Yale Postdoctoral Positions

The Center for Industrial Ecology at Yale University has a Postdoctoral Scholar position available for a project involving the life cycle assessment of additive manufacturing. 3D printing is an emerging manufacturing technology that has gained increasing attention and interest in the industry and the industry itself is looking to improve its environmental footprint overall. The goal of this project is to understand the potential environmental impacts and economic implications of additive manufacturing compared to conventional manufacturing pathways. The postdoc will work with Prof. Marian Chertow and Prof. Yuan Yao.

The position will focus on:

1. Conducting environmental life cycle assessment (LCA) and life cycle cost analysis (LCC) for metal industrial parts manufactured by binder jetting 3D printing and conventional technologies (e.g., CNC).
2. Evaluating the potential environmental benefits of lightweighting and part geometry optimization.
3. Working with internal and external researchers in engineering, environmental science, and industrial ecology and leading the LCA for different additive manufacturing scenarios and technology pathways.

The ideal candidate should have a Ph.D. in Mechanical Engineering or other engineering disciplines with LCA and LCC experience in 3D printing and manufacturing technologies. Candidates with strong publications in relevant topics are highly encouraged.

Interested candidates should email a cover letter and their CV, along with relevant publications and a list of at least three references to Prof. Marian Chertow marian.chertow@yale.edu and Prof. Yuan Yao, y.yao@yale.edu. The position will be open until filled.

A postdoctoral position is available in the laboratory of Dr. Caroline H. Johnson at the Department of Environmental Health Sciences, Yale School of Public Health, Connecticut, USA. The applicant will use LC-MS-based metabolomics analysis to understand the role of dietary and microbial metabolites in colorectal cancer and related signaling pathways. The type of analysis will include preparation of biological samples, mass spectrometry analysis (QTOF), data processing and statistical analysis. The applicant can also be involved in the development of mechanistic studies under additional supervision.

Applicant skills

The individual must hold a Ph.D. degree in a Chemistry or Life Sciences discipline and have demonstrated experience in LC-MS-based metabolomics. Experience in R programming is desirable. The candidate will be expected to apply for additional external postdoctoral funding and assist in writing other grant applications.

Interested applicants should submit a CV, cover letter, and contact information for 3 references.

Please apply online: http://apply.interfolio.com/96418

For questions, please contact Dr. Johnson at caroline.johnson@yale.edu.

http://medicine.yale.edu/lab/cjohnson/

Daniel Vatner M.D., Ph.D. in the Yale School of Medicine Section of Endocrinology and Metabolism is looking to hire a highly motivated postdoctoral fellow to do exciting translational basic science studies, with an emphasis on in vivo physiology and molecular biology.  We investigate the physiology of the metabolic syndrome, studying numerous rodent models and human subjects with state of the art techniques.  We seek to understand the metabolic fluxes that drive excess triglyceride production in the setting of insulin resistance; additionally, in collaboration with other laboratories at the School of Medicine, we are investigating links between metabolic dysfunction and the progression of nonalcoholic fatty liver to NASH.  The postdoctoral fellow will work on projects both independently and in multi-laboratory collaborations (working alongside students, fellows, technicians, and other investigators).

Candidates for this position should be recent graduates with a PhD, MD, or equivalent degree.  Expectations include those important for growing the fellow’s research career, including presenting at meetings and preparing manuscripts, and those important for a properly-functioning laboratory, including participation in mouse colony maintenance and laboratory organization.

Interested applicants should send a cover letter briefly outlining research experiences, career goals, references, and expected availability date, along with a CV to daniel.vatner@yale.edu.

A postdoctoral position is available in the laboratory of Carson Thoreen in the Department of Cellular and Molecular Physiology at Yale School of Medicine. We are a multi-disciplinary lab that studies the mTOR signaling pathway, a master regulator of growth and metabolism. Our lab previously discovered how mTOR post-transcriptionally controls the ATF4 transcription factor, a master regulator of amino acid metabolism (Park et al. Cell Reports, 2017), and terminal oligopyrimidine (TOP) mRNAs, a conserved mRNA family that encode hundreds of essential proteins (Thoreen et al, Nature, 2012; Philippe et al., PNAS, 2020).

A position is currently available for creative and motivated RNA-loving candidates. Strong organizational and communication skills are a must. Proficiency in transcriptome-scale methodology, RNA biochemistry, and basic bioinformatics are desired. Available projects are focused on new mechanisms linking mRNA translation and stability, nutrient regulation of mRNA translation in the liver, and localized translation of mRNAs in neurons.

Applicants should email a current CV and cover letter describing research interests to carson.thoreen@yale.edu. Lab website: http://campuspress.yale.edu/thoreenlab.

The Reilly Lab in the Genetics Department Yale School of Medicine is seeking postdoctoral researchers for funded projects to understand how genetic variants impact human health, evolution, and disease. We seek to answer a fundamental question remaining in biology: “how do genetic changes lead to functional changes at the molecular, cellular, and phenotypic level?”

We’re especially interested in understanding the role of non-coding, cis-regulatory elements (CREs) in the genome, with a focus on variation within them. Genome-wide association studies have identified hundreds of thousands of genetic variants associated with human health and disease, but mechanistic traction has been limited. Similarly, natural selection is a powerful driver of human genetic variation between populations and may still impact modern traits or disease (e.g. height, sickle cell anemia).

The Reilly lab develops and applies new high-throughput experimental approaches to interrogate the genome, such as non-coding CRISPR screens and the Massively Parallel Reporter Assay, as part of our work in an ENCODE functional characterization center. Computationally, we also develop machine-learning approaches to predict the functions of these CRE perturbations. Together with these new tools, we use evolution as a powerful lens for characterizing genomic signals of positive selection that impact modern human phenotypes and diseases.

