Title of the Position: Postdoctoral Associate/Fellow
Department and School: Department of Neurosurgery, Yale School of Medicine
Anticipated Appointment Dates: Start date flexible (Review of applications begins immediately)
Email/Website: tanyeri.barak@yale.edu
Introduction of School/Department
The Department of Neurosurgery at the Yale School of Medicine is a world-renowned center for clinical excellence and cutting-edge research. The Department fosters a highly collaborative environment, integrating genomic, transcriptomic, and proteomic strategies to unravel the molecular mechanisms of neurological disorders. Prospective researchers will join a vibrant academic community dedicated to innovation and mentorship.
Overview of the Position
The Barak Lab is seeking a highly motivated Postdoctoral Associate/Fellow to join our team focused on the molecular and cellular mechanisms of cerebrovascular disorders (including Intracranial Aneurysms, Moyamoya Disease, Vascular Malformations). Our lab heavily utilizes multiomic techniques and various model systems—including iPSC-derived blood vessel organoids, patient-derived models, and model organisms—to dissect the molecular landscape of the pathology.
Education:
The appointee will receive advanced training designed to transition them into an independent investigator role. For candidates pursuing a career in academia or industry, this position offers critical experience in project management, grant writing, and scientific communication. The training provided in the Barak Lab will build upon the appointee’s doctoral research, expanding their expertise into high-throughput omics and translational vascular biology.
Training:
The appointee will receive comprehensive hands-on training in state-of-the-art technologies. While strong experience in routine wet lab techniques is required, the Barak Lab offers unique opportunities to learn and apply:
- Gene discovery with Whole Exome Sequencing (WES) analysis in a large patient-cohort.
- Single and spatial transcriptomics/proteomics/epigenomics.
- Generation and maintenance of iPSC-derived blood vessels and cortical organoids.
- 3D bioprinting of vascular tissues for disease modeling.
- Phenotypic and mechanistic characterization of cerebrovascular disorders using zebrafish and mouse models.
Mentoring:
The Postdoctoral Associate/Fellow will
- Participate in weekly one-on-one meetings with the Principal Investigator to discuss data, experimental design, and career goals.
- Present research findings at weekly lab meetings and departmental seminars.
- Collaborate closely with a multidisciplinary team of neurosurgeons, bioinformaticians, and biologists.
- Receive guidance on manuscript preparation and grant application writing.
Location:
Barak Lab is located within the Department of Neurosurgery at the Anlyan Center, Yale School of Medicine, New Haven, CT.
Appointment Terms:
Postgraduate/Postdoctoral appointments are typically one-year appointments with the possibility of annual renewal based on performance and funding availability.
Qualifications
Minimum Qualifications:
- Ph.D., M.D./Ph.D., or M.D. in Vascular Biology, Cell Biology, Immunology or a related field.
Preferred Qualifications & Experience:
- Proficiency in standard molecular biology techniques (Western blotting, PCR, immunostaining) and cell culture is essential.
- Demonstrated experience in vascular biology functional assays or immune cell characterization is highly desirable.
- A strong willingness to learn and troubleshoot novel protocols, specifically iPSC differentiation, organoid development and 3D bioprinting.
Process to Apply
Deadline to apply:
Rolling basis; position remains open until filled.
Required Documents:
Interested candidates should submit the following materials in a single PDF:
- Cover Letter: Briefly describe your research background, scientific interests, and why you are interested in joining the Barak Lab.
- Curriculum Vitae (CV): Including a full list of publications and technical skills.
- References: Names and contact information for three references.
Submission:
Please email materials to tanyeri.barak@yale.edu with the subject line “Barak Lab Postdoc Application – [Your Last Name]”.