills, collaborate with other outstanding scientists, and to enhance grant writing skills.

The candidate will work within an integrated, multidisciplinary team composed of basic scientists, computational biologists, pathologists, medical oncologists, and radiologists, with significant resources for bioinformatics support, access to clinical specimens, and studies in human and animal tissues.

Experience with several of the following activities are desirable: characterization of genetically engineered mouse models, work with patient-derived xenografts or organoids, and culture of primary cells. Initial salary is commensurate with experience. Applying for independent funding is not required but is strongly encouraged for the career development of the candidate.

Qualified candidates should send a curriculum vitae, a cover letter detailing research interests and career goals, and contact information for three references to Dr. Luisa Escobar-Hoyos (Luisa.escobar-hoyos@yale.edu ).

Contact Information:

Dr. Luisa Escobar-Hoyos

A Postdoctoral Research Associate is sought in the Braddock laboratory to assist with our development efforts on investigating the pathogenesis and treatment of Rare Diseases. The Braddock lab demonstrable success designing and validating biologic therapeutics for human disease, and the position will span biochemistry, cell biology, protein design, and murine models of human disease. A major focus of the position will be in vitro and in vivo experiments to define the mechanism of a newly described form of osteoporosis described by our laboratory (J Bone Miner Res. 2020 Mar;35(3):528-539). The candidate may also participate in a newly developing project on autoimmune disease and tumor metastasis, and be involved in characterizing an newly developed animal model of metabolic disease associated with polymorphisms in ENPP1.

As discussed above, the candidate must be comfortable performing animal studies. Candidates with experience in primary eukaryotic cell culture, lentiviral transfection assays, murine models of tumor metastasis, and experience with RNAseq and bioinformatics are especially encouraged to apply, but all recent graduates from strong PhD programs in the biological sciences interested in translational research are also encouraged.

Applicants are requested to submit an application packet consisting of a cover letter, updated CV, the names of 3 references, and a copy of their academic transcripts.

Demetrios Braddock M.D. Ph.D.

Associate Professor of Pathology

Yale University School of Medicine

310 Cedar Street

New Haven CT 06510

Demetrios.braddock@yale.edu

Yale School of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (PCCSM), is looking to hire a highly motivated Postdoctoral Associate to drive innovative translational research forward in the Yale ILD Center of Excellence.

The post-doctoral associate will work under the supervision of Dr. Erica Herzog and Dr. Danielle Antin-Ozerkis on human oriented research projects aimed at developing molecular biomarkers and treatments for patients with pulmonary fibrosis and related disorders.  The post-doctoral associate should be able to work independently as well as in a team of translational lung biologists in the lab which include pulmonologists, postdocs, clinical fellows and students. The major experimental tools that will be used include FACS, single cell RNA sequencing, ELISA, PCR on samples from patients with several forms of pulmonary fibrosis and interstitial lung disease.  

Job Qualification:

1. A recent graduate or about to graduate with an MD, or a PhD in the field of biology and immunology or similarly related fields.

2. Experience with translational work and biomarker studies is preferred but not necessary. Knowledge of major cellular and biochemical techniques such as FACS, single cell sequencing, ELISA and PCR is a plus.  

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The individual will be expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected.  It is an excellent opportunity to learn about biomarker work in the context of clinical medicine and interventional trials.

Review of applications will begin immediately and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to erica.herzog@yale.edu

The laboratory of Joseph Schlessinger in the Department of Pharmacology at the Yale School of Medicine has immediate openings for highly motivated Postdoctoral Associates to investigate mechanisms involved in cell signaling.

The Schlessinger Lab has been at the forefront of cell signaling, helping to define cell signaling by receptor tyrosine kinases (RTKs) and making many seminal discoveries within the field. The research in the Schlessinger lab is focused on structural elucidation, biophysical and biochemical analyses as well as studying the role RTKs and other signaling molecules in murine model systems of RTK signaling.