The lab has three main foci:

1. Developing new, large-scale experimental screens to perturb CREs, and new computational tools to model their function
2. Identifying evolutionary adaptive alleles likely impacting modern human phenotypes
3. Applying these functional genomic tools to phenotypically interesting loci important for human disease and evolution.

We’re looking for inquisitive, creative, and passionate researchers to join our team. We’re a multi-disciplinary group with a variety of backgrounds including genomics, math, biochemistry, machine-learning, and population genetics. Similar backgrounds are a good fit, but many PhD or MDs interested in human evolution, building new genomic tools, or analyzing complex data would find a project in our lab. The lab prides itself on building an inclusive, supportive, and collaborative environment, deeply committed to the tailored professional development of all of the lab’s trainees.

Interested applications should email Steve<mailto:steven.k.reilly@yale.edu>, briefly describing your scientific interests, how they intersect with our lab’s interests, and include your CV. Post-doctoral applicants should also submit a Diversity, Equity, and Inclusion statement and include copies of their major manuscripts.

Application Deadline: Applications are reviewed on a rolling basis and reviews will begin on October 1, 2021.

http://apply.interfolio.com/95240

Fellowship Overview

The Center for Methods in Implementation and Prevention Science (CMIPS) in the Yale School of Public Health and the Yale School of Medicine are seeking a Postdoctoral Research Fellow on Qualitative Methods for Implementation Science in Heart, Lung, and Blood Health Promotion to contribute to research advancing the use and development of qualitative methods in implementation science research. Expertise in implementation science theories, models and frameworks, and/or interest in gaining expertise in these and their application to implementation science are important aspects of this Fellowship. Current projects that may be of interest to applicants include (but are not limited to) qualitative and implementation science research on integration of hypertension screening and treatment into HIV clinics in Sub-Saharan Africa; reduction of cardiometabolic risk through improvements in the workplace food and physical activity environment in India, Nepal and South Africa; developing rapid approaches for qualitative research in global multilingual settings, a systematic review identifying trends and gaps in qualitative methods use in implementation research, and developing qualitative approaches to complement digital health technology implementation. The Fellow will have the opportunity to pursue a Masters in Health Science focused on implementation science through the Yale Medical School, supported by this training grant.

We invite scholars from diverse backgrounds to apply for this Fellowship. The Fellow should be prepared to address critical gaps in knowledge by 1) conducting research to inform the development, implementation, and evaluation of qualitative methods in intervention-based or implementation research focused on the prevention, screening and treatment of heart, lung and blood disorders, 2) innovating new and improved qualitative methodological approaches, and 3) provide technical assistance and training to other scholars, students, and communities in the use of qualitative  and implementation science approaches to research. The primary goal of the Fellowship is to support the further career development of a scholar with the potential to become an innovative research leader working to enhance qualitative and implementation science methods. We seek scholars who can publish at the highest level, reach the widest audience, and impact both their substantive topical field, and the methodological field. The postdoctoral fellow will receive mentorship and support from CMIPS, Yale School of Public Health and Yale Medical School leadership and staff and closely collaborate on projects.

Requirements

Required qualifications include a Ph.D. in public health, anthropology, sociology, or a related field. Candidates should demonstrate qualitative research skills, experience in qualitative data analysis, excellence in scientific written and oral communication skills, experience or training in qualitative methods, and a strong commitment and passion to advance methods innovation, appreciation for the importance of racial/ethnic diversity in science, and the desire and ability to work both independently and collaboratively as part of a team. Applicants must be US citizens or non-citizen nationals, or individuals lawfully admitted for permanent residence at the time of appointment. Additional details on citizenship requirements are available in the HHS Grants Policy Statement.

The position will be at least 1 year, renewed annually, for at least two years, as interest and funding permit. The position will begin as early as February 2022, but is flexible depending on the candidate’s timeline. 

To apply, please provide a cover letter outlining qualifications specific to this description, a paragraph outlining two potential ideas for qualitative methods innovation in health intervention research, your academic CV, and the names and emails of 3 individuals who could serve as references via the application portal. This is a 100% FTE position using the standard NIH postdoctoral position salary range.

Any questions related to the position can be directed to Professor Ashley Hagaman, Department of Social and Behavioral Sciences and Center for Methods in Implementation and Prevention Science, Yale School of Public Health, at ashley.hagaman@yale.edu..

Apply here: http://apply.interfolio.com/95240

Post-doctoral positions available for highly motivated and creative candidates to join the Mathieu Bakhoum Laboratory at Yale University School of Medicine.

Candidates with a background in cell biology, genetics, epigenetics or mouse work are highly encouraged to apply.

The Bakhoum laboratory (www.bakhoumlab.org) focuses on understanding mechanisms that drive metastasis in melanoma. Our goal is to translate this knowledge to develop non-invasive biomarkers for diagnosis and metastatic surveillance, and to identify targets that can be employed to treat the primary and metastatic disease.

Approaches utilized will include next-Generation sequencing, single-cell genomics, high-resolution imaging, mouse models, molecular cloning and biochemical assays.

Postdoctoral researchers will have direct access to state-of-the-art microscopy as well as world-class animal and core facilities. Furthermore, they will be part of a vibrant and collaborative scientific environment at Yale University.

Post-doctoral fellow candidates must hold a PhD., MD., or other equivalent doctoral degree and have strong laboratory and analytical skills.

