Postdoctoral Position, Yale University, USA
The Nicoli Lab (Scan QR Code) is seeking a highly motivated Postdoctoral Researcher with expertise in RNA biology to inves:gate localized mRNA processes—such as selective translation, transport, phase separation, and localization—that enable cells to respond to mechanical stimuli.
This project will explore RNA-based regulatory mechanisms in mechanotransduction, aiming to understand how the regulation of mRNAs influences cell behavior in response to extracellular matrix and blood flow-induced hemodynamics. Ultimately, our goal is to uncover how mRNA can serve as a building block for tissue engineering and regenerative therapies, with applications in stem cell development, wound healing, and cardiovascular disease treatment.
Key Responsibilities
Design and conduct experiments on post-transcriptional mRNA regulation in the context of cell biology and tissue ex-vivo and in vivo mechanotransduction.
Investigate RNA-mediated processes governing cellular responses to mechanical cues.
Utilize advanced molecular and imaging techniques to study RNA localization and function.
Collaborate within a multidisciplinary team at the intersection of RNA biology and biomechanics.
Present findings in scientific conferences and author top notch publications.
Qualifications:
- PhD in Molecular Biology, RNA Biology, Biophysics, or a related field.
- Strong background in RNA biology, gene regulation, or mechanotransduction.
- Experience with RNA imaging, ribosome profiling, or related transcriptomic techniques.
- Excellent problem-solving skills and ability to work independently.
If you are excited about unraveling RNA-driven mechanisms in cellular responses to mechanical forces, we encourage you to apply!
To apply, please send your CV, a brief cover letter, and contact information for three references to stefania.nicoli@yale.edu.