Priority will be given to applicants with a Ph.D. degree with extensive experiences in developing and analyzing the phenotypes and underlying physiological mechanism of genetically modified murine model systems, and excellent written and oral communication skills.

Positions are also available for candidates with a Ph.D. degree with experiences in recombinant protein production (E.coli and mammalian cells), mammalian cell culture and quantitative biophysical analyses including structural biology technique (X-ray crystallography or cryo-EM), and excellent written and oral communication skills.

Interested candidates should send a current CV, a statement of research interests, and the names and contact information of three references to: Joseph Schlessinger (joseph.schlessinger@yale.edu) and Nathan Kucera (nathan.kucera@yale.edu).

Postdoctoral research fellowships for highly qualified applicants are now available in the lab of Dr. Derek Steinbacher at the Yale School of Medicine. The laboratory focuses on a broad range of questions relevant to our understanding of bone, chondrogenic, and adipose tissue engineering. We are seeking postdoctoral scholars interested in research on the regenerative and immunomodulating effects of stem cells derived from various tissue sources (e.g. adipose, bone, muscle).

Among the current research projects include: 1) how chondrocyte respond to crush injury when combined with adipose-derived stem cells in vitro 2) how adipose-derived stem cells modulate vascularization and bone regeneration in 3D-printed bone scaffolds; and 3) how arteriovenous microvascular flow channels can enhance bone regeneration. The postdoctoral scholar will reside in a supportive environment with experienced mentors that will provide a research experience combined with training in grant writing and other critical academic skills. Applicants with a recent Ph.D. or M.D./Ph.D., publications in major journals and a strong background in tissue engineering, stem cell biology, immunology, cell biology, animal models and/or imaging are encouraged to apply.

Interested applicants should have a recent PhD degree in Biology, Biotechnology, Bioengineering Genetics, Biochemistry or equivalent research related field in addition to a strong background in molecular biology assays. Ideally, these will include experience with mammalian cell culture techniques, PCR, qPCR, immunostaining, ELISA, Western blot and FACS analysis. Experience in stem cell or bone biology is a plus. Prospective candidates will be part of a research team and expected to be highly motivated, passionate about science and collaborative.

Qualifications Required/Academic Background
Applicants with a recent Ph.D. or M.D./Ph.D., publications in major journals and a strong background in tissue engineering, stem cell biology, immunology, cell biology, animal models and/or imaging are encouraged to apply.

Salary/Stipend
commensurate with previous accomplishments and experience.

Application Procedure
Please submit interests, Curriculum Vita and names of three references to:  Derek.Steinbacher@yale.edu

Derek Steinbacher MD DMD, Professor, Yale School of Medicine
Director, Cleft and Craniofacial Surgery

Chief, Oral and Maxillofacial Surgery
Department of Surgery

A Postdoctoral Fellowship position is available in the laboratory of Dr. Nita Ahuja at the Department of Surgery, Yale School of Medicine. The research in the Ahuja laboratory is focused on understanding the epigenetic dysregulation in various cancers during disease progression using patient samples, patient derived organoids, PDX mouse and various cell line models, as well as translating the findings to develop novel detection biomarkers and identify novel treatment targets.

We are looking for motivated individuals interested in studying the molecular, cellular, and epigenetic dysregulation of gastrointestinal cancers and other disorders. Applicants should have a PhD or MD/PhD in biological sciences, molecular/cell biology, genetics or related fields. The candidate should be self-motivated and have a proven track record of productivity. Experience in RNA biology, epigenetic techniques, CRISPR and other gene editing techniques, immune-priming using epigenetic drugs, and analyzing genomic data sets will be an advantage. Candidates with a PhD in epigenetics would be given preference; however, candidates with 1 to 2 years of post-doctoral experience with a strong focus in epigenetics would also be considered. Any relevant experience in chromatin modulation biology will be plus. The candidate should possess excellent written and verbal communication skills, as well as ability to work collaboratively.

Qualified applicants should email the application package (statement of interest, CV, and contact information for three referees) as a single pdf document. To apply or any other questions regarding the position please directly contact Anup Sharma (anup.sharma@yale.edu) for consideration.