All applications should be sent to mbakhoumlab@gmail.com and include the following items merged as a single-PDF file:

1) Cover letter (2-page maximum) indicating current and future research interests and expected availability dates;
2) Curriculum Vitae;
3) Reprints of up to two publications (optional);
4) Names of three references

A postdoctoral position is available in the laboratory of Dr. Abhijit Patel at the Yale Cancer Center and the Yale School of Medicine (www.patel-lab.org).  Our laboratory has a highly translational focus, with the overall goal of developing non-invasive diagnostic tools for early detection and surveillance of cancer.  We have developed innovative technologies to enable ultrasensitive measurement of cancer-associated genomic and epigenomic alterations in cell-free DNA in blood.  Most recently, we have developed methods for measuring genome-wide methylation signatures in blood to identify early-stage cancers or early recurrences after therapy.  In addition, this platform technology is generating rich whole-methylome datasets from which insights can be gained on tumor heterogeneity, clonal evolution, and therapeutic sensitivity/resistance.  Our lab is currently focused on establishing the clinical utility of these technologies and exploring potential new translational applications.

We seek a highly motivated individual with an interest in cancer genomics, epigenomics, and translational cancer research.  Candidates must have a strong research track record, and must hold a Ph.D. and/or M.D. degree.  A background in nucleic acid biochemistry, bioinformatics, and/or data science is advantageous, but we welcome talented applicants from all fields of biomedicine.  Researchers with a background in chemistry might find our lab to be a particularly good fit. 

If you would like to join our efforts to create new diagnostic tools with the ultimate goal of improving cancer outcomes, please send your CV and a brief cover letter to:  abhijit.patel@yale.edu

Selected candidates will be asked to provide contact information for telephone references. Interviews can be conducted in person or via Zoom, depending on geographic constraints.

Two postdoctoral associate positions are now available for enthusiastic individuals who are interested in studying protein tyrosine phosphatases and chemokine-GPCR’s. The projects involve 1) investigating the mechanisms of MAP kinase phosphatases as novel therapeutic targets for the treatment of human diseases such as metabolic disease, heart disease and cancer and 2) using mouse genetics to generate and characterize humanized chemokine and GPCR models of cancer. These projects will utilize chemical biology, structural biology, biochemical and mouse genetic techniques to define the molecular basis of MAP kinase phosphatase and chemokine-GPCR signaling. There are opportunities to study small molecules and other biological and cell-based therapeutics under development. The two individuals will be responsible for developing and maintaining an independent research project and will require expertise in either structural and chemical biology or biochemical and mouse genetic skills.The position will necessitate a high level of collaborative interactions with other research teams at Yale University in a multi-disciplinary environment. Support for academic enrichment and career development will be core to the postdoctoral research positions.

Successful candidates should have a Ph.D. with experience in mouse genetics, molecular biology, signaling, and biochemistry. Interested candidates that have a broad interest in intracellular signal transduction should send their CV and names of three references to:

Professors Anton M. Bennett, Ph.D. 

and Elias Lolis, Ph.D.

Yale University School of Medicine

Department of Pharmacology

333 Cedar Street

New Haven, CT 06520-8066

anton.bennett@yale.edu

elias.lolis@yale.edu

Postdoctoral Associate position in Stem Cell and Organoid Modeling for Dyslexia available in the Departments of Pediatrics, Genetics,the Yale Progam for Learning Disability Research, and the Yale Child Health Research Center at the Yale University School of Medicine. This is a position in a collaborative, multi-disciplinary laboratory studying the function of dyslexia genetic variants in neurons and brain organoids differentiated from human embryonic stem cells (hESCs). The Gruen lab uses genomic approaches including CRISPR/CAS to interrogate mechanisms of genes associated with learning disabilities, especially dyslexia, specific language impairment, and verbal trait disorders.

The current research focus is directed toward characterizing the role of dyslexia genes and variants: 1) in neuronal differentiation and migration; 2) knock-out/knock-down/knock-in models and their effects on transcription, neuronal stage-specific markers of differentiation, electrophysiologic properties, and conductivity; 3) cerebellar differentiation and cerebellar-cortical connections; and 4) in critical metabolic pathways that could be tested as potential small-molecule drug targets. These studies capitalize on the laboratory’s expertise in human genetics, stem cell biology, imaging-genetics, and computational methods.

Candidates should have a PhD with experience in stem cell biology, related areas of biology or genetics, and possess skills in stem cells and approaches to genomic editing. Candidates should understand the context and implications of the research so as to be able to interpret and apply the theoretical knowledge required to conduct these studies. The range of duties includes, but is not limited to: project planning, experimental design, developing methodology, conducting procedures, modifying procedures as needed, data collection and analysis, project management. The candidate will be expected to regularly develop and deliver presentations at lab meetings, and prepare publications and reports. Candidates will also have the opportunity to present to the larger Yale community and external scientific community through national and international meetings. Candidates with a strong interest in neurobehavioral genetics—including reading disability, attention deficit/hyperactivity disorder, and language impairment—are particularly encouraged to apply.

Postdoctoral positions are available in the Department of Internal Medicine Section of Infectious Diseases, (Priti Kumar, PI) at the Yale University, School.  Our lab conducts translational research with a focus on treatment of diseases caused by RNA viruses such as HIV-1, SARS-Cov2, and West Nile (https://medicine.yale.edu/profile/priti_kumar/).

We are looking for highly talented, creative, and independent-minded post-doc candidates to fit into any one of the major endeavors of the lab:

-Developing targeted in vivo delivery systems for CRISPR/Cas-based tools as gene therapy for HIV

-Investigating therapeutics for the cure of HIV in humanized mouse models of HIV infection

-Investigating interventions for the treatment of SARS-Cov2 in rodent models

The expertise/experiences required for this position include:

• Expertise in basic virology/molecular/cell biology/immunology techniques such as virus culture, neutralization detection, lentiviral vector production molecular cloning, cell culture, Western blot, flow cytometry, ELISA, protein expression and purification, knowledge of CRISPR technology, microscopy, etc.);
• Prior experience in working with animal model systems is highly desirable. Experience in generating humanized mouse models is a strong positive, but not a requirement. Relevant training is available upon hire.
• Previous experience working in BSL-3 laboratories is a plus;
• Basic statistical knowledge is highly desirable;
• Excellent oral communication and written skills in English, with good organizational and analytical abilities.

