The Department of Pathology at Yale School of Medicine is an internationally recognized leader in molecular and cellular pathology, disease mechanisms, and translational research. Our faculty pursue fundamental discoveries in neurobiology, immunology, and therapeutic innovation through interdisciplinary collaboration and advanced imaging and molecular technologies.
The Ramakrishnan Laboratory invites applications for a Postgraduate Associate position in Aging and Neuropathology. Our group investigates how aging reprograms protein synthesis, vesicle biogenesis, secretion, and turnover in neuronal and neuroendocrine systems. The position lies at the interface of neuroscience, cell biology, and bioengineering and is conducted in close collaboration with Dr. Roshan Gunasekara (Neurology) and Dr. Pallavi Gopal (Pathology). The project integrates human iPSC-derived neuronal models, extracellular vesicle (EV) biogenesis and uptake, advanced imaging, and quantitative biophysics to understand EV-uptake mediated intercellular propagation of neuropathology. The appointment provides strong research training for recent graduates preparing for Ph.D., M.D./Ph.D., or M.D., programs in neuroscience, molecular biology, or related disciplines.
Education:
The trainee will gain comprehensive exposure to cellular and molecular neuroscience. Using human iPSC-derived neuronal and disease models, the project examines how EV uptake influences neuronal communication, stress response, and degeneration. The trainee will use high-content cellular screening, advanced imaging methods, and microfluidic platforms that enable controlled studies of neural interactions within defined circuitries. This integrative framework contributes to the development of next-generation human models of neuronal aging and neuropathology, designed to resolve how genetic variants, cell types, and molecular functions intersect in disease-relevant contexts.
Training:
The Postgraduate Associate will assist the Principal Investigator in ongoing studies. The trainee will support daily research operations, perform bench-level experiments, maintain cultures, and contribute to data analysis and figure preparation. Under close mentorship, the trainee will develop expertise in iPSC neuronal differentiation, EV isolation and uptake assays, advanced microscopy, microfluidics, 3D bioprinting of neural organoids, while learning to communicate findings through presentations and written reports.
Mentorship:
Working across the Ramakrishnan, Gunasekara, and Gopal groups provides cross-disciplinary mentorship (Pathology and Neurology), access to complementary expertise and core facilities, and expanded networking with basic scientists and clinicians. The trainee will have opportunities to coordinate experiments between labs, present in joint lab meetings, help standardize SOPs, and mentor high school and undergraduate students. These practical leadership experiences strengthen future graduate/medical school applications.
Qualifications:
A Bachelor’s or Master’s degree in Cell Biology, Neuroscience, Biomedical Engineering, or a related field is required. Prior research experience in neuronal cell culture and imaging is preferred. The ideal candidate will demonstrate strong organizational and communication skills and intellectual curiosity. The ability to work effectively within a team and across collaborative laboratories is essential.
Appointment Details:
Full-time, one-year appointment with the possibility of renewal based on performance. Research conducted at the Nanobiology Institute, Yale School of Medicine (West Campus). Competitive Yale compensation and benefits for Postgraduate Associates. Start date: Immediate.
Application Instructions:
To apply, please send the following materials to Dr. Sathish Ramakrishnan at sathish.ramakrishnan@yale.edu. Include “Post-graduate Associate” in the subject of the email. Include your CV and a cover letter stating your motivation for pursuing the opportunity, your research interests and experience, and your formal qualifications. The CV should include the contact information of 2-3 referees.