A full-time position is available for a Postdoctoral Research Associate in the laboratory of Dr. Vincent Pieribone at the John B. Pierce Laboratory (http://jbpierce.org/research-laboratory/cellular-neurophysiology/), a nonprofit research institute affiliated with Yale University.

The Pieribone lab is developing state-of-the-art genetically encoded fluorescent voltage indicators and bioluminescent indicators for recording neuronal activity. The projects also include the study of bioluminescence pathways in native organisms in efforts to identify and characterize novel luciferases and their substrates that can be adopted for functional imaging.

The work involves design and development of high throughput screening platforms, and further optimization of the indicators for in vitro and in vivo imaging in various model organisms using multi- and single-photon microscopy.

REQUIREMENTS:
Candidates should hold a PhD in the field of Neuroscience, Molecular Biology, or Biochemistry and have an interest in systems neuroscience and the development and application of optical methods to study neuronal activity. Techniques of interest include electrophysiology, behavior, optical imaging using 2P and 1P microscopy, molecular cloning, protein expression and purification, protein engineering, and biochemistry. Applicants are expected to be able to design and execute independent research projects.

A coterminous postdoctoral appointment in the Department of Cellular and Molecular Physiology in the Yale School of Medicine is anticipated. The John B. Pierce Laboratory offers excellent benefits with employer paid health insurance and free parking.

TO APPLY:

Please submit a single PDF file to pdneuro@jbpierce.org including:
1) A cover letter with a (brief) statement of research experience and interest, 2) Curriculum Vitae, and 3) A list of three references.

Job Code: VP010

The John B. Pierce Laboratory is an Equal Employment Opportunity employer that does not unlawfully discriminate in any of its programs or activities on the basis of race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity or expression, or on any other basis prohibited by applicable law.

Two postdoctoral positions in the fields of microbial pathogenesis and translational medicine are available immediately. Ph.D. and M.D./Ph.D. degree with prior experience in the fields of cellular, molecular biology, genetics and biochemistry is required. Yale University offers a competitive postdoctoral salary, a comprehensive benefits package, and an excellent work environment.

To apply please send a curriculum vitae, description of research experience, and three references to: Dr. Choukri Ben Mamoun, Professor of Medicine and Microbial Pathogenesis, Department of Internal Medicine, Section of Infectious Disease, Yale School of Medicine. TAC-S215, 300 Cedar Street, New Haven, CT 06520. Email: choukri.benmamoun@yale.edu.

The Hayman Lab, led by Thomas Hayman, MD, PhD, in the Department of Therapeutic Radiology at Yale University is recruiting a highly motivated and creative postdoctoral associate.  We are a cancer biology lab that is focused on utilizing genetic approaches to understand and exploit resistance mechanisms to DNA damage. 

Our research program has a particular interest in studying the interplay between the cell intrinsic immune machinery and DNA repair processes using in vitro cell models, genetic screens (such as CRISPR and RNA interference), and animal models.  We have a strong translational focus that is founded in a preclinical mechanistic understanding of basic biological processes with the ultimate goal of shaping these discoveries into therapeutic strategies for cancer patients.

We are seeking a candidate who will contribute to the discovery and translation of biological processes that modulate tumor responses to DNA damaging therapies (e.g. radiation) and immunotherapy.  Interested applicants should hold a PhD. or M.D. with considerable laboratory experience and a strong background in cancer biology, molecular biology, genetics, radiation biology or other related fields.  Prior experience with in vivo animal tumor models, CRISPR/Cas9, IF/IHC and DNA damage assays is highly desired, but not a requirement.  The candidate should be self-motivated and have a proven track record of productivity.  Excellent written and oral communication skills are expected. 

How to Apply:

Candidates should send a Curriculum Vitae, a cover letter detailing research interests and career goals, and contact information for three references to Dr. Thomas Hayman (thomas.hayman@yale.edu).