Candidates should have a Ph.D.  in Biological Sciences such as immunology, virology, biochemistry, molecular and cell biology, and other related fields. The salary will be according to NIH guideline, and commensurate with experience.

Applicants should submit (in a single PDF file) a brief letter of interest summarizing qualifications, a curriculum vitae, and the names and addresses of three individuals willing to provide letters of reference to Priti Kumar, PhD via email: priti.kumar@yale.edu

To understand the background of the Oktay laboratory’s theme, please refer to our recent publications in Science Translational Medicine, Scientific Reports and Journal of Clinical Oncology.   

1. Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, Dickler M, Robson M, Moy F, Goswami S, Oktay K. Sci Transl Med. 2013 Feb 13;5(172):172ra21. doi: 10.1126/scitranslmed.3004925
2. Turan V, Lambertini M, Lee DY, Wang E, Clatot F, Karlan BY, Demeestere I, Bang H, Oktay K. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. J Clin Oncol. 2021 Jun 20;39(18):2016-2024. doi: 10.1200/JCO.20.02880. Epub 2021 Apr 23. PMID: 33891474; PMCID: PMC8260903
3. Titus S, Szymanska KJ, Musul B, Turan V, Taylan E, Garcia-Milian R, Mehta S, Oktay K. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation. Sci Rep. 2021 Jan 11;11(1):407. doi: 10.1038/s41598-020-79643-x. PMID: 33431979; PMCID: PMC7801500.).

Education:  Leading NIH-funded laboratory in ovarian biology, aging, and fertility preservation is looking for a postdoctoral candidate with strong background in molecular biology. Experience with single-cell qRT-PCR and RNA sequencing, epigenomics, bisulfite sequencing techniques will be preferred. Interpersonal skills will be highly important as this is a multidisciplinary translational project.

Training:  The Postdoctoral Fellow will train and work on the role of DNA repair in oocyte aging as well as the relationship of BRCA and related mutations to reproductive and overall aging.

Mentoring:  Mentorship is provided by Kutluk Oktay, MD, PhD, Principal Investigator.

Those who feel strongly qualified can email a cover letter and a CV to Colleen.Goble@Yale.edu, Faculty & Staff Affairs Manager, Department of Obstetrics, Gynecology, and Reproductive Sciences.

The DNA Diagnostics Laboratory seeks highly motivated candidates for a position in cutting-edge translational human genomics.  The focus of this laboratory is application of high-throughput DNA and RNA sequencing technology for diagnosis of human disease.  Elements of this position include:

• Learning to interpret whole-exome and whole genome sequence data from patients with hereditary disorders including gaining skills with human-genetics databases, reviewing medical literature to identify and summarize evidence of pathogenicity for genetic variants, and becoming familiar with medical standards of care in reporting genetic tests to health care providers and patients
• Helping to assure accurate and efficient operation of the laboratory in the context of quality control regulations that guide clinical laboratories (e.g., CLIA)
• Participation in the development and validation of software for variant interpretation
• Independent development of new wet-lab or bioinformatic technologies for applications such as clinical use of RNAseq, long-read genomic sequencing, and epigenetic analysis.

Applicants must have a PhD and/or MD degree in genetics or bioinformatics with experience in human genetics.  Clear, concise written and oral communication with a multidisciplinary team will be an essential part of this job. Successful candidates should have keen organizational skills, attention to detail, and ability to work efficiently to complete projects within assigned deadlines.  This position provides an excellent background to those interested in a future fellowship in Laboratory Genetics and Genomics. 

Candidates should send a Curriculum Vitae, a personal statement of relevant background and future plans, and three references (include names / contact information) to: hui.zhang@yale.edu and allen.bale@yale.edu

The Division of Neurocritical Care in the Department of Neurology at Yale University is inviting applications for a two-to-three-year postdoctoral position with experience in one or more of the following: physiologic signal processing (e.g., EEG), image processing and machine learning methods. The applicant would be joining the lab of Dr. Jennifer A. Kim MD-PhD, which focuses on predicting complications and poor outcomes after acute brain injuries injuries, such as trauma, stroke or brain hemorrhage, using data from multiple diagnostic modalities.

The main goal of the research will be development of signal processing and/or image processing and machine learning methods for prediction of complications and poor outcomes after acute brain injury. The position will require both the processing of already collected datasets as well as assistance with the ongoing effort of establishing a larger data set of recordings and images, which may include some practical implementation, execution, storage, and transfer of new data.

Applicant must have a background in signal processing, or image processing and some experience in statistical modeling or machine learning methods. Programming experience in Matlab, Python and/or R is a prerequisite. Experience with EEG, other brain physiology recordings and/or MRI analyses is an advantage but not required. Experience with a range of machine learning methods including random forest and deep learning methods also an advantage, but not required.

Good oral and written English communication skills, the ability to work both independently and as part of a team, is a prerequisite. Candidates must be self-motivated. Responsibilities will include design, implementation and dissemination of research including data processing, modeling, and drafting manuscripts.

This appointment as a postdoctoral researcher requires academic qualifications at the PhD or MD level, preferably in Computational Neuroscience, Engineering, Bio/Statistics, Computer Science, or related areas.

To apply: Please send an email with your CV, contact information for 3 references, and cover letter to: Sara.jasak@yale.edu

The Girgenti Laboratory at Yale University is recruiting a behavioral neuroscience post-doctoral position, available in the fall.

