Title of the Position: Post-doc working on infectious neurodegenerative disease (Transmissible spongiform encephalopathy, TSE)
Department and School: Department of Surgery
Anticipated Appointment Dates: 11.01.2025
Email/Website: laura.manuelidis@yale.edu https://medicine.yale.edu/lab/manuelidis/
Introduction of School/Department:
The Yale School of Medicine’s mission is to cultivate collaborative excellence by educating leaders and researchers in medicine and science, advancing discovery, while its vision is to elevate the next generation of medical and scientific leaders through a diverse, inclusive, and innovative community that improves the health of all people. This is achieved through fostering curiosity, partnership, and the open exchange of knowledge to enhance health outcomes in local, national, and global communities.
Overview of the Position:
The project covers 3 related approaches whose overarching aim is to discover the essential molecular components and minimal structural form of the TSE infectious agent:
- What molecules can be removed from the infectious TSE-particle to produce a more purified essential particle versus what treatments lead to a significant loss of titer?
- Structural analyses and characterization of integral proteins in selected purified agent particle preparations.
- Sequential dissociation of molecules in the highest titer infectious particles purified in 1 & 2 above.
The PI, lab associates and close colleagues (faculty and fellows) will do the training. EHS will supply any additional required training.
The candidate will participate in weekly group lab meetings, other small seminars of relevance in addition to large lectures (several a week) from the Medical School, biological, and medical science departments.
The candidate will have the opportunity to attend national meetings and present data.
The training takes place in the Yale Medical School, Department of Surgery, Section of Neuropathology in BML and FMB.
Qualifications:
- Ph.D. in medical, biological, chemical science, preferably in neurodegeneration, infectious disease and/ or molecular biology or similar
- Experience in Tissue Culture
- Experience with standard procedures (Western blotting, qPCR, protein assays…) and microscopy (e.g., confocal…)
- Experience in viral and protein science (e.g. infectivity assays)
- Curious and motivated mindset
Process to Apply:
- Deadline: 10.31.2025
- Required document: cover letter, CV, publication list and contact information of two references
- Please send to: laura.manuelidis@yale.edu