Postdoctoral Associate, Yale School of Medicine in Genetics-Computational (Lake Lab)

Posting Date: 

We are seeking a motivated, passionate postdoctoral scientist to join our growing and dynamic team in the Yale Center of Genomic Health and Department of Genetics, Yale School of Medicine. Our lab uses computational and functional genomics methods to determine how genetic variation in our mitochondria underlies health and disease. This work has implications across rare and common diseases, and other processes such as development and aging. We also prioritize translating our research into practical tools that benefit research and clinical communities.

We are looking for a computational postdoctoral scientist to spearhead the development and application of methods for assessing the functional and clinical impact of genetic variation, focusing on mitochondrial genomics, and highly value diversity of backgrounds in our team. We seek candidates who can commit to a multiyear appointment, reviewed annually. The start date can be flexible, and as soon as January 2024.

The lab is located in the Department of Genetics in the Yale School of Medicine which offers an outstanding training environment for postdoctoral scientists, with state-of-the-art research facilities and vast resources to support professional development. For more information about our lab, past publications, and our research see our website:


  • Design, plan, and perform research analyses on large-scale genomics datasets
  • Develop new algorithms and pipelines for analyzing human genetic variation
  • Prepare high-impact manuscripts for publication and conference presentations
  • Attend and present at lab meetings, journal clubs, and departmental seminars
  • Contribute to the mentoring of students and junior scientists in the lab
  • Assist in the preparation of grant proposals
  • Maintain code and pipelines, and support lab operations as needed
  • Positively contribute to our collaborative, communicative, and collegial lab culture

Mentoring & Professional Development

The Lake Lab has a strong emphasis on mentorship and values the opportunity to train future leaders in genetics research. The Principal Investigator will work with the successful candidate to develop and implement a mentorship plan tailor-made for their goals, interests, and needs, and provide ongoing support for the advancement of research and career goals via regular meetings. Dedicated mentorship will also be provided for fellowship applications, preparation of manuscripts, scientific presentations, and developing skills for independence. 

The successful candidate will also gain access to a wide range of career development opportunities at Yale. This includes Yale seminars from internationally renowned researchers and ‘Meet the Speaker’ lunches, the Genetics Postdoctoral Mentoring Program which pairs postdocs with additional faculty mentors, as well as professional development and networking activities via the Yale Postdoctoral Association, Yale Office for Career Strategy, and other offices at Yale.


Candidates should have or be close to obtaining a PhD in either genetics, genomics, computational biology, bioinformatics, or a related field.

Experience with programming languages and the command line interface is required. Experience with one or more of the following is desired: machine learning methods, statistical genetics, large-scale genomic analyses, cloud computing, and single-cell and or bulk sequencing analysis.

The ideal candidate will also demonstrate:

  • A high level of drive and initiative, and track record of impactful research outcomes
  • Experience writing manuscripts published in peer-reviewed journals
  • Ability to work both independently and as part of a team
  • Eagerness to learn and establish new methods, and good problem-solving skills
  • Excellent communication skills, both written and verbal
  • Desire to contribute to the mentorship of students and junior scientists in the lab
  • Experience in, or strong understanding of, human genetics research.

Application Instructions

To apply, please email Dr. Nicole Lake at using the subject ‘Postdoctoral Application-Lake Lab’ and include (1) a cover letter summarizing your experiences, research interests, and career goals, and why you are interested in pursuing a postdoc in our lab, (2) your CV, including contact details of three references, and (3) when you are available to start.

For further information and inquiries about this position, please contact Dr. Lake and or visit the lab website at

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

Job Type: 
Academic Jobs - Yale
Posting Date Field: 
Monday, December 4, 2023