Research in the Girgenti lab is directed at determining the molecular pathologies underlying stress disorders such post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and suicidal behavior. We are looking for an enthusiastic and motivated postdoctoral researcher to take a key role in planning and executing both behavioral and basic neuroscience experiments. Major projects in the lab include translational neuroscience projects designed to derive biological meaning from large-scale genomic findings and characterize the behavioral and molecular mechanisms of stress disorders. Trainee-led projects are also encouraged, and there are ample opportunities for growth in the lab and at Yale.  We have world class collaborations locally, nationally, and abroad to support an exciting and rich training experience. Please reach out if you have any questions.

Required Qualifications

• A Ph.D. and relevant research experience in neuroscience or related fields (e.g. Biological Psychology, Behavioral Neuroscience, Pharmacology).
• Highly organized and extremely reliable.
• Prior experience working with mice and rats and conducting behavioral studies, and also have technical experience with rodent surgery (e.g. stereotaxic, catheterization). Special consideration will be given to those with experience in behavioral models of chronic and traumatic stress and anxiety.

To apply:

Please send an email with your CV, contact information for 3 references, and cover letter to: Dr. Matt Girgenti (matthew.girgenti@yale.edu) using the subject line: Postdoctoral applicant: Your name. Applicants are encouraged to outline research projects of interest.

More information about our labs can be found at: https://medicine.yale.edu/profile/matthew_girgenti/.

The Yale Psychology Department is pleased to announce a postdoctoral scholar position in honor of Professor Susan Nolen-Hoeksema that has been endowed by her husband, Richard Nolen-Hoeksema. The Susan Nolen-Hoeksema Postdoctoral Associate in Integrative Psychology is for a two-year period. Eligible applicants must have a PhD in Psychology or a related field by June 30 of the year in which the appointment begins. Applications in any area of psychology are encouraged, especially from candidates with research interests that are integrative across areas and levels of analysis and applicable to one or more domains of psychopathology or its treatment (i.e., areas in which Professor Nolen-Hoeksema took special interest).

Applicants for the position, to begin July 1, 2022, should identify one or more Yale faculty member(s) with whom they desire to work during the term of the appointment, and include a personal statement, curriculum vitae, reprints of selected papers, and letters of recommendation from two to three individuals familiar with the applicant’s research background and promise. Review of applications will begin on December 1, 2021 and continue until the position is filled.

Applications should be submitted via Interfolio: http://apply.interfolio.com/90895

For questions please contact Jessica Hermann, Senior Administrative Assistant, Jessica.hermann@yale.edu

The Wilson laboratory in the Section of Medical Oncology and the Yale Cancer Center is seeking highly-motivated candidates for a postdoctoral position.  Interests in the laboratory focus on identifying and characterizing genetic vulnerabilities in cancer and molecular mechanisms of drug resistance with an emphasis on lung cancer therapeutics (https://medicine.yale.edu/bbs/people/frederick_wilson-1.profile). The lab leverages genome-scale CRISPR-based functional genomic screening platforms to identify genetic cancer vulnerabilities and to dissect resistance mechanisms in relevant cancer cell models.  The lab also applies DNA- and RNA-based next-generation sequencing technologies to identify candidate driver gene alterations and other potentially actionable genomic features from patient tumor specimens.  Mechanistic studies are then leveraged in cell model systems to assess the functional impact of identified genetic alterations.  A major priority is to translate laboratory findings into therapeutic strategies for patients with advanced lung and other cancers.

A major emphasis in the laboratory is to provide scientific mentorship through regular meetings with the principal investigator and opportunities for professional development in a supportive and collaborative environment.  An important goal is for the postdoc to generate a body of scientific work leading to a first-author peer-reviewed publication.
 
Applicants must have experience in molecular biology, genetics / genomics, cancer biology, or other related field in the biological sciences.  The candidate must have a recent PhD or MD/PhD degree in a relevant field with a proven track record of scientific productivity including at least one first author publication in a peer-reviewed journal.  Excellent written and oral communication skills are expected.  The candidate will be expected to work independently in the design and execution of experiments with guidance from the principal investigator.  As projects in the laboratory are often highly collaborative, the candidate should be able to work effectively and enthusiastically in a team environment.
 
Candidates should send a Curriculum Vitae, a statement of research interests and career goals, and names / contact information for three references to: frederick.wilson@yale.edu.
 

The Yale/Yale New Haven Hospital Center for Outcomes Research and Evaluation (CORE) is a leading national outcomes research center dedicated to transforming healthcare for the betterment of people and society by leveraging data, analytics, and technology. We have assembled a talented, multidisciplinary group who are committed to developing solutions to the practical needs of medicine and healthcare. Our organization combines the highest academic ideals with a pragmatic approach that emphasizes the production of useful knowledge. We are distinguished by our creativity, dedication, experience, and skills – and our commitment to having our work make a tangible difference to patients, the public, and society. For additional information on CORE, please visit our website: www.medicine.yale.edu/core.

CORE is recruiting a Postdoctoral Associate for its ongoing research program in computational health. The program is recruiting candidates with coding experience in Python and R, with a specific background in analytics on large relational datasets and the electronic health record (EHR). The specific skills include masters or doctoral training in computer science/informatics with an understanding of basics of informatics, and distributed computing with Spark (using Python or R). Successful candidates will participate in a range of research projects spanning various disease conditions with the opportunity to work with leading investigators in the space working on the next generation of knowledge generation in medicine. Career development will be supported through scholarly contributions, including research publications and presentations at national meetings. A PhD or equivalent is a requirement for this position; a background in healthcare analytics is preferred, but not required. The position is currently being offered for 2 years, with the option for extending beyond that time. The renumeration for the position is in line with Yale’s institutional standards.

Interested applicants should send a brief statement of interest and curriculum vitae with contact information for three references to kendall.getek@yale.edu.

A postdoctoral position is available for a highly motivated graduate student to join a productive and collaborative research group working on the genetics of psychiatric illness – especially PTSD and substance use disorders. Work will focus on (1) genetics of posttraumatic stress disorder, depression and anxiety, substance use disorders, and many related psychiatric traits in the uniquely-informative Million Veteran Program dataset; and (2) Psychiatric Genomics Consortium projects including these traits, and (3) studies in non-European populations. Through these and several other current projects, we explore large datasets including the Million Veteran Program and the Psychiatric Genomics Consortium. Other projects include a pharmacogenomics clinical trial for depression taking place in the VA system; a study of methamphetamine genetics in Thailand; a new mental health biobank project in the MVP; and studies of epigenetics of psychiatric traits.

The ideal candidate should hold an MD or PhD, and have a strong background in human genetics, including knowledge of genomewide methods, including GWAS and post-GWAS analysis; and comfort with bioinformatics. The candidate should also be able to work cooperatively with peers at Yale and with many other collaborators nationally and internationally; and bring research to publication. Faculty in our closely-collaborative division at Yale School of Medicine includes Drs Renato Polimanti, Janitza Montalvo-Ortiz, and Daniel Levey. Start date is flexible. Applicants should preferably have US citizenship or permanent residency.

Please send application (including CV and contact information for at least three references) by email to Prof. Joel Gelernter at joel.gelernter@yale.edu<mailto:joel.gelernter@yale.edu>

We are looking for a postdoctoral associate to join a collaborative project between the laboratories of Dr. Liang Liang and Dr. Michael Crair in the Department of Neuroscience at Yale School of Medicine. The project will focus on understanding how neural activity contributes to the establishment of thalamic visual function during development. The Liang lab has established an advanced in vivo imaging platform for studying the detailed functional and spatial organization of the visual thalamus in adult mice. The Crair lab has extensive experience imaging and manipulating neural activity in early postnatal mice, and has identified characteristic spatiotemporal patterns of retinal activity that guide neural circuit development. The postdoctoral associate is expected to bridge strengths from both labs to unveil the mechanisms underlying the development of functional selectivity in the early visual system. This position is funded by a Kavli Institute Innovative Research Award. The candidate is expected to lead the project and will be co-mentored by Dr. Liang Liang and Dr. Michael Crair.

An ideal applicant will be someone who can demonstrate the following:

Essential

• The candidate should be in his/her last year of a PhD program in Neuroscience, Biology or related field, or within 1 year of receiving his/her PhD degree. 
• An outstanding record of research and scholarly activity.
• A demonstrable commitment to scientific discovery.
• Be creative, thoughtful, strongly self-driven and well organized.
• Have skills and experience in advanced neurophysiological techniques and quantitative data analysis.
• Have skills and experience with complex surgery in model organisms.

Desirable

• A good track record of securing fellowship and research funding.
• In-depth knowledge of a programing language.
• A good knowledge of the visual system.
• Have skills and experience in two-photon calcium imaging and image processing

Interested candidates should contact Dr. Liang Liang (liang.liang@yale.edu) and Dr. Michael Crair (michael.crair@yale.edu). The application should include: (1) CV; (2) A brief description of research interests and motivation; (3) Contact information for 3 references.

Research in the Konnikova group is directed at studying the development and maintenance of mucosal immunity at barrier sites such as the intestine and placenta. We are interested in understanding how homeostasis is established and maintained in humans and what goes awry to cause disease such as necrotizing enterocolitis and inflammatory bowel disease in relationship to intestinal health and preterm labor in case of placental biology. We are seeking a motivated and dynamic postdoctoral candidate to join our team who is interested in applying cutting edge techniques including mass cytometry and single cell RNA sequencing in combination with cell biology and organoid approaches to studying development of human mucosal immunity at barrier sites. My group has access to the CyTOF and genomics cores at Yale as well as state-of-the-art cell and molecular imaging facilities. During this time, the successful applicant will obtain further training in translational research, in vivo model systems and a range of immunological techniques.

The candidate will be expected to have an MD, PhD, or MD/PhD with experience in immunology. Preference to candidates with involvement in human immunology will be given, but it is not a requirement. The successful candidate will be self-motivated and have the capacity for independent evaluation of the literature. Prior knowledge in primary cell isolation, flow cytometry, imaging techniques and single cell techniques would be an added benefit. For more information on our group, please visit our website – www.konnikovalab.com.

Interested applicants should send a brief statement of interest and curriculum vitae with contact information for three references to the Principal Investigator, Dr. Liza Konnikova – liza.konnikova@yale.edu.

The Damsky lab in the Department of Dermatology is seeking a postdoctoral associate. Broadly, our group studies the immunology of inflammatory skin diseases and novel treatment approaches. More specifically, our interests include:

• Understanding basic mechanisms of inflammation in the skin
• Evaluating novel therapies in clinical trials with translational immunologic components that teach us how a targeted intervention alters the underlying immune response
• Current disease areas include atopic dermatitis, psoriasis, sarcoidosis, alopecia areata, other inflammatory alopecias, granuloma annulare, and others.
• We also have active projects to evaluate novel molecular diagnostics to inform personalized disease selection in these areas
• We are also developing new murine models of skin inflammation

Depending on the applicant’s specific interests there would be an opportunity to take a leading role in multiple areas.

Qualifications

• PhD in relevant fields such as immunobiology, cellular biology, or molecular biology
• Experience in cell culture, flow cytometry, and other cellular methods
• Experience with basic molecular techniques, experience with RNAseq, scRNAseq, ATAC-seq a plus but not required
• Experience with immunofluorescence staining of tissue and fluorescence microscopy a plus but not required
• Experience with data analysis in R a big plus, if not, a willingness to learn
• Experience working with mice a plus but not required

Interested candidates should email a CV to:

william.damsky@yale.edu

We are looking to hire immediately and will review applications as they are received, continuing until the position is filled.

Our group is interested in comparative analyses of normal lymphocyte development and malignant transformation towards leukemia. We cover research areas with relevance to Immunology, Hematology and Cancer Biology. Our research involves experiments with primary human leukemia cells, normal lymphocyte development in humanized mice, leukemia and stem cell transplantation models, mouse genetics, gene editing, genetic biosensors of signal transduction, optogenetics, classical molecular and cell biology, a strong emphasis on mechanistic studies in oncogenic signal transduction. We strive to promote a culture of diversity and inclusivity for all its members, focusing on career development and innovative approaches to science.

Qualifications: PhD in cell or molecular biology, enthusiasm for science, willingness to think beyond established concepts and to try and learn new experimental and analytical tools. The lab takes a team science approach, being collaborative is important as well.

Your application should include in one single PDF:

CV, brief motivation statement, coordinates of three scientific mentors (references)

Methods/Techniques: Flow cytometry, mass spectrometry/quantitative phosphoprofiling, genetic biosensors of signal transduction, optogenetics, mouse genetics, bone marrow transplantation assays, retroviral gene delivery, whole exome sequencing and RNA-seq-analysis of clonal evolution of leukemia, pre-clinical drug testing in xenotransplantation models.

Recent work of the laboratory: To prevent the production of harmful autoantibodies and autoimmune disease, autoreactive B-cells and pre-malignant clones are eliminated by a process termed negative selection. Despite strict and rigorous negative selection, B-cells frequently give rise to autoimmune diseases and B-cell malignancies such as leukemia and lymphoma. Since humans can live without B-cells for extended periods of time, the Müschen laboratory systematically investigated lineage-specific vulnerabilities that are common in B-cell leukemia/lymphoma but not any other cell type. Contrary to the established dogma, these mechanisms are not only active in preventing autoimmune disease but also represent a novel class of therapeutic oncogenic targets in malignant B-cell tumors. Over the past five years, the Müschen Laboratory established innovative conceptual frameworks for the understanding of B-cell signaling mechanisms and negative selection, some of which are summarized below:

·      We discovered regulation of energy-abundance as the central determinant of negative B-cell selection: Hyperactivation of kinases downstream of an autoreactive B-cell receptor induces ATP-depletion and energy stress (Chen Nature 2015, Shojaee Nature Med 2016, Chan Nature 2017; Pan PNAS 2020).

·      Studying changes of energy-metabolism during B-cell transformation, we discovered that glucose carbon-flux was diverted in a way that left transformed B-cells uniquely vulnerable to inhibition of PP2A, an enzyme that coordinates glycolytic flux with antioxidant protection (Xiao Cell 2018).

·      We discovered that changes in cell-size are orchestrated by BCL6 and MYC. Opposed by MYC, BCL6 decreases cell-size by transcriptionally repressing glucose-uptake in favor of autophagy (Duy Nature 2012; Geng Cancer Cell 2015; Hurtz Genes & Dev 2019).

·      Tracking mechanisms of leukemia-initiation in 1,100 patients, we discovered pathway convergence as a novel therapeutic vulnerability in B-ALL. Only mutations that converged on one central pathway promoted leukemia progression. Genetic reactivation of divergent (suppressed) pathways engaged conflicting biochemical and transcriptional programs and subverted leukemia development. Pharmacological pathway reactivation to create a diverse signaling environment represents a novel strategy to prevent B-ALL relapse and drug-resistance (Chan Nature 2020).

·      Studying biophysical mechanisms of B-cell activation, we discovered that the short endosomal protein IFITM3 acts as a central scaffold for lipid-raft assembly and surface-expression of rafts-associated receptors. Membrane-recruitment of IFITM3 was essential for the initiation of PI3K-signaling, antibody affinity maturation and oncogenic B-cell transformation (Lee Nature 2020).

https://medicine.yale.edu/lab/muschen/

http://www.hhmi.org/scientists/markus-muschen

A postdoctoral position is available immediately to study a novel tumor-targeting antibody for cancer therapy. Research in the lab is focused on developing novel approaches to cancer therapy by exploiting synthetic lethal vulnerabilities and leveraging tumor targeting strategies and fundamental mechanistic studies of cancer biology. Recent publications include Sulkowski Nature 2020 (PMID: 32494005) and Kaplan Science Translational Medicine 2019 (PMID: 31092693).

We offer a dynamic and stimulating work environment for conducting cutting-edge research and for facilitating career development. Interested candidates should have a strong research track record. While prior experience in cancer biology, molecular biology, and mouse tumor models is advantageous, we welcome researchers from all biomedical research backgrounds.

Qualified candidates should send their CV and contact information for at least two references to Peter Glazer, Departments of Therapeutic Radiology and Genetics, Yale School of Medicine at: peter.glazer@yale.edu

Yale School of Medicine, Section of Digestive Diseases is looking to hire a highly motivated Postdoctoral Associate to drive innovative translational research forward in the field of colorectal cancer. The post-doctoral associate will work under the supervision of Dr. Xavier Llor and Dr. Rosa Xicola on human oriented research projects aimed at understanding several colorectal cancer aspects including disparities, early age of onset, and hereditary forms. The projects encompass a range of aspects that include organoid harvesting and growth, molecular biology, and large data set curation and analysis. The individual will also manage the high-risk registry database. The post-doctoral associate should be able to work independently as well as in a team of translational researchers in the lab and along with other, postdocs, clinical staff, fellows and students. The major experimental tools that will be used include: tissue harvesting and organoid establishment, cell line growth, next-generation sequencing, and data set management and analysis.

Job Qualification:

1. A recent graduate or about to graduate with an MD, MD-PhD, or a PhD in the field of biology or similarly related fields.

2. Experience with translational work is preferred but not necessary.

3. Knowledge of major molecular biology techniques

3. Candidate should be willing to write independent funding applications after first few years of their post-doctoral position with the goal for a career as independent investigator.

The individual will be expected to make a significant contribution to the educational and research missions of the section. There will be opportunities to work on projects autonomously while working collaboratively with faculty, staff, post docs, and students. Supervision of other research personnel and other related duties will be expected. It is an excellent opportunity to learn about biomarker work in the context of clinical medicine and interventional trials.

Review of applications will begin immediately and will continue until the position is filled.  To apply, please submit a cover letter in the body of an email and CV/references as attachments to stacy.giangrande@yale.edu

Yale University and Boehringer Ingelheim are seeking applications for Postdoctoral Researchers for a newly launched Biomedical Data Science Fellowship, which is a three-year full-time program. Applicants with strong biomedical data science background and research experience are invited to submit research proposals for consideration. If approved for a fellowship, they will be jointly mentored throughout the research process by Yale’s faculty and scientists from Boehringer Ingelheim. Fellows will not only have access to Yale’s robust computational resources, biomedical data repositories and faculty expertise, but also benefit from access to Boehringer Ingelheim’s corporate labs, scientists and executives. In addition to receiving research funding and mentorship, program fellows will be invited to participate in campus and corporate visits, networking events, and annual symposia.

A joint selection committee comprising representatives of Yale and Boehringer Ingelheim will set annual data-driven research themes for the program. These themes may include such topics as genomic analysis, biomarkers, data-driven therapeutic research, medical image informatics, precision medicine, and translational medicine. The selection committee will consider proposed research projects’ alignment with prioritized themes in judging submissions and post-doctoral applicants.

The ideal candidate will have earned a PhD degree in the area of, computational biology, bioinformatics, data science, or relevant scientific disciplines, as well as excellent computing skills.

They will have demonstrated analytical and communication skills, including the ability to effectively describe scientific material to both specialized and lay audiences, and strong CVs, preferably having published in high-impact journals and presented at international meetings.

Applicants should submit current CV, short summary of past accomplishments, project proposal that includes a detailed research plan, summary of how the submitted project proposal aligns with the Theme, and a statement of how the Program aligns with your educational and career goals. All information from the applicant should be submitted electronically through https://medicine.yale.edu/cbds/bdsfellowship/application/

The program will be based at the Center for Biomedical Data Science (CBDS) in New Haven, Connecticut. The center is an essential part of a growing data science hub at Yale University, which has identified integrated data science as one of its primary investment areas over the next decade. CBDS is located within Yale School of Medicine and currently supports faculty members and researchers representing such disciplines as bioinformatics, modeling, statistics, computer science, artificial intelligence, mathematics, biology, precision medicine, and public health.

Compensation is competitive and includes health insurance and other benefits afforded to postdoctoral associates at Yale.

Submission deadline: June 21, 2021 12:00am (ET) Review of applications will begin immediately.

Notification to applicants: July 19, 2021

Program start date: September 1, 2021

For more information see https://medicine.yale.edu/cbds/bdsfellowship/            

For questions concerning this search, please contact cbds@yale.edu

The Yale Child Study Center Bereavement Project is seeking a Postdoctoral Associate to support a grant funded program which provides training and resources for healthcare professionals on topics related to child and family bereavement. The postdoctoral associate’s primary responsibilities will include (1) adapting training materials and developing curricula for various healthcare audiences on topics including (but not limited to) grief theory, child grief, parental grief, perinatal grief, traumatic grief, and how this impacts healthcare professionals, (2) delivering virtual and in-person trainings to nursing students, medical students, residents, fellows, and faculty (3) tracking and evaluating trainings delivered, (4) researching national climate of grief training in medical settings and applying these findings to further adaptations of the curriculum. Under the leadership of Dr. Amanda Lowell (project director) and Dr. Linda Mayes (PI and director of the Yale Child Study Center), the postdoctoral associate will also have a unique opportunity to select and engage in additional research and/or clinical opportunities of interest.

Qualified candidates are those who have recently completed a PhD in psychology, social work, psychiatric nursing, or related field. Competitive applicants will have demonstrated experience in program development, particularly in university health systems. Preference will be given to candidates with prior experience providing trainings, and those with interest in pediatrics and/or grief. Applicants must have strong interpersonal and public speaking skill, as well as the ability to work both independently and collaboratively. Applicants must be citizens or permanent residents of the United States. Applicants need not be licensed in a clinical discipline, as some opportunity for supervised clinical experience will be available if desired.

The position may start remotely in accordance with Yale University guidance around COVID-19 until the university resumes regular on campus operations, which is planned for August 1, 2021 and as determined by the business needs of the department.Review of applications will begin immediately and continue until the position is filled.

In accordance with university requirements for a safe return to in-person university operations, all faculty, staff, and postdoctoral and postgraduate trainees will be required to be fully vaccinated against COVID-19 by August 1. For additional information, please visit  https://your.yale.edu/work-yale/workplace-guidance/workplace-guidance-faqs

To apply, please send a single PDF documenting the following to amanda.lowell@yale.edu

1. Cover letter

2. Curriculum vitae

3. Names and contact information of three academic or clinical references familiar with the applicant’s skills and experience (reference letters are not needed at this time)